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  1. Article ; Online: TRP channels in COVID-19 disease: Potential targets for prevention and treatment.

    Jaffal, Sahar M / Abbas, Manal A

    Chemico-biological interactions

    2021  Volume 345, Page(s) 109567

    Abstract: Coronavirus disease 2019 [COVID-19] is a global health threat caused by severe acute respiratory syndrome coronavirus 2 [SARS-CoV2] that requires two proteins for entry: angiotensin-converting enzyme 2 [ACE2] and -membrane protease serine 2 [TMPRSS2]. ... ...

    Abstract Coronavirus disease 2019 [COVID-19] is a global health threat caused by severe acute respiratory syndrome coronavirus 2 [SARS-CoV2] that requires two proteins for entry: angiotensin-converting enzyme 2 [ACE2] and -membrane protease serine 2 [TMPRSS2]. Many patients complain from pneumonia, cough, fever, and gastrointestinal (GI) problems. Notably, different TRP channels are expressed in various tissues infected by SARS-CoV-2. TRP channels are cation channels that show a common architecture with high permeability to calcium [Ca
    MeSH term(s) COVID-19/drug therapy ; COVID-19/metabolism ; COVID-19/prevention & control ; Humans ; Molecular Targeted Therapy ; Transient Receptor Potential Channels/metabolism
    Chemical Substances Transient Receptor Potential Channels
    Language English
    Publishing date 2021-06-22
    Publishing country Ireland
    Document type Journal Article ; Review
    ZDB-ID 218799-1
    ISSN 1872-7786 ; 0009-2797
    ISSN (online) 1872-7786
    ISSN 0009-2797
    DOI 10.1016/j.cbi.2021.109567
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    Zs.A 686: Show issues Location:
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  2. Article ; Online: Interaction of the synthetic cannabinoid WIN55212 with tramadol on nociceptive thresholds and core body temperature in a chemotherapy-induced peripheral neuropathy pain model.

    Haddad, Mansour / Alsalem, Mohammad / Saleh, Tareq / Jaffal, Sahar M / Barakat, Noor A / El-Salem, Khalid

    Neuroreport

    2023  Volume 34, Issue 8, Page(s) 441–448

    Abstract: Chemotherapy-induced peripheral neuropathy (CIPN) is a significant adverse effect of many anticancer drugs. Current strategies for the management of CIPN pain are still largely unmet. The aim of this study is to investigate the antinociceptive potential ... ...

    Abstract Chemotherapy-induced peripheral neuropathy (CIPN) is a significant adverse effect of many anticancer drugs. Current strategies for the management of CIPN pain are still largely unmet. The aim of this study is to investigate the antinociceptive potential of combining tramadol with the synthetic cannabinoid WIN55212, and to evaluate their associated adverse effects, separately or in combination, in a CIPN rat model, and to investigate their ability to modulate the transient receptor potential vanilloid 1 (TRPV1) receptor activity. Von Frey filaments were used to determine the paw withdrawal threshold in adult male Sprague-Dawley rats (200-250 g) following intraperitoneal (i.p) injection of cisplatin. Single cell ratiometric calcium imaging was used to investigate WIN55212/tramadol combination ability to modulate the TRPV1 receptor activity. Both tramadol and WIN55212 produced dose-dependent antinociceptive effect when administered separately. The lower dose of tramadol (1 mg/kg) significantly enhanced the antinociceptive effects of WIN55212 without interfering with core body temperature. Mechanistically, capsaicin (100 nM) produced a robust increase in [Ca 2+ ] i in dorsal root ganglia (DRG) neurons ex vivo . Capsaicin-evoked calcium responses were significantly reduced upon pre-incubation of DRG neurons with only the highest concentration of tramadol (10 µM), but not with WIN55212 at any concentration (0.1, 1 and 10 µM). However, combining sub-effective doses of WIN55212 (1 µM) and tramadol (0.1 µM) produced a significant inhibition of capsaicin-evoked calcium responses. Combining WIN55212 with tramadol shows better antinociceptive effects with no increased risk of hypothermia, and provides a potential pain management strategy for CIPN.
    MeSH term(s) Rats ; Male ; Animals ; Tramadol/pharmacology ; Rats, Sprague-Dawley ; Capsaicin/pharmacology ; Calcium ; Nociception ; Body Temperature ; Pain ; Peripheral Nervous System Diseases/chemically induced ; Peripheral Nervous System Diseases/drug therapy ; Cannabinoids/pharmacology ; Antineoplastic Agents/pharmacology ; Analgesics/pharmacology ; Analgesics/therapeutic use ; Ganglia, Spinal
    Chemical Substances Tramadol (39J1LGJ30J) ; Capsaicin (S07O44R1ZM) ; Calcium (SY7Q814VUP) ; Cannabinoids ; Antineoplastic Agents ; Analgesics
    Language English
    Publishing date 2023-04-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1049746-8
    ISSN 1473-558X ; 0959-4965
    ISSN (online) 1473-558X
    ISSN 0959-4965
    DOI 10.1097/WNR.0000000000001910
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  3. Article ; Online: Antinociceptive action of Achillea biebersteinii methanolic flower extract is mediated by interaction with cholinergic receptor in mouse pain models.

    Jaffal, Sahar M / Abbas, Manal A

    Inflammopharmacology

    2018  Volume 27, Issue 5, Page(s) 961–968

    Abstract: Achillea biebersteinii is a perennial aromatic herb that grows in the Mediterranean area. The leaves of this plant are used in foods as bittering and appetizing agents. In folk medicine, it is used for the treatment of stomachache and abdominal pain. In ... ...

    Abstract Achillea biebersteinii is a perennial aromatic herb that grows in the Mediterranean area. The leaves of this plant are used in foods as bittering and appetizing agents. In folk medicine, it is used for the treatment of stomachache and abdominal pain. In this study, the analgesic effect of A. biebersteinii methanolic flower extract was tested in three pain models, namely: writhing, tail-flick and paw-licking (formalin) tests. A. biebersteinii extract inhibited abdominal cramps produced by acetic acid. The effect of A. biebersteinii was better than that of 70 mg/kg indomethacin. In tail flick, A. biebersteinii extract increased latency at 30 min and was as effective as 100 mg/kg diclofenac sodium. In formalin test, A. biebersteinii extracts decreased paw-licking and flinching response in early and late phases. Atropine blocked the action of A. biebersteinii extract (300 mg/kg) in the late phase of formalin test as well as in writhing and tail-flick tests. GC-MS analysis revealed that ascaridole and iso-ascaridole were the main constituents of A. biebersteinii flower extract. In conclusion, this study shows for the first time that the antinociceptive effect of A. biebersteinii is mediated by the cholinergic receptor.
    MeSH term(s) Achillea/chemistry ; Analgesics/pharmacology ; Animals ; Disease Models, Animal ; Female ; Flowers/chemistry ; Methanol/chemistry ; Mice ; Mice, Inbred BALB C ; Pain/drug therapy ; Pain/metabolism ; Pain Measurement/methods ; Phytotherapy/methods ; Plant Extracts/pharmacology ; Plant Leaves/chemistry ; Receptors, Cholinergic/metabolism
    Chemical Substances Analgesics ; Plant Extracts ; Receptors, Cholinergic ; Methanol (Y4S76JWI15)
    Language English
    Publishing date 2018-09-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1080058-x
    ISSN 1568-5608 ; 0925-4692
    ISSN (online) 1568-5608
    ISSN 0925-4692
    DOI 10.1007/s10787-018-0524-7
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  4. Article ; Online: Anti-nociceptive effect of Arbutus andrachne L. methanolic leaf extract mediated by CB1, TRPV1 and PPARs in mouse pain models.

    Jaffal, Sahar M / Oran, Sawsan A / Alsalem, Mohammad

    Inflammopharmacology

    2020  Volume 28, Issue 6, Page(s) 1567–1577

    Abstract: Arbutus andrachne L. is a medicinal plant that grows in Jordan and has many valuable effects. In the present study, the anti-nociceptive effect of A. andrachne methanolic leaf extract was determined in mice using thermal and chemical tests. Our findings ... ...

    Abstract Arbutus andrachne L. is a medicinal plant that grows in Jordan and has many valuable effects. In the present study, the anti-nociceptive effect of A. andrachne methanolic leaf extract was determined in mice using thermal and chemical tests. Our findings show that different doses of A. andrachne extract reduced the number of writhings significantly compared to control group. The leaf extract also reduced the time of paw licking in the early and late phases of formalin test. In all the conducted tests, 300 mg/kg body wt. was the best effective dose. A peroxisome proliferator-activated receptor alpha (PPARα) antagonist reversed the action of the plant extract in the early phase of formalin test while antagonists of the PPARα, PPAR gamma (PPARγ) and cannabinoid 1 (CB1) receptors were responsible for abolishing its effect in the late phase of this test. Also, the extract administration increased the latency time in hot plate and tail flick, an effect that was reversed by the antagonists of PPARγ, CB1 and transient receptor potential vanilloid 1 (TRPV1). No effect was noticed for α
    MeSH term(s) Analgesics/pharmacology ; Animals ; Anti-Inflammatory Agents/pharmacology ; Disease Models, Animal ; Ericaceae/chemistry ; Male ; Methanol/chemistry ; Mice ; Mice, Inbred BALB C ; PPAR gamma/metabolism ; Pain/drug therapy ; Pain/metabolism ; Pain Management/methods ; Plant Extracts/pharmacology ; Plant Leaves/chemistry ; Receptor, Cannabinoid, CB1/metabolism ; TRPV Cation Channels/metabolism
    Chemical Substances Analgesics ; Anti-Inflammatory Agents ; PPAR gamma ; Plant Extracts ; Receptor, Cannabinoid, CB1 ; TRPV Cation Channels ; TRPV1 protein, mouse ; TRPV1 receptor ; Methanol (Y4S76JWI15)
    Language English
    Publishing date 2020-09-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1080058-x
    ISSN 1568-5608 ; 0925-4692
    ISSN (online) 1568-5608
    ISSN 0925-4692
    DOI 10.1007/s10787-020-00746-y
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  5. Article ; Online: Gastroprotective activity of

    Abbas, Manal A / Kandil, Yasser I / Disi, Ahmad M / Jaffal, Sahar M

    Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme

    2019  Volume 44, Issue 12, Page(s) 1283–1288

    Abstract: Loranthus ... ...

    Abstract Loranthus acaciae
    MeSH term(s) Animals ; Cyclooxygenase 2/metabolism ; Esomeprazole/pharmacology ; Ethanol/adverse effects ; Female ; Flowers/chemistry ; Gastric Mucosa/drug effects ; Glutathione/analysis ; Loranthaceae/chemistry ; Plant Extracts/pharmacology ; Rats ; Rats, Wistar ; Rutin ; Stomach Ulcer/chemically induced ; Stomach Ulcer/drug therapy
    Chemical Substances Plant Extracts ; Ethanol (3K9958V90M) ; Rutin (5G06TVY3R7) ; Cyclooxygenase 2 (EC 1.14.99.1) ; Ptgs2 protein, rat (EC 1.14.99.1) ; Glutathione (GAN16C9B8O) ; Esomeprazole (N3PA6559FT)
    Language English
    Publishing date 2019-04-22
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2236708-1
    ISSN 1715-5320 ; 1715-5312
    ISSN (online) 1715-5320
    ISSN 1715-5312
    DOI 10.1139/apnm-2019-0166
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Antinociceptive Action of

    Jaffal, Sahar M. / Al-Najjar, Belal O. / Abbas, Manal A. / Oran, Sawsan A.

    Balkan medical journal

    2020  Volume 37, Issue 4, Page(s) 189–195

    Abstract: Background: Moringa peregrina (M. peregrina): Aims: To study the antinociceptive effects of the leaf extract of : Study design: Animal experimentation.: Methods: We employed thermal (hot plate and tail-immersion tests) and chemical (writhing ... ...

    Abstract Background: Moringa peregrina (M. peregrina)
    Aims: To study the antinociceptive effects of the leaf extract of
    Study design: Animal experimentation.
    Methods: We employed thermal (hot plate and tail-immersion tests) and chemical (writhing and formalin tests) pain models in male BALB/c mice (eight animals per group) to investigate the mechanisms involved in the antinociceptive actions of
    Results: In the writhing test, 200 mg/kg of
    Conclusion: Interaction with the α
    MeSH term(s) Analgesics/therapeutic use ; Animals ; Disease Models, Animal ; Mice, Inbred BALB C ; Moringa ; Pain/drug therapy ; Pain Management/methods ; Pain Management/standards ; Pain Management/statistics & numerical data ; Plant Extracts/therapeutic use ; Receptors, Adrenergic, alpha-2/therapeutic use
    Chemical Substances Analgesics ; Plant Extracts ; Receptors, Adrenergic, alpha-2
    Language English
    Publishing date 2020-03-04
    Publishing country Turkey
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2612982-6
    ISSN 2146-3131 ; 2146-3123
    ISSN (online) 2146-3131
    ISSN 2146-3123
    DOI 10.4274/balkanmedj.galenos.2020.2019.11.14
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Cough reflex hypersensitivity: A role for neurotrophins.

    El-Hashim, Ahmed Z / Jaffal, Sahar M

    Experimental lung research

    2017  Volume 43, Issue 2, Page(s) 93–108

    Abstract: Cough is one of the most common complaints for which sufferers seek medical assistance. However, currently available drugs are not very effective in treating cough, particularly that which follows an upper respiratory tract infection. Nonetheless, there ... ...

    Abstract Cough is one of the most common complaints for which sufferers seek medical assistance. However, currently available drugs are not very effective in treating cough, particularly that which follows an upper respiratory tract infection. Nonetheless, there has been a significant increase in our understanding of the mechanisms and pathways of the defensive cough as well as the hypersensitive/pathophysiological cough, both at airway and central nervous system (CNS) levels. Numerous molecules and signaling pathways have been identified as potential targets for antitussive drugs, including neurotrophins (NTs). NTs belong to a family of trophic factors and are critical for the development and maintenance of neurons in the central and peripheral nervous system including sympathetic efferents, sensory neuron afferents, and immune cells. Nerve growth factor (NGF) was the first member of the NT family to be discovered, with wide ranging actions associated with synapse formation, survival, proliferation, apoptosis, axonal and dendritic outgrowth, expression and activity of functionally important proteins such as ion channels, receptors, and neurotransmitters. In addition, NGF has been implicated in several disease states particularly neuropathic pain and most recently in the sensitization of the cough reflex. This review will briefly address the peripheral and central sensitization mechanisms of airway neurons and will then focus on NGF signaling and its role in cough hypersensitivity.
    Language English
    Publishing date 2017-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 603791-4
    ISSN 1521-0499 ; 0190-2148
    ISSN (online) 1521-0499
    ISSN 0190-2148
    DOI 10.1080/01902148.2017.1290162
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    Zs.A 1568: Show issues Location:
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  8. Article: Gastroprotective activity of Loranthus acaciae flower extract in a rodent model of ethanol-induced ulcer

    Abbas, Manal A / Kandil, Yasser I / Disi, Ahmad M / Jaffal, Sahar M

    Applied physiology, nutrition and metabolism. 2019, v. 44, no. 12

    2019  

    Abstract: Loranthus acaciae (Loranthaceae) is a perennial green semi-parasitic plant used in ethnopharmacological medicine for healing wounds. The protective effect of L. acaciae on gastric ulcer induced by ethanol was investigated in a rat model. Ulcer index and ... ...

    Abstract Loranthus acaciae (Loranthaceae) is a perennial green semi-parasitic plant used in ethnopharmacological medicine for healing wounds. The protective effect of L. acaciae on gastric ulcer induced by ethanol was investigated in a rat model. Ulcer index and total glutathione level were measured and histological and immunohistochemical studies for the expression of cyclooxygenase-2 were performed. Furthermore, chemical constituents of the flower extract were analyzed. Ulcer index was significantly lowered in L. acaciae-treated groups. Protection ratios were 75.9%, 98.9%, and 70.7% for 250 mg/kg and 500 mg/kg of L. acaciae and 40 mg/kg of esomeprazole, respectively. Histological examination revealed fewer hemorrhage in mucosa and less edema in submucosa of L. acaciae-treated groups compared with control. In the esomeprazole-treated group, there was mild disruption in the surface epithelium and mild hemorrhage. However, edema and leucocytes infiltration in the submucosa layer were present. Immunohistochemical staining of stomach sections for cyclooxygenase-2 (COX-2) was negative in the control group as well as in the L. acaciae-treated groups. Total glutathione level in mucosa layer of the stomach was higher in L. acaciae-treated groups compared with control. Liquid chromatography-mass spectrometric analysis revealed the presence of loranthin and rutin as the major constituents. It can be concluded that L. acaciae imparted a gastroprotective action against ethanol-induced ulcer in rats. Novelty 500 mg/kg L. acaciae protected the stomach by 98.9% from ulcerogenic effect of ethanol. L. acaciae increased total glutathione level but not COX-2 expression in gastric mucosa. Loranthin and rutin were the major constituents in L. acaciae flower extract.
    Keywords Loranthus ; animal models ; chemical composition ; edema ; ethanol ; flower extracts ; gastric mucosa ; glutathione ; hemorrhage ; immunohistochemistry ; leukocytes ; liquid chromatography ; prostaglandin synthase ; protective effect ; rats ; rutin ; staining ; stomach ulcers ; traditional medicine
    Language English
    Size p. 1283-1288.
    Publishing place NRC Research Press
    Document type Article
    ZDB-ID 2236708-1
    ISSN 1715-5320 ; 1715-5312
    ISSN (online) 1715-5320
    ISSN 1715-5312
    DOI 10.1139/apnm-2019-0166
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: The role of adenosine receptor ligands on inflammatory pain: possible modulation of TRPV1 receptor function.

    Haddad, Mansour / Alsalem, Mohammad / Aldossary, Sara A / Kalbouneh, Heba / Jaffal, Sahar M / Alshawabkeh, Qusai / Al Hayek, Sa'ed / Abdelhai, Omar / Barakat, Noor A / El-Salem, Khalid

    Inflammopharmacology

    2022  Volume 31, Issue 1, Page(s) 337–347

    Abstract: Chronic pain has a debilitating consequences on health and lifestyle. The currently available analgesics are often ineffective and accompanied by undesirable adverse effects. Although adenosine receptors (AR) activation can affect nociceptive, ... ...

    Abstract Chronic pain has a debilitating consequences on health and lifestyle. The currently available analgesics are often ineffective and accompanied by undesirable adverse effects. Although adenosine receptors (AR) activation can affect nociceptive, inflammatory, and neuropathic pain states, the specific regulatory functions of its subtypes (A
    MeSH term(s) Rats ; Male ; Animals ; Rats, Sprague-Dawley ; Calcium/metabolism ; TRPV Cation Channels ; Chronic Pain ; Receptors, Purinergic P1 ; Antineoplastic Agents
    Chemical Substances TRPV1 receptor ; Calcium (SY7Q814VUP) ; TRPV Cation Channels ; Receptors, Purinergic P1 ; Antineoplastic Agents ; Trpv1 protein, rat
    Language English
    Publishing date 2022-12-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1080058-x
    ISSN 1568-5608 ; 0925-4692
    ISSN (online) 1568-5608
    ISSN 0925-4692
    DOI 10.1007/s10787-022-01127-3
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  10. Article ; Online: The desensitization of the transient receptor potential vanilloid 1 by nonpungent agonists and its resensitization by bradykinin.

    Alsalem, Mohammad / Aldossary, Sara A / Haddad, Mansour / Altarifi, Ahmad / Kalbouneh, Heba / Azab, Belal / Mustafa, Ayman G / Jaffal, Sahar M / El-Salem, Khalid

    Neuroreport

    2020  Volume 31, Issue 11, Page(s) 781–786

    Abstract: Transient receptor potential vanilloid type-1 (TRPV1) channels have crucial roles in inflammatory hyperalgesia. Different inflammatory mediators can modulate TRPV1 sensitization. Bradykinin is an algogenic substance released at the site of inflammation. ... ...

    Abstract Transient receptor potential vanilloid type-1 (TRPV1) channels have crucial roles in inflammatory hyperalgesia. Different inflammatory mediators can modulate TRPV1 sensitization. Bradykinin is an algogenic substance released at the site of inflammation. The aim of the present study is to investigate the desensitization of TRPV1 receptor by nonpungent agonists and to determine how bradykinin and prostaglandin E2 receptors (EP3 and EP4) modulate the resensitization of TRPV1 receptor after being desensitized by nonpungent agonists. Tail flick test was used to investigate capsaicin-induced thermal hyperalgesia and the desensitization of TRPV1 by the nonpungent agonists (olvanil and arvanil) in male BALB/c mice weighed (22-25 g). Resensitization of TRPV1 by bradykinin and the role of prostaglandin receptors in mediating sensitization of TRPV1 were also investigated. Intraplantar injection of capsaicin (0.3 µg) produced a robust thermal hyperalgesia in mice, while olvanil (0.3 µg) or arvanil (0.3 µg) produced no hyperalgesia, emphasizing their lack of pungency. Olvanil and arvanil significantly attenuated capsaicin-induced thermal hyperalgesia in mice. Bradykinin significantly reversed the desensitizing effects of arvanil, but not olvanil. EP4 but not EP3 receptors mediate the sensitization of TRPV1 By bradykinin in vivo. The present study provides evidence for a novel signaling pathway through which bradykinin can regulate the TRPV1 ion channel function via EP4 receptor.
    MeSH term(s) Animals ; Bradykinin/metabolism ; Capsaicin/analogs & derivatives ; Capsaicin/pharmacology ; Hyperalgesia/chemically induced ; Hyperalgesia/metabolism ; Male ; Mice ; Mice, Inbred BALB C ; Nociception/physiology ; Receptors, Prostaglandin E, EP3 Subtype/metabolism ; Receptors, Prostaglandin E, EP4 Subtype/metabolism ; Sensory System Agents/pharmacology ; TRPV Cation Channels/metabolism
    Chemical Substances Receptors, Prostaglandin E, EP3 Subtype ; Receptors, Prostaglandin E, EP4 Subtype ; Sensory System Agents ; TRPV Cation Channels ; TRPV1 protein, mouse ; arvanil ; olvanil (4P7KIU7003) ; Capsaicin (S07O44R1ZM) ; Bradykinin (S8TIM42R2W)
    Language English
    Publishing date 2020-07-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1049746-8
    ISSN 1473-558X ; 0959-4965
    ISSN (online) 1473-558X
    ISSN 0959-4965
    DOI 10.1097/WNR.0000000000001485
    Database MEDical Literature Analysis and Retrieval System OnLINE

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