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  1. Article: HIT the nail on the head.

    Ashraf, Sara / Jafri, Mohammad Ali Syed

    Stem cell investigation

    2017  Volume 4, Page(s) 63

    Language English
    Publishing date 2017-07-17
    Publishing country China
    Document type Case Reports
    ZDB-ID 2884645-X
    ISSN 2313-0792 ; 2306-9759
    ISSN (online) 2313-0792
    ISSN 2306-9759
    DOI 10.21037/sci.2017.06.09
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  2. Article ; Online: Utilization of a Virtual Tumor Board for the Care of Patients With Renal Masses: Experience From a Quality Improvement Collaborative.

    Hijazi, Mahmoud A / Prebay, Zachary J / Johnson, Anna / Wilder, Samantha / Patel, Amit / Mehra, Rohit / Montie, James E / Noyes, Sabrina L / Mirza, Mahin / Jafri, Mohammad / Weizer, Alon / Sarle, Richard / Ghani, Khurshid R / Rogers, Craig / Lane, Brian R

    Urology practice

    2023  Volume 10, Issue 4, Page(s) 380–388

    Abstract: Introduction: Multidisciplinary tumor board meetings are useful sources of insight and collaboration when establishing treatment approaches for oncologic cases. However, such meetings can be time intensive and inconvenient. We implemented a virtual ... ...

    Abstract Introduction: Multidisciplinary tumor board meetings are useful sources of insight and collaboration when establishing treatment approaches for oncologic cases. However, such meetings can be time intensive and inconvenient. We implemented a virtual tumor board within the Michigan Urological Surgery Improvement Collaborative to discuss and improve the management of complicated renal masses.
    Methods: Urologists were invited to discuss decision-making for renal masses through voluntary engagement. Communication was performed exclusively through email. Case details were collected and responses were tabulated. All participants were surveyed about their perceptions of the virtual tumor board.
    Results: Fifty renal mass cases were reviewed in a virtual tumor board that included 53 urologists. Patients ranged from 20-90 years old and 94% had localized renal mass. The cases generated 355 messages, ranging from 2-16 (median 7) per case; 144 responses (40.6%) were sent via smartphone. All urologists (100%) who submitted to the virtual tumor board had their questions answered. The virtual tumor board provided suggestions to those with no stated treatment plan in 42% of cases, confirmed the physician's initial approach to their case in 36%, and offered alternative approaches in 16% of cases. Eighty-three percent of survey respondents felt the experience was "Beneficial" or "Very Beneficial," and 93% stated increased confidence in their case management.
    Conclusions: Michigan Urological Surgery Improvement Collaborative's initial experience with a virtual tumor board showed good engagement. The format reduced barriers to multi-institutional and multi-disciplinary discussions and improved the quality of care for selected patients with complex renal masses.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Humans ; Middle Aged ; Young Adult ; Kidney/pathology ; Kidney Neoplasms/surgery ; Quality Improvement ; Surveys and Questionnaires ; Urologists
    Language English
    Publishing date 2023-04-04
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ISSN 2352-0787
    ISSN (online) 2352-0787
    DOI 10.1097/UPJ.0000000000000399
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  3. Article ; Online: Role of miRNAs in human cancer metastasis: Implications for therapeutic intervention.

    Jafri, Mohammad Alam / Al-Qahtani, Mohammed Hussein / Shay, Jerry William

    Seminars in cancer biology

    2017  Volume 44, Page(s) 117–131

    Abstract: Metastasis is the spread and growth of localized cancer to new locations in the body and is considered the main cause of cancer-related deaths. Metastatic cancer cells display distinct genomic and epigenomic profiles and almost universally an aggressive ... ...

    Abstract Metastasis is the spread and growth of localized cancer to new locations in the body and is considered the main cause of cancer-related deaths. Metastatic cancer cells display distinct genomic and epigenomic profiles and almost universally an aggressive pathophysiology. A better understanding of the molecular mechanisms and regulation of metastasis, including how metastatic tumors grow and survive in the nascent niche and the interactions of the emergent metastatic cancer cells within the local microenvironment may provide tools to design strategies to restrict metastatic dissemination. Aberrant microRNAs (miRNA) expression has been reported in metastatic cancer cells. MicroRNAs are known to regulate divergent and/or convergent metastatic gene pathways including activation of reprogramming switches during metastasis. An in-depth understanding of role of miRNAs in the metastatic cascade may lead to the identification of novel targets for anti-metastatic therapeutics as well as potential candidate miRNAs for cancer treatment. This review primarily focuses on the role of miRNAs in the mechanisms of cancer metastasis as well as implications for metastatic cancer treatment.
    MeSH term(s) Gene Expression Regulation, Neoplastic ; Genomics ; Humans ; MicroRNAs/genetics ; Neoplasm Metastasis/genetics ; Neoplasm Metastasis/therapy ; Neoplasms/genetics ; Neoplasms/pathology ; Neoplasms/therapy
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2017
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 1033980-2
    ISSN 1096-3650 ; 1044-579X
    ISSN (online) 1096-3650
    ISSN 1044-579X
    DOI 10.1016/j.semcancer.2017.02.004
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  4. Article ; Online: Reply by Authors.

    Hijazi, Mahmoud A / Prebay, Zachary J / Johnson, Anna / Wilder, Samantha / Patel, Amit / Mehra, Rohit / Montie, James E / Noyes, Sabrina L / Mirza, Mahin / Jafri, Mohammad / Weizer, Alon / Sarle, Richard / Ghani, Khurshid R / Rogers, Craig / Lane, Brian R

    Urology practice

    2023  Volume 10, Issue 4, Page(s) 389

    Language English
    Publishing date 2023-05-04
    Publishing country United States
    Document type Journal Article
    ISSN 2352-0787
    ISSN (online) 2352-0787
    DOI 10.1097/UPJ.0000000000000399.03
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  5. Article ; Online: Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies.

    Jafri, Mohammad A / Ansari, Shakeel A / Alqahtani, Mohammed H / Shay, Jerry W

    Genome medicine

    2016  Volume 8, Issue 1, Page(s) 69

    Abstract: Telomeres maintain genomic integrity in normal cells, and their progressive shortening during successive cell divisions induces chromosomal instability. In the large majority of cancer cells, telomere length is maintained by telomerase. Thus, telomere ... ...

    Abstract Telomeres maintain genomic integrity in normal cells, and their progressive shortening during successive cell divisions induces chromosomal instability. In the large majority of cancer cells, telomere length is maintained by telomerase. Thus, telomere length and telomerase activity are crucial for cancer initiation and the survival of tumors. Several pathways that regulate telomere length have been identified, and genome-scale studies have helped in mapping genes that are involved in telomere length control. Additionally, genomic screening for recurrent human telomerase gene hTERT promoter mutations and mutations in genes involved in the alternative lengthening of telomeres pathway, such as ATRX and DAXX, has elucidated how these genomic changes contribute to the activation of telomere maintenance mechanisms in cancer cells. Attempts have also been made to develop telomere length- and telomerase-based diagnostic tools and anticancer therapeutics. Recent efforts have revealed key aspects of telomerase assembly, intracellular trafficking and recruitment to telomeres for completing DNA synthesis, which may provide novel targets for the development of anticancer agents. Here, we summarize telomere organization and function and its role in oncogenesis. We also highlight genomic mutations that lead to reactivation of telomerase, and mechanisms of telomerase reconstitution and trafficking that shed light on its function in cancer initiation and tumor development. Additionally, recent advances in the clinical development of telomerase inhibitors, as well as potential novel targets, will be summarized.
    MeSH term(s) Adaptor Proteins, Signal Transducing/genetics ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; DNA Helicases/genetics ; Enzyme Inhibitors/pharmacology ; Enzyme Inhibitors/therapeutic use ; Humans ; Mutation ; Neoplasms/diagnosis ; Neoplasms/drug therapy ; Neoplasms/genetics ; Nuclear Proteins/genetics ; Promoter Regions, Genetic ; Telomerase/antagonists & inhibitors ; Telomerase/genetics ; Telomere/drug effects ; Telomere/physiology ; Telomere Homeostasis ; X-linked Nuclear Protein
    Chemical Substances Adaptor Proteins, Signal Transducing ; Antineoplastic Agents ; DAXX protein, human ; Enzyme Inhibitors ; Nuclear Proteins ; TERT protein, human (EC 2.7.7.49) ; Telomerase (EC 2.7.7.49) ; DNA Helicases (EC 3.6.4.-) ; ATRX protein, human (EC 3.6.4.12) ; X-linked Nuclear Protein (EC 3.6.4.12)
    Language English
    Publishing date 2016--20
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2484394-5
    ISSN 1756-994X ; 1756-994X
    ISSN (online) 1756-994X
    ISSN 1756-994X
    DOI 10.1186/s13073-016-0324-x
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  6. Article ; Online: Assessment of prognostic value of tissue inhibitors of metalloproteinase 3 (TIMP3) protein in ovarian cancer.

    Hakamy, Sahar / Assidi, Mourad / Jafri, Mohammad A / Nedjadi, Taoufik / Alkhatabi, Heba / Al-Qahtani, Abrar / Al-Maghrabi, Jaudah / Sait, Khalid / Al-Qahtani, Mohammed / Buhmeida, Abdelbaset / Chaudhary, Adeel

    The Libyan journal of medicine

    2021  Volume 16, Issue 1, Page(s) 1937866

    Abstract: ... ...

    Abstract Background
    MeSH term(s) Female ; Humans ; Kaplan-Meier Estimate ; Metalloproteases ; Ovarian Neoplasms ; Prognosis ; Tissue Inhibitor of Metalloproteinase-3
    Chemical Substances TIMP3 protein, human ; Tissue Inhibitor of Metalloproteinase-3 ; Metalloproteases (EC 3.4.-)
    Language English
    Publishing date 2021-07-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2273005-9
    ISSN 1819-6357 ; 1819-6357
    ISSN (online) 1819-6357
    ISSN 1819-6357
    DOI 10.1080/19932820.2021.1937866
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  7. Article: Paraneoplastic syndromes in lung cancer and their management.

    Anwar, Asad / Jafri, Firas / Ashraf, Sara / Jafri, Mohammad Ali S / Fanucchi, Michael

    Annals of translational medicine

    2017  Volume 7, Issue 15, Page(s) 359

    Abstract: Paraneoplastic syndromes are most frequently associated with lung cancer. This review considers a variety of paraneoplastic syndromes associated with lung cancer and discusses their pathophysiology, clinical features and management options. ...

    Abstract Paraneoplastic syndromes are most frequently associated with lung cancer. This review considers a variety of paraneoplastic syndromes associated with lung cancer and discusses their pathophysiology, clinical features and management options.
    Language English
    Publishing date 2017-07-26
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm.2019.04.86
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  8. Article: Role of Nanodiamonds in Drug Delivery and Stem Cell Therapy.

    Ansari, Shakeel Ahmed / Satar, Rukhsana / Jafri, Mohammad Alam / Rasool, Mahmood / Ahmad, Waseem / Kashif Zaidi, Syed

    Iranian journal of biotechnology

    2017  Volume 14, Issue 3, Page(s) 130–141

    Abstract: Context: The use of nanotechnology in medicine and more specifically drug delivery is set to spread rapidly. Currently many substances are under investigation for drug delivery and more specifically for cancer therapy.: Evidence acquisition: ... ...

    Abstract Context: The use of nanotechnology in medicine and more specifically drug delivery is set to spread rapidly. Currently many substances are under investigation for drug delivery and more specifically for cancer therapy.
    Evidence acquisition: Nanodiamonds (NDs) have contributed significantly in the development of highly efficient and successful drug delivery systems, and in stem cell therapy. Drug delivery through NDs is an intricate and complex process that deserves special attention to unravel underlying molecular mechanisms in order to overcome certain bottlenecks associated with it. It has already been established that NDs based drug delivery systems have excellent biocompatibility, nontoxicity, photostability and facile surface functionalization properties.
    Results: There is mounting evidence that suggests that such conjugated delivery systems well retain the properties of nanoparticles like small size, large surface area to volume ratio that provide greater biocatalytic activity to the attached drug in terms of selectivity, loading and stability.
    Conclusions: NDs based drug delivery systems may form the basis for the development of effective novel drug delivery vehicles with salient features that may facilitate their utility in fluorescence imaging, target specificity and sustainedrelease.
    Language English
    Publishing date 2017-09-14
    Publishing country Iran
    Document type Journal Article ; Review
    ZDB-ID 2223669-7
    ISSN 2322-2921 ; 1728-3043
    ISSN (online) 2322-2921
    ISSN 1728-3043
    DOI 10.15171/ijb.1320
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  9. Article ; Online: A Patient With Pancytopenia, Intractable Epistaxis, and Metastatic Prostate Cancer: How Correct Diagnosis of Primary Hyperfibrinolysis Helps to Stop the Bleeding.

    Jafri, Mohammad A S / Cohen, Justine V / Much, Melissa A / Petrylak, Daniel P / Podoltsev, Nikolai A

    Clinical genitourinary cancer

    2016  Volume 14, Issue 5, Page(s) e545–e548

    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2225121-2
    ISSN 1938-0682 ; 1558-7673
    ISSN (online) 1938-0682
    ISSN 1558-7673
    DOI 10.1016/j.clgc.2016.05.002
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    Zs.A 6168: Show issues Location:
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  10. Article ; Online: Inhibition of endoplasmic reticulum stress and oxidative stress by vitamin D in endothelial cells.

    Haas, Michael J / Jafri, Mohammad / Wehmeier, Kent R / Onstead-Haas, Luisa M / Mooradian, Arshag D

    Free radical biology & medicine

    2016  Volume 99, Page(s) 1–10

    Abstract: Endoplasmic reticulum (ER) stress and oxidative stress promote endothelial dysfunction and atherosclerosis. Since vitamin D has been shown in several studies to lower the risk of cardiovascular disease, we examined the effects of vitamin D on ER stress ... ...

    Abstract Endoplasmic reticulum (ER) stress and oxidative stress promote endothelial dysfunction and atherosclerosis. Since vitamin D has been shown in several studies to lower the risk of cardiovascular disease, we examined the effects of vitamin D on ER stress and oxidative stress in endothelial cells. ER stress was measured using the placental secreted alkaline phosphatase assay and oxidative stress was measured by hydroethidine fluorescence. Expression of ER stress markers, including glucose-regulated protein 78, c-jun N-terminal kinase 1 phosphorylation, and eukaryotic initiation factor 2α phosphorylation, as well as X-box binding protein-1 splicing were measured in tunicamycin (TM)-treated human umbilical endothelial cells (HUVEC) treated with 1,25-dihydroxyvitamin D
    MeSH term(s) 24,25-Dihydroxyvitamin D 3/pharmacology ; Antioxidants/pharmacology ; Biomarkers/metabolism ; Calcitriol/analogs & derivatives ; Calcitriol/pharmacology ; Cell Survival/drug effects ; Endoplasmic Reticulum Stress/drug effects ; Eukaryotic Initiation Factor-2/genetics ; Eukaryotic Initiation Factor-2/metabolism ; Gene Expression ; Glucose/antagonists & inhibitors ; Glucose/pharmacology ; Heat-Shock Proteins/genetics ; Heat-Shock Proteins/metabolism ; Human Umbilical Vein Endothelial Cells/cytology ; Human Umbilical Vein Endothelial Cells/drug effects ; Human Umbilical Vein Endothelial Cells/metabolism ; Humans ; JNK Mitogen-Activated Protein Kinases/genetics ; JNK Mitogen-Activated Protein Kinases/metabolism ; Oxidative Stress/drug effects ; Phosphorylation ; Receptors, Calcitriol/genetics ; Receptors, Calcitriol/metabolism ; Tunicamycin/antagonists & inhibitors ; Tunicamycin/pharmacology ; Vitamin D/analogs & derivatives ; Vitamin D/pharmacology ; X-Box Binding Protein 1/genetics ; X-Box Binding Protein 1/metabolism
    Chemical Substances Antioxidants ; Biomarkers ; Eukaryotic Initiation Factor-2 ; Heat-Shock Proteins ; Receptors, Calcitriol ; VDR protein, human ; X-Box Binding Protein 1 ; ZK 191784 ; molecular chaperone GRP78 ; Tunicamycin (11089-65-9) ; Vitamin D (1406-16-2) ; 24,25-Dihydroxyvitamin D 3 (40013-87-4) ; 25-hydroxyvitamin D (A288AR3C9H) ; JNK Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Calcitriol (FXC9231JVH) ; Glucose (IY9XDZ35W2) ; seocalcitol (Q0OZ0D9223)
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article
    ZDB-ID 807032-5
    ISSN 1873-4596 ; 0891-5849
    ISSN (online) 1873-4596
    ISSN 0891-5849
    DOI 10.1016/j.freeradbiomed.2016.07.020
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