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  1. Article ; Online: Vascular polycystin proteins in health and disease.

    Mbiakop, Ulrich C / Jaggar, Jonathan H

    Microcirculation (New York, N.Y. : 1994)

    2023  Volume 31, Issue 4, Page(s) e12834

    Abstract: PKD1 (polycystin 1) and PKD2 (polycystin 2) are expressed in a variety of different cell types, including arterial smooth muscle and endothelial cells. PKD1 is a transmembrane domain protein with a large extracellular N-terminus that is proposed to act ... ...

    Abstract PKD1 (polycystin 1) and PKD2 (polycystin 2) are expressed in a variety of different cell types, including arterial smooth muscle and endothelial cells. PKD1 is a transmembrane domain protein with a large extracellular N-terminus that is proposed to act as a mechanosensor and receptor. PKD2 is a member of the transient receptor potential (TRP) channel superfamily which is also termed TRPP1. Mutations in the genes which encode PKD1 and PKD2 lead to autosomal dominant polycystic kidney disease (ADPKD). ADPKD is one of the most prevalent monogenic disorders in humans and is associated with extrarenal and vascular complications, including hypertension. Recent studies have uncovered mechanisms of activation and physiological functions of PKD1 and PKD2 in arterial smooth muscle and endothelial cells. It has also been found that PKD function is altered in the vasculature during ADPKD and hypertension. We will summarize this work and discuss future possibilities for this area of research.
    MeSH term(s) TRPP Cation Channels/metabolism ; TRPP Cation Channels/genetics ; Humans ; Polycystic Kidney, Autosomal Dominant/metabolism ; Polycystic Kidney, Autosomal Dominant/genetics ; Polycystic Kidney, Autosomal Dominant/physiopathology ; Animals ; Muscle, Smooth, Vascular/metabolism ; Hypertension/metabolism ; Hypertension/physiopathology ; Mutation ; Endothelial Cells/metabolism
    Chemical Substances TRPP Cation Channels ; polycystic kidney disease 1 protein ; polycystic kidney disease 2 protein
    Language English
    Publishing date 2023-10-12
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1217758-1
    ISSN 1549-8719 ; 1073-9688
    ISSN (online) 1549-8719
    ISSN 1073-9688
    DOI 10.1111/micc.12834
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    Zs.A 4187: Show issues Location:
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  2. Article ; Online: Physiological functions and pathological involvement of ion channel trafficking in the vasculature.

    Peixoto-Neves, Dieniffer / Jaggar, Jonathan H

    The Journal of physiology

    2023  

    Abstract: A variety of ion channels regulate membrane potential and calcium influx in arterial smooth muscle and endothelial cells to modify vascular functions, including contractility. The current (I) generated by a population of ion channels is equally dependent ...

    Abstract A variety of ion channels regulate membrane potential and calcium influx in arterial smooth muscle and endothelial cells to modify vascular functions, including contractility. The current (I) generated by a population of ion channels is equally dependent upon their number (N), open probability (Po) and single channel current (i), such that I = N.P
    Language English
    Publishing date 2023-10-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP285007
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  3. Article ; Online: STIMulating blood pressure.

    Garrud, Tessa A C / Jaggar, Jonathan H

    eLife

    2022  Volume 11

    Abstract: The protein STIM1 helps to maintain membrane coupling sites in smooth muscle cells that regulate arterial contractility and blood pressure. ...

    Abstract The protein STIM1 helps to maintain membrane coupling sites in smooth muscle cells that regulate arterial contractility and blood pressure.
    MeSH term(s) Blood Pressure ; Calcium Signaling/physiology ; Muscle, Smooth, Vascular/metabolism ; Myocytes, Smooth Muscle/metabolism ; Stromal Interaction Molecule 1/metabolism
    Chemical Substances Stromal Interaction Molecule 1
    Language English
    Publishing date 2022-03-24
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.77978
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  4. Article ; Online: Extracellular glucose and dysfunctional insulin receptor signaling independently upregulate arterial smooth muscle TMEM16A expression.

    Raghavan, Somasundaram / Brishti, Masuma Akter / Bernardelli, Angelica / Mata-Daboin, Alejandro / Jaggar, Jonathan H / Leo, M Dennis

    American journal of physiology. Cell physiology

    2024  Volume 326, Issue 4, Page(s) C1237–C1247

    Abstract: Diabetes alters the function of ion channels responsible for regulating arterial smooth muscle membrane potential, resulting in vasoconstriction. Our prior research demonstrated an elevation of TMEM16A in diabetic arteries. Here, we explored the ... ...

    Abstract Diabetes alters the function of ion channels responsible for regulating arterial smooth muscle membrane potential, resulting in vasoconstriction. Our prior research demonstrated an elevation of TMEM16A in diabetic arteries. Here, we explored the mechanisms involved in Transmembrane protein 16A (
    MeSH term(s) Animals ; Mice ; Anoctamin-1/metabolism ; Arteries/metabolism ; Diabetes Mellitus/metabolism ; Insulins ; Muscle, Smooth, Vascular/metabolism ; Receptor, Insulin/metabolism
    Chemical Substances Anoctamin-1 ; Insulins ; Receptor, Insulin (EC 2.7.10.1) ; ANO1 protein, mouse
    Language English
    Publishing date 2024-03-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392098-7
    ISSN 1522-1563 ; 0363-6143
    ISSN (online) 1522-1563
    ISSN 0363-6143
    DOI 10.1152/ajpcell.00555.2023
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  5. Article ; Online: WNK kinase is a vasoactive chloride sensor in endothelial cells.

    Garrud, Tessa A C / Bell, Briar / Mata-Daboin, Alejandro / Peixoto-Neves, Dieniffer / Collier, Daniel M / Cordero-Morales, Julio F / Jaggar, Jonathan H

    Proceedings of the National Academy of Sciences of the United States of America

    2024  Volume 121, Issue 15, Page(s) e2322135121

    Abstract: Endothelial cells (ECs) line the wall of blood vessels and regulate arterial contractility to tune regional organ blood flow and systemic pressure. Chloride ( ... ...

    Abstract Endothelial cells (ECs) line the wall of blood vessels and regulate arterial contractility to tune regional organ blood flow and systemic pressure. Chloride (Cl
    MeSH term(s) Mice ; Animals ; Protein Serine-Threonine Kinases/genetics ; Protein Serine-Threonine Kinases/metabolism ; Chlorides/metabolism ; Endothelial Cells/metabolism ; TRPV Cation Channels/metabolism ; Signal Transduction/physiology
    Chemical Substances Protein Serine-Threonine Kinases (EC 2.7.11.1) ; Chlorides ; TRPV Cation Channels
    Language English
    Publishing date 2024-04-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2322135121
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  6. Article ; Online: The 2019 FASEB Science Research Conference on Smooth Muscle, July 14-19, 2019, Palm Beach Florida, USA.

    Jaggar, Jonathan H / Gomez, Maria F

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

    2019  Volume 33, Issue 12, Page(s) 13068–13070

    MeSH term(s) Animals ; Clustered Regularly Interspaced Short Palindromic Repeats/genetics ; Congresses as Topic ; Florida ; Humans ; Muscle, Smooth/metabolism ; p300-CBP Transcription Factors/metabolism
    Chemical Substances p300-CBP Transcription Factors (EC 2.3.1.48) ; p300-CBP-associated factor (EC 2.3.1.48)
    Language English
    Publishing date 2019-09-26
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 639186-2
    ISSN 1530-6860 ; 0892-6638
    ISSN (online) 1530-6860
    ISSN 0892-6638
    DOI 10.1096/fj.201902633
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    Zs.A 2266: Show issues Location:
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  7. Article ; Online: Cholesterol activates BK channels by increasing KCNMB1 protein levels in the plasmalemma.

    Bukiya, Anna N / Leo, M Dennis / Jaggar, Jonathan H / Dopico, Alex M

    The Journal of biological chemistry

    2021  Volume 296, Page(s) 100381

    Abstract: Calcium-/voltage-gated, large-conductance potassium channels (BKs) control critical physiological processes, including smooth muscle contraction. Numerous observations concur that elevated membrane cholesterol (CLR) inhibits the activity of homomeric BKs ...

    Abstract Calcium-/voltage-gated, large-conductance potassium channels (BKs) control critical physiological processes, including smooth muscle contraction. Numerous observations concur that elevated membrane cholesterol (CLR) inhibits the activity of homomeric BKs consisting of channel-forming alpha subunits. In mammalian smooth muscle, however, native BKs include accessory KCNMB1 (β
    MeSH term(s) Animals ; Calcium Channels/metabolism ; Cell Membrane/metabolism ; Cerebral Arteries/cytology ; Cerebral Arteries/metabolism ; Cholesterol/metabolism ; Cholesterol/physiology ; Coronary Vessels/metabolism ; Large-Conductance Calcium-Activated Potassium Channel beta Subunits/metabolism ; Large-Conductance Calcium-Activated Potassium Channel beta Subunits/physiology ; Large-Conductance Calcium-Activated Potassium Channels/metabolism ; Male ; Membrane Proteins/metabolism ; Mice ; Mice, Inbred C57BL ; Muscle Cells/metabolism ; Muscle, Smooth, Vascular/metabolism ; Potassium Channels/metabolism ; Potassium Channels/physiology ; Rats ; Rats, Sprague-Dawley ; Vasoconstriction
    Chemical Substances Calcium Channels ; KCNMB1 protein, rat ; Large-Conductance Calcium-Activated Potassium Channel beta Subunits ; Large-Conductance Calcium-Activated Potassium Channels ; Membrane Proteins ; Potassium Channels ; Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2021-02-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1016/j.jbc.2021.100381
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    Uc I Zs.108: Show issues Location:
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  8. Article ; Online: Trafficking of BK channel subunits controls arterial contractility.

    Leo, M Dennis / Jaggar, Jonathan H

    Oncotarget

    2017  Volume 8, Issue 63, Page(s) 106149–106150

    Language English
    Publishing date 2017-12-05
    Publishing country United States
    Document type Editorial
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.22280
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  9. Article ; Online: Vasodilators mobilize SK3 channels in endothelial cells to produce arterial relaxation.

    Peixoto-Neves, Dieniffer / Yadav, Shambhu / MacKay, Charles E / Mbiakop, Ulrich C / Mata-Daboin, Alejandro / Leo, M Dennis / Jaggar, Jonathan H

    Proceedings of the National Academy of Sciences of the United States of America

    2023  Volume 120, Issue 31, Page(s) e2303238120

    Abstract: Endothelial cells (ECs) line the lumen of all blood vessels and regulate functions, including contractility. Physiological stimuli, such as acetylcholine (ACh) and intravascular flow, activate transient receptor potential vanilloid 4 (TRPV4) channels, ... ...

    Abstract Endothelial cells (ECs) line the lumen of all blood vessels and regulate functions, including contractility. Physiological stimuli, such as acetylcholine (ACh) and intravascular flow, activate transient receptor potential vanilloid 4 (TRPV4) channels, which stimulate small (SK3)- and intermediate (IK)-conductance Ca
    MeSH term(s) Vasodilator Agents/pharmacology ; TRPV Cation Channels/metabolism ; Endothelial Cells/metabolism ; Small-Conductance Calcium-Activated Potassium Channels/metabolism ; Arteries/metabolism ; Vasodilation ; Acetylcholine/metabolism ; Endothelium, Vascular/metabolism
    Chemical Substances Vasodilator Agents ; TRPV Cation Channels ; Small-Conductance Calcium-Activated Potassium Channels ; Acetylcholine (N9YNS0M02X)
    Language English
    Publishing date 2023-07-26
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2303238120
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  10. Article ; Online: K

    Hasan, Raquibul / Jaggar, Jonathan H

    Microcirculation (New York, N.Y. : 1994)

    2017  Volume 25, Issue 1

    Abstract: Membrane potential is a principal regulator of arterial contractility. Arterial smooth muscle cells express several different types of ion channel that control membrane potential, including ... ...

    Abstract Membrane potential is a principal regulator of arterial contractility. Arterial smooth muscle cells express several different types of ion channel that control membrane potential, including K
    MeSH term(s) Animals ; Hemodynamics ; Humans ; Myocytes, Smooth Muscle/chemistry ; Myocytes, Smooth Muscle/metabolism ; Potassium Channels, Voltage-Gated/metabolism ; Potassium Channels, Voltage-Gated/physiology ; Vasoconstriction ; Vasodilation
    Chemical Substances Potassium Channels, Voltage-Gated
    Language English
    Publishing date 2017-10-26
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1217758-1
    ISSN 1549-8719 ; 1073-9688
    ISSN (online) 1549-8719
    ISSN 1073-9688
    DOI 10.1111/micc.12418
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