LIVIVO - Search results -

Search results

Result 1 - 10 of total 18

Search options

Article ; Online: The prevalence, risk factors and outcomes of anaemia in South African pregnant women

Vinogrin Dorsamy / Chauntelle Bagwandeen / Jagidesa Moodley

Systematic Reviews, Vol 11, Iss 1, Pp 1-

a systematic review and meta-analysis

2022 Volume 16

Abstract: Abstract Background Anaemia is associated with maternal and perinatal morbidity and mortality. The pooled prevalence of anaemia in the South African (SA) pregnant population was ascertained by systematically reviewing available literature. Severity, risk ...

Abstract	Abstract Background Anaemia is associated with maternal and perinatal morbidity and mortality. The pooled prevalence of anaemia in the South African (SA) pregnant population was ascertained by systematically reviewing available literature. Severity, risk factors (HIV, tuberculosis, race, province, year of study), maternal morbidity and mortality (hypertensive disorders of pregnancy), birth outcomes (including low birth weight) and supplementation during pregnancy were also described. Methods Eligible studies reported on haemoglobin concentration or prevalence of anaemia in a SA pregnant population and were available in full text. Case-control and estimation studies were excluded with no restriction on the date of publication. PubMed, CINAHL, EMBASE, EBSCO, Ovid maternity and infant care databases, Cochrane Database of Systematic Reviews, Web of Science and SCOPUS were searched, using the keywords ‘anaemia’, ’haemoglobin’, ‘pregnancy’, ‘South Africa’. Risk of bias was conducted using the Hoy tool and the Doi plot and LFK ratio. Overall study quality was assessed using the GRADE tool. Due to heterogeneity amongst studies subgroup analyses were performed (random effects and quality effects model) using MetaXL addon tool for Microsoft Excel. Results The initial search yielded 7010 articles and 26 were selected for inclusion. Twenty studies were cross-sectional, three were longitudinal and one a randomised control trial. Studies ranged in publication year from 1969 to 2020. The pooled prevalence of anaemia in pregnant women in SA was determined to be 31% (95% CI, 23–40%). Hypertensive disorders of pregnancy and low birth weight were associated with anaemia. While iron deficiency was reported as the main cause, other risk factors included HIV and other infections. Discussion Limitations There was limited data reporting on prevalence of anaemia and direct maternal and foetal outcomes. Heterogeneity amongst studies was not explained by subgroup analysis. Majority of cross-sectional study designs reduced the ability to ...
Keywords	Pregnant ; Anaemia ; Maternal ; Haemoglobin ; South Africa ; Medicine ; R
Subject code	610
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Hysterosalpingographic evaluation of human immunodeficiency virus-infected and uninfected infertile women

Dolongo C. Onyangunga / Jagidesa Moodley

South African Journal of Radiology, Vol 24, Iss 1, Pp e1-e

2020 Volume 4

Abstract: Background: Hysterosalpingography (HSG) is an outpatient fluoroscopy-guided procedure that evaluates the uterine cavity and fallopian tube patency in infertile women. Its cost-effective use is being challenged with the human immunodeficiency virus (HIV) ... ...

Abstract	Background: Hysterosalpingography (HSG) is an outpatient fluoroscopy-guided procedure that evaluates the uterine cavity and fallopian tube patency in infertile women. Its cost-effective use is being challenged with the human immunodeficiency virus (HIV) burden in KwaZulu-Natal, which characteristically affects multiple organs. Objectives: The aim of this study was to describe the HSG findings in a group of HIV-infected and uninfected infertile women. Method: This was a retrospective study conducted over a 4-year period (2012–2016) in which the HSG images and reports of 178 infertile patients from records of the Radiology Department were re-reviewed for abnormalities of the cervix, uterus and fallopian tubes. Their clinical data and radiological findings were entered into a pre-coded data sheet and analysed. Results: The frequency of HIV infection amongst patients with infertility was found to be 32.6%. Forty-four patients were on antiretroviral therapy at the time of the HSG examination, whereas three had not yet started treatment. From the 178 HSG reports, 109 (61.2%) were abnormal. Tubal pathologies were the most common abnormalities, accounting for 79 of the 109 cases and was higher in HIV-infected women than in HIV-uninfected women (p = 0.001). Uterine filling defects were demonstrated in 13 of the 109 cases. There were two cases of cervical abnormalities. Conclusion: The study demonstrated that tubal abnormalities were the most common findings amongst infertile women undergoing HSG and occurred predominantly in HIV-infected patients.
Keywords	hysterosalpingography ; infertility ; hiv ; sexually transmitted diseases ; fallopian tubes ; radiology ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	616
Language	English
Publishing date	2020-03-01T00:00:00Z
Publisher	AOSIS
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Maternal deaths due to eclampsia in teenagers

Jagidesa Moodley / Nnabuike C. Ngene

African Journal of Primary Health Care & Family Medicine, Vol 12, Iss 1, Pp e1-e

Lessons from assessment of maternal deaths in South Africa

2020 Volume 6

Abstract: Background: Eclampsia remains a major cause of maternal mortality, particularly in teenage pregnancies. Healthcare professionals providing antenatal must regard teenagers as a high risk group for the pre-eclampsia-eclampsia syndrome. Setting: Data ... ...

Abstract	Background: Eclampsia remains a major cause of maternal mortality, particularly in teenage pregnancies. Healthcare professionals providing antenatal must regard teenagers as a high risk group for the pre-eclampsia-eclampsia syndrome. Setting: Data extracted from the South African Saving Mothers Report: 2014–2016. Aim: To establish the clinical details in teenage maternal deaths owing to eclampsia. Method: Retrospective review of the case records and maternal death assessment forms of teenagers that died due to eclampsia during 2014–2016. Results: There were 47 teenagers (aged 14 to 19 years) who died from eclampsia. Of these 18 out of 47 (38%) deaths occurred in the post-partum period. Forty (85.1%) of the patients had antenatal care. Three (6.4%) had post-partum eclampsia, and of the remaining 44 of the 47 (93.6%), the gestational age at first occurrence of a seizure ranged from 25 to 39 weeks. The blood pressures at the time of seizure ranged from systolic of 131 to 210 mmHg and diastolic of 89 to 130 mmHg. The commonest final causes of death were intracerebral haemorrhage associated with severe hypertension and multi-organ failure. Avoidable factors included transport delays, referral to the wrong levels of health care and poor care by health professionals. Conclusion: Teenage pregnancy is a risk factor for eclampsia-related death; awareness of borderline elevations of blood pressure levels from baseline values (prehypertension levels) and taking following national guidelines on the management of hypertensive disorders of pregnancy will decrease deaths from eclampsia.
Keywords	teenage pregnancies ; eclampsia ; clinical lessons ; obstetrics ; gynaecology ; Medicine ; R ; Public aspects of medicine ; RA1-1270
Subject code	610
Language	English
Publishing date	2020-07-01T00:00:00Z
Publisher	AOSIS
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Pre-eclampsia with severe features

Nnabuike Chibuoke Ngene / Jagidesa Moodley

The Pan African Medical Journal, Vol 36, Iss

management of antihypertensive therapy in the postpartum period

2020 Volume 216

Abstract: INTRODUCTION: there is variance in both the types and combinations of antihypertensive drugs used for managing pre-eclampsia in the postpartum period. Knowledge of the most common and suitable single or combination antihypertensive drug therapies in the ... ...

Abstract	INTRODUCTION: there is variance in both the types and combinations of antihypertensive drugs used for managing pre-eclampsia in the postpartum period. Knowledge of the most common and suitable single or combination antihypertensive drug therapies in the postpartum period will minimize harmful effects, promote adherence to medications, overcome any fears that lactating mothers may have about these drugs and will assist in healthcare planning.
Keywords	alpha-methyldopa ; antihypertensive drug combination therapy ; amlodipine ; postpartum hypertension ; severe preeclampsia ; Medicine ; R
Language	English
Publishing date	2020-07-01T00:00:00Z
Publisher	The Pan African Medical Journal
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Perspectives on COVID-19 vaccination for pregnant women in South Africa

Mehreen Hunter / Jagidesa Moodley / Neil Moran

African Journal of Primary Health Care & Family Medicine, Vol 13, Iss 1, Pp e1-e

2021 Volume 3

Abstract: Coronavirus disease 2019 (COVID-19) is a pandemic that has created a global health crisis and upended conventional methodologies, both in the governance and clinical structures of Health Care Systems. The spread of COVID-19 has necessitated a coordinated ...

Abstract	Coronavirus disease 2019 (COVID-19) is a pandemic that has created a global health crisis and upended conventional methodologies, both in the governance and clinical structures of Health Care Systems. The spread of COVID-19 has necessitated a coordinated public health response in an effective, extensive and expedited vaccination rollout strategy with the ultimate aim of limiting all nidi of infection for the pathogen. For this goal to be realised, pregnant women, as a cohort, cannot reasonably be excluded from this initiative, despite the initial reluctance to include them in clinical trials for various ethical and legal reasons. Weighing the detrimental complications of COVID-19 on maternal and perinatal outcomes against the hypothetical risk of vaccination in the context of promising, albeit indirect, safety and efficacy data, this report argues that all pregnant women should be offered the choice of whether or not to receive the COVID-19 vaccine based on the available evidence and their individualised risk-benefit ratio.
Keywords	covid-19 ; vaccination ; pregnancy ; arguments ; women ; Medicine ; R ; Public aspects of medicine ; RA1-1270
Subject code	360
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	AOSIS
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Misrepresentation about vaccines that are scaring women

Jagidesa Moodley / Olive P. Khaliq / Princess Z. Mkhize

African Journal of Primary Health Care & Family Medicine, Vol 13, Iss 1, Pp e1-e

2021 Volume 2

Abstract: The coronavirus disease 2019 (COVID-19) pandemic has contributed greatly to morbidity and mortality worldwide. The production of COVID-19 vaccines has been tested for efficacy and safety via clinical trials. However, false information on the side effects ...

Abstract	The coronavirus disease 2019 (COVID-19) pandemic has contributed greatly to morbidity and mortality worldwide. The production of COVID-19 vaccines has been tested for efficacy and safety via clinical trials. However, false information on the side effects of the vaccine has been spread via social media, creating fear of vaccination. Currently, the vaccine has been falsely reported to cause infertility in women of reproductive age and miscarriages in pregnant women. There is no evidence to support this information as the COVID-19 vaccines have been clinically approved for safety. Furthermore, pregnant and lactating women were not included in the clinical trials. Therefore, the objective of this report is to raise awareness that the rumours on the vaccine are false and to encourage every individual to accept the vaccination for their safety and the safety of their loved ones.
Keywords	misrepresentation ; vaccines ; infertility ; social media ; covid-19 ; Medicine ; R ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	AOSIS
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Exosomal MicroRNAs in Pregnancy Provides Insight into a Possible Cure for Cancer

Preenan Pillay / Kogi Moodley / Manu Vatish / Jagidesa Moodley

International Journal of Molecular Sciences, Vol 21, Iss 5384, p

2020 Volume 5384

Abstract: The biological links between cancer and pregnancy are of recent interest due to parallel proliferative, immunosuppressive and invasive mechanisms between tumour and trophoblast development. Therefore, understanding “cancer-like” mechanisms in pregnancy ... ...

Abstract	The biological links between cancer and pregnancy are of recent interest due to parallel proliferative, immunosuppressive and invasive mechanisms between tumour and trophoblast development. Therefore, understanding “cancer-like” mechanisms in pregnancy could lead to the development of novel cancer therapeutics, however, little is understood on how tumour and trophoblast cells recapitulate similar molecular mechanisms. Based on our observations from a previous study, it was not only evident that exosomal miRNAs are involved in the pathophysiology of preeclampsia but also contained cancer-specific miRNAs, which suggested that “pseudo-malignant-like” exosomal-mediated mechanisms exist in pregnancy. The presented study therefore aimed to identify exosomal miRNAs (exomiR) in pregnancy which can be repurposed towards preventing tumour metastasis and immunosuppression. It was identified that exomiR-302d-3p, exomiR-223-3p and exomiR-451a, commonly associated with cancer metastasis, were found to be highly expressed in pregnancy. Furthermore, computational merging and meta-analytical pathway analysis (DIANA miRPath) of significantly expressed exomiRs between 38 ± 1.9 vs. 30 ± 1.11 weeks of gestation indicated controlled regulation of biological pathways associated with cancer metastasis and immunosuppression. Therefore, the observations made in this study provide the experimental framework for the repurposing of exosomal miRNA molecular mechanisms in pregnancy towards treating and preventing cancer.
Keywords	exosome diagnostics ; cancer therapeutics ; pregnancy ; exosomal microRNA ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	610 ; 150
Language	English
Publishing date	2020-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Prevalance of abnormal vault cytology after hysterectomy for cervical intraepithelial neoplasia, Pietermaritzburg

Sanele S. Mbuyisa / Thandekile L. Khumalo / Bongumusa S. Makhathini / Jagidesa Moodley

South African Family Practice, Vol 64, Iss 1, Pp e1-e

2022 Volume 5

Abstract: Background: A simple hysterectomy is considered the definitive treatment modality for cervical intraepithelial neoplasia (CIN). However, it is associated with recurrence of vaginal intraepithelial neoplasia (VAIN) of up to 7.4%. We sought to determine ... ...

Abstract	Background: A simple hysterectomy is considered the definitive treatment modality for cervical intraepithelial neoplasia (CIN). However, it is associated with recurrence of vaginal intraepithelial neoplasia (VAIN) of up to 7.4%. We sought to determine recurrence rates of VAIN, in women living with HIV (WLWH) and non-infected women. Methods: This was a descriptive retrospective review of patients who received a simple hysterectomy for CIN between January 2015 and December 2017 in Pietermaritzburg. Results: Fifty-eight files were reviewed. Forty-two (72.4%) WLWH were seen; amongst those, 76.2% were virally suppressed. Abnormal vault cytology was only seen in patients with CIN grades 2 and 3. The recurrence rates for high-grade squamous intraepithelial lesion (HSIL) were 6.1% and 5.0% at 6 and 12 months, respectively. Human immunodeficiency virus co-infection was associated with 26.2% versus 13.3% of abnormal vault cytology compared to the HIV-negative counterparts (p = 0.164). Virologically suppressed patients had more abnormal cytology (28.1% vs. 0%) compared to the unsuppressed patients. There was a 17.2% and 65.5% loss- to follow-up rates at 6 and 12 months, respectively. Recurrence of premalignant lesions was noted amongst those who had the abdominal approach. Conclusion: The recurrence rates were comparable to the previous literature. A 6-month cytology follow-up showed no added benefit. Human immunodeficiency virus co-infection didn’t show a statistical significance on the recurrence rates; however, more structured studies are required to address this. Primary health care-based post operative surveillance can be a solution to address high loss to follow-up.
Keywords	cervical intraepithelial neoplasia ; recurrence rates ; simple hysterectomy ; vaginal intraepithelial neoplasia ; vain ; Medicine ; R
Subject code	610
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	AOSIS
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Prevalence of Vitamin D deficiency in a multiracial female population in KwaZulu-Natal province, South Africa

Yeshnee Naidoo / Jagidesa Moodley / Lorna Madurai / Thajasvarie Naicker

South African Family Practice, Vol 61, Iss

2019 Volume 3

Abstract: Objective: Vitamin D deficiency is a global health issue affecting many countries, especially those in temperate climates. The aim of this study was to determine the prevalence of Vitamin D deficiency and level of 25-hydroxyvitamin D [25(OH)D] in females ...

Abstract	Objective: Vitamin D deficiency is a global health issue affecting many countries, especially those in temperate climates. The aim of this study was to determine the prevalence of Vitamin D deficiency and level of 25-hydroxyvitamin D [25(OH)D] in females categorised by age and race. Methods: The study was performed between January 2015 and January 2016. This study consisted of 1 976 females stratified by age into 18, reproductive age (18–45) and 45 years. Demographic variables were recorded and serum 25(OH)D levels measured by chemiluminescent emission. Results: The predictors of lower 25(OH)D levels included age and race, (p 0.0001 for each predictor). Approximately 46% of females had 20 ng/ml 25(OH)D level, the majority of whom were Indian (35%). The 25(OH)D level varied by race (White 27.33 ng/ml; Black 23.43 ng/ml and Indian 15.05 ng/ml; p 0.0001). In the 18-year age category, White and Black women had significantly higher 25(OH)D levels when compared with Indian women (38.25 ng/ml vs. 37.51 ng/ml vs. 13.68 ng/ml respectively; p 0.0001). Similarly, in the reproductive age category (18–45 years); White (27.63 ng/ml) and Black (20.93 ng/ml) women had a significantly higher 25(OH)D level compared with Indian (13.15 ng/ml) women (p 0.0001). Moreover, similar data were observed within the 45-year age category, where the White and Black women had higher 25(OH)D levels compared with Indian women (25.46 ng/ml vs. 22.73 ng/ml vs. 17.04 ng/ml; p 0.0001) respectively. Irrespective of age category, severe vitamin D deficiency was highest amongst Indian females. Conclusion: This study demonstrates a significant difference in 25(OH)D concentration in healthy females living in Durban, with Indians presenting with the highest vitamin D deficiency. These findings clearly highlight the need for a policy on vitamin D supplementation and/or fortification of food. Further studies are under way to assess the genetic predisposition of women to vitamin D deficiency.
Keywords	vitamin d ; vitamin d deficiency ; race ; age ; Medicine ; R
Subject code	360 ; 320
Language	English
Publishing date	2019-07-01T00:00:00Z
Publisher	AOSIS
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: The performance of pre-delivery serum concentrations of angiogenic factors in predicting postpartum antihypertensive drug therapy following abdominal delivery in severe preeclampsia and normotensive pregnancy.

Nnabuike Chibuoke Ngene / Jagidesa Moodley / Thajasvarie Naicker

PLoS ONE, Vol 14, Iss 4, p e

2019 Volume 0215807

Abstract: Background The imbalance between circulating concentrations of anti- and pro-angiogenic factors is usually intense in preeclampsia with severe features (sPE). It is possible that pre-delivery circulating levels of angiogenic factors in sPE may be ... ...

Abstract	Background The imbalance between circulating concentrations of anti- and pro-angiogenic factors is usually intense in preeclampsia with severe features (sPE). It is possible that pre-delivery circulating levels of angiogenic factors in sPE may be associated with postpartum antihypertensive drug requirements. Objective To determine the predictive association between maternal pre-delivery serum concentrations of angiogenic factors and the use of ≥3 slow- and/or a rapid-acting antihypertensive drug therapy in sPE on postpartum days zero to three following caesarean delivery. Study design Women with sPE (n = 50) and normotensive pregnancies (n = 90) were recruited prior to childbirth. Serum samples were obtained from each participant < 48 hours before delivery to assess the concentrations of placental growth factor (PIGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) using the Roche Elecsys platform. Each participant was followed up on postpartum days zero, one, two and three to monitor BP and confirm antihypertensive treatment. The optimal cut-off thresholds of sFlt-1/PIGF ratio from receiver operating characteristic curve predictive of the antihypertensive therapy were subjected to diagnostic accuracy assessment. Results The majority 58% (29/50) of sPE had multiple severe features of preeclampsia in the antenatal period with the commonest presentation being severe hypertension in 88% (44/50) of this group, followed by features of impending eclampsia which occurred in 42% (21/50). The median gestational age at delivery was 38 (Interquartile range, IQR 1) vs 36 (IQR 6) weeks, p < 0.001 in normotensive and sPE groups respectively. Notably, the median sFlt-1/PIGF ratio in normotensive and sPE groups were 7.3 (IQR 17.9) and 179.1 (IQR 271.2) respectively, p < 0.001. Of the 50 sPE participants, 34% (17/50) had early-onset preeclampsia. The median (IQR) of sFlt-1/PIGF in the early- and late-onset preeclampsia groups were 313.52 (502.25), and 166.59(195.37) respectively, p = 0.006. From postpartum days zero to ...
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2019-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

Your last searches

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED