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Article ; Online: Regulatory T Cells Know What Is Needed to Regenerate.

Jahn, Christopher / Weidinger, Gilbert

2017 Volume 43, Issue 6, Page(s) 651–652

Abstract: Adaptive immunity has been suggested to limit regeneration in mammals. However, in this issue of Developmental Cell, Hui et al. (2017) report that regulatory T cells are required for regeneration of heart, spinal cord, and retina in the zebrafish. ... ...

Abstract	Adaptive immunity has been suggested to limit regeneration in mammals. However, in this issue of Developmental Cell, Hui et al. (2017) report that regulatory T cells are required for regeneration of heart, spinal cord, and retina in the zebrafish. Intriguingly, in each organ system, T
MeSH term(s)	Animals ; Organogenesis ; Regeneration ; T-Lymphocytes, Regulatory ; Zebrafish ; Zebrafish Proteins
Chemical Substances	Zebrafish Proteins
Language	English
Publishing date	2017-12-19
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2054967-2
ISSN	1878-1551 ; 1534-5807
ISSN (online)	1878-1551
ISSN	1534-5807
DOI	10.1016/j.devcel.2017.12.010
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Zs.A 5742: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 76: Show issues

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Article ; Online: Generation of human induced pluripotent stem cell line MHHi029-A from a male Fabry disease patient carrying c.959A > T mutation.

Jahn, Christopher / Juchem, Malte / Sonnenschein, Kristina / Gietz, Anika / Buchegger, Theresa / Lachmann, Nico / Göhring, Gudrun / Behrens, Yvonne Lisa / Bär, Christian / Thum, Thomas / Hoepfner, Jeannine

Stem cell research

2024 Volume 77, Page(s) 103404

Abstract: Fabry disease (FD) is a rare and inherited monogenetic disease caused by mutations in the X-chromosomal alpha-galactosidase A gene GLA concomitant with accumulation of its substrate globotriaosylceramide (Gb3) and multi-organ symptoms. We derived an ... ...

Abstract	Fabry disease (FD) is a rare and inherited monogenetic disease caused by mutations in the X-chromosomal alpha-galactosidase A gene GLA concomitant with accumulation of its substrate globotriaosylceramide (Gb3) and multi-organ symptoms. We derived an induced pluripotent stem cell line, MHHi029-A, from a male FD patient carrying a c.959A > T missense mutation in the GLA gene. The hiPSCs show a normal karyotype, expression of pluripotency markers and trilineage differentiation capacity. Importantly, they present the patient-specific mutation in the GLA gene and are therefore a valuable resource for investigating the FD mechanism and identifying novel therapies.
Language	English
Publishing date	2024-03-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2393143-7
ISSN	1876-7753 ; 1873-5061
ISSN (online)	1876-7753
ISSN	1873-5061
DOI	10.1016/j.scr.2024.103404
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Article ; Online: CircSlc8a1, breaking a vicious circle in cardiac hypertrophy.

Jahn, Christopher / Bär, Christian / Thum, Thomas

Cardiovascular research

2019 Volume 115, Issue 14, Page(s) 1946–1947

MeSH term(s)	Cardiomegaly ; Humans ; Myocytes, Cardiac ; RNA, Circular
Chemical Substances	RNA, Circular
Language	English
Publishing date	2019-05-29
Publishing country	England
Document type	Editorial ; Comment
ZDB-ID	80340-6
ISSN	1755-3245 ; 0008-6363
ISSN (online)	1755-3245
ISSN	0008-6363
DOI	10.1093/cvr/cvz147
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Article ; Online: SARS-CoV-2 receptor ACE2-dependent implications on the cardiovascular system: From basic science to clinical implications.

Groß, Sonja / Jahn, Christopher / Cushman, Sarah / Bär, Christian / Thum, Thomas

Journal of molecular and cellular cardiology

2020 Volume 144, Page(s) 47–53

Abstract: The current COVID-19 pandemic started several months ago and is still exponentially growing in most parts of the world - this is the most recent and alarming update. COVID-19 requires the collaboration of nearly 200 countries to curb the spread of SARS- ... ...

Abstract	The current COVID-19 pandemic started several months ago and is still exponentially growing in most parts of the world - this is the most recent and alarming update. COVID-19 requires the collaboration of nearly 200 countries to curb the spread of SARS-CoV-2 while gaining time to explore and improve treatment options especially for cardiovascular disease (CVD) and immunocompromised patients, who appear to be at high-risk to die from cardiopulmonary failure. Currently unanswered questions are why elderly people, particularly those with pre-existing comorbidities seem to exhibit higher mortality rates after SARS-CoV-2 infection and whether intensive care becomes indispensable for these patients to prevent multi-organ failure and sudden death. To face these challenges, we here summarize the molecular insights into viral infection mechanisms and implications for cardiovascular disease. Since the infection starts in the upper respiratory system, first flu-like symptoms develop that spread throughout the body. The wide range of affected organs is presumably based on the common expression of the major SARS-CoV-2 entry-receptor angiotensin-converting enzyme 2 (ACE2). Physiologically, ACE2 degrades angiotensin II, the master regulator of the renin-angiotensin-aldosterone system (RAAS), thereby converting it into vasodilatory molecules, which have well-documented cardio-protective effects. Thus, RAAS inhibitors, which may increase the expression levels of ACE2, are commonly used for the treatment of hypertension and CVD. This, and the fact that SARS-CoV-2 hijacks ACE2 for cell-entry, have spurred controversial discussions on the role of ACE2 in COVID-19 patients. In this review, we highlight the state-of-the-art knowledge on SARS-CoV-2-dependent mechanisms and the potential interaction with ACE2 expression and cell surface localization. We aim to provide a list of potential treatment options and a better understanding of why CVD is a high risk factor for COVID-19 susceptibility and further discuss the acute as well as long-term cardiac consequences.
MeSH term(s)	Angiotensin-Converting Enzyme 2 ; Antiviral Agents/pharmacology ; Betacoronavirus/pathogenicity ; COVID-19 ; Cardiovascular Diseases/complications ; Cardiovascular Diseases/physiopathology ; Coronavirus Infections/drug therapy ; Coronavirus Infections/etiology ; Host-Pathogen Interactions ; Humans ; Molecular Targeted Therapy ; Pandemics ; Peptidyl-Dipeptidase A/metabolism ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/etiology ; Renin-Angiotensin System/physiology ; Risk Factors ; SARS-CoV-2 ; COVID-19 Drug Treatment
Chemical Substances	Antiviral Agents ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
Keywords	covid19
Language	English
Publishing date	2020-04-30
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	80157-4
ISSN	1095-8584 ; 0022-2828
ISSN (online)	1095-8584
ISSN	0022-2828
DOI	10.1016/j.yjmcc.2020.04.031
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Zs.A 426: Show issues

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Book ; Online ; Thesis: Investigation of the cellular Fabry disease phenotype using human iPSC-derived cardiomyocytes

Jahn, Christopher [Verfasser] / Thum, Thomas [Akademischer Betreuer] / Bär, Christian [Akademischer Betreuer] / Schambach, Axel [Akademischer Betreuer] / Naujok, Ortwin [Akademischer Betreuer]

2023

Author's details	Christopher Jahn ; Akademische Betreuer: Thomas Thum, Christian Bär, Axel Schambach, Ortwin Naujok ; Hannover Biomedical Research School, Institut für Molekulare und Translationale Therapiestrategien
Keywords	Medizin, Gesundheit ; Medicine, Health
Subject code	sg610
Language	English
Publisher	Bibliothek der Medizinischen Hochschule Hannover
Publishing place	Hannover
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article ; Online: Zebrafish fin and heart: what's special about regeneration?

Sehring, Ivonne M / Jahn, Christopher / Weidinger, Gilbert

Current opinion in genetics & development

2016 Volume 40, Page(s) 48–56

Abstract: Many organs regenerate well in adult zebrafish, but most research has been directed toward fin and heart regeneration. Cells have been found to remain generally lineage-restricted during regeneration, and proliferative regenerative progenitors can be ... ...

Abstract	Many organs regenerate well in adult zebrafish, but most research has been directed toward fin and heart regeneration. Cells have been found to remain generally lineage-restricted during regeneration, and proliferative regenerative progenitors can be formed by dedifferentiation from differentiated cells. Recent studies begin to shed light on the molecular underpinnings of differences between development and regeneration. Retinoic acid, BMP and NF-κB signaling are emerging as regulators of cellular dedifferentiation. Reactive oxygen species promote regeneration, and the dynamics of ROS signaling might help explain differences between wound healing and regeneration. Finally, the heart has been added to those organs that require a nerve supply to regenerate, and a trade-off between regeneration and tumor suppression has been proposed to help explain why mammals regenerate poorly.
MeSH term(s)	Animal Fins/growth & development ; Animals ; Bone Morphogenetic Proteins/metabolism ; Cell Dedifferentiation/genetics ; Heart/growth & development ; NF-kappa B/genetics ; Reactive Oxygen Species/metabolism ; Regeneration/genetics ; Signal Transduction/genetics ; Tretinoin/metabolism ; Wound Healing/genetics ; Zebrafish/genetics ; Zebrafish/growth & development
Chemical Substances	Bone Morphogenetic Proteins ; NF-kappa B ; Reactive Oxygen Species ; Tretinoin (5688UTC01R)
Language	English
Publishing date	2016-06-25
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1077312-5
ISSN	1879-0380 ; 0959-437X
ISSN (online)	1879-0380
ISSN	0959-437X
DOI	10.1016/j.gde.2016.05.011
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Zs.A 3240: Show issues

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Article: SARS-CoV-2 receptor ACE2-dependent implications on the cardiovascular system: From basic science to clinical implications

Groß, Sonja / Jahn, Christopher / Cushman, Sarah / Bär, Christian / Thum, Thomas

J Mol Cell Cardiol

Abstract	The current COVID-19 pandemic started several months ago and is still exponentially growing in most parts of the world - this is the most recent and alarming update. COVID-19 requires the collaboration of nearly 200 countries to curb the spread of SARS-CoV-2 while gaining time to explore and improve treatment options especially for cardiovascular disease (CVD) and immunocompromised patients, who appear to be at high-risk to die from cardiopulmonary failure. Currently unanswered questions are why elderly people, particularly those with pre-existing comorbidities seem to exhibit higher mortality rates after SARS-CoV-2 infection and whether intensive care becomes indispensable for these patients to prevent multi-organ failure and sudden death. To face these challenges, we here summarize the molecular insights into viral infection mechanisms and implications for cardiovascular disease. Since the infection starts in the upper respiratory system, first flu-like symptoms develop that spread throughout the body. The wide range of affected organs is presumably based on the common expression of the major SARS-CoV-2 entry-receptor angiotensin-converting enzyme 2 (ACE2). Physiologically, ACE2 degrades angiotensin II, the master regulator of the renin-angiotensin-aldosterone system (RAAS), thereby converting it into vasodilatory molecules, which have well-documented cardio-protective effects. Thus, RAAS inhibitors, which may increase the expression levels of ACE2, are commonly used for the treatment of hypertension and CVD. This, and the fact that SARS-CoV-2 hijacks ACE2 for cell-entry, have spurred controversial discussions on the role of ACE2 in COVID-19 patients. In this review, we highlight the state-of-the-art knowledge on SARS-CoV-2-dependent mechanisms and the potential interaction with ACE2 expression and cell surface localization. We aim to provide a list of potential treatment options and a better understanding of why CVD is a high risk factor for COVID-19 susceptibility and further discuss the acute as well as long-term cardiac consequences.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #154815
Database	COVID19

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Article ; Online: SARS-CoV-2 receptor ACE2-dependent implications on the cardiovascular system

Groß, Sonja / Jahn, Christopher / Cushman, Sarah / Bär, Christian / Thum, Thomas

Journal of Molecular and Cellular Cardiology

From basic science to clinical implications

2020 Volume 144, Page(s) 47–53

Keywords	Molecular Biology ; Cardiology and Cardiovascular Medicine ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	80157-4
ISSN	1095-8584 ; 0022-2828
ISSN (online)	1095-8584
ISSN	0022-2828
DOI	10.1016/j.yjmcc.2020.04.031
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Circular RNA circZFPM2 regulates cardiomyocyte hypertrophy and survival.

Neufeldt, Dimyana / Schmidt, Arne / Mohr, Elisa / Lu, Dongchao / Chatterjee, Shambhabi / Fuchs, Maximilian / Xiao, Ke / Pan, Wen / Cushman, Sarah / Jahn, Christopher / Juchem, Malte / Hunkler, Hannah Jill / Cipriano, Giuseppe / Jürgens, Bjarne / Schmidt, Kevin / Groß, Sonja / Jung, Mira / Hoepfner, Jeannine / Weber, Natalie /

Foo, Roger / Pich, Andreas / Zweigerdt, Robert / Kraft, Theresia / Thum, Thomas / Bär, Christian

Basic research in cardiology

2024

Abstract: Hypertrophic cardiomyopathy (HCM) constitutes the most common genetic cardiac disorder. However, current pharmacotherapeutics are mainly symptomatic and only partially address underlying molecular mechanisms. Circular RNAs (circRNAs) are a recently ... ...

Abstract	Hypertrophic cardiomyopathy (HCM) constitutes the most common genetic cardiac disorder. However, current pharmacotherapeutics are mainly symptomatic and only partially address underlying molecular mechanisms. Circular RNAs (circRNAs) are a recently discovered class of non-coding RNAs and emerged as specific and powerful regulators of cellular functions. By performing global circRNA-specific next generation sequencing in cardiac tissue of patients with hypertrophic cardiomyopathy compared to healthy donors, we identified circZFPM2 (hsa_circ_0003380). CircZFPM2, which derives from the ZFPM2 gene locus, is a highly conserved regulatory circRNA that is strongly induced in HCM tissue. In vitro loss-of-function experiments were performed in neonatal rat cardiomyocytes, human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), and HCM-patient-derived hiPSC-CMs. A knockdown of circZFPM2 was found to induce cardiomyocyte hypertrophy and compromise mitochondrial respiration, leading to an increased production of reactive oxygen species and apoptosis. In contrast, delivery of recombinant circZFPM2, packaged in lipid-nanoparticles or using AAV-based overexpression, rescued cardiomyocyte hypertrophic gene expression and promoted cell survival. Additionally, HCM-derived cardiac organoids exhibited improved contractility upon CM-specific overexpression of circZFPM2. Multi-Omics analysis further promoted our hypothesis, showing beneficial effects of circZFPM2 on cardiac contractility and mitochondrial function. Collectively, our data highlight that circZFPM2 serves as a promising target for the treatment of cardiac hypertrophy including HCM.
Language	English
Publishing date	2024-04-19
Publishing country	Germany
Document type	Journal Article
ZDB-ID	189755-x
ISSN	1435-1803 ; 0300-8428 ; 0175-9418
ISSN (online)	1435-1803
ISSN	0300-8428 ; 0175-9418
DOI	10.1007/s00395-024-01048-y
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Article ; Online: Use of the TetON System to Study Molecular Mechanisms of Zebrafish Regeneration.

Wehner, Daniel / Jahn, Christopher / Weidinger, Gilbert

Journal of visualized experiments : JoVE

2015 , Issue 100, Page(s) e52756

Abstract: The zebrafish has become a very important model organism for studying vertebrate development, physiology, disease, and tissue regeneration. A thorough understanding of the molecular and cellular mechanisms involved requires experimental tools that allow ... ...

Abstract	The zebrafish has become a very important model organism for studying vertebrate development, physiology, disease, and tissue regeneration. A thorough understanding of the molecular and cellular mechanisms involved requires experimental tools that allow for inducible, tissue-specific manipulation of gene expression or signaling pathways. Therefore, we and others have recently adapted the TetON system for use in zebrafish. The TetON system facilitates temporally and spatially-controlled gene expression and we have recently used this tool to probe for tissue-specific functions of Wnt/beta-catenin signaling during zebrafish tail fin regeneration. Here we describe the workflow for using the TetON system to achieve inducible, tissue-specific gene expression in the adult regenerating zebrafish tail fin. This includes the generation of stable transgenic TetActivator and TetResponder lines, transgene induction and techniques for verification of tissue-specific gene expression in the fin regenerate. Thus, this protocol serves as blueprint for setting up a functional TetON system in zebrafish and its subsequent use, in particular for studying fin regeneration.
MeSH term(s)	Animals ; Animals, Genetically Modified ; Gene Expression ; Regeneration/genetics ; Regeneration/physiology ; Tail/physiology ; Tetracycline/pharmacology ; Transcriptional Activation ; Zebrafish/genetics ; Zebrafish/physiology
Chemical Substances	Tetracycline (F8VB5M810T)
Language	English
Publishing date	2015-06-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Video-Audio Media
ISSN	1940-087X
ISSN (online)	1940-087X
DOI	10.3791/52756
Database	MEDical Literature Analysis and Retrieval System OnLINE

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