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Article: Locally Advanced Breast Cancer: Response Evaluation to Neoadjuvant Chemotherapy by Clinico-Histopathological Parameters and Molecular Imaging.

Jain, Amit Kumar

2023 Volume 14, Issue 2, Page(s) 279–287

Abstract: In India, breast cancer (BC) is not only the commonest cancer but also the commonest cause of cancer mortality among females. Advanced BC constitutes >70% of BC cases at initial presentation in India, among which locally advanced breast cancer (LABC) ... ...

Abstract	In India, breast cancer (BC) is not only the commonest cancer but also the commonest cause of cancer mortality among females. Advanced BC constitutes >70% of BC cases at initial presentation in India, among which locally advanced breast cancer (LABC) requires a multi-disciplinary approach with a combination of systemic and locoregional therapies. This descriptive hospital-based study was conducted over 1½ years after seeking approval from the institutional ethics committee. Fifty-five patients satisfying all the criteria of the study were enrolled. The data, thus, collected was pooled into Excel spreadsheet and analyzed using appropriate statistical tools. Most of the patients were postmenopausal, multiparous with breast lump being the commonest symptom. Mean baseline characteristics were age - 48 years, SUV max - 9.2, and Ki-67 - 17.8%. cT4 and cN2 were the commonest pre-NACT tumor and lymph node stage. Invasive ductal carcinoma was the commonest tumor type with the most common tumor grade being grade 3. Hormone receptor positivity and HER2 overexpression were seen in 33 and 17 patients respectively. Post-NACT 32 patients underwent breast-conserving surgery. Pathological complete response (pCR), i.e., ypT0N0, was seen in 13 patients (23.6%). There was slight alteration in hormone receptor status, HER2 expression and Ki-67 in the post-NACT resected tumor. pCR, which is a surrogate marker for improved clinical outcome (DFS and OS) in LABC patients, occurred more commonly in patients with pre-NACT grade 3 tumors, high Ki-67, hormone receptor-negative, and HER2 overexpressing BC (overall, in triple negative BC) but was statistically significant only with Ki-67. Post-NACT, SUV max with a cut off ≤1.5, and ΔSUV max of >80% correlated closely with pCR.
Language	English
Publishing date	2023-02-06
Publishing country	India
Document type	Journal Article
ZDB-ID	2568289-1
ISSN	0976-6952 ; 0975-7651
ISSN (online)	0976-6952
ISSN	0975-7651
DOI	10.1007/s13193-023-01711-1
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Article ; Online: Evaluation of change in pterygium induced keratometric astigmatism in patients following pterygium excision with autologous graft surgery.

Jain, Amit Kumar / Pandey, Dadan Ji

Nepalese journal of ophthalmology : a biannual peer-reviewed academic journal of the Nepal Ophthalmic Society : NEPJOPH

2021 Volume 12, Issue 24, Page(s) 191–200

Abstract: Pterygium is a common surface disorder of the eye that may cause change in visual acuity of patients by inducing astigmatic refractive error. Surgical excision with grafting is considered the most effective recommended treatment for pterygium. The ... ...

Abstract	Pterygium is a common surface disorder of the eye that may cause change in visual acuity of patients by inducing astigmatic refractive error. Surgical excision with grafting is considered the most effective recommended treatment for pterygium. The objective of this study was to evaluate the outcomes of pterygium excision with autologous graft surgery on keratometric astigmatism and visual acuity. Materials and methods: In this study total 64 eyes of 64 patients were enrolled having the diagnosis of pterygium. Prior to the pterygium excision surgery all the enrolled patients were studied for grading of pterygium, clinical symptoms, keratometric values and best corrected visual acuity (BCVA). Postoperatively, BCVA and keratometric readings were recorded at one week, one month, two months and four months intervals. Results: Mean age of study participants was 34.16 ± 8.24 years in the age group of 18-60 years. 42 (65.62%) eyes had grade II pterygium, while 16 (25.0 %) and 6 (9.38%) eyes were having grade III and grade IV pterygium, respectively. Preoperative median and quartiles (25% -75%) horizontal and vertical keratometric values were 43.00 (42.50-44.00) D and 44.25 (43.75-44.50) D, respectively and both reduced significantly to 42.50 (42.50-42.94) D and 42.50 (42.50- 43.00) D, respectively after four months postoperatively. Median keratometric astigmatism before surgery was 1.37 (1.25-1.93) D which reduced significantly to 0.50 (0.32-0.75) D after four months of pterygium excision. Similarly, BCVA improved significantly [0.20(0.16-0.25) vs 0.53 (0.50-0.80)] when assessed postoperatively after four months. Conclusion: Excision of pterygium with autologous graft reduced pterygium-induced keratometric astigmatism and improved BCVA significantly.
MeSH term(s)	Adolescent ; Adult ; Astigmatism/diagnosis ; Astigmatism/epidemiology ; Astigmatism/etiology ; Conjunctiva ; Cornea/surgery ; Humans ; Middle Aged ; Pterygium/diagnosis ; Pterygium/surgery ; Refraction, Ocular ; Young Adult
Language	English
Publishing date	2021-05-12
Publishing country	Nepal
Document type	Journal Article
ZDB-ID	2596436-7
ISSN	2091-0320 ; 2091-0320
ISSN (online)	2091-0320
ISSN	2091-0320
DOI	10.3126/nepjoph.v12i2.28287
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Article: Next Generation Sequencing

Bhat, Guruprasad / Jain, Amit Kumar

Indian Journal of Medical and Paediatric Oncology

2020 Volume 41, Issue 03, Page(s) 381–382

Language	English
Publishing date	2020-05-01
Publisher	Thieme Medical and Scientific Publishers Pvt. Ltd.
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2181724-8
ISSN	0975-2129 ; 0971-5851 ; 0975-2129
ISSN (online)	0975-2129
ISSN	0971-5851 ; 0975-2129
DOI	10.4103/ijmpo.ijmpo_28_20
Database	Thieme publisher's database

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Article ; Online: Assessment of Antimicrobial Prescribing Pattern in the Outpatient Department of Ophthalmology in a Tertiary Care Hospital of Western Uttar Pradesh, India.

Jain, Amit Kumar / Naimi, Shahzar / Jain, Seema

Nepalese journal of ophthalmology : a biannual peer-reviewed academic journal of the Nepal Ophthalmic Society : NEPJOPH

2019 Volume 10, Issue 20, Page(s) 130–138

Abstract: Introduction: Assessment of prescribing pattern at regular interval is essential to avoid inappropriate use of drugs, especially of antimicrobial drugs.: Objectives: The present study was performed to evaluate the prescribing pattern of antimicrobial ...

Abstract	Introduction: Assessment of prescribing pattern at regular interval is essential to avoid inappropriate use of drugs, especially of antimicrobial drugs. Objectives: The present study was performed to evaluate the prescribing pattern of antimicrobial drugs in the Ophthalmology Out-Patient Department (OPD) of Santosh Medical College and Hospital, Ghaziabad, India. Material and method: The present study included a total 600 prescriptions of patients attending OPD. A structured proforma was used to record all necessary information of each patient including demographic profi le of patient, diagnosis, total number of drugs and antimicrobials prescribed, group of antimicrobial prescribed, the percentage of antimicrobials prescribed by generic name etc. Results: Total 600 prescriptions were evaluated. Mean age of the study subjects was 28.4 ± 15.05 years. Total 720 antimicrobials were prescribed and the average number of antimicrobial drugs per prescription was 1.2. Fluoroquinolones were most commonly prescribed antimicrobial drugs followed by aminoglycosides and macrolides. 85% of drugs were prescribed in the form of eye drops while 15% were in the form of an ointment. 1.2% of antimicrobial drugs were prescribed by generic names. Out of total antimicrobials drugs, 420 drugs were in the form of fi xed dose combination. Only 1.6% of drugs were prescribed from National Essential Medicines List (NEML) 2015, India. Conclusion: Most of the antimicrobials were prescribed by brand names which require important consideration to promote rational use of antimicrobial drugs. In addition, the number of drugs prescribed from NEML was very less, indicating the need of sensitization among prescribers for the promotion of rational use of drugs.
MeSH term(s)	Adolescent ; Adult ; Ambulatory Care Facilities ; Anti-Bacterial Agents/pharmacology ; Child ; Child, Preschool ; Drug Prescriptions/statistics & numerical data ; Drug Utilization/statistics & numerical data ; Female ; Humans ; India ; Male ; Medical Audit ; Middle Aged ; Ophthalmology ; Outpatients ; Practice Patterns, Physicians' ; Prospective Studies ; Tertiary Care Centers ; Young Adult
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2019-05-04
Publishing country	Nepal
Document type	Journal Article ; Observational Study
ZDB-ID	2596436-7
ISSN	2091-0320 ; 2072-6805
ISSN (online)	2091-0320
ISSN	2072-6805
DOI	10.3126/nepjoph.v10i2.23014
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Article: Glaucoma the Silent Thief of Vision! A Study to Assess Current Trends on Awareness and Knowledge About Glaucoma

Jain, Amit Kumar / Singh, Neha / Singh, Naveen Kumar / Singh, Praveen Kumar / Rajpoot, Suman

Annals of the National Academy of Medical Sciences (India)

2023 Volume 59, Issue 04, Page(s) 202–208

Abstract: Introduction: Worldwide nearly 70 million populations are affected by glaucoma, a leading cause of irreversible blindness. Awareness and knowledge about glaucoma is the key to early diagnosis and effective management to prevent debilitating blindness. ... ...

Abstract	Introduction: Worldwide nearly 70 million populations are affected by glaucoma, a leading cause of irreversible blindness. Awareness and knowledge about glaucoma is the key to early diagnosis and effective management to prevent debilitating blindness. In India, the literature has shown that the level of awareness ranges from 0.32 to 13.5%, much lower than developed countries. Previous studies found higher levels of education and socioeconomic status along with positive family history of ocular diseases were directly related to improved levels of awareness and knowledge about glaucoma. Considering the improvement in literacy standards, socioeconomic status, and better utilization of medical care in the past few years, we aimed to assess the current trends in levels of awareness and knowledge about glaucoma in the North Indian population. Methodology: This prospective cross-sectional questionnaire-based study included 1,536 participants enrolled from the outpatient department of a tertiary care teaching hospital. Data for the study were collected from the responses given by participants from two sets of questionnaires adopted and validated from previous similar work on awareness of glaucoma. Statistical analysis was done by applying the chi-square test and Fisher exact probability test using IBM SPSS Statistics version 20. Results: In total, 7.74% of study participants were aware of glaucoma and the newspaper was the most common source of (57.9%) information. A significant correlation ( p < 0.05) was found for male sex, education status, and past medical history between aware and not aware participants; however, non-significant ( p = 0.182) correlation was seen for upper and lower socioeconomic status among the same group participants. Only 16% of aware participants had a good knowledge of glaucoma. Conclusion: In current trends, the state of awareness and knowledge on glaucoma in the Indian population was poor compared to that in the Western world, although the levels of education status and the presence of past medical history had significant correlation among aware and not aware population, but socioeconomic status had no significant correlation. Electronic media and health camps were among the least common source of information; hence, improvised awareness programs and opportunistic screening of glaucoma is the answer to control this silent thief of vision called glaucoma.
Keywords	Glaucoma ; awareness ; knowledge ; literacy ; north India
Language	English
Publishing date	2023-10-01
Publisher	Thieme Medical and Scientific Publishers Pvt. Ltd.
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	632986-x
ISSN	2454-5635 ; 0379-038X
ISSN (online)	2454-5635
ISSN	0379-038X
DOI	10.1055/s-0043-1772215
Database	Thieme publisher's database

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Article: An experience with Goel-Harms C1-C2 fixation for type II odontoid fractures.

Jain, Amit Kumar / Tawari, Manish / Rathore, Lavlesh / Sahana, Debabrata / Mishra, Harshit / Kumar, Sanjeev / Sahu, Rajiv Kumar

Journal of craniovertebral junction & spine

2022 Volume 13, Issue 2, Page(s) 175–181

Abstract: Objective: Type II odontoid fractures need surgical stabilization for disabling neck pain and instability. Anterior odontoid screw fixation is a well-known technique. However, certain patients require posterior fixation. We present our surgical results ... ...

Abstract	Objective: Type II odontoid fractures need surgical stabilization for disabling neck pain and instability. Anterior odontoid screw fixation is a well-known technique. However, certain patients require posterior fixation. We present our surgical results and experiences with nine cases managed by the Goel-Harms technique. Materials and methods: This is a retrospective review of nine patients operated on between January 2019 and December 2021 for Type II odontoid fractures with posterior fixation technique. Their clinical profile was collected from case files. The radiological data were retrieved from radiology archives. The indications for surgery were instability and refractory neck pain. The surgical decision for posterior fixation was guided by fracture morphology. Results: The mean age of presentation was 37.22 ± 9.85 years. Seven patients had Type II, and two had Type IIa odontoid fracture. All patients presented with unbearable neck pain. One patient had a quadriparesis. The fracture line was anterior-inferior sloping in six, posterior-inferior sloping in two, and transverse in one case. The anterior-posterior displacement of fracture ranged from 0 to 7 mm (mean 2.44 ± 2.18 mm). Partial transverse ligament tear without the Atlanto Axial Dislocation was present in three patients. The C1-C2 joint distraction was required in five cases. C1-C2 joint spacer was required in two cases. Following surgery, neck pain was relieved in all cases. Complete fracture alignment was achieved in eight patients. There were no postoperative complications. At the mean follow-up of 16.22 ± 9.61 months, there was no implant failure. Conclusions: Posterior C1-C2 fixation by the Goel-Harms technique is an excellent alternative to anterior fixation in selected cases.
Language	English
Publishing date	2022-06-13
Publishing country	India
Document type	Journal Article
ZDB-ID	2573344-8
ISSN	0976-9285 ; 0974-8237
ISSN (online)	0976-9285
ISSN	0974-8237
DOI	10.4103/jcvjs.jcvjs_22_22
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Article: An Unusual Case of Pancytopenia: The Lessons Learnt.

Nair, Ragesh R / Singh, Pawan K / Sharma, Jeetendra / Gambhir, Isha / Khanna, Shivangi / Jain, Amit Kumar / Haldar, Rohan / Bhar, Vikrant S

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

2022 Volume 26, Issue 1, Page(s) 141–144

Abstract: Pancytopenia is a common hematological abnormality encountered in clinical practice. We here report a 36-year-old male who presented to emergency department with complaints of weakness of bilateral lower limbs, burning sensation in all four limbs with ... ...

Abstract	Pancytopenia is a common hematological abnormality encountered in clinical practice. We here report a 36-year-old male who presented to emergency department with complaints of weakness of bilateral lower limbs, burning sensation in all four limbs with history of loose stools, and vomiting 5 days back. The complete blood count of patient showed pancytopenia with no circulating atypical cells. Bone marrow examination performed showed nonspecific but characteristic findings. After excluding the possibility of infective etiology, a possibility of heavy metal toxicity was suspected in multidisciplinary meeting. The urine and blood levels of arsenic done came out very high, and a diagnosis of arsenic poisoning was made. Patient had multisystemic involvement with features characteristic of arsenic poisoning. The present case was a diagnostic challenge in face of nonforthcoming history. This case beautifully highlighted the importance of multidepartmental approach in such cases to arrive at unerring diagnosis and the unique bone marrow findings, although nonspecific were sufficient enough to indicate the possibility of acute insult to the hematopoiesis.
Language	English
Publishing date	2022-01-13
Publishing country	India
Document type	Journal Article
ZDB-ID	2121263-6
ISSN	1998-359X ; 0972-5229
ISSN (online)	1998-359X
ISSN	0972-5229
DOI	10.5005/jp-journals-10071-24087
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Article: Liquid Biopsy

Jain, Amit Kumar / Bhat, Guruprasad / Gupta, Vineet Govinda / Goyal, Hari

Indian Journal of Medical and Paediatric Oncology

2021 Volume 42, Issue 01, Page(s) 77–79

Language	English
Publishing date	2021-02-01
Publisher	Thieme Medical and Scientific Publishers Private Ltd.
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2181724-8
ISSN	0975-2129 ; 0971-5851 ; 0975-2129
ISSN (online)	0975-2129
ISSN	0971-5851 ; 0975-2129
DOI	10.1055/s-0041-1729434
Database	Thieme publisher's database

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Article ; Online: Assessment of metabolic syndrome in HIV-infected individuals.

Theengh, Diki Palmu / Yadav, Pushpa / Jain, Amit Kumar / Nandy, Parvati

Indian journal of sexually transmitted diseases and AIDS

2018 Volume 38, Issue 2, Page(s) 152–156

Abstract: Background: Metabolic syndrome (MS) is a cluster of risk factors for cardiovascular disease and Type 2 diabetes mellitus.: Objectives: The aim is to assess the prevalence of MS in HIV patients receiving highly active antiretroviral therapy (HAART) ... ...

Abstract	Background: Metabolic syndrome (MS) is a cluster of risk factors for cardiovascular disease and Type 2 diabetes mellitus. Objectives: The aim is to assess the prevalence of MS in HIV patients receiving highly active antiretroviral therapy (HAART) and to compare it with treatment naïve HIV patients. Methods: Cross-sectional study carried out in a teaching hospital in North India. A total of 116 HIV positive patients who were on HAART and those who were treatment naïve were included in the study. Adult Treatment Panel III (ATP III) and International Diabetes Foundation (IDF) definitions were used to define MS. Clinical and laboratory investigations were performed as per requirement and then analyzed using SPSS software. Results: A high prevalence of MS was observed in HIV positive patients (ATP III - 19.8% and IDF - 25.9%). The prevalence of MS was higher in the anti-retroviral therapy (ART) group (ATP III - 33.3% and IDF - 36.4%) than ART-naïve group (ATP III - 2% and IDF - 12%). Conclusions: A sincere effort should always be made to detect MS in patients on HAART, especially in Indian subcontinent where there is a genetic predisposition to cardiovascular risk.
Language	English
Publishing date	2018-08-22
Publishing country	India
Document type	Journal Article
ZDB-ID	2622183-4
ISSN	2589-0565 ; 2589-0565
ISSN (online)	2589-0565
ISSN	2589-0565
DOI	10.4103/ijstd.IJSTD_55_16
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Article ; Online: Multivariate and Online Prediction of Closing Price Using Kernel Adaptive Filtering.

Mishra, Shambhavi / Ahmed, Tanveer / Mishra, Vipul / Kaur, Manjit / Martinetz, Thomas / Jain, Amit Kumar / Alshazly, Hammam

Computational intelligence and neuroscience

2021 Volume 2021, Page(s) 6400045

Abstract: This paper proposes a multivariate and online prediction of stock prices via the paradigm of kernel adaptive filtering (KAF). The prediction of stock prices in traditional classification and regression problems needs independent and batch-oriented nature ...

Abstract	This paper proposes a multivariate and online prediction of stock prices via the paradigm of kernel adaptive filtering (KAF). The prediction of stock prices in traditional classification and regression problems needs independent and batch-oriented nature of training. In this article, we challenge this existing notion of the literature and propose an online kernel adaptive filtering-based approach to predict stock prices. We experiment with ten different KAF algorithms to analyze stocks' performance and show the efficacy of the work presented here. In addition to this, and in contrast to the current literature, we look at granular level data. The experiments are performed with quotes gathered at the window of one minute, five minutes, ten minutes, fifteen minutes, twenty minutes, thirty minutes, one hour, and one day. These time windows represent some of the common windows frequently used by traders. The proposed framework is tested on 50 different stocks making up the Indian stock index: Nifty-50. The experimental results show that online learning and KAF is not only a good option, but practically speaking, they can be deployed in high-frequency trading as well.
MeSH term(s)	Algorithms ; Investments
Language	English
Publishing date	2021-12-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2388208-6
ISSN	1687-5273 ; 1687-5265
ISSN (online)	1687-5273
ISSN	1687-5265
DOI	10.1155/2021/6400045
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