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  1. AU="Jain, Divyanu"
  2. AU="Halpert, Richard"
  3. AU="Alkorta, Ibon"
  4. AU="Kwon, Kyungmi"
  5. AU="Bernardo Salasnich"
  6. AU="Hassan, Zurina"
  7. AU="Belarbi, M"
  8. AU="Rout, Ranjeet K"
  9. AU="Moreira, Catarina"
  10. AU=Warn-Cramer Bonnie J
  11. AU="Morral, Núria"
  12. AU="Silman, Miles R."
  13. AU="Palfi Salavat, Mădălina-Casiana"
  14. AU="Mohamed, Eid"
  15. AU="Hudson, Lance"
  16. AU="Imane Mihoub" AU="Imane Mihoub"
  17. AU="D. M. Wuchenich"

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  1. Artikel: Time to Stop Complicating a Complex Disease: Adopt Simple Treatment for Polycystic Ovarian Syndrome.

    Jain, Divyanu / Sood, Abha / Jain, Ajay K

    Gynecology and minimally invasive therapy

    2020  Band 9, Heft 2, Seite(n) 110–111

    Sprache Englisch
    Erscheinungsdatum 2020-04-28
    Erscheinungsland India
    Dokumenttyp Journal Article
    ISSN 2213-3070
    ISSN 2213-3070
    DOI 10.4103/GMIT.GMIT_121_19
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: A Strategic Program for Risk Assessment and Intervention to Mitigate Environmental Stressor-Related Adverse Pregnancy Outcomes in the Indian Population.

    Jain, Divyanu / Jain, Ajay K / Metz, Gerlinde A S / Ballanyi, Nina / Sood, Abha / Linder, Rupert / Olson, David M

    Frontiers in reproductive health

    2021  Band 3, Seite(n) 673118

    Abstract: The Problem: ...

    Abstract The Problem:
    Sprache Englisch
    Erscheinungsdatum 2021-05-28
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ISSN 2673-3153
    ISSN (online) 2673-3153
    DOI 10.3389/frph.2021.673118
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Inhibitory effects of amniotic fluid on the activated protein C anticoagulation system in maternal plasma.

    Jain, Divyanu / Oda, Tomoaki / Kawai, Kenta / Horikoshi, Yoshimasa / Matsumoto, Masako / Narumi, Megumi / Kohmura-Kobayashi, Yukiko / Furuta-Isomura, Naomi / Yaguchi, Chizuko / Uchida, Toshiyuki / Suzuki, Kazunao / Kanayama, Naohiro / Itoh, Hiroaki / Tamura, Naoaki

    Journal of thrombosis and thrombolysis

    2021  Band 53, Heft 1, Seite(n) 208–212

    Abstract: Pulmonary thromboembolism (PTE) is one of the leading causes of maternal mortality. We previously reported that possible contamination of amniotic fluid (AF) into maternal circulation accelerated thrombin production and activated platelet function in ... ...

    Abstract Pulmonary thromboembolism (PTE) is one of the leading causes of maternal mortality. We previously reported that possible contamination of amniotic fluid (AF) into maternal circulation accelerated thrombin production and activated platelet function in maternal blood through the extrinsic pathway, which may be associated with the high incidence of PTE in early puerperium. However, it remains unclear whether the maternal anticoagulation system, e.g., the activated protein C (APC) pathway, contributes to the hypercoagulable condition induced by AF. Our previous study using an endogenous thrombin potential (ETP)-based assay revealed that sensitivity to APC was reduced during the postpartum first day, i.e., immediately after delivery, when parturients were supposed to be exposed to AF. Our aim is to investigate the susceptibility of maternal plasma to APC when mixed with AF. We collected plasma from 51 pregnant females and mixed with AF as well as APC. APC-sensitivity ratio (APC-sr) was calculated using the ETP-based assay. Addition of AF to maternal plasma showed a significant increase of ETP in the presence of APC. APC-sr was significantly increased, indicating decreased sensitivity to APC, after AF mixture to maternal plasma. The present APC-sr difference with AF contamination was smaller than that we reported previously in venous thromboembolism cases. The inhibitory effects of AF on the APC anticoagulation pathway may contribute, at least partly, to further promotion of thrombin production induced by AF. Combined with other classical thrombophilic risk factors, the present findings support possible involvements of AF exposure in the high incidence of PTE in early puerperium.
    Mesh-Begriff(e) Amniotic Fluid/metabolism ; Anticoagulants/therapeutic use ; Blood Coagulation ; Female ; Humans ; Pregnancy ; Protein C ; Thrombin/metabolism
    Chemische Substanzen Anticoagulants ; Protein C ; Thrombin (EC 3.4.21.5)
    Sprache Englisch
    Erscheinungsdatum 2021-07-06
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 1230645-9
    ISSN 1573-742X ; 0929-5305
    ISSN (online) 1573-742X
    ISSN 0929-5305
    DOI 10.1007/s11239-021-02513-4
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4352: Hefte anzeigen Standort:
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  4. Artikel ; Online: Acute inflammation in the uterine isthmus coincides with postpartum acute myometritis in the uterine body involving refractory postpartum hemorrhage of unknown etiology after cesarean delivery.

    Jain, Divyanu / Oda, Tomoaki / Kohmura-Kobayashi, Yukiko / Furuta-Isomura, Naomi / Yaguchi, Chizuko / Uchida, Toshiyuki / Suzuki, Kazunao / Itoh, Hiroaki / Kanayama, Naohiro / Tamura, Naoaki

    Journal of reproductive immunology

    2020  Band 139, Seite(n) 103116

    Abstract: Uterine atony is a major cause of postpartum hemorrhage. We recently proposed the new histological concept of postpartum acute myometritis (PAM) for the pathophysiology of refractory uterine atony of unknown etiology, which is characterized by the ... ...

    Abstract Uterine atony is a major cause of postpartum hemorrhage. We recently proposed the new histological concept of postpartum acute myometritis (PAM) for the pathophysiology of refractory uterine atony of unknown etiology, which is characterized by the diffuse activation of mast cells and the complement system as well as the massive infiltration of macrophages and neutrophils into the uterine body. We herein focused on the uterine isthmus just adjacent to the body. The isthmus becomes significantly elongated throughout pregnancy. It is composed of myocytes and fibroblasts with an extracellular matrix that forms a passive lower segment during labor. The aim of this study was to histologically examine the uterine isthmus in cases of PAM in the uterine body. Under the amniotic fluid embolism-registry program in Japan, we selected PAM cases from uterine samples obtained by cesarean hysterectomy and delivered to us for analyses between 2011 and 2017. Control tissues were collected during elective cesarean section. We investigated the isthmus tissues of these cases and performed immunohistochemistry for inflammatory cell markers, i.e. neutrophil elastase, mast cell tryptase, CD68, CD3, and C5a receptor (C5aR). The numbers of tryptase-positive degranulating mast cells, elastase-positive neutrophils, CD68-positive macrophages, and C5aR-positive cells in the isthmus were significantly higher in uteri with PAM in the body than in controls without PAM. CD3 was negative in both groups. In conclusion, inflammation and an anaphylactoid reaction were histologically detected not only in the uterine body, but in the isthmus among cases of refractory PPH of unknown etiology after cesarean section.
    Mesh-Begriff(e) Acute Disease ; Adult ; Cell Degranulation ; Cesarean Section ; Embolism, Amniotic Fluid/etiology ; Embolism, Amniotic Fluid/immunology ; Female ; Humans ; Inflammation/immunology ; Macrophages/immunology ; Mast Cells/immunology ; Myometrium/immunology ; Neutrophils/immunology ; Pancreatic Elastase ; Postoperative Complications/immunology ; Postpartum Hemorrhage/etiology ; Postpartum Hemorrhage/immunology ; Pregnancy ; Receptor, Anaphylatoxin C5a/metabolism ; Tryptases/metabolism ; Uterus/physiology ; Young Adult
    Chemische Substanzen C5AR1 protein, human ; Receptor, Anaphylatoxin C5a ; Pancreatic Elastase (EC 3.4.21.36) ; Tryptases (EC 3.4.21.59)
    Sprache Englisch
    Erscheinungsdatum 2020-03-10
    Erscheinungsland Ireland
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 424421-7
    ISSN 1872-7603 ; 0165-0378
    ISSN (online) 1872-7603
    ISSN 0165-0378
    DOI 10.1016/j.jri.2020.103116
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 1483: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Artikel ; Online: Plasticity of histone modifications around Cidea and Cidec genes with secondary bile in the amelioration of developmentally-programmed hepatic steatosis.

    Urmi, Jeenat Ferdous / Itoh, Hiroaki / Muramatsu-Kato, Keiko / Kohmura-Kobayashi, Yukiko / Hariya, Natsuyo / Jain, Divyanu / Tamura, Naoaki / Uchida, Toshiyuki / Suzuki, Kazunao / Ogawa, Yoshihiro / Shiraki, Nobuaki / Mochizuki, Kazuki / Kubota, Takeo / Kanayama, Naohiro

    Scientific reports

    2019  Band 9, Heft 1, Seite(n) 17100

    Abstract: We recently reported that a treatment with tauroursodeoxycholic acid (TUDCA), a secondary bile acid, improved developmentally-deteriorated hepatic steatosis in an undernourishment (UN, 40% caloric restriction) in utero mouse model after a postnatal high- ... ...

    Abstract We recently reported that a treatment with tauroursodeoxycholic acid (TUDCA), a secondary bile acid, improved developmentally-deteriorated hepatic steatosis in an undernourishment (UN, 40% caloric restriction) in utero mouse model after a postnatal high-fat diet (HFD). We performed a microarray analysis and focused on two genes (Cidea and Cidec) because they are enhancers of lipid droplet (LD) sizes in hepatocytes and showed the greatest up-regulation in expression by UN that were completely recovered by TUDCA, concomitant with parallel changes in LD sizes. TUDCA remodeled developmentally-induced histone modifications (dimethylation of H3K4, H3K27, or H3K36), but not DNA methylation, around the Cidea and Cidec genes in UN pups only. Changes in these histone modifications may contribute to the markedly down-regulated expression of Cidea and Cidec genes in UN pups, which was observed in the alleviation of hepatic fat deposition, even under HFD. These results provide an insight into the future of precision medicine for developmentally-programmed hepatic steatosis by targeting histone modifications.
    Mesh-Begriff(e) Animals ; Apoptosis Regulatory Proteins/genetics ; Cholagogues and Choleretics/pharmacology ; Diet, High-Fat/adverse effects ; Fatty Liver/drug therapy ; Fatty Liver/etiology ; Fatty Liver/genetics ; Gene Expression Profiling ; Gene Expression Regulation, Developmental/drug effects ; Histone Code/drug effects ; Male ; Mice ; Mice, Inbred C57BL ; Protein Processing, Post-Translational ; Proteins/genetics ; Taurochenodeoxycholic Acid/pharmacology
    Chemische Substanzen Apoptosis Regulatory Proteins ; Cholagogues and Choleretics ; Cidea protein, mouse ; Proteins ; fat-specific protein 27, mouse ; Taurochenodeoxycholic Acid (516-35-8) ; ursodoxicoltaurine (60EUX8MN5X)
    Sprache Englisch
    Erscheinungsdatum 2019-11-19
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-019-52943-7
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Technical Aspects and Clinical Limitations of Sperm DNA Fragmentation Testing in Male Infertility: A Global Survey, Current Guidelines, and Expert Recommendations.

    Agarwal, Ashok / Farkouh, Ala'a / Saleh, Ramadan / Hamoda, Taha Abo-Almagd Abdel-Meguid / Salvio, Gianmaria / Boitrelle, Florence / Harraz, Ahmed M / Ghayda, Ramy Abou / Kavoussi, Parviz / Gül, Murat / Toprak, Tuncay / Russo, Giorgio Ivan / Durairajanayagam, Damayanthi / Rambhatla, Amarnath / Birowo, Ponco / Cannarella, Rossella / Phuoc, Nguyen Ho Vinh / Zini, Armand / Arafa, Mohamed /
    Wyns, Christine / Tremellen, Kelton / Sarıkaya, Selçuk / Lewis, Sheena / Evenson, Donald P / Ko, Edmund / Calogero, Aldo E / Bahar, Fahmi / Martínez, Marlon / Ambar, Rafael F / Colpi, Giovanni M / Bakircioglu, Mustafa Emre / Henkel, Ralf / Kandil, Hussein / Serefoglu, Ege Can / Alfakhri, Abdullah / Tsujimura, Akira / Kheradmand, Alireza / Marino, Angelo / Adamyan, Aram / Zilaitiene, Birute / Ozer, Cevahir / Pescatori, Edoardo / Vogiatzi, Paraskevi / Busetto, Gian Maria / Balercia, Giancarlo / Elbardisi, Haitham / Akhavizadegan, Hamed / Sajadi, Hesamoddin / Taniguchi, Hisanori / Park, Hyun Jun / Maldonado Rosas, Israel / Al-Marhoon, Mohamed / Sadighi Gilani, Mohammad Ali / Alhathal, Naif / Quang, Nguyen / Pinggera, Germar-Michael / Kothari, Priyank / Micic, Sava / Homa, Sheryl / Long, Tran Quang Tien / Zohdy, Wael / Atmoko, Widi / Ibrahim, Wael / Sabbaghian, Marjan / Abumelha, Saad Mohammed / Chung, Eric / Ugur, Muhammet Rasit / Ozkent, Mehmet Serkan / Selim, Osama / Darbandi, Mahsa / Fukuhara, Shinichiro / Jamali, Mounir / de la Rosette, Jean / Kuroda, Shinnosuke / Smith, Ryan P / Baser, Aykut / Kalkanli, Arif / Tadros, Nicholas N / Aydos, Kaan / Mierzwa, Tiago Cesar / Khalafalla, Kareim / Malhotra, Vineet / Moussa, Mohamad / Finocchi, Federica / Rachman, Rinaldo Indra / Giulioni, Carlo / Avidor-Reiss, Tomer / Kahraman, Oguzhan / Çeker, Gökhan / Zenoaga-Barbăroșie, Cătălina / Barrett, Trenton L / Yilmaz, Mehmet / Kadioglu, Ates / Jindal, Sunil / Omran, Huda / Bocu, Kadir / Karthikeyan, Vilvapathy Senguttuvan / Franco, Giorgio / Solorzano, Jesús Fernando / Vishwakarma, Ranjit B / Arianto, Eko / Garrido, Nicolas / Jain, Divyanu / Gherabi, Nazim / Sokolakis, Ioannis / Palani, Ayad / Calik, Gokhan / Kulaksiz, Deniz / Simanaviciene, Vaida / Simopoulou, Mara / Güngör, Nur Dokuzeylül / Blecher, Gideon / Falcone, Marco / Jezek, Davor / Preto, Mirko / Amar, Edouard / Le, Tan V / Ahn, Sun Tae / Rezano, Andri / Singh, Keerti / Rocco, Lucia / Savira, Missy / Rajmil, Osvaldo / Darbandi, Sara / Sogutdelen, Emrullah / Boeri, Luca / Hernández, Guadalupe / Hakim, Lukman / Morimoto, Yoshiharu / Japari, Andrian / Sofikitis, Nikolaos / Altay, Baris / Metin Mahmutoglu, Asli / Al Hashimi, Manaf / Ziouziou, Imad / Anagnostopoulou, Christina / Lin, Haocheng / Shah, Rupin

    The world journal of men's health

    2023  Band 42, Heft 1, Seite(n) 202–215

    Abstract: Purpose: Sperm DNA fragmentation (SDF) is a functional sperm abnormality that can impact reproductive potential, for which four assays have been described in the recently published sixth edition of the WHO laboratory manual for the examination and ... ...

    Abstract Purpose: Sperm DNA fragmentation (SDF) is a functional sperm abnormality that can impact reproductive potential, for which four assays have been described in the recently published sixth edition of the WHO laboratory manual for the examination and processing of human semen. The purpose of this study was to examine the global practices related to the use of SDF assays and investigate the barriers and limitations that clinicians face in incorporating these tests into their practice.
    Materials and methods: Clinicians managing male infertility were invited to complete an online survey on practices related to SDF diagnostic and treatment approaches. Their responses related to the technical aspects of SDF testing, current professional society guidelines, and the literature were used to generate expert recommendations via the Delphi method. Finally, challenges related to SDF that the clinicians encounter in their daily practice were captured.
    Results: The survey was completed by 436 reproductive clinicians. Overall, terminal deoxynucleotidyl transferase deoxyuridine triphosphate Nick-End Labeling (TUNEL) is the most commonly used assay chosen by 28.6%, followed by the sperm chromatin structure assay (24.1%), and the sperm chromatin dispersion (19.1%). The choice of the assay was largely influenced by availability (70% of respondents). A threshold of 30% was the most selected cut-off value for elevated SDF by 33.7% of clinicians. Of respondents, 53.6% recommend SDF testing after 3 to 5 days of abstinence. Although 75.3% believe SDF testing can provide an explanation for many unknown causes of infertility, the main limiting factors selected by respondents are a lack of professional society guideline recommendations (62.7%) and an absence of globally accepted references for SDF interpretation (50.3%).
    Conclusions: This study represents the largest global survey on the technical aspects of SDF testing as well as the barriers encountered by clinicians. Unified global recommendations regarding clinician implementation and standard laboratory interpretation of SDF testing are crucial.
    Sprache Englisch
    Erscheinungsdatum 2023-08-24
    Erscheinungsland Korea (South)
    Dokumenttyp Journal Article
    ZDB-ID 2719786-4
    ISSN 2287-4690 ; 2287-4208
    ISSN (online) 2287-4690
    ISSN 2287-4208
    DOI 10.5534/wjmh.230076
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: Global Practice Patterns and Variations in the Medical and Surgical Management of Non-Obstructive Azoospermia: Results of a World-Wide Survey, Guidelines and Expert Recommendations.

    Rambhatla, Amarnath / Shah, Rupin / Ziouziou, Imad / Kothari, Priyank / Salvio, Gianmaria / Gul, Murat / Hamoda, Taha / Kavoussi, Parviz / Atmoko, Widi / Toprak, Tuncay / Birowo, Ponco / Ko, Edmund / Arafa, Mohamed / Ghayda, Ramy Abou / Karthikeyan, Vilvapathy Senguttuvan / Russo, Giorgio Ivan / Pinggera, Germar-Michael / Chung, Eric / Harraz, Ahmed M /
    Martinez, Marlon / Phuoc, Nguyen Ho Vinh / Tadros, Nicholas / Saleh, Ramadan / Savira, Missy / Colpi, Giovanni M / Zohdy, Wael / Pescatori, Edoardo / Park, Hyun Jun / Fukuhara, Shinichiro / Tsujimura, Akira / Rojas-Cruz, Cesar / Marino, Angelo / Mak, Siu King / Amar, Edouard / Ibrahim, Wael / Sindhwani, Puneet / Alhathal, Naif / Busetto, Gian Maria / Al Hashimi, Manaf / El-Sakka, Ahmed / Ramazan, Asci / Dimitriadis, Fotios / Timpano, Massimiliano / Jezek, Davor / Altay, Baris / Zylbersztejn, Daniel Suslik / Wong, Michael Yc / Moon, Du Geon / Wyns, Christine / Gamidov, Safar / Akhavizadegan, Hamed / Franceschelli, Alessandro / Aydos, Kaan / Quang, Nguyen / Ashour, Shedeed / Al Dayel, Adel / Al-Marhoon, Mohammed S / Micic, Sava / Binsaleh, Saleh / Hussein, Alayman / Elbardisi, Haitham / Mostafa, Taymour / Ramsay, Jonathan / Zachariou, Athanasios / Abdelrahman, Islam Fathy Soliman / Rajmil, Osvaldo / Kalkanli, Arif / Molina, Juan Manuel Corral / Bocu, Kadir / Duarsa, Gede Wirya Kusuma / Çeker, Gökhan / Serefoglu, Ege Can / Bahar, Fahmi / Gherabi, Nazim / Kuroda, Shinnosuke / Bouzouita, Abderrazak / Gudeloglu, Ahmet / Ceyhan, Erman / Hasan, Mohamed Saeed Mohamed / Musa, Muhammad Ujudud / Motawi, Ahmad / Cho, Chak-Lam / Taniguchi, Hisanori / Ho, Christopher Chee Kong / Vazquez, Jesus Fernando Solorzano / Mutambirwa, Shingai / Gungor, Nur Dokuzeylul / Bendayan, Marion / Giulioni, Carlo / Baser, Aykut / Falcone, Marco / Boeri, Luca / Blecher, Gideon / Kheradmand, Alireza / Sethupathy, Tamilselvi / Adriansjah, Ricky / Narimani, Nima / Konstantinidis, Charalampos / Nguyen, Tuan Thanh / Japari, Andrian / Dolati, Parisa / Singh, Keerti / Ozer, Cevahir / Sarikaya, Selcuk / Sheibak, Nadia / Bosco, Ndagijimana Jean / Özkent, Mehmet Serkan / Le, Sang Thanh / Sokolakis, Ioannis / Katz, Darren / Smith, Ryan / Truong, Manh Nguyen / Le, Tan V / Huang, Zhongwei / Deger, Muslim Dogan / Arslan, Umut / Calik, Gokhan / Franco, Giorgio / Rashed, Ayman / Kahraman, Oguzhan / Andreadakis, Sotiris / Putra, Rosadi / Balercia, Giancarlo / Khalafalla, Kareim / Cannarella, Rossella / Tuân, Anh Ðăng / El Meliegy, Amr / Zilaitiene, Birute / Ramirez, Marlene Lizbeth Zamora / Giacone, Filippo / Calogero, Aldo E / Makarounis, Konstantinos / Jindal, Sunil / Hoai, Bac Nguyen / Banthia, Ravi / Peña, Marcelo Rodriguez / Moorthy, Dharani / Adamyan, Aram / Kulaksiz, Deniz / Kandil, Hussein / Sofikitis, Nikolaos / Salzano, Ciro / Jungwirth, Andreas / Banka, Surendra Reddy / Mierzwa, Tiago Cesar / Turunç, Tahsin / Jain, Divyanu / Avoyan, Armen / Salacone, Pietro / Kadıoğlu, Ateş / Gupta, Chirag / Lin, Haocheng / Shamohammadi, Iman / Mogharabian, Nasser / Barrett, Trenton / Danacıoğlu, Yavuz Onur / Crafa, Andrea / Daoud, Salima / Malhotra, Vineet / Almardawi, Abdulmalik / Selim, Osama Mohamed / Moussa, Mohamad / Haghdani, Saeid / Duran, Mesut Berkan / Kunz, Yannic / Preto, Mirko / Eugeni, Elena / Nguyen, Thang / Elshahid, Ahmed Rashad / Suyono, Seso Sulijaya / Parikesit, Dyandra / Nada, Essam / Orozco, Eduardo Gutiérrez / Boitrelle, Florence / Trang, Nguyen Thi Minh / Jamali, Mounir / Nair, Raju / Ruzaev, Mikhail / Gadda, Franco / Thomas, Charalampos / Ferreira, Raphael Henrique / Gul, Umit / Maruccia, Serena / Kanbur, Ajay / Kinzikeeva, Ella / Abumelha, Saad Mohammed / Kosgi, Raghavender / Gokalp, Fatih / Soebadi, Mohammad Ayodhia / Paul, Gustavo Marquesine / Sajadi, Hesamoddin / Gupte, Deepak / Ambar, Rafael F / Sogutdelen, Emrullah / Singla, Karun / Basukarno, Ari / Kim, Shannon Hee Kyung / Gilani, Mohammad Ali Sadighi / Nagao, Koichi / Brodjonegoro, Sakti Ronggowardhana / Rezano, Andri / Elkhouly, Mohamed / Mazzilli, Rossella / Farsi, Hasan M A / Ba, Hung Nguyen / Alali, Hamed / Kafetzis, Dimitrios / Long, Tran Quang Tien / Alsaid, Sami / Cuong, Hoang Bao Ngoc / Oleksandr, Knigavko / Mustafa, Akhmad / Acosta, Herik / Pai, Hrishikesh / Şahin, Bahadır / Arianto, Eko / Teo, Colin / Jayaprakash, Sanjay Prakash / Rachman, Rinaldo Indra / Yenice, Mustafa Gurkan / Sefrioui, Omar / Priyadarshi, Shivam / Tanic, Marko / Alfatlaw, Noor Kareem / Rizaldi, Fikri / Vishwakarma, Ranjit B / Kanakis, George / Cherian, Dinesh Thomas / Lee, Joe / Galstyan, Raisa / Keskin, Hakan / Wurzacher, Janan / Seno, Doddy Hami / Noegroho, Bambang S / Margiana, Ria / Javed, Qaisar / Castiglioni, Fabrizio / Tanwar, Raman / Puigvert, Ana / Kaya, Coşkun / Purnomo, Medianto / Yazbeck, Chadi / Amir, Azwar / Borges, Edson / Bellavia, Marina / Deswanto, Isaac Ardianson / Kv, Vinod / Liguori, Giovanni / Minh, Dang Hoang / Siddiqi, Kashif / Colombo, Fulvio / Zini, Armand / Patel, Niket / Çayan, Selahittin / Al-Kawaz, Ula / Ragab, Maged / Hebrard, Guadalupe Hernández / de la Rosette, Jean / Efesoy, Ozan / Hoffmann, Ivan / Teixeira, Thiago Afonso / Saylam, Barış / Delgadillo, Daniela / Agarwal, Ashok

    The world journal of men's health

    2024  

    Abstract: Purpose: Non-obstructive azoospermia (NOA) is a common, but complex problem, with multiple therapeutic options and a lack of clear guidelines. Hence, there is considerable controversy and marked variation in the management of NOA. This survey evaluates ... ...

    Abstract Purpose: Non-obstructive azoospermia (NOA) is a common, but complex problem, with multiple therapeutic options and a lack of clear guidelines. Hence, there is considerable controversy and marked variation in the management of NOA. This survey evaluates contemporary global practices related to medical and surgical management for patients with NOA.
    Materials and methods: A 56-question online survey covering various aspects of the evaluation and management of NOA was sent to specialists around the globe. This paper analyzes the results of the second half of the survey dealing with the management of NOA. Results have been compared to current guidelines, and expert recommendations have been provided using a Delphi process.
    Results: Participants from 49 countries submitted 336 valid responses. Hormonal therapy for 3 to 6 months was suggested before surgical sperm retrieval (SSR) by 29.6% and 23.6% of participants for normogonadotropic hypogonadism and hypergonadotropic hypogonadism respectively. The SSR rate was reported as 50.0% by 26.0% to 50.0% of participants. Interestingly, 46.0% reported successful SSR in <10% of men with Klinefelter syndrome and 41.3% routinely recommended preimplantation genetic testing. Varicocele repair prior to SSR is recommended by 57.7%. Half of the respondents (57.4%) reported using ultrasound to identify the most vascularized areas in the testis for SSR. One-third proceed directly to microdissection testicular sperm extraction (mTESE) in every case of NOA while others use a staged approach. After a failed conventional TESE, 23.8% wait for 3 months, while 33.1% wait for 6 months before proceeding to mTESE. The cut-off of follicle-stimulating hormone for positive SSR was reported to be 12-19 IU/mL by 22.5% of participants and 20-40 IU/mL by 27.8%, while 31.8% reported no upper limit.
    Conclusions: This is the largest survey to date on the real-world medical and surgical management of NOA by reproductive experts. It demonstrates a diverse practice pattern and highlights the need for evidence-based international consensus guidelines.
    Sprache Englisch
    Erscheinungsdatum 2024-04-04
    Erscheinungsland Korea (South)
    Dokumenttyp Journal Article
    ZDB-ID 2719786-4
    ISSN 2287-4690 ; 2287-4208
    ISSN (online) 2287-4690
    ISSN 2287-4208
    DOI 10.5534/wjmh.230339
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: Global Practice Patterns in the Evaluation of Non-Obstructive Azoospermia: Results of a World-Wide Survey and Expert Recommendations.

    Shah, Rupin / Rambhatla, Amarnath / Atmoko, Widi / Martinez, Marlon / Ziouziou, Imad / Kothari, Priyank / Tadros, Nicholas / Phuoc, Nguyen Ho Vinh / Kavoussi, Parviz / Harraz, Ahmed / Salvio, Gianmaria / Gul, Murat / Hamoda, Taha / Toprak, Tuncay / Birowo, Ponco / Ko, Edmund / Arafa, Mohamed / Ghayda, Ramy Abou / Karthikeyan, Vilvapathy Senguttuvan /
    Saleh, Ramadan / Russo, Giorgio Ivan / Pinggera, Germar-Michael / Chung, Eric / Savira, Missy / Colpi, Giovanni M / Zohdy, Wael / Pescatori, Edoardo / Park, Hyun Jun / Fukuhara, Shinichiro / Tsujimura, Akira / Rojas-Cruz, Cesar / Marino, Angelo / Mak, Siu King / Amar, Edouard / Ibrahim, Wael / Sindhwani, Puneet / Alhathal, Naif / Busetto, Gian Maria / Al Hashimi, Manaf / El-Sakka, Ahmed / Ramazan, Asci / Dimitriadis, Fotios / Timpano, Massimiliano / Jezek, Davor / Altay, Baris / Zylbersztejn, Daniel Suslik / Wong, Michael Yc / Moon, Du Geon / Wyns, Christine / Gamidov, Safar / Akhavizadegan, Hamed / Franceschelli, Alessandro / Aydos, Kaan / Quang, Vinh Nguyen / Ashour, Shedeed / Al Dayel, Adel / Al-Marhoon, Mohamed S / Micic, Sava / Binsaleh, Saleh / Hussein, Alayman / Elbardisi, Haitham / Mostafa, Taymour / Taha, Emad / Ramsay, Jonathan / Zachariou, Athanasios / Abdelrahman, Islam Fathy Soliman / Rajmil, Osvaldo / Kalkanli, Arif / Molina, Juan Manuel Corral / Bocu, Kadir / Duarsa, Gede Wirya Kusuma / Ceker, Gokhan / Serefoglu, Ege Can / Bahar, Fahmi / Gherabi, Nazim / Kuroda, Shinnosuke / Bouzouita, Abderrazak / Gudeloglu, Ahmet / Ceyhan, Erman / Hasan, Mohamed Saeed Mohamed / Musa, Muhammad Ujudud / Motawi, Ahmad / Chak-Lam, Cho / Taniguchi, Hisanori / Ho, Christopher Chee Kong / Vazquez, Jesus Fernando Solorzano / Mutambirwa, Shingai / Gungor, Nur Dokuzeylul / Bendayan, Marion / Giulioni, Carlo / Baser, Aykut / Falcone, Marco / Boeri, Luca / Blecher, Gideon / Kheradmand, Alireza / Sethupathy, Tamilselvi / Adriansjah, Ricky / Narimani, Nima / Konstantinidis, Charalampos / Nguyen, Tuan Thanh / Japari, Andrian / Dolati, Parisa / Singh, Keerti / Ozer, Cevahir / Sarikaya, Selcuk / Sheibak, Nadia / Bosco, Ndagijimana Jean / Özkent, Mehmet Serkan / Le, Sang Thanh / Sokolakis, Ioannis / Katz, Darren / Smith, Ryan / Truong, Manh Nguyen / Le, Tan V / Huang, Zhongwei / Deger, Muslim Dogan / Arslan, Umut / Calik, Gokhan / Franco, Giorgio / Rashed, Ayman / Kahraman, Oguzhan / Andreadakis, Sotiris / Putra, Rosadi / Balercia, Giancarlo / Khalafalla, Kareim / Cannarella, Rossella / Tuân, Anh Ðăng / El Meliegy, Amr / Zilaitiene, Birute / Ramirez, Marlene Lizbeth Zamora / Giacone, Filippo / Calogero, Aldo E / Makarounis, Konstantinos / Jindal, Sunil / Hoai, Bac Nguyen / Banthia, Ravi / Peña, Marcelo Rodriguez / Moorthy, Dharani / Adamyan, Aram / Kulaksiz, Deniz / Kandil, Hussein / Sofikitis, Nikolaos / Salzano, Ciro / Jungwirth, Andreas / Banka, Surendra Reddy / Mierzwa, Tiago Cesar / Turunç, Tahsin / Jain, Divyanu / Avoyan, Armen / Salacone, Pietro / Kadıoğlu, Ateş / Gupta, Chirag / Lin, Haocheng / Shamohammadi, Iman / Mogharabian, Nasser / Barrett, Trenton / Danacıoğlu, Yavuz Onur / Crafa, Andrea / Daoud, Salima / Malhotra, Vineet / Almardawi, Abdulmalik / Selim, Osama Mohamed / Moussa, Mohamad / Haghdani, Saeid / Duran, Mesut Berkan / Kunz, Yannic / Preto, Mirko / Eugeni, Elena / Nguyen, Thang / Elshahid, Ahmed Rashad / Suyono, Seso Sulijaya / Parikesit, Dyandra / Nada, Essam / Orozco, Eduardo Gutiérrez / Boitrelle, Florence / Trang, Nguyen Thi Minh / Jamali, Mounir / Nair, Raju / Ruzaev, Mikhail / Gadda, Franco / Thomas, Charalampos / Ferreira, Raphael Henrique / Gul, Umit / Maruccia, Serena / Kanbur, Ajay / Kinzikeeva, Ella / Abumelha, Saad / Quang, Nguyen / Kosgi, Raghavender / Gokalp, Fatih / Soebadi, Mohammad Ayodhia / Paul, Gustavo Marquesine / Sajadi, Hesamoddin / Gupte, Deepak / Ambar, Rafael F / Sogutdelen, Emrullah / Singla, Karun / Basurkano, Ari / Kim, Shannon Hee Kyung / Gilani, Mohammad Ali Sadighi / Nagao, Koichi / Brodjonegoro, Sakti Ronggowardhana / Rezano, Andri / Elkhouly, Mohamed / Mazzilli, Rossella / Farsi, Hasan M A / Ba, Hung Nguyen / Alali, Hamed / Kafetzis, Dimitrios / Long, Tran Quang Tien / Alsaid, Sami / Cuong, Hoang Bao Ngoc / Oleksandr, Knigavko / Mustafa, Akhmad / Acosta, Herik / Pai, Hrishikesh / Şahin, Bahadır / Arianto, Eko / Teo, Colin / Jayaprakash, Sanjay Prakash / Rachman, Rinaldo Indra / Yenice, Mustafa Gurkan / Sefrioui, Omar / Paghdar, Smit / Priyadarshi, Shivam / Tanic, Marko / Alfatlawy, Noor Kareem / Rizaldi, Fikri / Vishwakarma, Ranjit B / Kanakis, George / Cherian, Dinesh Thomas / Lee, Joe / Galstyan, Raisa / Keskin, Hakan / Wurzacher, Jana / Seno, Doddy Hami / Noegroho, Bambang S / Margiana, Ria / Javed, Qaisar / Castiglioni, Fabrizio / Tanwar, Raman / Puigvert, Ana / Kaya, Coşkun / Purnomo, Medianto / Yazbeck, Chadi / Amir, Azwar / Borges, Edson / Bellavia, Marina / Deswanto, Isaac Ardianson / V, Vinod K / Liguori, Giovanni / Minh, Dang Hoang / Siddiqi, Kashif / Colombo, Fulvio / Zini, Armand / Patel, Niket / Çayan, Selahittin / Al-Kawaz, Ula / Ragab, Maged / Hebrard, Guadalupe Hernández / Hoffmann, Ivan / Efesoy, Ozan / Saylam, Barış / Agarwal, Ashok

    The world journal of men's health

    2024  

    Abstract: Purpose: Non-obstructive azoospermia (NOA) represents the persistent absence of sperm in ejaculate without obstruction, stemming from diverse disease processes. This survey explores global practices in NOA diagnosis, comparing them with guidelines and ... ...

    Abstract Purpose: Non-obstructive azoospermia (NOA) represents the persistent absence of sperm in ejaculate without obstruction, stemming from diverse disease processes. This survey explores global practices in NOA diagnosis, comparing them with guidelines and offering expert recommendations.
    Materials and methods: A 56-item questionnaire survey on NOA diagnosis and management was conducted globally from July to September 2022. This paper focuses on part 1, evaluating NOA diagnosis. Data from 367 participants across 49 countries were analyzed descriptively, with a Delphi process used for expert recommendations.
    Results: Of 336 eligible responses, most participants were experienced attending physicians (70.93%). To diagnose azoospermia definitively, 81.7% requested two semen samples. Commonly ordered hormone tests included serum follicle-stimulating hormone (FSH) (97.0%), total testosterone (92.9%), and luteinizing hormone (86.9%). Genetic testing was requested by 66.6%, with karyotype analysis (86.2%) and Y chromosome microdeletions (88.3%) prevalent. Diagnostic testicular biopsy, distinguishing obstructive azoospermia (OA) from NOA, was not performed by 45.1%, while 34.6% did it selectively. Differentiation relied on physical examination (76.1%), serum hormone profiles (69.6%), and semen tests (68.1%). Expectations of finding sperm surgically were higher in men with normal FSH, larger testes, and a history of sperm in ejaculate.
    Conclusions: This expert survey, encompassing 367 participants from 49 countries, unveils congruence with recommended guidelines in NOA diagnosis. However, noteworthy disparities in practices suggest a need for evidence-based, international consensus guidelines to standardize NOA evaluation, addressing existing gaps in professional recommendations.
    Sprache Englisch
    Erscheinungsdatum 2024-04-03
    Erscheinungsland Korea (South)
    Dokumenttyp Journal Article
    ZDB-ID 2719786-4
    ISSN 2287-4690 ; 2287-4208
    ISSN (online) 2287-4690
    ISSN 2287-4208
    DOI 10.5534/wjmh.230333
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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