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  1. Article ; Online: Low dose inocula of SARS-CoV-2 Alpha variant transmits more efficiently than earlier variants in hamsters

    Bobo Wing-Yee Mok / Honglian Liu / Shaofeng Deng / Jiayan Liu / Anna Jinxia Zhang / Siu-Ying Lau / Siwen Liu / Rachel Chun-Yee Tam / Conor J. Cremin / Timothy Ting-Leung Ng / Jake Siu-Lun Leung / Lam-Kwong Lee / Pui Wang / Kelvin Kai-Wang To / Jasper Fuk-Woo Chan / Kwok-Hung Chan / Kwok-Yung Yuen / Gilman Kit-Hang Siu / Honglin Chen

    Communications Biology, Vol 4, Iss 1, Pp 1-

    2021  Volume 8

    Abstract: Bobo Wing-Yee Mok et al. observe that the Alpha (B.1.1.7) variant of SARS-CoV-2 exhibits increased competitive fitness over earlier lineages at lower doses in a hamster model of viral transmission. Their results suggest that the Alpha variant’s ability ... ...

    Abstract Bobo Wing-Yee Mok et al. observe that the Alpha (B.1.1.7) variant of SARS-CoV-2 exhibits increased competitive fitness over earlier lineages at lower doses in a hamster model of viral transmission. Their results suggest that the Alpha variant’s ability to initiate effective infection with a low dose may underlie its ability to rapidly transmit throughout a population.
    Keywords Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Complementation of contact tracing by mass testing for successful containment of beta COVID-19 variant (SARS-CoV-2 VOC B.1.351) epidemic in Hong Kong

    Vincent Chi-Chung Cheng / Gilman Kit-Hang Siu / Shuk-Ching Wong / Albert Ka-Wing Au / Cecilia Suk-Fun Ng / Hong Chen / Xin Li / Lam-Kwong Lee / Jake Siu-Lun Leung / Kelvin Keru Lu / Hazel Wing-Hei Lo / Evelyn Yin-Kwan Wong / Shik Luk / Bosco Hoi-Shiu Lam / Wing-Kin To / Rodney Allan Lee / David Christopher Lung / Mike Yat-Wah Kwan / Herman Tse /
    Shuk-Kwan Chuang / Kelvin Kai-Wang To / Kwok-Yung Yuen

    The Lancet Regional Health. Western Pacific, Vol 17, Iss , Pp 100281- (2021)

    2021  

    Abstract: Background: Global dissemination of SARS-CoV-2 Variants of Concern (VOCs) remains a concern. The aim of this study is to describe how mass testing and phylogenetic analysis successfully prevented local transmission of SARS-CoV-2 VOC in a densely ... ...

    Abstract Background: Global dissemination of SARS-CoV-2 Variants of Concern (VOCs) remains a concern. The aim of this study is to describe how mass testing and phylogenetic analysis successfully prevented local transmission of SARS-CoV-2 VOC in a densely populated city with low herd immunity for COVID-19. Methods: In this descriptive study, we conducted contact tracing, quarantine, and mass testing of the potentially exposed contacts with the index case. Epidemiological investigation and phylogeographic analysis were performed. Findings: Among 11,818 laboratory confirmed cases of COVID-19 diagnosed till 13th May 2021 in Hong Kong, SARS-CoV-2 VOCs were found in 271 (2.3%) cases. Except for 10 locally acquired secondary cases, all SARS-CoV-2 VOCs were imported or acquired in quarantine hotels. The index case of this SARS-CoV-2 VOC B.1.351 epidemic, an inbound traveler with asymptomatic infection, was diagnosed 9 days after completing 21 days of quarantine. Contact tracing of 163 contacts in household, hotel, and residential building only revealed 1 (0.6%) secondary case. A symptomatic foreign domestic helper (FDH) without apparent epidemiological link but infected by virus with identical genome sequence was subsequently confirmed. Mass testing of 0.34 million FDHs identified two more cases which were phylogenetically linked. A total of 10 secondary cases were identified that were related to two household gatherings. The clinical attack rate of household close contact was significantly higher than non-household exposure during quarantine (7/25, 28% vs 0/2051, 0%; p<0.001). Interpretation: The rising epidemic of SARS-CoV-2 VOC transmission could be successfully controlled by contact tracing, quarantine, and rapid genome sequencing complemented by mass testing. Funding: Health and Medical Research Fund Commissioned Research on Control of Infectious Disease (see acknowledgments for full list).
    Keywords SARS-CoV-2 ; Variants of Concern ; Contact tracing ; Mass testing ; Phylogenetic analysis ; Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2021-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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