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  1. AU="Jakielska, Ewelina"
  2. AU="Sholl, Lynette"
  3. AU="Izquierdo, Inmaculada"
  4. AU="Miller, Andrew S"
  5. AU="Vincent-Levy-Frebault, V"
  6. AU="Willis, Zachary I"
  7. AU="Kruger, Eric S"
  8. AU="Ge, Shiyu"
  9. AU="Srivastava, Rajat"
  10. AU="Nemanja Vuksanovic"

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  1. Artikel: Effects of PCSK9 inhibitors on metabolic-associated fatty liver disease: a short review.

    Jakielska, Ewelina / Głuszak, Paweł / Walczak, Marta / Bryl, Wiesław

    Przeglad gastroenterologiczny

    2023  Band 18, Heft 2, Seite(n) 148–153

    Abstract: Metabolic-associated fatty liver disease (MAFLD), previously known as non-alcoholic fatty liver disease, is a significant epidemiological problem and a well-known cardiovascular risk factor. The increasing number of cases creates the need for new ... ...

    Abstract Metabolic-associated fatty liver disease (MAFLD), previously known as non-alcoholic fatty liver disease, is a significant epidemiological problem and a well-known cardiovascular risk factor. The increasing number of cases creates the need for new therapeutic methods aimed at improving patient outcomes. Recent studies have highlighted the relationship between MAFLD and proprotein convertase subtilisin/kexin type 9 (PCSK9). Based on the available data, PCSK9 inhibitors appear to have beneficial effects in patients with MAFLD, and they may be a treatment option in the future. Further research is necessary to better evaluate the efficiency of PCSK9 inhibitors in MAFLD treatment.
    Sprache Englisch
    Erscheinungsdatum 2023-03-23
    Erscheinungsland Poland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2596134-2
    ISSN 1897-4317 ; 1895-5770
    ISSN (online) 1897-4317
    ISSN 1895-5770
    DOI 10.5114/pg.2023.126054
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: How current biologic therapies affect the risk of major adverse cardiovascular events in patients with plaque psoriasis? A systematic review and meta-analysis of randomized controlled trials.

    Nartowicz, Sonia / Jakielska, Ewelina / Priadka, Monika / Adamski, Zygmunt / Ratajczak, Piotr / Kus, Krzysztof

    Postepy dermatologii i alergologii

    2021  Band 37, Heft 6, Seite(n) 986–994

    Abstract: Introduction: Concerns have been raised about an increased risk of major adverse cardiovascular events (MACEs) - stroke, myocardial infarction and sudden cardiac death - in patients with plaque psoriasis receiving biologic therapies.: Aim: This ... ...

    Abstract Introduction: Concerns have been raised about an increased risk of major adverse cardiovascular events (MACEs) - stroke, myocardial infarction and sudden cardiac death - in patients with plaque psoriasis receiving biologic therapies.
    Aim: This review and meta-analysis of randomized controlled trials (RCTs) was to evaluate the risk difference of MACEs between experimental and comparator interventions.
    Material and methods: We searched MEDLINE database for suitable trials. Prior to that we identified the search strategy and eligibility criteria. Each RCT was double-blind, placebo controlled and scored five points in Jadad scale. We calculated risk difference (RD) with use of the Mantel-Haenszel fixed-effect method with 95% confidence intervals (CIs) and calculated i2 statistic to assess heterogeneity. A total of 43 RCTs were included, involving 19,161 patients. Overall, the risk of MACEs in the included studies was 0.1% (
    Results: There were no statistically significant risk differences in patients treated with biologic therapy vs. placebo (
    Conclusions: Further trials are needed, including longer follow-up and patients with an increased cardiovascular risk, to assess the risk of MACEs.
    Sprache Englisch
    Erscheinungsdatum 2021-01-06
    Erscheinungsland Poland
    Dokumenttyp Journal Article
    ZDB-ID 2596142-1
    ISSN 1642-395X
    ISSN 1642-395X
    DOI 10.5114/ada.2020.102121
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Controversial Interactions of Tacrolimus with Dietary Supplements, Herbs and Food.

    Miedziaszczyk, Miłosz / Bajon, Aleksander / Jakielska, Ewelina / Primke, Marta / Sikora, Jędrzej / Skowrońska, Dagmara / Idasiak-Piechocka, Ilona

    Pharmaceutics

    2022  Band 14, Heft 10

    Abstract: Tacrolimus is an immunosuppressive calcineurin inhibitor used to prevent rejection in allogeneic organ transplant recipients, such as kidney, liver, heart or lung. It is metabolized in the liver, involving the cytochrome P450 (CYP3A4) isoform CYP3A4, and ...

    Abstract Tacrolimus is an immunosuppressive calcineurin inhibitor used to prevent rejection in allogeneic organ transplant recipients, such as kidney, liver, heart or lung. It is metabolized in the liver, involving the cytochrome P450 (CYP3A4) isoform CYP3A4, and is characterized by a narrow therapeutic window, dose-dependent toxicity and high inter-individual and intra-individual variability. In view of the abovementioned facts, the aim of the study is to present selected interactions between tacrolimus and the commonly used dietary supplements, herbs and food. The review was based on the available scientific literature found in the PubMed, Scopus and Cochrane databases. An increase in the serum concentration of tacrolimus can be caused by CYP3A4 inhibitors, such as grapefruit, pomelo, clementine, pomegranate, ginger and turmeric, revealing the side effects of this drug, particularly nephrotoxicity. In contrast, CYP3A4 inducers, such as St. John's Wort, may result in a lack of therapeutic effect by reducing the drug concentration. Additionally, the use of
    Sprache Englisch
    Erscheinungsdatum 2022-10-10
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics14102154
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Clinical factors affecting survival in patients with D-transposition of the great arteries after atrial switch repair: A meta-analysis.

    Nartowicz, Sonia Alicja / Jakielska, Ewelina / Ciepłucha, Aleksandra / Ratajczak, Piotr / Grajek, Stefan / Lesiak, Maciej / Trojnarska, Olga

    Kardiologia polska

    2022  Band 81, Heft 1, Seite(n) 38–47

    Abstract: Background: Atrial switch repair (AtrSR) was the initial operation method in patients with D-transposition of the great arteries (D-TGA) constituting the right ventricle as a systemic one. Currently, it has been replaced with arterial switch operation ( ... ...

    Abstract Background: Atrial switch repair (AtrSR) was the initial operation method in patients with D-transposition of the great arteries (D-TGA) constituting the right ventricle as a systemic one. Currently, it has been replaced with arterial switch operation (ASO), but the cohort of adults after AtrSR is still large and requires strict cardiological management of late complications. For this reason, we aimed to evaluate potential long-term mortality risk factors in patients with D-TGA after AtrSR (either Mustard or Senning procedures) Methods: We searched the MEDLINE database for suitable trials. We included 22 retrospective and prospective cohort studies of patients with D-TGA with at least 5 years mean/median follow-up time after Mustard or Senning procedures, with an endpoint of non-sudden cardiac death (n-SCD) and sudden cardiac death (SCD) after at least 30 days following surgery.
    Results: A total of 2912 patients were enrolled, of whom 351 met the combined endpoint of n-SCD/SCD. The long-term mortality risk factors were New York Heart Association (NYHA) class ≥III/heart failure hospitalization (odds ratio [OR], 7.25; 95% confidence interval [CI], 2.67-19.7), tricuspid valve regurgitation (OR, 4.64; 95% CI, 1.95-11.05), Mustard procedure (OR, 2.15; 95% CI, 1.37-3.35), complex D-TGA (OR, 2.41; 95% CI, 1.31-4.43), and right ventricular dysfunction (OR, 1.94; 95% CI, 0.99-3.79). Supraventricular arrhythmia (SVT; OR, 2.07; 95% CI, 0.88-4.85) and pacemaker implantation (OR, 2.37; 95% CI, 0.48-11.69) did not affect long-term survival in this group of patients. In an additional analysis, SVT showed a statistically significant impact on SCD (OR, 2.74; 95% CI, 1.36-5.53) but not on n-SCD (OR, 1.5; 95% CI, 0.37-6.0).
    Conclusions: This meta-analysis demonstrated that at least moderate tricuspid valve regurgitation, NYHA class ≥III/heart failure hospitalization, right ventricular dysfunction, complex D-TGA, and Mustard procedure are risk factors for long-term mortality in patients after AtrSR.
    Mesh-Begriff(e) Adult ; Humans ; Arterial Switch Operation/adverse effects ; Transposition of Great Vessels/surgery ; Transposition of Great Vessels/complications ; Tricuspid Valve Insufficiency ; Retrospective Studies ; Ventricular Dysfunction, Right/surgery ; Ventricular Dysfunction, Right/complications ; Prospective Studies ; Heart Failure/etiology ; Death, Sudden, Cardiac/etiology ; Arteries ; Follow-Up Studies ; Treatment Outcome
    Sprache Englisch
    Erscheinungsdatum 2022-09-09
    Erscheinungsland Poland
    Dokumenttyp Meta-Analysis ; Journal Article
    ZDB-ID 411492-9
    ISSN 1897-4279 ; 0022-9032
    ISSN (online) 1897-4279
    ISSN 0022-9032
    DOI 10.33963/KP.a2022.0209
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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