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  1. Book: Molecular allergy diagnostics

    Kleine-Tebbe, Jörg / Jakob, Thilo

    innovation for a better patient management

    2017  

    Author's details Jörg Kleine-Tebbe, Thilo Jakob, editors
    Keywords Hypersensitivity / diagnosis ; Molecular Diagnostic Techniques ; Allergen ; Anaphylaxis ; Component Resolved Diagnostics ; Immunoglobulin E IgE ; Personalized medicine
    Subject code 610
    Language English
    Size xx, 531 Seiten, 119 Illustrationen, 23.5 cm x 15.5 cm, 0 g
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT019570051
    ISBN 978-3-319-42498-9 ; 3-319-42498-X ; 9783319424996 ; 3319424998
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2018 A 205 available for loan (reading room) Lesesaal EG

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  2. Book: Molekulare Allergiediagnostik

    Kleine-Tebbe, Jörg / Jakob, Thilo

    2015  

    Author's details Jörg Kleine-Tebbe ; Thilo Jakob (Hrsg.)
    Keywords Hypersensitivity / diagnosis ; Molecular Diagnostic Techniques ; Allergie gegen Schalenfrüchte ; Markerallergene ; Anaphylaxie ; Immuntherapie ; Pricktest ; Inhalative Allergene ; Erdnussallergie ; Bet v 1 ; Anaphylaktischer Schock ; Epitope ; Proteinfamilien ; Allergische Sofortreaktionen ; Allergie ; Molekulare Diagnostik
    Subject Molekulardiagnostik ; Hypersensibilität ; Allergose ; Allergische Krankheit ; Allergische Reaktion ; Allergien
    Language German
    Size XVII, 392 S. : Ill., graph. Darst., 240 mm x 168 mm, 0 g
    Publisher Springer
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT018775666
    ISBN 978-3-662-45220-2 ; 978-3-662-45221-9 ; 3-662-45220-0 ; 3-662-45221-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2015 A 3487 available for loan (reading room) Lesesaal EG

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  3. Article ; Online: Potential and limitations of epitope mapping and molecular targeting in Hymenoptera venom allergy.

    Fernandes, Luís Gustavo Romani / Spillner, Edzard / Jakob, Thilo

    Frontiers in allergy

    2023  Volume 4, Page(s) 1327391

    Abstract: Hymenoptera venom (HV) allergy can lead to life threatening conditions by specific IgE (sIgE)-mediated anaphylactic reactions. The knowledge about major allergens from venom of different clinically relevant species increased in the last decades, allowing ...

    Abstract Hymenoptera venom (HV) allergy can lead to life threatening conditions by specific IgE (sIgE)-mediated anaphylactic reactions. The knowledge about major allergens from venom of different clinically relevant species increased in the last decades, allowing the development of component-resolved diagnostics in which sIgE to single allergens is analysed. Despite these advances, the precise regions of the allergens that bind to IgE are only known for few HV allergens. The detailed characterization of IgE epitopes may provide valuable information to improve immunodiagnostic tests and to develop new therapeutic strategies using allergen-derived peptides or other targeted approaches. Epitope-resolved analysis is challenging, since the identification of conformational epitopes present in many allergens demands complex technologies for molecular analyses. Furthermore, functional analysis of the epitopeś interaction with their respective ligands is needed to distinguish epitopes that can activate the allergic immune response, from those that are recognized by irrelevant antibodies or T cell receptors from non-effector cells. In this review, we focus on the use of mapping and molecular targeting approaches for characterization of the epitopes of the major venom allergens of clinically relevant Hymenoptera species. The screening of the most relevant allergen peptides by epitope mapping could be helpful for the development of molecules that target major and immunodominant epitopes blocking the allergen induced cellular reactions as novel approach for the treatment of HV allergy.
    Language English
    Publishing date 2023-12-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 2673-6101
    ISSN (online) 2673-6101
    DOI 10.3389/falgy.2023.1327391
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: [No title information]

    Jakob, Thilo / Klimek, Ludger

    Allergo Journal : interdisziplinare Zeitschrift fur Allergologie und Umweltmedizin : Organ der Deutschen Gesellschaft fur Allergie- und Immunitatsforschung

    2021  Volume 30, Issue 5, Page(s) 3

    Title translation Erfreuliches in COVID-19-Zeiten: Allergo Journal im JCR gelistet!
    Language German
    Publishing date 2021-08-13
    Publishing country Germany
    Document type Editorial
    ZDB-ID 1136943-7
    ISSN 0941-8849
    ISSN 0941-8849
    DOI 10.1007/s15007-021-4871-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3566: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: [No title information]

    Jakob, Thilo / Klimek, Ludger

    Allergo Journal : interdisziplinare Zeitschrift fur Allergologie und Umweltmedizin : Organ der Deutschen Gesellschaft fur Allergie- und Immunitatsforschung

    2021  Volume 30, Issue 3, Page(s) 3

    Title translation Aktuelles zu COVID-19 und Allergien.
    Language German
    Publishing date 2021-05-07
    Publishing country Germany
    Document type Editorial
    ZDB-ID 1136943-7
    ISSN 0941-8849
    ISSN 0941-8849
    DOI 10.1007/s15007-021-4805-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3566: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: [No title information]

    Jakob, Thilo / Klimek, Ludger

    Allergo Journal : interdisziplinare Zeitschrift fur Allergologie und Umweltmedizin : Organ der Deutschen Gesellschaft fur Allergie- und Immunitatsforschung

    2021  Volume 30, Issue 7, Page(s) 3

    Title translation Endlich wieder: Austausch von Angesicht zu Angesicht.
    Language German
    Publishing date 2021-11-08
    Publishing country Germany
    Document type Editorial
    ZDB-ID 1136943-7
    ISSN 0941-8849
    ISSN 0941-8849
    DOI 10.1007/s15007-021-4913-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3566: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: [No title information]

    Klimek, Ludger / Jakob, Thilo

    Allergo Journal : interdisziplinare Zeitschrift fur Allergologie und Umweltmedizin : Organ der Deutschen Gesellschaft fur Allergie- und Immunitatsforschung

    2021  Volume 30, Issue 2, Page(s) 3

    Title translation Darf's noch etwas mehr (Bürokratie und Regulierungswut) sein?
    Language German
    Publishing date 2021-03-26
    Publishing country Germany
    Document type Editorial
    ZDB-ID 1136943-7
    ISSN 0941-8849
    ISSN 0941-8849
    DOI 10.1007/s15007-021-4787-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3566: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: [No title information]

    Klimek, Ludger / Jakob, Thilo

    Allergo Journal : interdisziplinare Zeitschrift fur Allergologie und Umweltmedizin : Organ der Deutschen Gesellschaft fur Allergie- und Immunitatsforschung

    2021  Volume 30, Issue 6, Page(s) 3

    Title translation COVID-19-Impfung: Welche Rolle spielt die Angst vor allergischen Reaktionen?
    Language German
    Publishing date 2021-09-24
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1136943-7
    ISSN 0941-8849
    ISSN 0941-8849
    DOI 10.1007/s15007-021-4897-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3566: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Atopic Keratoconjunctivitis: Pathophysiology, Clinic, and Potential New Therapeutic Concepts.

    Lapp, Thabo / Mann, Caroline / Jakob, Thilo / Reinhard, Thomas / Maier, Philip Christian

    Klinische Monatsblatter fur Augenheilkunde

    2024  

    Abstract: Atopic dermatitis (AD) is a chronic recurrent inflammatory skin disease with a bipolar age distribution in childhood, adolescence and middle adulthood. Up to 50% of AD patients show ocular involvement, which can be potentially sight threatening. ... ...

    Title translation Atopische Keratokonjunktivitis: Pathophysiologie, Klinik und potenzielle neue Therapiekonzepte.
    Abstract Atopic dermatitis (AD) is a chronic recurrent inflammatory skin disease with a bipolar age distribution in childhood, adolescence and middle adulthood. Up to 50% of AD patients show ocular involvement, which can be potentially sight threatening. Clinically, the majority of cases present with atopic blepharo(kerato)conjunctivitis or atopic keratoconjunctivitis (AKC); other clinical variants from this group of inflammatory ocular surface diseases are keratoconjunctivitis vernalis in childhood and adolescence and allergic conjunctivitis. In addition to the aforementioned blepharitis, keratitis and conjunctivitis, AD is also associated with eyelid involvement with subsequent eyelid malposition, limbal insufficiency with the development of pseudopterygia, (chronic) cicatrizing conjunctivitis with symblephara formation and fornix shortening, as well as ocular surface malignancies such as conjunctival intraepithelial neoplasia (CIN) and squamous cell carcinoma. In addition, an association with AD or AKC has been described for keratoconus. Whereas the therapy of AD in dermatology has made revolutionary advances in recent years through the use of biologicals, the primary use of these biologicals in ophthalmological complications is still very hesitant. Treatment here is often provided using topical steroids and calcineurin inhibitors. The following article summarises recent developments in basic and clinical dermatological research and discusses them in the context of current concepts for ophthalmological therapy.
    Language German
    Publishing date 2024-04-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 80175-6
    ISSN 1439-3999 ; 0344-6360 ; 0344-6387 ; 0023-2165
    ISSN (online) 1439-3999
    ISSN 0344-6360 ; 0344-6387 ; 0023-2165
    DOI 10.1055/a-2244-2885
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: [No title information]

    Hötzenecker, Wolfram / Klimek, Ludger / Jakob, Thilo

    Allergo Journal : interdisziplinare Zeitschrift fur Allergologie und Umweltmedizin : Organ der Deutschen Gesellschaft fur Allergie- und Immunitatsforschung

    2022  Volume 31, Issue 7, Page(s) 3

    Title translation Österreichische Spezialisierung in Allergologie nimmt Fahrt auf.
    Language German
    Publishing date 2022-10-31
    Publishing country Germany
    Document type Editorial
    ZDB-ID 1136943-7
    ISSN 0941-8849
    ISSN 0941-8849
    DOI 10.1007/s15007-022-5617-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3566: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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