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  1. Book ; Online: New Therapies in the Field of Rheumatology

    Gerosa, Maria / Beatrice Chighizola, Cecilia / Jakobsson, Per-Johan

    2020  

    Keywords Science: general issues ; Pharmacology ; autoimmune diseases ; rheumatoid arthritis ; systemic lupus erythematosus ; disease modifing anti- rheumatic drugs ; biological therapies
    Size 1 electronic resource (144 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021231249
    ISBN 9782889635450 ; 2889635457
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: The anti-inflammatory and vasoprotective properties of mPGES-1 inhibition offer promising therapeutic potential.

    Steinmetz-Späh, Julia / Jakobsson, Per-Johan

    Expert opinion on therapeutic targets

    2023  Volume 27, Issue 11, Page(s) 1115–1123

    Abstract: Introduction: Prostaglandin E: Areas covered: The article briefly describes prostanoid history and metabolism with a strong focus on the vascular effects of prostanoids. Recent advances in mPGES-1 inhibitor development and results from pre-clinical ... ...

    Abstract Introduction: Prostaglandin E
    Areas covered: The article briefly describes prostanoid history and metabolism with a strong focus on the vascular effects of prostanoids. Recent advances in mPGES-1 inhibitor development and results from pre-clinical and clinical studies are presented. Prostanoid shunting after mPGES-1 inhibition is highlighted and particularly discussed in the context of cardiovascular diseases.
    Expert opinion: The newest research demonstrates that inhibition of mPGES-1 is a potent anti-inflammatory treatment strategy and beneficial and safer regarding cardiovascular side effects compared to NSAIDs. Inhibitors of mPGES-1 hold great potential to advance to the clinic and there are ongoing phase-II trials in endometriosis.
    MeSH term(s) Female ; Humans ; Prostaglandin-E Synthases/metabolism ; Prostaglandins/metabolism ; Anti-Inflammatory Agents/pharmacology ; Dinoprostone/metabolism ; Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Cyclooxygenase 2/metabolism
    Chemical Substances Prostaglandin-E Synthases (EC 5.3.99.3) ; Prostaglandins ; Anti-Inflammatory Agents ; Dinoprostone (K7Q1JQR04M) ; Anti-Inflammatory Agents, Non-Steroidal ; Cyclooxygenase 2 (EC 1.14.99.1)
    Language English
    Publishing date 2023-12-07
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2055208-7
    ISSN 1744-7631 ; 1472-8222
    ISSN (online) 1744-7631
    ISSN 1472-8222
    DOI 10.1080/14728222.2023.2285785
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Editorial: Insights in inflammation pharmacology: 2022.

    Patrignani, Paola / Ballerini, Patrizia / Jakobsson, Per-Johan / Steinhilber, Dieter

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1223761

    Language English
    Publishing date 2023-06-05
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1223761
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Thesis: Studies on leukotriene B 4 biosynthesis in B-lymphocytes

    Jakobsson, Per-Johan

    1994  

    Author's details av Per-Johan Jakobsson
    Language English
    Size Getr. Zählung : Ill., graph. Darst.
    Publishing country Sweden
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Stockholm, Karolinska Inst., Diss., 1994
    HBZ-ID HT006393753
    ISBN 91-628-1270-X ; 978-91-628-1270-6
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    94 E 1843 order for loan Magazin

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  5. Article: Editorial: Disease-modifying antirheumatic drugs: Approaches and lessons learned from traditional medicine.

    Mei, Liyan / Gao, Kaixin / He, Xiaojuan / Jakobsson, Per-Johan / Huang, Runyue

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1135803

    Language English
    Publishing date 2023-02-03
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1135803
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Microsomal prostaglandin E synthase-1 inhibition promotes shunting in arachidonic acid metabolism during inflammatory responses in vitro.

    Liu, Jianyang / Peng, Bing / Steinmetz-Späh, Julia / Idborg, Helena / Korotkova, Marina / Jakobsson, Per-Johan

    Prostaglandins & other lipid mediators

    2023  Volume 167, Page(s) 106738

    Abstract: Microsomal Prostaglandin E Synthase 1 (mPGES-1) is the key enzyme for the generation of the pro-inflammatory lipid mediator prostaglandin ... ...

    Abstract Microsomal Prostaglandin E Synthase 1 (mPGES-1) is the key enzyme for the generation of the pro-inflammatory lipid mediator prostaglandin E
    MeSH term(s) Mice ; Animals ; Prostaglandin-E Synthases/metabolism ; Cyclooxygenase 2/metabolism ; Arachidonic Acid ; Prostaglandins ; Inflammation/drug therapy ; Inflammation/metabolism ; Dinoprostone/metabolism ; Eicosanoids
    Chemical Substances Prostaglandin-E Synthases (EC 5.3.99.3) ; Cyclooxygenase 2 (EC 1.14.99.1) ; Arachidonic Acid (27YG812J1I) ; Prostaglandins ; Dinoprostone (K7Q1JQR04M) ; Eicosanoids
    Language English
    Publishing date 2023-04-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1426962-4
    ISSN 2212-196X ; 1098-8823 ; 0090-6980
    ISSN (online) 2212-196X
    ISSN 1098-8823 ; 0090-6980
    DOI 10.1016/j.prostaglandins.2023.106738
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Editorial: New Therapies in the Field of Rheumatology.

    Chighizola, Cecilia Beatrice / Jakobsson, Per-Johan / Gerosa, Maria

    Frontiers in pharmacology

    2020  Volume 10, Page(s) 1604

    Language English
    Publishing date 2020-01-28
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2019.01604
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: In early rheumatoid arthritis, anticitrullinated peptide antibodies associate with low number of affected joints and rheumatoid factor associates with systemic inflammation.

    Pertsinidou, Eleftheria / Saevarsdottir, Saedis / Manivel, Vivek Anand / Klareskog, Lars / Alfredsson, Lars / Mathsson-Alm, Linda / Hansson, Monika / Cornillet, Martin / Serre, Guy / Holmdahl, Rikard / Skriner, Karl / Jakobsson, Per-Johan / Westerlind, Helga / Askling, Johan / Rönnelid, Johan

    Annals of the rheumatic diseases

    2024  Volume 83, Issue 3, Page(s) 277–287

    Abstract: Objectives: To investigate how individual rheumatoid arthritis (RA) autoantibodies associate with individual signs and symptoms at the time of RA diagnosis.: Methods: IgA, IgG, IgM rheumatoid factor (RF), antibodies against cyclic citrullinated ... ...

    Abstract Objectives: To investigate how individual rheumatoid arthritis (RA) autoantibodies associate with individual signs and symptoms at the time of RA diagnosis.
    Methods: IgA, IgG, IgM rheumatoid factor (RF), antibodies against cyclic citrullinated peptide version 2 (anti-CCP2) and 16 individual antibodies against citrullinated protein (ACPA) reactivities were analysed centrally in baseline sera from 1600 patients with RA classified according to the 1987 American College of Rheumatology (ACR) criteria. These results were related to C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), number of swollen and tender joints (SJC and TJC), 28-joint disease activity scores (DAS28 and DAS28CRP), global disease activity evaluated by the patients and Health Assessment Questionnaire, all obtained at baseline.
    Results: Individually, all autoantibodies except immunoglobulin G (IgG) RF associated with low SJC and TJC and with high ESR. In IgM RF-negative patients, ACPA associated strictly with low number of swollen and tender joints. This association persisted in multiple regression and stratified analyses where IgM and IgA RF instead associated with inflammation expressed as ESR. Among subjects without any ACPA peptide reactivity, there was no association between RF isotypes and ESR. The effect of RF on ESR increased with the number of ACPA reactivities, especially for IgM RF. In patients fulfilling the 1987 ACR criteria without taking RF into account, associations between IgM RF and high ESR, as well as between ACPA and low joint counts, remained.
    Conclusion: Whereas ACPA associate with low counts of affected joints in early RA, RF associates with elevated measures of systemic inflammation in an ACPA-dependent manner. This latter finding corroborates in vitro models of ACPA and RF in immune complex-induced inflammation. These phenotypic associations are independent of classification criteria.
    MeSH term(s) Humans ; Rheumatoid Factor ; Arthritis, Rheumatoid ; Inflammation ; Autoantibodies ; Peptides, Cyclic ; Immunoglobulin G ; Immunoglobulin M ; Immunoglobulin A
    Chemical Substances Rheumatoid Factor (9009-79-4) ; Autoantibodies ; Peptides, Cyclic ; Immunoglobulin G ; Immunoglobulin M ; Immunoglobulin A
    Language English
    Publishing date 2024-02-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/ard-2023-224728
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 167: Show issues

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  9. Article: A review on mPGES-1 inhibitors: From preclinical studies to clinical applications.

    Bergqvist, Filip / Morgenstern, Ralf / Jakobsson, Per-Johan

    Prostaglandins & other lipid mediators

    2019  Volume 147, Page(s) 106383

    Abstract: Prostaglandin ... ...

    Abstract Prostaglandin E
    MeSH term(s) Animals ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Clinical Trials as Topic ; Drug Evaluation, Preclinical/methods ; Humans ; Prostaglandin-E Synthases/antagonists & inhibitors ; Prostaglandin-E Synthases/metabolism
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; PTGES protein, human (EC 5.3.99.3) ; Prostaglandin-E Synthases (EC 5.3.99.3) ; Ptges protein, mouse (EC 5.3.99.3)
    Language English
    Publishing date 2019-11-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1426962-4
    ISSN 2212-196X ; 1098-8823 ; 0090-6980
    ISSN (online) 2212-196X
    ISSN 1098-8823 ; 0090-6980
    DOI 10.1016/j.prostaglandins.2019.106383
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  10. Article ; Online: Anca Catrina 1971-2021.

    Klareskog, Lars / Rethi, Bence / Hensvold, Aase / Wähämaa, Heidi / Jakobsson, Per-Johan

    European journal of immunology

    2021  Volume 51, Issue 6, Page(s) 1309

    Language English
    Publishing date 2021-06-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.202170067
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