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Article ; Online: Mass spectrometric data on the cluster ions formed in mixtures of sodium dodecyl sulfate with divalent metal salts.

Jakubowska, Anna

2022 Volume 41, Page(s) 107943

Abstract: This paper reports the data obtained from electrospray mass spectra of sodium dodecyl sulfate (SDS) recorded at different concentrations of electrolytes in the positive and negative ion mode, for five different times of acquisition. Using the Excel ... ...

Abstract	This paper reports the data obtained from electrospray mass spectra of sodium dodecyl sulfate (SDS) recorded at different concentrations of electrolytes in the positive and negative ion mode, for five different times of acquisition. Using the Excel program, we show the changes in intensities of the peak assigned to a given cluster ion with increasing acquisition time and increasing salt concentration. Moreover, for DS monomers and dimers the correlations were found between the relative peak intensities,
Language	English
Publishing date	2022-02-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2786545-9
ISSN	2352-3409 ; 2352-3409
ISSN (online)	2352-3409
ISSN	2352-3409
DOI	10.1016/j.dib.2022.107943
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Mass spectrometric data on the cluster ions formed in mixtures of sodium dodecyl sulfate with divalent metal salts

Jakubowska, Anna

Data in Brief. 2022 Apr., v. 41

2022

Abstract	This paper reports the data obtained from electrospray mass spectra of sodium dodecyl sulfate (SDS) recorded at different concentrations of electrolytes in the positive and negative ion mode, for five different times of acquisition. Using the Excel program, we show the changes in intensities of the peak assigned to a given cluster ion with increasing acquisition time and increasing salt concentration. Moreover, for DS monomers and dimers the correlations were found between the relative peak intensities, PMₑ/Nₐ, and concentration ratios, [Me]/[DS] ([Me] and [DS] are concentrations of metal and dodecyl sulfate ions, respectively). The PMₑ/Nₐ values are numerical measures of the competition between metal, Me, and sodium, Na, cations in their binding with DS monomers and dimers. Generally, the data presented herein may be used to predict the type of cluster ions formed in a given mixture of an anionic surfactant with a divalent metal salt and a possible correlation between the peak height of a given cluster ion and the electrolyte concentration and acquisition time. For a broad discussion of the dataset obtained for [Me]/[DS] = 1, please refer to the research article “Interactions of divalent metal cations with headgroups of monomers, dimers, and trimers of anionic surfactant” (Jakubowska, 2021).
Keywords	anionic surfactants ; data collection ; divalent metals ; mass spectrometry ; salt concentration ; sodium ; sodium dodecyl sulfate ; sulfates
Language	English
Dates of publication	2022-04
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	2786545-9
ISSN	2352-3409
ISSN	2352-3409
DOI	10.1016/j.dib.2022.107943
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Article ; Online: Genetic Aspects of Problematic and Risky Internet Use in Young Men-Analysis of ANKK1, DRD2 and NTRK3 Gene Polymorphism.

Rył, Aleksandra / Tomska, Natalia / Jakubowska, Anna / Ogrodniczak, Alicja / Palma, Joanna / Rotter, Iwona

Genes

2024 Volume 15, Issue 2

Abstract: Background: Internet addiction disorder (IAD) is characterized by an excess of uncontrolled preoccupations, urges, or behaviors related to computer use and Internet access that culminate in negative outcomes or individual distress. PIU includes ... ...

Abstract	Background: Internet addiction disorder (IAD) is characterized by an excess of uncontrolled preoccupations, urges, or behaviors related to computer use and Internet access that culminate in negative outcomes or individual distress. PIU includes excessive online activities (such as video gaming, social media use, streaming, pornography viewing, and shopping). The aim of this study was to analyze the association of gene polymorphisms that may influence the severity of risky behaviors in young men with the frequency of Internet use. We speculate that there are individual differences in the mechanisms of Internet addiction and that gene-hormone associations may represent useful biomarkers for subgroups of individuals. Materials and methods: The study was conducted in a sample of 407 adult males. Subjects were asked to complete the Problematic Internet Use Test (PIUT). Serum was analyzed to determine concentrations of luteinizing hormone (LH), follicle stimulating hormone (FSH), testosterone (TT), sex hormone binding protein (SHBG), dehydroepiandrosterone sulfate (DHEA-S), estradiol (E2), prolactin (PRL), insulin (I), serotonin (5-HT), and dopamine (DA), as well as DRD2, ANKK1, and NTRK3 gene polymorphisms. Results: In the analysis of the ANKK1 gene, there was a specific association between ANKK1 polymorphisms and PRL and 5-HT blood concentrations. There was also an association between the ANKK1 polymorphisms and LH and DA concentrations. When analyzing the DRD2 gene polymorphism, we found that in the group with a moderate level of Internet dependence, there was an association between both the G/GG and GG/GG polymorphisms and FSH concentration. Conclusions: Our study found that there may be an association between the NTRK3 gene polymorphism and PIU. The polymorphisms of ANKK1 and DRD2 genes may be factors that influence the concentrations of hormones (PRL, 5-HT, DA) that are associated with the results obtained in PIU.
MeSH term(s)	Male ; Adult ; Humans ; Genotype ; Internet Use ; Serotonin ; Polymorphism, Single Nucleotide ; Receptors, Dopamine D2/genetics ; Protein Serine-Threonine Kinases/genetics ; Follicle Stimulating Hormone/genetics
Chemical Substances	Serotonin (333DO1RDJY) ; Receptors, Dopamine D2 ; Protein Serine-Threonine Kinases (EC 2.7.11.1) ; Follicle Stimulating Hormone (9002-68-0) ; ANKK1 protein, human (EC 2.7.11.1) ; DRD2 protein, human
Language	English
Publishing date	2024-01-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes15020169
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Article ; Online: Interactions of univalent counterions with headgroups of monomers and dimers of an anionic surfactant.

Jakubowska, Anna

Langmuir : the ACS journal of surfaces and colloids

2015 Volume 31, Issue 11, Page(s) 3293–3300

Abstract: Specific ion effects in solution are related to the hydrated ion size and ion hydration, electrostatic interactions, dispersion forces, ion effects on water structure, and ion modification of surface tension. In this study, we tried to identify which ... ...

Abstract	Specific ion effects in solution are related to the hydrated ion size and ion hydration, electrostatic interactions, dispersion forces, ion effects on water structure, and ion modification of surface tension. In this study, we tried to identify which factor determines the ion specificity observed. The preference and energy of metal cations binding with the headgroups of dodecylsulfate (DS) monomers and dimers were determined by mass spectrometry. In the gas phase, cation binding to DS dimer headgroups depends strongly on the cation radius. On the other hand, the interactions between DS monomer headgroups and chaotropic ions depend on the cation polarizability, and the binding of kosmotropic cations to DS monomer headgroups strongly depends on the Gibbs free energies of ion hydration. DS dimers are related to surfactants having doubly charged headgroups, and DS monomers are related to surfactants with singly charged headgroups. Our spectrometric study of the strength of counterion binding to free monomers of a surfactant provides insight into surfactant-counterion interactions at micellar interfaces in bulk solution.
MeSH term(s)	Anions/chemistry ; Surface-Active Agents/chemistry
Chemical Substances	Anions ; Surface-Active Agents
Language	English
Publishing date	2015-03-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2005937-1
ISSN	1520-5827 ; 0743-7463
ISSN (online)	1520-5827
ISSN	0743-7463
DOI	10.1021/la5049002
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Article: Annexin V in children with idiopathic nephrotic syndrome treated with cyclosporine A.

Jakubowska, Anna / Kiliś-Pstrusińska, Katarzyna

Advances in clinical and experimental medicine : official organ Wroclaw Medical University

2020 Volume 29, Issue 5, Page(s) 603–609

Abstract: Background: Treatment with cyclosporine A (CsA), a calcineurin inhibitor, is effective in children with difficult idiopathic nephrotic syndrome (INS). Prolonged CsA treatment can result in several adverse effects, the most significant being ... ...

Abstract	Background: Treatment with cyclosporine A (CsA), a calcineurin inhibitor, is effective in children with difficult idiopathic nephrotic syndrome (INS). Prolonged CsA treatment can result in several adverse effects, the most significant being nephrotoxicity (CsAN). The plasma and urine levels of the proteins annexin V (AnV) and uromodulin (UM) were investigated in order to assess their usefulness as indicators of early-stage CsAN. Uromodulin is considered a distal tubular damage marker. Annnexin V is present in the distal tubules. Objectives: To measure AnV in children with INS receiving CsA treatment and to assess the usefulness of this biomarker for monitoring CsAN and as an indicator of changes in the distal tubules of the nephron. Material and methods: The prospective study included 30 patients with INS and 22 controls. Plasma and urinary AnV levels were measured 3 times: before CsA treatment, and after 6 and 12 months of therapy. The AnV levels were compared to those of UM. Results: The urinary AnV and UM levels were significantly higher in the INS patients before CsA therapy in comparison to the reference group. A progressive increase of urinary AnV was observed after 6 and 12 months of therapy. Urinary UM only increased after 6 months. No significant correlations were found between plasma and urinary concentrations of the proteins studied. Conclusions: The increased urinary excretion of AnV in children with INS receiving CsA treatment may suggest its usefulness as an early marker of subclinical CsAN. Annexin V seems to be a more sensitive indicator of tubular damage in the course of CsA therapy than UM, though large, multicenter studies are needed.
MeSH term(s)	Annexin A5/blood ; Annexin A5/urine ; Calcineurin Inhibitors/therapeutic use ; Case-Control Studies ; Child ; Cyclosporine/therapeutic use ; Female ; Humans ; Immunosuppressive Agents/therapeutic use ; Male ; Nephrotic Syndrome/blood ; Nephrotic Syndrome/drug therapy ; Nephrotic Syndrome/urine ; Prospective Studies ; Treatment Outcome ; Uromodulin/blood ; Uromodulin/urine
Chemical Substances	Annexin A5 ; Calcineurin Inhibitors ; Immunosuppressive Agents ; Uromodulin ; Cyclosporine (83HN0GTJ6D)
Language	English
Publishing date	2020-05-29
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2270257-X
ISSN	1899-5276 ; 1230-025X
ISSN	1899-5276 ; 1230-025X
DOI	10.17219/acem/121519
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Article ; Online: GWAS markers in diagnostics of breast cancer risk

Jakubowska Anna

Hereditary Cancer in Clinical Practice , Vol 10, Iss Suppl 4, p A

2012 Volume 14

Keywords	Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Oncology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Language	English
Publishing date	2012-12-01T00:00:00Z
Publisher	BioMed Central
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Case-inspired exploration of renin mutations in autosomal dominant tubulointerstitial kidney disease: not all paths lead to the endoplasmic reticulum.

Niedbalska-Tarnowska, Joanna / Jakubowska, Anna / Majkowski, Michał / Pęcherz, Michalina / Medyńska, Anna / Mroczek, Robert / Kiliś-Pstrusińska, Katarzyna / Cebrat, Małgorzata / Łaszkiewicz, Agnieszka

Pediatric nephrology (Berlin, Germany)

2024

Abstract: Background: Autosomal dominant tubulointerstitial kidney disease (ADTKD) results from mutations in various genes, including REN, UMOD, MUC1, and HNF1B. ADTKD due to REN mutations (ADTKD-REN) is often characterized as a proteinopathy that triggers the ... ...

Abstract	Background: Autosomal dominant tubulointerstitial kidney disease (ADTKD) results from mutations in various genes, including REN, UMOD, MUC1, and HNF1B. ADTKD due to REN mutations (ADTKD-REN) is often characterized as a proteinopathy that triggers the endoplasmic reticulum stress (ERS) cascade, potentially sharing similarities with ADTKD-UMOD and ADTKD-MUC1 at the cellular level. This study, inspired by a patient harboring a W17R mutation, investigates ERS activation by this mutation alongside two other renin variants, W10R and L381P. Methods: We established stable cell lines expressing both wild-type and mutated renin forms (W17R, W10R, and L381P). Using luciferase reporter assays, RT-qPCR, and confocal microscopy, we evaluated ERS activation, determined the cellular localization of the renin variants, and characterized the mitochondrial network in the W17R line. Results: The L381P line exhibited ERS activation, including transcriptional upregulation of MANF and CRELD2. No ERS activation was observed in the W17R line, while the W10R line exhibited intermediate characteristics. Notably, the W17R variant was misrouted to the mitochondria resulting in changes of the mitochondrial network organisation. Conclusions: ERS activation is not a universal response to different renin mutations in ADTKD-REN. The pathogenesis of the W17R mutation may involve mitochondrial dysfunction rather than the ER pathway, albeit further research is needed to substantiate this hypothesis fully. Testing CRELD2 and MANF as targeted therapy markers for a specific subgroup of ADTKD-REN patients is recommended. Additionally, fludrocortisone treatment has shown efficacy in stabilizing the renal function of our patient over a four-year period without significant side effects.
Language	English
Publishing date	2024-03-23
Publishing country	Germany
Document type	Journal Article
ZDB-ID	631932-4
ISSN	1432-198X ; 0931-041X
ISSN (online)	1432-198X
ISSN	0931-041X
DOI	10.1007/s00467-024-06350-4
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Article: Interactions of Univalent Counterions with Headgroups of Monomers and Dimers of an Anionic Surfactant

Jakubowska, Anna

Langmuir. 2015 Mar. 24, v. 31, no. 11

2015

Abstract	Specific ion effects in solution are related to the hydrated ion size and ion hydration, electrostatic interactions, dispersion forces, ion effects on water structure, and ion modification of surface tension. In this study, we tried to identify which factor determines the ion specificity observed. The preference and energy of metal cations binding with the headgroups of dodecylsulfate (DS) monomers and dimers were determined by mass spectrometry. In the gas phase, cation binding to DS dimer headgroups depends strongly on the cation radius. On the other hand, the interactions between DS monomer headgroups and chaotropic ions depend on the cation polarizability, and the binding of kosmotropic cations to DS monomer headgroups strongly depends on the Gibbs free energies of ion hydration. DS dimers are related to surfactants having doubly charged headgroups, and DS monomers are related to surfactants with singly charged headgroups. Our spectrometric study of the strength of counterion binding to free monomers of a surfactant provides insight into surfactantâcounterion interactions at micellar interfaces in bulk solution.
Keywords	anionic surfactants ; cations ; electrostatic interactions ; energy ; gases ; Gibbs free energy ; mass spectrometry ; surface tension
Language	English
Dates of publication	2015-0324
Size	p. 3293-3300.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	2005937-1
ISSN	1520-5827 ; 0743-7463
ISSN (online)	1520-5827
ISSN	0743-7463
DOI	10.1021%2Fla5049002
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Evaluation of Wool Quality Parameters of Polish Sheep Breeds

Kicinska- Jakubowska, Anna / Morales Villavicencio, Anna / Zimniewska, Malgorzata / Przybylska, Patrycja / Kwiatkowska, Edyta

Journal of Natural Fibers. 2022 Dec. 01, v. 19, no. 13 p.5880-5887

2022

Abstract: The aim of the study was exploration of the properties of wool derived from sheep reared in Poland. Twenty-nine breeds of sheep diverse from the type of farming, e.g. for meat, dual-purpose breeds for wool-milk, and versatile wool are bred in Poland, but ...

Abstract	The aim of the study was exploration of the properties of wool derived from sheep reared in Poland. Twenty-nine breeds of sheep diverse from the type of farming, e.g. for meat, dual-purpose breeds for wool-milk, and versatile wool are bred in Poland, but only few of them have uniform wool. Because there is a lack of data determining quality and quantity of Polish wool, the wool-based textile industry in Poland uses mainly imported raw material. Wool quality has an impact on processing efficiency and determines possibility of its further use. In order to assess the wool quality from the local sheep breeds (Polish Merino, Olkuska, Żelaźnieńska, Polish Lowland Sheep), fiber parameters were evaluated: average fiber diameter, length, curvature, and comfort factor. The wool was subjected to microscopic analysis and color examination. Results of the study showed that wool from the above-mentioned sheep breeds varies greatly in terms of quality. The obtained data helps fill the information gap on Polish wool.
Keywords	Merino ; color ; meat ; raw materials ; sheep ; textile industry ; wool ; Poland ; Polish wool ; quality parameters ; microscopic analysis ; diameter ; curvature
Language	English
Dates of publication	2022-1201
Size	p. 5880-5887.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	2182715-1
ISSN	1544-046X ; 1544-0478
ISSN (online)	1544-046X
ISSN	1544-0478
DOI	10.1080/15440478.2021.1902895
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Carotid Artery Calcifications on Panoramic Radiographs.

Janiszewska-Olszowska, Joanna / Jakubowska, Anna / Gieruszczak, Ewa / Jakubowski, Kacper / Wawrzyniak, Piotr / Grocholewicz, Katarzyna

International journal of environmental research and public health

2022 Volume 19, Issue 21

Abstract: Objective: The objective of this study was to evaluate the prevalence of carotid artery calcifications (CACs) on panoramic radiographs of Polish dental patients.: Methods: Panoramic radiographs made between 2005 and 2012 in 4000 patients born between ...

Abstract	Objective: The objective of this study was to evaluate the prevalence of carotid artery calcifications (CACs) on panoramic radiographs of Polish dental patients. Methods: Panoramic radiographs made between 2005 and 2012 in 4000 patients born between 1922 and 1958 were accessed from the server of the Department of Radiology and analyzed for the presence or absence of CACs by a group of trained dentists. Results: The anatomical area covered by the analysis was visible in 2189 images (54.73%). Calcifications in the carotid arteries were found in 468 (21.68%) patients, including 327 (14.94%) unilaterally and 141 (6.44%) bilaterally. CACs were found in 284 (60.68%) women and 184 (39.32%) men. Conclusions: The prevalence rate of CACs detected on panoramic radiographs in patients aged 54 and older was 21.68%, which makes it an important clinical problem.
MeSH term(s)	Male ; Humans ; Female ; Radiography, Panoramic ; Carotid Artery Diseases/diagnostic imaging ; Carotid Artery Diseases/epidemiology ; Carotid Arteries/diagnostic imaging ; Calcinosis/diagnostic imaging ; Calcinosis/epidemiology ; Prevalence ; Carotid Stenosis
Language	English
Publishing date	2022-10-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph192114056
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