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  1. Article ; Online: Occupational exposure to vapors, gasses, dusts, and fumes in relation to causes of death during 24 years in Helsinki, Finland.

    Jalasto, Juuso / Luukkonen, Ritva / Lindqvist, Ari / Langhammer, Arnulf / Kankaanranta, Hannu / Backman, Helena / Rönmark, Eva / Sovijärvi, Anssi / Piirilä, Päivi / Kauppi, Paula

    International archives of occupational and environmental health

    2023  Volume 97, Issue 2, Page(s) 145–154

    Abstract: Purpose: Environmental particulate matter (PM) exposure has been shown to cause excess all-cause and disease-specific mortality. Our aim was to compare disease-specific mortality by estimated occupational exposure to vapors, gasses, dusts, and fumes ( ... ...

    Abstract Purpose: Environmental particulate matter (PM) exposure has been shown to cause excess all-cause and disease-specific mortality. Our aim was to compare disease-specific mortality by estimated occupational exposure to vapors, gasses, dusts, and fumes (VGDF).
    Methods: The data source is the Helsinki part of the population-based FinEsS study on chronic obstructive pulmonary diseases including information on age, education level, main occupation, sex, and tobacco smoking combined with death registry information. We compared estimated VGDF exposure to mortality using adjusted competing-risks regression for disease-specific survival analysis for a 24-year follow-up.
    Results: Compared to the no-exposure group, the high occupational VGDF exposure group had sub-hazard ratios (sHR) of 1.7 (95% CI 1.3-2.2) for all cardiovascular-related and sHR 2.1 (1.5-3.9) for just coronary artery-related mortality. It also had sHR 1.7 (1.0-2.8) for Alzheimer's or vascular dementia-related mortality and sHR 1.7(1.2-2.4) for all respiratory disease-related mortality.
    Conclusion: Long-term occupational exposure to VGDF increased the hazard of mortality- to cardiovascular-, respiratory-, and dementia-related causes. This emphasizes the need for minimizing occupational long-term respiratory exposure to dust, gasses, and fumes.
    MeSH term(s) Humans ; Dust/analysis ; Cause of Death ; Finland/epidemiology ; Occupational Diseases/etiology ; Occupational Exposure/adverse effects ; Occupational Exposure/analysis ; Pulmonary Disease, Chronic Obstructive/etiology ; Gases/analysis ; Risk Factors
    Chemical Substances Dust ; Gases
    Language English
    Publishing date 2023-12-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 129038-1
    ISSN 1432-1246 ; 0340-0131 ; 0367-9977
    ISSN (online) 1432-1246
    ISSN 0340-0131 ; 0367-9977
    DOI 10.1007/s00420-023-02031-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Un I Zs.366: Show issues Location:
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  2. Article ; Online: Mortality Associated With Occupational Exposure in Helsinki, Finland-A 24-Year Follow-up.

    Jalasto, Juuso / Luukkonen, Ritva / Lindqvist, Ari / Langhammer, Arnulf / Kankaanranta, Hannu / Backman, Helena / Rönmark, Eva / Sovijärvi, Anssi / Kauppi, Paula / Piirilä, Päivi

    Journal of occupational and environmental medicine

    2022  Volume 65, Issue 1, Page(s) 22–28

    Abstract: Objectives: Our objective was to study mortality related to different obstructive lung diseases, occupational exposure, and their potential joint effect in a large, randomized population-based cohort.: Methods: We divided the participants based on ... ...

    Abstract Objectives: Our objective was to study mortality related to different obstructive lung diseases, occupational exposure, and their potential joint effect in a large, randomized population-based cohort.
    Methods: We divided the participants based on the answers to asthma and chronic obstructive pulmonary disease (COPD) diagnoses and occupational exposure and used a combined effects model and compared the results to no asthma or COPD with no occupational exposure.
    Results: High exposure had a hazards ratio (HR) of 1.34 (1.11-1.62) and asthma and COPD coexistence of 1.58 (1.10-2.27). The combined effects of intermediate exposure and coexistence had an HR of 2.20 (1.18-4.09), high exposure with coexistence of 1.94 (1.10-3.42) for overall mortality, and sub-HR for respiratory-related mortality of 3.21 (1.87-5.50).
    Conclusions: High occupational exposure increased overall but not respiratory-related mortality hazards, while coexisting asthma and COPD overall and respiratory-related hazards of mortality.
    MeSH term(s) Humans ; Asthma/etiology ; Asthma/mortality ; Finland/epidemiology ; Follow-Up Studies ; Occupational Diseases/epidemiology ; Occupational Exposure/adverse effects ; Pulmonary Disease, Chronic Obstructive/etiology ; Pulmonary Disease, Chronic Obstructive/mortality ; Risk Factors
    Language English
    Publishing date 2022-10-06
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1223932-x
    ISSN 1536-5948 ; 1076-2752
    ISSN (online) 1536-5948
    ISSN 1076-2752
    DOI 10.1097/JOM.0000000000002718
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Self-Reported Physician Diagnosed Asthma with COPD is Associated with Higher Mortality than Self-Reported Asthma or COPD Alone - A Prospective 24-Year Study in the Population of Helsinki, Finland.

    Jalasto, Juuso / Kauppi, Paula / Luukkonen, Ritva / Lindqvist, Ari / Langhammer, Arnulf / Kankaanranta, Hannu / Backman, Helena / Rönmark, Eva / Sovijärvi, Anssi / Piirilä, Päivi

    COPD

    2022  Volume 19, Issue 1, Page(s) 226–235

    Abstract: Asthma and COPD are common chronic obstructive respiratory diseases. COPD is associated with increased mortality, but for asthma the results are varying. Their combination has been less investigated, and the results are contradictory. The aim of this ... ...

    Abstract Asthma and COPD are common chronic obstructive respiratory diseases. COPD is associated with increased mortality, but for asthma the results are varying. Their combination has been less investigated, and the results are contradictory. The aim of this prospective study was to observe the overall mortality in obstructive pulmonary diseases and how mortality was related to specific causes using postal questionnaire data. This study included data from 6,062 participants in the FinEsS Helsinki Study (1996) linked to mortality data during a 24-year follow-up. According to self-reported physician diagnosed asthma, COPD, or smoking status, the population was divided into five categories: combined asthma and COPD, COPD alone and asthma alone, ever-smokers without asthma or COPD and never-smokers without asthma or COPD (reference group). For the specific causes of death both the underlying and contributing causes of death were used. Participants with asthma and COPD had the highest hazard of mortality 2.4 (95% CI 1.7-3.5). Ever-smokers without asthma or COPD had a 9.5 (3.7-24.2) subhazard ratio (sHR) related to lower respiratory tract disease specific causes. For asthma, COPD and combined, the corresponding figures were 10.8 (3.4-34.1), 25.0 (8.1-77.4), and 56.1 (19.6-160), respectively. Ever-smokers without asthma or COPD sHR 1.7 (95% CI 1.3-2.5), and participants with combined asthma and COPD 3.5 (1.9-6.3) also featured mortality in association with coronary artery disease. Subjects with combined diseases had the highest hazard of overall mortality and combined diseases also showed the highest hazard of mortality associated with lower respiratory tract causes or coronary artery causes.
    MeSH term(s) Asthma/diagnosis ; Finland/epidemiology ; Humans ; Physicians ; Prospective Studies ; Pulmonary Disease, Chronic Obstructive/complications ; Risk Factors ; Self Report ; Smoking/epidemiology
    Language English
    Publishing date 2022-04-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2171107-0
    ISSN 1541-2563 ; 1541-2555
    ISSN (online) 1541-2563
    ISSN 1541-2555
    DOI 10.1080/15412555.2022.2061935
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Underdiagnosis and misclassification of COPD in Sweden - A Nordic Epilung study.

    Axelsson, Malin / Backman, Helena / Nwaru, Bright I / Stridsman, Caroline / Vanfleteren, Lowie / Hedman, Linnea / Piirilä, Päivi / Jalasto, Juuso / Langhammer, Arnulf / Kankaanranta, Hannu / Rådinger, Madeleine / Ekerljung, Linda / Rönmark, Eva / Lindberg, Anne

    Respiratory medicine

    2023  Volume 217, Page(s) 107347

    Abstract: Introduction: The prevalence of COPD tends to level off in populations with decreasing prevalence of smoking but the extent of underdiagnosis in such populations needs further investigation.: Aim: To investigate underdiagnosis and misclassification ... ...

    Abstract Introduction: The prevalence of COPD tends to level off in populations with decreasing prevalence of smoking but the extent of underdiagnosis in such populations needs further investigation.
    Aim: To investigate underdiagnosis and misclassification of COPD with a focus on socio-economy, lifestyle determinants and healthcare utilization.
    Method: The 1839 participants were selected from two ongoing large-scale epidemiological research programs: The Obstructive Lung Disease in Northern Sweden Studies and the West Sweden Asthma Study. COPD
    Results: Among the 128 participants who fulfilled the criteria for COPD
    Conclusion: In the high income country Sweden, the underdiagnosis of COPD was highly prevalent. Reduced underdiagnosis can contribute to risk factor modification, medical treatment and self-management strategies in early stages of the disease, which may prevent disease progression and improve the quality of life among those affected. Therefore, there is a need to increase the use of spirometry in primary care to improve the diagnostic accuracy.
    MeSH term(s) Male ; Female ; Humans ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Quality of Life ; Sweden/epidemiology ; Forced Expiratory Volume ; Asthma/diagnosis ; Asthma/epidemiology ; Risk Factors ; Spirometry ; Prevalence
    Language English
    Publishing date 2023-07-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1003348-8
    ISSN 1532-3064 ; 0954-6111
    ISSN (online) 1532-3064
    ISSN 0954-6111
    DOI 10.1016/j.rmed.2023.107347
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui III Zs.19: Show issues Location:
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  5. Article ; Online: Occupation, socioeconomic status and chronic obstructive respiratory diseases - The EpiLung study in Finland, Estonia and Sweden.

    Jalasto, Juuso / Lassmann-Klee, Paul / Schyllert, Christian / Luukkonen, Ritva / Meren, Mari / Larsson, Matz / Põlluste, Jaak / Sundblad, Britt-Marie / Lindqvist, Ari / Krokstad, Steinar / Kankaanranta, Hannu / Kauppi, Paula / Sovijärvi, Anssi / Haahtela, Tari / Backman, Helena / Lundbäck, Bo / Piirilä, Päivi

    Respiratory medicine

    2021  Volume 191, Page(s) 106403

    Abstract: Objective: To study occupational groups and occupational exposure in association with chronic obstructive respiratory diseases.: Methods: In early 2000s, structured interviews on chronic respiratory diseases and measurements of lung function as well ... ...

    Abstract Objective: To study occupational groups and occupational exposure in association with chronic obstructive respiratory diseases.
    Methods: In early 2000s, structured interviews on chronic respiratory diseases and measurements of lung function as well as fractional expiratory nitric oxide (F
    Results: COPD, smoking and occupational exposure were most common in Estonia, while asthma and occupations requiring higher educational levels in Sweden and Finland. In an adjusted regression model, non-manual workers had a three-fold risk for physician-diagnosed asthma (OR 3.18, 95%CI 1.07-9.47) compared to professionals and executives, and the risk was two-fold for healthcare & social workers (OR 2.28, 95%CI 1.14-4.59) compared to administration and sales. An increased risk for physician-diagnosed COPD was seen in manual workers, regardless of classification system, but in contrast to asthma, the risk was mostly explained by smoking and less by occupational exposure to VGDF. For F
    Conclusions: In this multicenter study from Finland, Sweden and Estonia, COPD was consistently associated with manual occupations with high smoking prevalence, highlighting the need to control for tobacco smoking in studies on occupational associations. In contrast, asthma tended to associate with non-manual occupations requiring higher educational levels. The occupational associations with asthma were not driven by eosinophilic inflammation presented by increased F
    MeSH term(s) Adult ; Estonia/epidemiology ; Finland/epidemiology ; Humans ; Occupational Diseases/etiology ; Occupational Exposure/adverse effects ; Occupations ; Pulmonary Disease, Chronic Obstructive ; Risk Factors ; Social Class ; Sweden/epidemiology
    Language English
    Publishing date 2021-05-03
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 1003348-8
    ISSN 1532-3064 ; 0954-6111
    ISSN (online) 1532-3064
    ISSN 0954-6111
    DOI 10.1016/j.rmed.2021.106403
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui III Zs.19: Show issues Location:
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