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  1. Article: Evolution of Antibiotic Resistance in

    Mączyńska, Beata / Frej-Mądrzak, Magdalena / Sarowska, Jolanta / Woronowicz, Krystyna / Choroszy-Król, Irena / Jama-Kmiecik, Agnieszka

    Journal of clinical medicine

    2023  Volume 12, Issue 6

    Abstract: In recent years, we have witnessed a growing drug resistance among bacteria, which is associated with the use and availability of an increasing number of broad-spectrum antimicrobial agents, as well as with their irrational and excessive use. The present ...

    Abstract In recent years, we have witnessed a growing drug resistance among bacteria, which is associated with the use and availability of an increasing number of broad-spectrum antimicrobial agents, as well as with their irrational and excessive use. The present study aims to analyze changes in the drug resistance of Gram-negative
    Language English
    Publishing date 2023-03-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12062414
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Changes in Antibiotic Resistance of

    Mączyńska, Beata / Jama-Kmiecik, Agnieszka / Sarowska, Jolanta / Woronowicz, Krystyna / Choroszy-Król, Irena / Piątek, Daniel / Frej-Mądrzak, Magdalena

    Journal of clinical medicine

    2023  Volume 12, Issue 15

    Abstract: In recent years, we have witnessed increasing drug resistance among bacteria, which is associated with the use and availability of an increasing number of broad-spectrum antimicrobials, as well as with their irrational and excessive use. The present ... ...

    Abstract In recent years, we have witnessed increasing drug resistance among bacteria, which is associated with the use and availability of an increasing number of broad-spectrum antimicrobials, as well as with their irrational and excessive use. The present study aims to analyze changes in the drug resistance of Gram-negative
    Language English
    Publishing date 2023-07-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12155020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Natural Products and Their Potential Anti-HAV Activity

    Jama-Kmiecik, Agnieszka / Sarowska, Jolanta / Wojnicz, Dorota / Choroszy-Król, Irena / Frej-Mądrzak, Magdalena

    Pathogens. 2021 Aug. 28, v. 10, no. 9

    2021  

    Abstract: The role of purified natural products in the prevention and treatment of countless diseases of bacterial, fungal, and viral origin cannot be overestimated. New antiviral drugs have been obtained from natural sources and transformed into preparations for ... ...

    Abstract The role of purified natural products in the prevention and treatment of countless diseases of bacterial, fungal, and viral origin cannot be overestimated. New antiviral drugs have been obtained from natural sources and transformed into preparations for prophylactic and therapeutic purposes. Flavonoids, polyphenols, saponins, proanthocyanins, polysaccharides, organic acids, proteins, polypeptides, and essential oils derived from plants, animals, or microorganisms can control and combat foodborne viral infections, including hepatitis A. The components of essential oils are characterized by numerous therapeutic and antioxidant properties and exhibit a broad spectrum of antimicrobial and antiviral activity. Due to these properties, they can be used to preserve meat, fruit, vegetables, and their products. Over the past two decades, much effort has been made to identify natural products, mostly of plant origin, to combat foodborne viruses. Natural plant extracts have several potential uses, not limited to increasing the safety of food products and improving their quality, but also as natural antiviral agents.
    Keywords antioxidants ; antiviral properties ; flavonoids ; food safety ; fruits ; fungi ; hepatitis A ; meat ; polypeptides ; polyphenols ; polysaccharides ; saponins ; therapeutics
    Language English
    Dates of publication 2021-0828
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens10091095
    Database NAL-Catalogue (AGRICOLA)

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  4. Article: Occurrence and Characteristics of Carbapenem-Resistant Klebsiella pneumoniae Strains Isolated from Hospitalized Patients in Poland—A Single Centre Study

    Sarowska, Jolanta / Choroszy-Krol, Irena / Jama-Kmiecik, Agnieszka / Mączyńska, Beata / Cholewa, Sylwia / Frej-Madrzak, Magdalena

    Pathogens. 2022 July 29, v. 11, no. 8

    2022  

    Abstract: The global emergence and spread of genes responsible for the production of ESBL (extended-spectrum beta-lactamases) and carbapenemases in Klebsiella pneumoniae isolates poses a serious threat to public health. The aim of this study was to retrospectively ...

    Abstract The global emergence and spread of genes responsible for the production of ESBL (extended-spectrum beta-lactamases) and carbapenemases in Klebsiella pneumoniae isolates poses a serious threat to public health. The aim of this study was to retrospectively analyze the frequency of occurrence and drug resistance of selected alarm agents isolated from patients of the specialist hospital in Wrocław. A total of 13,528 clinical materials collected from patients of a specialist hospital in Wrocław were analyzed in the period from 1 January 2020 to 31 December 2020. Overall, 3894 bacterial strains were isolated from clinical materials, including 416 K. pneumoniae isolates. K. pneumoniae that showed resistance to ETP (ertapenem) and/or MEM (meropenem) were tested using phenotypic tests for the detection of KPC (carbapenemase-producing Klebsiella), MBL (metallo-β-lactamase) and OXA-48 (oxacilinase-48) carbapenemases. In the case of a positive or doubtful result of the phenotypic test, immunochromatographic tests and the CarbaNP test were performed. In total, 58 K. pneumoniae isolates resistant to 1 or more carbapenem antibiotics were isolated. Of the 58 strains, 16 (27.6%) were isolated from rectal swabs conducted on CPE (carbapenemase-producing Enterobacteriaceae) carriers. In the case of CRE (carbapenem-resistant Enterobacteriaceae) K. pneumoniae, carbapenemases were detected in 28/58 (48.3%) isolates. Notably, 23/28 K. pneumoniae isolates produced MBL/NDM (New Delhi metallo-β-lactamase) (82.1%), 5/28 produced VIM (Verona-intergon-encoded metallo-β-lactamase) (14.3%), and one produced MBL/NDM + OXA-48. Carbapenemases were detected in 13 of 16 (81.3%) carbapenem-resistant K. pneumoniae isolates derived from rectal swabs. The significant participation of CRE and CPE isolates in the infections proves the need to test patients admitted to hospital wards for their status as a CPE carrier in order to limit the emergence of new epidemic outbreaks.
    Keywords Klebsiella pneumoniae ; beta-lactamase ; drug resistance ; ertapenem ; hospitals ; immunoaffinity chromatography ; meropenem ; phenotype ; public health
    Language English
    Dates of publication 2022-0729
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens11080859
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Antiviral Potential of Plants against Noroviruses.

    Sarowska, Jolanta / Wojnicz, Dorota / Jama-Kmiecik, Agnieszka / Frej-Mądrzak, Magdalena / Choroszy-Król, Irena

    Molecules (Basel, Switzerland)

    2021  Volume 26, Issue 15

    Abstract: Human noroviruses, which belong to the enterovirus family, are one of the most common etiological agents of food-borne diseases. In recent years, intensive research has been carried out regarding the antiviral activity of plant metabolites that could be ... ...

    Abstract Human noroviruses, which belong to the enterovirus family, are one of the most common etiological agents of food-borne diseases. In recent years, intensive research has been carried out regarding the antiviral activity of plant metabolites that could be used for the preservation of fresh food, because they are safer for consumption when compared to synthetic chemicals. Plant preparations with proven antimicrobial activity differ in their chemical compositions, which significantly affects their biological activity. Our review aimed to present the results of research related to the characteristics, applicability, and mechanisms of the action of various plant-based preparations and metabolites against norovirus. New strategies to combat intestinal viruses are necessary, not only to ensure food safety and reduce infections in humans but also to lower the direct health costs associated with them.
    MeSH term(s) Animals ; Antiviral Agents/pharmacology ; Caliciviridae Infections/drug therapy ; Caliciviridae Infections/virology ; Humans ; Norovirus/drug effects ; Plant Extracts/pharmacology
    Chemical Substances Antiviral Agents ; Plant Extracts
    Language English
    Publishing date 2021-08-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules26154669
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  6. Article: Natural Products and Their Potential Anti-HAV Activity.

    Jama-Kmiecik, Agnieszka / Sarowska, Jolanta / Wojnicz, Dorota / Choroszy-Król, Irena / Frej-Mądrzak, Magdalena

    Pathogens (Basel, Switzerland)

    2021  Volume 10, Issue 9

    Abstract: The role of purified natural products in the prevention and treatment of countless diseases of bacterial, fungal, and viral origin cannot be overestimated. New antiviral drugs have been obtained from natural sources and transformed into preparations for ... ...

    Abstract The role of purified natural products in the prevention and treatment of countless diseases of bacterial, fungal, and viral origin cannot be overestimated. New antiviral drugs have been obtained from natural sources and transformed into preparations for prophylactic and therapeutic purposes. Flavonoids, polyphenols, saponins, proanthocyanins, polysaccharides, organic acids, proteins, polypeptides, and essential oils derived from plants, animals, or microorganisms can control and combat foodborne viral infections, including hepatitis A. The components of essential oils are characterized by numerous therapeutic and antioxidant properties and exhibit a broad spectrum of antimicrobial and antiviral activity. Due to these properties, they can be used to preserve meat, fruit, vegetables, and their products. Over the past two decades, much effort has been made to identify natural products, mostly of plant origin, to combat foodborne viruses. Natural plant extracts have several potential uses, not limited to increasing the safety of food products and improving their quality, but also as natural antiviral agents.
    Language English
    Publishing date 2021-08-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens10091095
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Occurrence and Characteristics of Carbapenem-Resistant

    Sarowska, Jolanta / Choroszy-Krol, Irena / Jama-Kmiecik, Agnieszka / Mączyńska, Beata / Cholewa, Sylwia / Frej-Madrzak, Magdalena

    Pathogens (Basel, Switzerland)

    2022  Volume 11, Issue 8

    Abstract: The global emergence and spread of genes responsible for the production of ESBL (extended-spectrum beta-lactamases) and carbapenemases ... ...

    Abstract The global emergence and spread of genes responsible for the production of ESBL (extended-spectrum beta-lactamases) and carbapenemases in
    Language English
    Publishing date 2022-07-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens11080859
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Exposing

    Choroszy-Król, Irena / Futoma-Kołoch, Bożena / Kuźnik, Klaudia / Wojnicz, Dorota / Tichaczek-Goska, Dorota / Frej-Mądrzak, Magdalena / Jama-Kmiecik, Agnieszka / Sarowska, Jolanta

    International journal of molecular sciences

    2023  Volume 24, Issue 19

    Abstract: European Union (EU) countries strive to improve the quality and safety of food of animal origin. Food production depends on a good microbiological quality of fodder. However, feed can be a reservoir or vector of pathogenic microorganisms, ... ...

    Abstract European Union (EU) countries strive to improve the quality and safety of food of animal origin. Food production depends on a good microbiological quality of fodder. However, feed can be a reservoir or vector of pathogenic microorganisms, including
    MeSH term(s) Animals ; Escherichia coli ; Vaccinium vitis-idaea ; Poultry ; Farms ; Salmonella ; Biofilms ; Formaldehyde/pharmacology ; Plant Extracts/pharmacology
    Chemical Substances Formaldehyde (1HG84L3525) ; Plant Extracts
    Language English
    Publishing date 2023-09-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241914579
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Comparative Characteristics and Pathogenic Potential of

    Sarowska, Jolanta / Olszak, Tomasz / Jama-Kmiecik, Agnieszka / Frej-Madrzak, Magdalena / Futoma-Koloch, Bozena / Gawel, Andrzej / Drulis-Kawa, Zuzanna / Choroszy-Krol, Irena

    Life (Basel, Switzerland)

    2022  Volume 12, Issue 6

    Abstract: The pathogenicity of many bacterial strains is determined by the acquisition of virulence genes and depends on many factors. The aim of this study was to analyse the phylogenetic background, virulence patterns, and drug susceptibility of ... ...

    Abstract The pathogenicity of many bacterial strains is determined by the acquisition of virulence genes and depends on many factors. The aim of this study was to analyse the phylogenetic background, virulence patterns, and drug susceptibility of 132
    Language English
    Publishing date 2022-06-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life12060845
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Streptococcus agalactiae and Chlamydia trachomatis detection in women without symptoms of infection.

    Frej-Mądrzak, Magdalena / Jama-Kmiecik, Agnieszka / Sarowska, Jolanta / Teryks-Wołyniec, Dorota / Gryboś, Anna / Gryboś, Marian / Choroszy-Król, Irena

    Advances in clinical and experimental medicine : official organ Wroclaw Medical University

    2020  Volume 29, Issue 6, Page(s) 707–713

    Abstract: Background: Chlamydia trachomatis (C. trachomatis) and Streptococcus agalactiae (GBS) may be present in the female cervical canal without any symptoms of infection. Chronic chlamydial infections lead to many serious complications and perinatal ... ...

    Abstract Background: Chlamydia trachomatis (C. trachomatis) and Streptococcus agalactiae (GBS) may be present in the female cervical canal without any symptoms of infection. Chronic chlamydial infections lead to many serious complications and perinatal infections, while the presence of GBS is a reservoir for infections of newborns or invasive streptococcal infection in adults.
    Objectives: To examine healthy women for C. trachomatis without symptoms from the reproductive system, assess the frequency of asymptomatic infections, detect GBS in the cervical canal, demonstrate differences in drug susceptibility, and determine the serotype of S. agalactiae strains and correlations among the ones present in the cervical canal.
    Material and methods: A total of 315 cervical swabs were collected for genetic and microbiological analysis for the presence of C. trachomatis and S. agalactiae. Latex and diffusion-disk methods were used to determine the serotype and susceptibility of streptococci.
    Results: Ten out of 315 women (3.2%) were C. trachomatis-positive. Using traditional methods of microscopy, culture and serology, 42 strains (13.3% of the subjects) obtained from patients were identified as S. agalactiae and further analyzed. The most common serotypes identified were II (18/42, 42.9%), V (11/42, 26.2%) and III (10/42, 23.8%). The less common serotypes found were VII (2/10, 4.8%), and Ib (1/10, 2.4%); no Ia, IV or VII serotypes were found. All the strains were susceptible to penicillin, while 71.4% of them were susceptible to erythromycin and 81.0% were susceptible to clindamycin. Seven isolates (16.7%) were concomitantly resistant to erythromycin and clindamycin.
    Conclusions: Chlamydia trachomatis was confirmed in 3.2% of the respondents, and GBS was found in 13.3%, despite a lack of symptoms of infection. The incidence of C. trachomatis infections and GBS colonization in Poland is similar to those in other European countries.
    MeSH term(s) Adult ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Chlamydia Infections/diagnosis ; Chlamydia Infections/drug therapy ; Chlamydia Infections/epidemiology ; Chlamydia trachomatis/isolation & purification ; Drug Resistance, Bacterial ; Female ; Humans ; Infant, Newborn ; Microbial Sensitivity Tests ; Poland/epidemiology ; Pregnancy ; Streptococcal Infections/diagnosis ; Streptococcal Infections/drug therapy ; Streptococcal Infections/epidemiology ; Streptococcus agalactiae/isolation & purification
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2020-07-14
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2270257-X
    ISSN 1899-5276 ; 1230-025X
    ISSN 1899-5276 ; 1230-025X
    DOI 10.17219/acem/122397
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6489: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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