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Article: The protective effects of nerol to prevent the toxicity of carbon tetrachloride to the liver in Sprague-Dawley rats.

Mondal, Milon / Bala, Jibanananda / Mondal, Kakoli Rani / Afrin, Sadia / Saha, Protyaee / Saha, Moumita / Jamaddar, Sarmin / Roy, Uttam Kumar / Sarkar, Chandan

Heliyon

2023 Volume 9, Issue 12, Page(s) e23065

Abstract: Introduction: Carbon-tetrachloride (CCl: Materials and methods: For the aim of this experiment, 35 male Sprague-Dawley rats ranging in body weight (BW) from 140 to 180 g were split into five separate groups. With the exception of vehicle control ... ...

Abstract	Introduction: Carbon-tetrachloride (CCl Materials and methods: For the aim of this experiment, 35 male Sprague-Dawley rats ranging in body weight (BW) from 140 to 180 g were split into five separate groups. With the exception of vehicle control group 1, all experimental rats were subjected to carbon tetrachloride exposure through intra-peritoneal injection at a 0.7 mL/kg body weight dose once a week for 4 weeks (28 days). The treatment groups 3 and 4 received oral administration of nerol at 50 and 100 mg/kg BW for 28 days. In the same time period, the standard control group received 100 mg/kg BW silymarin. Results: Serum hepatic markers, lipid profiles, albumin, globulin, bilirubin, and total protein were all substantially improved in nerol-treated rats in a dose-dependent manner that had been exposed to CCl Conclusion: According to the findings of our investigation, nerol has potential as a functional element to shield the liver from harm brought on by ROS that are caused by CCL
Language	English
Publishing date	2023-11-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e23065
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Therapeutic perspectives of the black cumin component thymoquinone: A review

Sarkar, Chandan / Jamaddar, Sarmin / Islam, Tawhida / Mondal, Milon / Islam, Muhammad Torequl / Mubarak, Mohammad S.

Food & function. 2021 July 20, v. 12, no. 14

2021

Abstract: The dietary phytochemical thymoquinone (TQ), belonging to the family of quinones, mainly obtained from the black and angular seeds of Nigella sativa, is one of the promising monoterpenoid hydrocarbons, which has been receiving massive attention for its ... ...

Abstract	The dietary phytochemical thymoquinone (TQ), belonging to the family of quinones, mainly obtained from the black and angular seeds of Nigella sativa, is one of the promising monoterpenoid hydrocarbons, which has been receiving massive attention for its therapeutic potential and pharmacological properties. It plays an important role as a chemopreventive and therapeutic agent in the treatment of various diseases and illnesses. The aim of this review is to present a summary of the most recent literature pertaining to the use of TQ for the prevention and treatment of various diseases along with possible mechanisms of action, and the potential use of this natural product as a complementary or alternative medicine. Research findings indicated that TQ exhibits numerous pharmacological activities including antioxidant, anti-inflammatory, cardioprotective, hepatoprotective, antidiabetic, neuroprotective, and anticancer, among others. Conclusions of this review on the therapeutic aspects of TQ highlight the medicinal and folk values of this compound against various diseases and ailments. In short, TQ could be a novel drug in clinical trials, as we hope.
Keywords	Nigella sativa ; alternative medicine ; antioxidants ; chemoprevention ; drugs ; monoterpenoids ; phytochemicals ; thymoquinone
Language	English
Dates of publication	2021-0720
Size	p. 6167-6213.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	2612033-1
ISSN	2042-650X ; 2042-6496
ISSN (online)	2042-650X
ISSN	2042-6496
DOI	10.1039/d1fo00401h
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Therapeutic perspectives of the black cumin component thymoquinone: A review.

Sarkar, Chandan / Jamaddar, Sarmin / Islam, Tawhida / Mondal, Milon / Islam, Muhammad Torequl / Mubarak, Mohammad S

Food & function

2021 Volume 12, Issue 14, Page(s) 6167–6213

Abstract	The dietary phytochemical thymoquinone (TQ), belonging to the family of quinones, mainly obtained from the black and angular seeds of Nigella sativa, is one of the promising monoterpenoid hydrocarbons, which has been receiving massive attention for its therapeutic potential and pharmacological properties. It plays an important role as a chemopreventive and therapeutic agent in the treatment of various diseases and illnesses. The aim of this review is to present a summary of the most recent literature pertaining to the use of TQ for the prevention and treatment of various diseases along with possible mechanisms of action, and the potential use of this natural product as a complementary or alternative medicine. Research findings indicated that TQ exhibits numerous pharmacological activities including antioxidant, anti-inflammatory, cardioprotective, hepatoprotective, antidiabetic, neuroprotective, and anticancer, among others. Conclusions of this review on the therapeutic aspects of TQ highlight the medicinal and folk values of this compound against various diseases and ailments. In short, TQ could be a novel drug in clinical trials, as we hope.
MeSH term(s)	Animals ; Anti-Inflammatory Agents/pharmacology ; Antineoplastic Agents/pharmacology ; Antioxidants/pharmacology ; Benzoquinones/pharmacokinetics ; Benzoquinones/pharmacology ; Benzoquinones/therapeutic use ; Cardiotonic Agents/pharmacology ; Humans ; Hypoglycemic Agents/pharmacology ; Mice ; Neuroprotective Agents/pharmacology ; Nigella sativa/chemistry ; Phytochemicals/pharmacology ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Rats ; Seeds/chemistry
Chemical Substances	Anti-Inflammatory Agents ; Antineoplastic Agents ; Antioxidants ; Benzoquinones ; Cardiotonic Agents ; Hypoglycemic Agents ; Neuroprotective Agents ; Phytochemicals ; Plant Extracts ; thymoquinone (O60IE26NUF)
Language	English
Publishing date	2021-06-04
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2612033-1
ISSN	2042-650X ; 2042-6496
ISSN (online)	2042-650X
ISSN	2042-6496
DOI	10.1039/d1fo00401h
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Article ; Online: Redox Activity of Flavonoids: Impact on Human Health, Therapeutics, and Chemical Safety.

Sarkar, Chandan / Chaudhary, Priya / Jamaddar, Sarmin / Janmeda, Pracheta / Mondal, Milon / Mubarak, Mohammad S / Islam, Muhammad Torequl

Chemical research in toxicology

2022 Volume 35, Issue 2, Page(s) 140–162

Abstract: The cost-effectiveness of presently used therapies is a problem in overall redox-based management, which is posing a significant financial burden on communities across the world. As a result, sophisticated treatment models that provide notions of ... ...

Abstract	The cost-effectiveness of presently used therapies is a problem in overall redox-based management, which is posing a significant financial burden on communities across the world. As a result, sophisticated treatment models that provide notions of predictive diagnoses followed by targeted preventive therapies adapted to individual patient profiles are gaining global acclaim as being beneficial to patients, the healthcare sector, and society as a whole. In this context, natural flavonoids were considered due to their multifaceted antioxidant, anti-inflammatory, and anticancer effects as well as their low toxicity and ease of availability. The aim of this review is to focus on the capacity of flavonoids to modulate the responsiveness of various diseases and ailments associated with redox toxicity. The review will also focus on the flavonoids' pathway-based redox activity and the advancement of redox-based therapies as well as flavonoids' antioxidant characteristics and their influence on human health, therapeutics, and chemical safety. Research findings indicated that flavonoids significantly exhibit various redox-based therapeutic responses against several diseases such as inflammatory, neurodegenerative, cardiovascular, and hepatic diseases and various types of cancer by activating the Nrf2/Keap1 transcription system, suppressing the nuclear factor κB (NF-κB)/IκB kinase inflammatory pathway, abrogating the function of the Hsp90/Hsf1 complex, inhibiting the PTEN/PI3K/Akt pathway, and preventing mitochondrial dysfunction. Some flavonoids, especially genistein, apigenin, amentoflavone, baicalein, quercetin, licochalcone A, and biochanin A, play a potential role in redox regulation. Conclusions of this review on the antioxidant aspects of flavonoids highlight the medicinal and folk values of these compounds against oxidative stress and various diseases and ailments. In short, treatment with flavonoids could be a novel therapeutic invention in clinical trials, as we hope.
MeSH term(s)	Anti-Inflammatory Agents/adverse effects ; Anti-Inflammatory Agents/chemistry ; Anti-Inflammatory Agents/metabolism ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/metabolism ; Antioxidants/adverse effects ; Antioxidants/chemistry ; Antioxidants/metabolism ; Delivery of Health Care ; Flavonoids/adverse effects ; Flavonoids/chemistry ; Flavonoids/metabolism ; Humans ; Molecular Structure ; Oxidation-Reduction
Chemical Substances	Anti-Inflammatory Agents ; Antineoplastic Agents ; Antioxidants ; Flavonoids
Language	English
Publishing date	2022-01-19
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	639353-6
ISSN	1520-5010 ; 0893-228X
ISSN (online)	1520-5010
ISSN	0893-228X
DOI	10.1021/acs.chemrestox.1c00348
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Article: Ethnomedicinal Uses, Phytochemistry, and Therapeutic Potentials of

Jamaddar, Sarmin / Raposo, António / Sarkar, Chandan / Roy, Uttam Kumar / Araújo, Isaac Moura / Coutinho, Henrique Douglas Melo / Alkhoshaiban, Ali Saleh / Alturki, Hmidan A / Saraiva, Ariana / Carrascosa, Conrado / Islam, Muhammad Torequl

Pharmaceuticals (Basel, Switzerland)

2022 Volume 16, Issue 1

Abstract: ... Litsea ... ...

Abstract	Litsea glutinosa
Language	English
Publishing date	2022-12-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2193542-7
ISSN	1424-8247
ISSN	1424-8247
DOI	10.3390/ph16010003
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Article ; Online: Natural products and their derivatives against coronavirus: A review of the non-clinical and pre-clinical data.

Islam, Muhammad T / Sarkar, Chandan / El-Kersh, Dina M / Jamaddar, Sarmin / Uddin, Shaikh J / Shilpi, Jamil A / Mubarak, Mohammad S

Phytotherapy research : PTR

2020 Volume 34, Issue 10, Page(s) 2471–2492

Abstract: Several corona viral infections have created serious threats in the last couple of decades claiming the death of thousands of human beings. Recently, corona viral epidemic raised the issue of developing effective antiviral agents at the earliest to ... ...

Abstract	Several corona viral infections have created serious threats in the last couple of decades claiming the death of thousands of human beings. Recently, corona viral epidemic raised the issue of developing effective antiviral agents at the earliest to prevent further losses. Natural products have always played a crucial role in drug development process against various diseases, which resulted in screening of such agents to combat emergent mutants of corona virus. This review focuses on those natural compounds that showed promising results against corona viruses. Although inhibition of viral replication is often considered as a general mechanism for antiviral activity of most of the natural products, studies have shown that some natural products can interact with key viral proteins that are associated with virulence. In this context, some of the natural products have antiviral activity in the nanomolar concentration (e.g., lycorine, homoharringtonine, silvestrol, ouabain, tylophorine, and 7-methoxycryptopleurine) and could be leads for further drug development on their own or as a template for drug design. In addition, a good number of natural products with anti-corona virus activity are the major constituents of some common dietary supplements, which can be exploited to improve the immunity of the general population in certain epidemics.
MeSH term(s)	Alkaloids/pharmacology ; Animals ; Antiviral Agents/pharmacology ; Biological Products/pharmacology ; Coronavirus/drug effects ; Coronavirus/metabolism ; Coronavirus/pathogenicity ; Coronavirus Infections/drug therapy ; Coronavirus Infections/prevention & control ; Coronavirus Infections/virology ; Drug Development ; Humans ; Indolizines/pharmacology ; Ouabain/pharmacology ; Phenanthrenes/pharmacology ; Plant Extracts/pharmacology ; Quinolizines/pharmacology ; Triterpenes/pharmacology ; Viral Proteins/metabolism ; Virus Replication/drug effects
Chemical Substances	7-methoxycryptopleurine ; Alkaloids ; Antiviral Agents ; Biological Products ; Indolizines ; Phenanthrenes ; Plant Extracts ; Quinolizines ; Triterpenes ; Viral Proteins ; silvestrol ; Ouabain (5ACL011P69) ; tylophorine (O41630Y8V3)
Keywords	covid19
Language	English
Publishing date	2020-04-17
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	639136-9
ISSN	1099-1573 ; 0951-418X
ISSN (online)	1099-1573
ISSN	0951-418X
DOI	10.1002/ptr.6700
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Article ; Online: Evaluation of the Binding Affinity of Anti-Viral Drugs against Main Protease of SARS-CoV-2 Through a Molecular Docking Study.

Mondal, Milon / Sarkar, Chandan / Jamaddar, Sarmin / Khalipha, Abul B R / Islam, Muhammad Torequl / Mahafzah, Azmi / Mubarak, Mohammad S

Infectious disorders drug targets

2020 Volume 21, Issue 7, Page(s) e160921188777

Abstract: Background: Coronavirus disease 2019 (COVID-19) is a life intimidating viral infection caused by a positive sense RNA virus belonging to the Coronaviridae family, named severe acute respiratory distress syndrome coronavirus 2 (SARA-CoV-2). Since its ... ...

Abstract	Background: Coronavirus disease 2019 (COVID-19) is a life intimidating viral infection caused by a positive sense RNA virus belonging to the Coronaviridae family, named severe acute respiratory distress syndrome coronavirus 2 (SARA-CoV-2). Since its outbreak in December 2019, the pandemic has spread to more than 200 countries, infected more than 26 million, and claimed the lives of more than 800,000 people. As a disease, COVID-19 can lead to severe and occasionally fatal respiratory problems in humans. Infection with this virus is associated with fever, cough, dyspnea, and muscle aches, and it may progress to pneumonia, multiple organ failure, and death. To date, there is no specific antiviral treatment against this virus. However, the main viral protease has been recently discovered and it is regarded as an appropriate target for antiviral agents in the search for the treatment of COVID-19, due to its pivotal role in polyproteins processing during viral replication. Aim: Consequently, this study intends to evaluate the effectiveness of FDA-approved anti-viral drugs against SARA-CoV-2 through a molecular docking study. Methods: AutoDock Vina in PyRx platform was used for docking analysis against the main viral protease (Mpro) (PDB ID 6LU7), and Computed Atlas of Surface Topography of proteins (CASTp 3.0) was applied for detecting and characterizing cavities, pockets, and channels of this protein structure. Results: Results revealed that among the conventional antiviral drugs, the protease inhibitors, lopinavir, amprenavir, indinavir, maraviroc, saquinavir, and daclatasvir showed high binding affinity and interacted with amino acid residues of the binding site. Conclusion: In conclusion, protease inhibitors may be effective potential antiviral agents against Mpro to combat SARS-CoV-2.
MeSH term(s)	Antiviral Agents/pharmacology ; COVID-19 ; Coronavirus 3C Proteases/antagonists & inhibitors ; Humans ; Molecular Docking Simulation ; SARS-CoV-2/drug effects
Chemical Substances	Antiviral Agents ; 3C-like proteinase, SARS-CoV-2 (EC 3.4.22.-) ; Coronavirus 3C Proteases (EC 3.4.22.28)
Language	English
Publishing date	2020-12-08
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2234298-9
ISSN	2212-3989 ; 1871-5265
ISSN (online)	2212-3989
ISSN	1871-5265
DOI	10.2174/1871526520666201207124408
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Article: Natural products and their derivatives against coronavirus: A review of the non‐clinical and pre‐clinical data

Islam, Muhammad T / Sarkar, Chandan / El‐Kersh, Dina M / Jamaddar, Sarmin / Uddin, Shaikh J / Shilpi, Jamil A / Mubarak, Mohammad S

Phytotherapy research. 2020 Oct., v. 34, no. 10

2020

Abstract	Several corona viral infections have created serious threats in the last couple of decades claiming the death of thousands of human beings. Recently, corona viral epidemic raised the issue of developing effective antiviral agents at the earliest to prevent further losses. Natural products have always played a crucial role in drug development process against various diseases, which resulted in screening of such agents to combat emergent mutants of corona virus. This review focuses on those natural compounds that showed promising results against corona viruses. Although inhibition of viral replication is often considered as a general mechanism for antiviral activity of most of the natural products, studies have shown that some natural products can interact with key viral proteins that are associated with virulence. In this context, some of the natural products have antiviral activity in the nanomolar concentration (e.g., lycorine, homoharringtonine, silvestrol, ouabain, tylophorine, and 7‐methoxycryptopleurine) and could be leads for further drug development on their own or as a template for drug design. In addition, a good number of natural products with anti‐corona virus activity are the major constituents of some common dietary supplements, which can be exploited to improve the immunity of the general population in certain epidemics.
Keywords	Orthocoronavirinae ; antiviral agents ; antiviral properties ; death ; dietary supplements ; disease outbreaks ; drug design ; humans ; immunity ; lycorine ; mutants ; ouabain ; phytotherapy ; population ; research ; screening ; viral proteins ; virulence ; virus replication ; viruses
Language	English
Dates of publication	2020-10
Size	p. 2471-2492.
Publishing place	John Wiley & Sons, Ltd.
Document type	Article
Note	NAL-light ; REVIEW
ZDB-ID	639136-9
ISSN	1099-1573 ; 0951-418X
ISSN (online)	1099-1573
ISSN	0951-418X
DOI	10.1002/ptr.6700
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Article ; Online: Plant-derived alkaloids acting on dengue virus and their vectors: from chemistry to pharmacology.

Sarkar, Chandan / Quispe, Cristina / Islam, Muhammad T / Jamaddar, Sarmin / Akram, Muhammad / Munior, Naveed / Martorell, Miquel / Kumar, Manoj / Sharifi-Rad, Javad / Cruz-Martins, Natália

Future microbiology

2021 Volume 17, Page(s) 143–155

Abstract: Dengue is a mosquito-borne viral infection, with its prevention and control depending on effective vector control measures. At present, dengue virus (DENV) is an epidemic in more than 100 countries of Southeast Asia, Africa, Eastern Mediterranean, the ... ...

Abstract	Dengue is a mosquito-borne viral infection, with its prevention and control depending on effective vector control measures. At present, dengue virus (DENV) is an epidemic in more than 100 countries of Southeast Asia, Africa, Eastern Mediterranean, the Americas and the Western Pacific. Several alkaloids isolated from natural herbs can serve as a reservoir for antiDENV drug development. Traditionally, plant extracts rich in alkaloids are used for the treatment of fever and have also revealed antimicrobial activity against various pathogenic bacteria, fungi and virus. The present narrative review collates the literature-based scenario of alkaloids and derivatives acting on DENV. The mechanism of action of such alkaloids with antiDENV and vector activity is also discussed.
MeSH term(s)	Aedes ; Alkaloids/pharmacology ; Animals ; Dengue/drug therapy ; Dengue/epidemiology ; Dengue Virus ; Mosquito Vectors
Chemical Substances	Alkaloids
Language	English
Publishing date	2021-12-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2254620-0
ISSN	1746-0921 ; 1746-0913
ISSN (online)	1746-0921
ISSN	1746-0913
DOI	10.2217/fmb-2021-0002
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Natural products and their derivatives against coronavirus: A review of the non-clinical and pre-clinical data

Islam, Muhammad T / Sarkar, Chandan / El-Kersh, Dina M / Jamaddar, Sarmin / Uddin, Shaikh J / Shilpi, Jamil A / Mubarak, Mohammad S

Phytother Res

Abstract	Several corona viral infections have created serious threats in the last couple of decades claiming the death of thousands of human beings. Recently, corona viral epidemic raised the issue of developing effective antiviral agents at the earliest to prevent further losses. Natural products have always played a crucial role in drug development process against various diseases, which resulted in screening of such agents to combat emergent mutants of corona virus. This review focuses on those natural compounds that showed promising results against corona viruses. Although inhibition of viral replication is often considered as a general mechanism for antiviral activity of most of the natural products, studies have shown that some natural products can interact with key viral proteins that are associated with virulence. In this context, some of the natural products have antiviral activity in the nanomolar concentration (e.g., lycorine, homoharringtonine, silvestrol, ouabain, tylophorine, and 7-methoxycryptopleurine) and could be leads for further drug development on their own or as a template for drug design. In addition, a good number of natural products with anti-corona virus activity are the major constituents of some common dietary supplements, which can be exploited to improve the immunity of the general population in certain epidemics.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #31516
Database	COVID19

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