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  1. Article ; Online: Connecting axons and dendrites: An oblique view.

    Jamann, Nora / Kole, Maarten H P

    Neuron

    2022  Volume 110, Issue 9, Page(s) 1438–1440

    Abstract: Cortical pyramidal neurons receive thousands of synaptic inputs and transform these into action potential output. In this issue of Neuron, Lafourcade et al. (2022) demonstrate that distinct long-range projections to retrosplenial cortex pyramidal neurons ...

    Abstract Cortical pyramidal neurons receive thousands of synaptic inputs and transform these into action potential output. In this issue of Neuron, Lafourcade et al. (2022) demonstrate that distinct long-range projections to retrosplenial cortex pyramidal neurons are coupled to diverse modes of dendritic integration.
    MeSH term(s) Action Potentials/physiology ; Axons/physiology ; Dendrites/physiology ; Neurons/physiology ; Pyramidal Cells/physiology
    Language English
    Publishing date 2022-04-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/j.neuron.2022.04.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2496: Show issues Location:
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  2. Book ; Online ; Thesis: Plasticity of the axon initial segment in the mouse barrel cortex

    Jamann, Nora [Verfasser] / Schultz, Christian [Akademischer Betreuer]

    2022  

    Author's details Nora Jamann ; Betreuer: Christian Schultz
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Universitätsbibliothek Heidelberg
    Publishing place Heidelberg
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  3. Article ; Online: Sodium channel endocytosis drives axon initial segment plasticity.

    Fréal, Amélie / Jamann, Nora / Ten Bos, Jolijn / Jansen, Jacqueline / Petersen, Naomi / Ligthart, Thijmen / Hoogenraad, Casper C / Kole, Maarten H P

    Science advances

    2023  Volume 9, Issue 37, Page(s) eadf3885

    Abstract: Activity-dependent plasticity of the axon initial segment (AIS) endows neurons with the ability to adapt action potential output to changes in network activity. Action potential initiation at the AIS highly depends on the clustering of voltage-gated ... ...

    Abstract Activity-dependent plasticity of the axon initial segment (AIS) endows neurons with the ability to adapt action potential output to changes in network activity. Action potential initiation at the AIS highly depends on the clustering of voltage-gated sodium channels, but the molecular mechanisms regulating their plasticity remain largely unknown. Here, we developed genetic tools to label endogenous sodium channels and their scaffolding protein, to reveal their nanoscale organization and longitudinally image AIS plasticity in hippocampal neurons in slices and primary cultures. We find that
    MeSH term(s) Axon Initial Segment ; Sodium Channels ; Action Potentials ; Cluster Analysis ; Endocytosis
    Chemical Substances Sodium Channels
    Language English
    Publishing date 2023-09-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.adf3885
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  4. Article ; Online: Activity-dependent axonal plasticity in sensory systems.

    Jamann, Nora / Jordan, Merryn / Engelhardt, Maren

    Neuroscience

    2018  Volume 368, Page(s) 268–282

    Abstract: The rodent whisker-to-barrel cortex pathway is a classic model to study the effects of sensory experience and deprivation on neuronal circuit formation, not only during development but also in the adult. Decades of research have produced a vast body of ... ...

    Abstract The rodent whisker-to-barrel cortex pathway is a classic model to study the effects of sensory experience and deprivation on neuronal circuit formation, not only during development but also in the adult. Decades of research have produced a vast body of evidence highlighting the fundamental role of neuronal activity (spontaneous and/or sensory-evoked) for circuit formation and function. In this context, it has become clear that neuronal adaptation and plasticity is not just a function of the neonatal brain, but persists into adulthood, especially after experience-driven modulation of network status. Mechanisms for structural remodeling of the somatodendritic or axonal domain include microscale alterations of neurites or synapses. At the same time, functional alterations at the nanoscale such as expression or activation changes of channels and receptors contribute to the modulation of intrinsic excitability or input-output relationships. However, it remains elusive how these forms of structural and functional plasticity come together to shape neuronal network formation and function. While specifically somatodendritic plasticity has been studied in great detail, the role of axonal plasticity, (e.g. at presynaptic boutons, branches or axonal microdomains), is rather poorly understood. Therefore, this review will only briefly highlight somatodendritic plasticity and instead focus on axonal plasticity. We discuss (i) the role of spontaneous and sensory-evoked plasticity during critical periods, (ii) the assembly of axonal presynaptic sites, (iii) axonal plasticity in the mature brain under baseline and sensory manipulation conditions, and finally (iv) plasticity of electrogenic axonal microdomains, namely the axon initial segment, during development and in the mature CNS.
    MeSH term(s) Animals ; Axons/physiology ; Nerve Net/growth & development ; Nerve Net/physiology ; Neuronal Plasticity/physiology ; Presynaptic Terminals/physiology ; Rodentia ; Somatosensory Cortex/growth & development ; Somatosensory Cortex/physiology
    Language English
    Publishing date 2018-01-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 196739-3
    ISSN 1873-7544 ; 0306-4522
    ISSN (online) 1873-7544
    ISSN 0306-4522
    DOI 10.1016/j.neuroscience.2017.07.035
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1215: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Experience shapes chandelier cell function and structure in the visual cortex.

    Seignette, Koen / Jamann, Nora / Papale, Paolo / Terra, Huub / Porneso, Ralph O / de Kraker, Leander / van der Togt, Chris / van der Aa, Maaike / Neering, Paul / Ruimschotel, Emma / Roelfsema, Pieter R / Montijn, Jorrit S / Self, Matthew W / Kole, Maarten H P / Levelt, Christiaan N

    eLife

    2024  Volume 12

    Abstract: Detailed characterization of interneuron types in primary visual cortex (V1) has greatly contributed to understanding visual perception, yet the role of chandelier cells (ChCs) in visual processing remains poorly characterized. Using viral tracing we ... ...

    Abstract Detailed characterization of interneuron types in primary visual cortex (V1) has greatly contributed to understanding visual perception, yet the role of chandelier cells (ChCs) in visual processing remains poorly characterized. Using viral tracing we found that V1 ChCs predominantly receive monosynaptic input from local layer 5 pyramidal cells and higher-order cortical regions. Two-photon calcium imaging and convolutional neural network modeling revealed that ChCs are visually responsive but weakly selective for stimulus content. In mice running in a virtual tunnel, ChCs respond strongly to events known to elicit arousal, including locomotion and visuomotor mismatch. Repeated exposure of the mice to the virtual tunnel was accompanied by reduced visual responses of ChCs and structural plasticity of ChC boutons and axon initial segment length. Finally, ChCs only weakly inhibited pyramidal cells. These findings suggest that ChCs provide an arousal-related signal to layer 2/3 pyramidal cells that may modulate their activity and/or gate plasticity of their axon initial segments during behaviorally relevant events.
    MeSH term(s) Animals ; Mice ; Neurons ; Pyramidal Cells ; Visual Cortex ; Interneurons ; Arousal
    Language English
    Publishing date 2024-01-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.91153
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  6. Article: Small domain, large consequences: the axon initial segment as a key player in neuronal excitability

    Engelhardt, Maren / Jamann, Nora / Wefelmeyer, Winnie

    Neuroforum

    2019  Volume 25, Issue 1, Page(s) 49

    Language German
    Document type Article
    ZDB-ID 1238592-x
    ISSN 0947-0875
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4805: Show issues Location:
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  7. Article ; Online: Sensory input drives rapid homeostatic scaling of the axon initial segment in mouse barrel cortex.

    Jamann, Nora / Dannehl, Dominik / Lehmann, Nadja / Wagener, Robin / Thielemann, Corinna / Schultz, Christian / Staiger, Jochen / Kole, Maarten H P / Engelhardt, Maren

    Nature communications

    2021  Volume 12, Issue 1, Page(s) 23

    Abstract: The axon initial segment (AIS) is a critical microdomain for action potential initiation and implicated in the regulation of neuronal excitability during activity-dependent plasticity. While structural AIS plasticity has been suggested to fine-tune ... ...

    Abstract The axon initial segment (AIS) is a critical microdomain for action potential initiation and implicated in the regulation of neuronal excitability during activity-dependent plasticity. While structural AIS plasticity has been suggested to fine-tune neuronal activity when network states change, whether it acts in vivo as a homeostatic regulatory mechanism in behaviorally relevant contexts remains poorly understood. Using the mouse whisker-to-barrel pathway as a model system in combination with immunofluorescence, confocal analysis and electrophysiological recordings, we observed bidirectional AIS plasticity in cortical pyramidal neurons. Furthermore, we find that structural and functional AIS remodeling occurs in distinct temporal domains: Long-term sensory deprivation elicits an AIS length increase, accompanied with an increase in neuronal excitability, while sensory enrichment results in a rapid AIS shortening, accompanied by a decrease in action potential generation. Our findings highlight a central role of the AIS in the homeostatic regulation of neuronal input-output relations.
    MeSH term(s) Aging/physiology ; Animals ; Axon Initial Segment/metabolism ; Cerebral Cortex/metabolism ; Exploratory Behavior ; Homeostasis ; Mice, Inbred C57BL ; Neuronal Plasticity/physiology ; Pyramidal Cells/physiology ; Sensory Deprivation ; Time Factors ; Vibrissae/physiology ; Mice
    Language English
    Publishing date 2021-01-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-020-20232-x
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  8. Article ; Online: Interneuron synaptopathy in developing rat cortex induced by the pro-inflammatory cytokine LIF.

    Engelhardt, Maren / Hamad, Mohammad I K / Jack, Alexander / Ahmed, Küpra / König, Jennifer / Rennau, Lisa Marie / Jamann, Nora / Räk, Andrea / Schönfelder, Sabine / Riedel, Christian / Wirth, Markus Joseph / Patz, Silke / Wahle, Petra

    Experimental neurology

    2018  Volume 302, Page(s) 169–180

    MeSH term(s) Animals ; Animals, Newborn ; Axons/drug effects ; Brain-Derived Neurotrophic Factor/pharmacology ; Calcium/metabolism ; Dendrites/drug effects ; In Vitro Techniques ; Interneurons/cytology ; Interneurons/drug effects ; Interneurons/metabolism ; Leukemia Inhibitory Factor/pharmacology ; Mitogen-Activated Protein Kinase Kinases/metabolism ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Neuropeptide Y/genetics ; Neuropeptide Y/metabolism ; Organ Culture Techniques ; Rats ; Rats, Long-Evans ; Shaw Potassium Channels/genetics ; Shaw Potassium Channels/metabolism ; Synapses/drug effects ; Synaptotagmin II/genetics ; Synaptotagmin II/metabolism ; Time Factors ; Visual Cortex/cytology
    Chemical Substances Brain-Derived Neurotrophic Factor ; Kcnc2 protein, rat ; Leukemia Inhibitory Factor ; Nerve Tissue Proteins ; Neuropeptide Y ; Shaw Potassium Channels ; Synaptotagmin II ; Syt2 protein, rat ; Mitogen-Activated Protein Kinase Kinases (EC 2.7.12.2) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2018-01-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 207148-4
    ISSN 1090-2430 ; 0014-4886
    ISSN (online) 1090-2430
    ISSN 0014-4886
    DOI 10.1016/j.expneurol.2017.12.011
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    Zs.A 184: Show issues Location:
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