LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 357

Search options

  1. Article: The Metropolitan Street Ambulance Association.

    James, Arthur

    The Hospital

    2018  Volume 35, Issue 909, Page(s) 397–398

    Language English
    Publishing date 2018-05-17
    Publishing country England
    Document type Journal Article
    ISSN 0267-6478
    ISSN 0267-6478
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: Graphical Editorial on the guidelines: Human factors in critical situations.

    James, Arthur / Clavier, Thomas / Rozencwajg, Sacha / Blet, Alice

    Anaesthesia, critical care & pain medicine

    2023  Volume 42, Issue 5, Page(s) 101295

    Language English
    Publishing date 2023-09-07
    Publishing country France
    Document type Editorial
    ISSN 2352-5568
    ISSN (online) 2352-5568
    DOI 10.1016/j.accpm.2023.101295
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Human Disease Phenotypes Associated with Loss and Gain of Function Mutations in STAT2: Viral Susceptibility and Type I Interferonopathy.

    Duncan, Christopher James Arthur / Hambleton, Sophie

    Journal of clinical immunology

    2021  Volume 41, Issue 7, Page(s) 1446–1456

    Abstract: STAT2 is distinguished from other STAT family members by its exclusive involvement in type I and III interferon (IFN-I/III) signaling pathways, and its unique behavior as both positive and negative regulator of IFN-I signaling. The clinical relevance of ... ...

    Abstract STAT2 is distinguished from other STAT family members by its exclusive involvement in type I and III interferon (IFN-I/III) signaling pathways, and its unique behavior as both positive and negative regulator of IFN-I signaling. The clinical relevance of these opposing STAT2 functions is exemplified by monogenic diseases of STAT2. Autosomal recessive STAT2 deficiency results in heightened susceptibility to severe and/or recurrent viral disease, whereas homozygous missense substitution of the STAT2-R148 residue is associated with severe type I interferonopathy due to loss of STAT2 negative regulation. Here we review the clinical presentation, pathogenesis, and management of these disorders of STAT2.
    MeSH term(s) Animals ; Gain of Function Mutation ; Genetic Diseases, Inborn/genetics ; Genetic Diseases, Inborn/immunology ; Genetic Predisposition to Disease ; Humans ; Immune System Diseases/genetics ; Immune System Diseases/immunology ; Interferon Type I/immunology ; Loss of Function Mutation ; Phenotype ; STAT2 Transcription Factor/chemistry ; STAT2 Transcription Factor/genetics ; STAT2 Transcription Factor/immunology ; Virus Diseases/genetics ; Virus Diseases/immunology
    Chemical Substances Interferon Type I ; STAT2 Transcription Factor ; STAT2 protein, human
    Language English
    Publishing date 2021-08-26
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 779361-3
    ISSN 1573-2592 ; 0271-9142
    ISSN (online) 1573-2592
    ISSN 0271-9142
    DOI 10.1007/s10875-021-01118-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1640: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Heterogeneity in defining multiple trauma: a systematic review of randomized controlled trials.

    Jeanmougin, Thomas / Cole, Elaine / Duceau, Baptiste / Raux, Mathieu / James, Arthur

    Critical care (London, England)

    2023  Volume 27, Issue 1, Page(s) 363

    Abstract: Introduction: While numerous randomized controlled trials (RCTs) have been conducted in the field of trauma, a substantial portion of them are yielding negative results. One potential contributing factor to this trend could be the lack of agreement ... ...

    Abstract Introduction: While numerous randomized controlled trials (RCTs) have been conducted in the field of trauma, a substantial portion of them are yielding negative results. One potential contributing factor to this trend could be the lack of agreement regarding the chosen definitions across different trials. The primary objective was to identify the terminology and definitions utilized for the characterization of multiple trauma patients within randomized controlled trials (RCTs).
    Methods: A systematic review of the literature was performed in MEDLINE, EMBASE and clinicaltrials.gov between January 1, 2002, and July 31, 2022. RCTs or RTCs protocols were eligible if they included multiple trauma patients. The terms employed to characterize patient populations were identified, and the corresponding definitions for these terms were extracted. The subsequent impact on the population recruited was then documented to expose clinical heterogeneity.
    Results: Fifty RCTs were included, and 12 different terms identified. Among these terms, the most frequently used were "multiple trauma" (n = 21, 42%), "severe trauma" (n = 8, 16%), "major trauma" (n = 4, 8%), and trauma with hemorrhagic shock" (n = 4, 8%). Only 62% of RCTs (n = 31) provided a definition for the terms used, resulting a total of 21 different definitions. These definitions primarily relied on the injury severity score (ISS) (n = 15, 30%), displaying an important underlying heterogeneity. The choice of the terms had an impact on the study population, affecting both the ISS and in-hospital mortality. Eleven protocols were included, featuring five different terms, with "severe trauma" being the most frequent, occurring six times (55%).
    Conclusion: This systematic review uncovers an important heterogeneity both in the terms and in the definitions employed to recruit trauma patients within RCTs. These findings underscore the imperative of promoting the use of a unique and consistent definition.
    MeSH term(s) Humans ; Randomized Controlled Trials as Topic ; Multiple Trauma/therapy ; Hospital Mortality ; Injury Severity Score ; Shock, Hemorrhagic
    Language English
    Publishing date 2023-09-22
    Publishing country England
    Document type Systematic Review ; Journal Article
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-023-04637-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5517: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: Biochar from agricultural residues for soil conditioning: Technological status and life cycle assessment

    James, Arthur / Sánchez, Ana / Prens, Josué / Yuan, Wenqiao

    Current opinion in environmental science & health. 2022 Feb., v. 25

    2022  

    Abstract: As a product/co-product of biomass thermochemical conversion, the yield and quality of biochar depend on its source material and the production process, so is its performance in soil conditioning. In this mini-review, various technologies, including slow ...

    Abstract As a product/co-product of biomass thermochemical conversion, the yield and quality of biochar depend on its source material and the production process, so is its performance in soil conditioning. In this mini-review, various technologies, including slow pyrolysis, fast pyrolysis, torrefaction, and gasification were briefly discussed, among which slow pyrolysis and torrefaction were found to give higher biochar yield. Because the yield of biochar and the emissions in the production process play a critical role in the outcomes of its life cycle assessment, it is important to carefully choose and optimize the production technology of biochar. The life cycle benefit of biochar for soil conditioning was found generally positive, indicated by its improvement of ecosystem quality, mitigation of climate change, and reduced resource consumption. However, the variability in biochar properties makes it challenging in technology upgrading, application, and commercialization, and the lack of regulations and standardization makes biochar acceptance difficult.
    Keywords biochar ; biomass ; climate change ; commercialization ; ecosystems ; gasification ; life cycle assessment ; production technology ; pyrolysis ; soil ; torrefaction
    Language English
    Dates of publication 2022-02
    Publishing place Elsevier B.V.
    Document type Article
    ISSN 2468-5844
    DOI 10.1016/j.coesh.2021.100314
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: Altmetrics scores: What are they?

    James, Arthur / Raux, Matthieu

    Anaesthesia, critical care & pain medicine

    2020  Volume 39, Issue 3, Page(s) 443–445

    MeSH term(s) Algorithms ; Anesthesiology ; Journal Impact Factor ; Periodicals as Topic
    Language English
    Publishing date 2020-03-14
    Publishing country France
    Document type Letter
    ISSN 2352-5568
    ISSN (online) 2352-5568
    DOI 10.1016/j.accpm.2020.03.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article ; Online: Reply to Vassallo et al., triage score needs a careful methodological evaluation.

    James, Arthur / Riou, Bruno / Raux, Mathieu

    European journal of emergency medicine : official journal of the European Society for Emergency Medicine

    2021  Volume 28, Issue 2, Page(s) 162–163

    MeSH term(s) Humans ; Mass Casualty Incidents ; Paris ; Terrorism ; Triage
    Language English
    Publishing date 2021-03-03
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1233544-7
    ISSN 1473-5695 ; 0969-9546
    ISSN (online) 1473-5695
    ISSN 0969-9546
    DOI 10.1097/MEJ.0000000000000807
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4264: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Post-acute COVID-19 Syndrome (PACS): A public health emergency.

    Rello, Jordi / James, Arthur / Reyes, Luis Felipe

    Anaesthesia, critical care & pain medicine

    2021  Volume 40, Issue 3, Page(s) 100882

    MeSH term(s) COVID-19/complications ; COVID-19/epidemiology ; Emergencies ; Follow-Up Studies ; Humans ; Public Health
    Language English
    Publishing date 2021-05-21
    Publishing country France
    Document type Editorial
    ISSN 2352-5568
    ISSN (online) 2352-5568
    DOI 10.1016/j.accpm.2021.100882
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article ; Online: Personalized medicine targeting different ARDS phenotypes: The future of pharmacotherapy for ARDS?

    Blanchard, Florian / James, Arthur / Assefi, Mona / Kapandji, Natacha / Constantin, Jean-Michel

    Expert review of respiratory medicine

    2023  Volume 17, Issue 1, Page(s) 41–52

    Abstract: Introduction: Acute respiratory distress syndrome (ARDS) still represents a major challenge with high mortality rates and altered quality of life. Many well-designed studies have failed to improve ARDS outcomes. Heterogeneity of etiologies, mechanisms ... ...

    Abstract Introduction: Acute respiratory distress syndrome (ARDS) still represents a major challenge with high mortality rates and altered quality of life. Many well-designed studies have failed to improve ARDS outcomes. Heterogeneity of etiologies, mechanisms of lung damage, different lung mechanics, and different treatment approaches may explain these failures. At the era of personalized medicine, ARDS phenotyping is not only a field of research, but a bedside consideration when implementing therapy. ARDS has moved from being a simple syndrome to a more complex area of subgrouping. Intensivists must understand these phenotypes and therapies associated with a better outcome.
    Areas covered: After a brief sum-up of the different type of ARDS phenotypes, we will present some relevant therapy that may be impacted by phenotyping. A focus on pharmacotherapy will be realized before a section on non-pharmaceutical strategies. Eventually, we will highlight the limits of our knowledge of phenotyping and the pitfalls of personalized medicine.
    Expert opinion: Biological and morphological ARDS phenotypes are now well studied. The future of ARDS therapy will go through phenotyping that allows a personalized medication for each patient. However, a better assessment of these phenotypes is required, and clinical trials should be conducted with an
    MeSH term(s) Humans ; Precision Medicine ; Quality of Life ; Respiratory Distress Syndrome/therapy ; Lung ; Phenotype
    Language English
    Publishing date 2023-02-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2479146-5
    ISSN 1747-6356 ; 1747-6348
    ISSN (online) 1747-6356
    ISSN 1747-6348
    DOI 10.1080/17476348.2023.2176302
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6963: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Prothrombin complex concentrate (PCC) for treatment of trauma-induced coagulopathy: systematic review and meta-analyses.

    Hannadjas, Ioannis / James, Arthur / Davenport, Ross / Lindsay, Charlotte / Brohi, Karim / Cole, Elaine

    Critical care (London, England)

    2023  Volume 27, Issue 1, Page(s) 422

    Abstract: Background: Trauma-induced coagulopathy (TIC) is common in trauma patients with major hemorrhage. Prothrombin complex concentrate (PCC) is used as a potential treatment for the correction of TIC, but the efficacy, timing, and evidence to support its use ...

    Abstract Background: Trauma-induced coagulopathy (TIC) is common in trauma patients with major hemorrhage. Prothrombin complex concentrate (PCC) is used as a potential treatment for the correction of TIC, but the efficacy, timing, and evidence to support its use in injured patients with hemorrhage are unclear.
    Methods: A systematic search of published studies was performed on MEDLINE and EMBASE databases using standardized search equations. Ongoing studies were identified using clinicaltrials.gov. Studies investigating the use of PCC to treat TIC (on its own or in combination with other treatments) in adult major trauma patients were included. Studies involving pediatric patients, studies of only traumatic brain injury (TBI), and studies involving only anticoagulated patients were excluded. Primary outcomes were in-hospital mortality and venous thromboembolism (VTE). Pooled effects of PCC use were reported using random-effects model meta-analyses. Risk of bias was assessed for each study, and we used the Grading of Recommendations Assessment, Development, and Evaluation to assess the quality of evidence.
    Results: After removing duplicates, 1745 reports were screened and nine observational studies and one randomized controlled trial (RCT) were included, with a total of 1150 patients receiving PCC. Most studies used 4-factor-PCC with a dose of 20-30U/Kg. Among observational studies, co-interventions included whole blood (n = 1), fibrinogen concentrate (n = 2), or fresh frozen plasma (n = 4). Outcomes were inconsistently reported across studies with wide variation in both measurements and time points. The eight observational studies included reported mortality with a pooled odds ratio of 0.97 [95% CI 0.56-1.69], and five reported deep venous thrombosis (DVT) with a pooled OR of 0.83 [95% CI 0.44-1.57]. When pooling the observational studies and the RCT, the OR for mortality and DVT was 0.94 [95% CI 0.60-1.45] and 1.00 [95% CI 0.64-1.55] respectively.
    Conclusions: Among published studies of TIC, PCCs did not significantly reduce mortality, nor did they increase the risk of VTE. However, the potential thrombotic risk remains a concern that should be addressed in future studies. Several RCTs are currently ongoing to further explore the efficacy and safety of PCC.
    MeSH term(s) Adult ; Humans ; Child ; Venous Thromboembolism ; Blood Coagulation Factors/therapeutic use ; Blood Coagulation Disorders/drug therapy ; Blood Coagulation Disorders/etiology ; Hemorrhage/drug therapy ; Hemorrhage/etiology ; Randomized Controlled Trials as Topic
    Chemical Substances prothrombin complex concentrates (37224-63-8) ; Blood Coagulation Factors
    Language English
    Publishing date 2023-11-02
    Publishing country England
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-023-04688-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5517: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top