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Article: Comparison of Rapid to Standard Volumetric Modulated Arc Therapy for Palliative Radiotherapy in Lung Cancer Patients.

Mak, David Y / Fraser, Ian / Ferris, Robynn / James, Kerry / Liu, Mitchell / Thomas, Steven D / McKenzie, Michael / Lefresne, Shilo

Cureus

2020 Volume 12, Issue 8, Page(s) e10055

Abstract: Patients with incurable lung cancer often present with debilitating symptoms that require urgent palliative radiotherapy. Volumetric modulated arc therapy (VMAT) provides several dosimetric advantages compared to basic non-conformal techniques, but ... ...

Abstract	Patients with incurable lung cancer often present with debilitating symptoms that require urgent palliative radiotherapy. Volumetric modulated arc therapy (VMAT) provides several dosimetric advantages compared to basic non-conformal techniques, but involves complex planning resulting in a slower turn-around time for treatment. A simplified planning technique known as 'rapid VMAT' was developed with an aim to deliver palliative treatment to patients within 48 hours. The purpose of this study was to prospectively compare the dosimetric quality of rapid VMAT plans to standard VMAT plans. Fourteen consecutive rapid VMAT cases were re-planned de novo as per standard VMAT planning guidelines. Planning target volume (PTV) and organs at risk (OARs) were then compared. PTV coverage and dose to OARs including the spinal canal, lung, heart, and esophagus were similar between rapid and standard VMAT. Each plan was ready for treatment within 48 hours of the CT simulation. This study describes an expedited process for which palliative radiotherapy can be delivered to lung tumors with a similar robust quality that is provided for curative intent VMAT radiotherapy plans.
Language	English
Publishing date	2020-08-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.10055
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Reproductive Hormone Concentrations and Associated Anatomical Responses: Does Soy Formula Affect Minipuberty in Boys?

Chin, Helen B / Kelly, Andrea / Adgent, Margaret A / Patchel, Stacy A / James, Kerry / Vesper, Hubert W / Botelho, Julianne C / Chandler, Donald Walt / Zemel, Babette S / Schall, Joan I / Ford, Eileen G / Darge, Kassa / Stallings, Virginia A / Baird, Donna D / Rogan, Walter J / Umbach, David M

The Journal of clinical endocrinology and metabolism

2021 Volume 106, Issue 9, Page(s) 2635–2645

Abstract: Context: Soy formula feeding is common in infancy and is a source of high exposure to phytoestrogens, documented to influence vaginal cytology in female infants. Its influence on minipuberty in males has not been established.: Objective: To assess ... ...

Abstract	Context: Soy formula feeding is common in infancy and is a source of high exposure to phytoestrogens, documented to influence vaginal cytology in female infants. Its influence on minipuberty in males has not been established. Objective: To assess the association between infant feeding practice and longitudinally measured reproductive hormones and hormone-responsive tissues in infant boys. Methods: The Infant Feeding and Early Development study was a prospective cohort of maternal-infant dyads requiring exclusive soy formula, cow milk formula, or breast milk feeding during study follow-up. In the 147 infant boy participants, serum testosterone, luteinizing hormone, stretched penile length, anogenital distance, and testis volume were longitudinally assessed from birth to 28 weeks. We examined feeding-group differences in age trajectories for these outcomes using mixed-effects regression splines. Results: Median serum testosterone was at pubertal levels at 2 weeks (176 ng/dL [quartiles: 124, 232]) and remained in this range until 12 weeks in all feeding groups. We did not observe differences in trajectories of hormone concentrations or anatomical measures between boys fed soy formula (n = 55) and boys fed cow milk formula (n = 54). Compared with breastfed boys (n = 38), soy formula-fed boys had a more rapid increase in penile length (P = .004) and slower initial lengthening of anogenital distance (P = .03), but no differences in hormone trajectories. Conclusion: Reproductive hormone concentrations and anatomical responses followed similar trajectories in soy and cow milk formula-fed infant boys. Our findings suggest that these measures of early male reproductive development do not respond to phytoestrogen exposure during infancy.
MeSH term(s)	Adult ; Breast Feeding ; Female ; Genitalia, Male/anatomy & histology ; Humans ; Infant ; Infant Formula ; Luteinizing Hormone/blood ; Male ; Penis/anatomy & histology ; Penis/growth & development ; Phytoestrogens/pharmacology ; Prospective Studies ; Glycine max ; Testis/anatomy & histology ; Testosterone/blood
Chemical Substances	Phytoestrogens ; Testosterone (3XMK78S47O) ; Luteinizing Hormone (9002-67-9)
Language	English
Publishing date	2021-05-16
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/clinem/dgab354
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Article ; Online: Response to Letter to the Editor From Pierre Bougnères: "Reproductive Hormone Concentrations and Associated Anatomical Responses: Does Soy Formula Affect Minipuberty in Boys?"

Chin, Helen B / Kelly, Andrea / Adgent, Margaret A / Patchel, Stacy A / James, Kerry / Chandler, Donald Walt / Zemel, Babette S / Schall, Joan I / Ford, Eileen G / Darge, Kassa / Stallings, Virginia A / Baird, Donna D / Rogan, Walter J / Umbach, David M

The Journal of clinical endocrinology and metabolism

2021 Volume 107, Issue 2, Page(s) e894–e895

MeSH term(s)	Humans ; Infant Formula ; Luteinizing Hormone ; Male
Chemical Substances	Luteinizing Hormone (9002-67-9)
Language	English
Publishing date	2021-10-06
Publishing country	United States
Document type	Letter ; Research Support, N.I.H., Intramural ; Comment
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/clinem/dgab718
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Book: Religious cooperation in the Pacific Islands

James, Kerry

1989

Author's details	[eds.: Kerry James ...]
Language	English
Size	XI, 219 S, Ill., Kt
Edition	Rev. and updated ed
Publisher	Inst. of Pacific Studies, Univ. of the South Pacific
Publishing place	Suva
Document type	Book
Database	Former special subject collection: coastal and deep sea fishing

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Article: Biological consequences of MLC calibration errors in IMRT delivery and QA.

Moiseenko, Vitali / Lapointe, Vincent / James, Kerry / Yin, Lingshu / Liu, Mitchell / Pawlicki, Todd

Medical physics

2012 Volume 39, Issue 4, Page(s) 1917–1924

Abstract: Purpose: The purpose of this work is threefold: (1) to explore biological consequences of the multileaf collimator (MLC) calibration errors in intensity modulated radiotherapy (IMRT) of prostate and head and neck cancers, (2) to determine levels of ... ...

Abstract	Purpose: The purpose of this work is threefold: (1) to explore biological consequences of the multileaf collimator (MLC) calibration errors in intensity modulated radiotherapy (IMRT) of prostate and head and neck cancers, (2) to determine levels of planning target volume (PTV) and normal tissue under- or overdose flagged with clinically used QA action limits, and (3) to provide biologically based input for MLC QA and IMRT QA action limits. Methods: Ten consecutive prostate IMRT cases and ten consecutive head and neck IMRT cases were used. Systematic MLC offsets (i.e., calibration error) were introduced for each control point of the plan separately for X1 and X2 leaf banks. Offsets were from - 2 to 2 mm with a 0.5 mm increment. The modified files were imported into the planning system for forward dose recalculation. The original plan served as the reference. The generalized equivalent uniform dose (gEUD) was used as the biological index for the targets, rectum, parotid glands, brainstem, and spinal cord. Each plan was recalculated on a CT scan of a 27 cm diameter cylindrical phantom with a contoured 0.6 cc ion chamber. Dose to ion chamber and 3D gamma analysis were compared to the reference plan. QA pass criteria: (1) at least 95% of voxels with a dose cutoff of 50% of maximum dose have to pass at 3 mm/3% and (2) dose to chamber within 2% of the reference dose. Results: For prostate cases, differences in PTV and rectum gEUD greater than 2% were identified. However, a larger proportion of plans leading to greater than 2% difference in prostate PTV gEUD passed the ion chamber QA but not 3D gamma QA. A similar trend was found for the rectum gEUD. For head and neck IMRT, the QA pass criteria flagged plans leading to greater than 4% differences in PTV gEUD and greater than 5% differences in the maximum dose to brainstem. If pass criteria were relaxed to 90% for gamma and 3% for ion chamber QA, plans leading to a 5% difference in PTV gEUD and a 5%-8% difference in brainstem maximum dose would likely pass IMRT QA. A larger proportion of head and neck plans with greater than 2% PTV gEUD difference passed 3D gamma QA compared to ion chamber QA. Conclusions: For low modulation plans, there is a better chance to catch MLC calibration errors with 3D gamma QA rather than ion chamber QA. Conversely, for high modulation plans, there is a better chance to catch MLC calibration errors with ion chamber QA rather than with 3D gamma QA. Ion chamber and 3D gamma analysis IMRT QA can detect greater than 2% change in gEUD for PTVs and critical structures for low modulation treatment plans. For high modulation treatment plans, ion chamber and 3D gamma analysis can detect greater than 2% change in gEUD for PTVs and a 5% change in critical structure gEUD since either QA methods passes the QA criteria. For gEUD changes less than those listed above, either QA method has the same proportion of passing rate.
MeSH term(s)	Calibration ; Canada ; Humans ; Neoplasms/radiotherapy ; Quality Assurance, Health Care/standards ; Radiometry/standards ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted/standards ; Radiotherapy, Conformal/instrumentation ; Radiotherapy, Conformal/standards ; Reproducibility of Results ; Sensitivity and Specificity
Language	English
Publishing date	2012-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	188780-4
ISSN	0094-2405
ISSN	0094-2405
DOI	10.1118/1.3692177
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Article: Pacific village economies

James, Kerry E

Pacific viewpoint : change, conflict, continuity 34 ,2, S. 135-270

opportunity and livelihood in small communities

1993

Author's details	guest ed.: Kerry James
Keywords	Entwicklung ; Ozeanien ; Melanesien
Language	English
Size	Graph. Darst
Publishing place	Wellington
Document type	Article
Note	Enth. 6 Beitr
ZDB-ID	417554-2
ISSN	0030-8978
Database	ECONomics Information System

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Article ; Online: A Longitudinal Study of Estrogen-Responsive Tissues and Hormone Concentrations in Infants Fed Soy Formula.

Adgent, Margaret A / Umbach, David M / Zemel, Babette S / Kelly, Andrea / Schall, Joan I / Ford, Eileen G / James, Kerry / Darge, Kassa / Botelho, Julianne C / Vesper, Hubert W / Chandler, Donald Walt / Nakamoto, Jon M / Rogan, Walter J / Stallings, Virginia A

The Journal of clinical endocrinology and metabolism

2018 Volume 103, Issue 5, Page(s) 1899–1909

Abstract: Purpose: Chemicals with hormonelike activity, such as estrogenic isoflavones, may perturb human development. Infants exclusively fed soy-based formula are highly exposed to isoflavones, but their physiologic responses remain uncharacterized. Estrogen- ... ...

Abstract	Purpose: Chemicals with hormonelike activity, such as estrogenic isoflavones, may perturb human development. Infants exclusively fed soy-based formula are highly exposed to isoflavones, but their physiologic responses remain uncharacterized. Estrogen-responsive postnatal development was compared in infants exclusively fed soy formula, cow-milk formula, and breast milk. Methods: We enrolled 410 infants born in Philadelphia-area hospitals between 2010 and 2014; 283 were exclusively fed soy formula (n = 102), cow-milk formula (n = 111), or breast milk (n = 70) throughout the study (birth to 28 or 36 weeks for boys and girls, respectively). We repeatedly measured maturation index (MI) in vaginal and urethral epithelial cells using standard cytological methods, uterine volume and breast-bud diameter using ultrasound, and serum estradiol and follicle-stimulating hormone levels. We estimated MI, organ-growth, and hormone trajectories by diet using mixed-effects regression splines. Results: Maternal demographics did not differ between cow-milk-fed and soy-fed infants but did differ between formula-fed and breastfed infants. Vaginal-cell MI trended higher (P = 0.01) and uterine volume decreased more slowly (P = 0.01) in soy-fed girls compared with cow-milk-fed girls; however, their trajectories of breast-bud diameter and hormone concentrations did not differ. We observed no significant differences between boys fed cow-milk vs soy formula; estradiol was not detectable. Breastfed infants differed from soy-formula-fed infants in vaginal-cell MI, uterine volume, and girls' estradiol and boys' breast-bud diameter trajectories. Conclusions: Relative to girls fed cow-milk formula, those fed soy formula demonstrated tissue- and organ-level developmental trajectories consistent with response to exogenous estrogen exposure. Studies are needed to further evaluate the effects of soy on child development.
MeSH term(s)	Animals ; Breast/drug effects ; Breast/growth & development ; Cattle ; Child Development/drug effects ; Estrogens/pharmacology ; Female ; Humans ; Infant ; Infant Formula/chemistry ; Infant Nutritional Physiological Phenomena ; Infant, Newborn ; Isoflavones/pharmacology ; Longitudinal Studies ; Male ; Milk/chemistry ; Milk/physiology ; Milk, Human/chemistry ; Milk, Human/physiology ; Phytoestrogens/pharmacology ; Urethra/drug effects ; Urethra/growth & development ; Uterus/drug effects ; Uterus/growth & development
Chemical Substances	Estrogens ; Isoflavones ; Phytoestrogens
Language	English
Publishing date	2018-02-10
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/jc.2017-02249
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Article: Tracking Medicaid managed care in rural communities: a fifty-state follow-up.

Silberman, Pam / Poley, Stephanle / James, Kerry / Slifkin, Rebecca

Health affairs (Project Hope)

2002 Volume 21, Issue 4, Page(s) 255–263

Abstract: This study updates a 1997 study examining implementation of rural Medicaid managed care programs. Most states operate Medicaid managed care programs for their beneficiaries, but the types of programs vary across urban and rural settings. Over the past ... ...

Abstract	This study updates a 1997 study examining implementation of rural Medicaid managed care programs. Most states operate Medicaid managed care programs for their beneficiaries, but the types of programs vary across urban and rural settings. Over the past four years the number of rural counties covered by Medicaid managed care, including fully capitated programs, has grown, although primary care case management (PCCM) remains the predominant program type in rural areas. Health plan withdrawals from rural areas have led some states with rural capitated programs to provide financial incentives or develop alternative approaches, such as enhanced PCCM programs.
MeSH term(s)	Budgets/legislation & jurisprudence ; Follow-Up Studies ; Health Care Surveys ; Managed Care Programs/organization & administration ; Managed Care Programs/statistics & numerical data ; Medicaid/organization & administration ; Medicaid/statistics & numerical data ; Organizational Objectives ; Rural Health Services/organization & administration ; Rural Health Services/statistics & numerical data ; State Health Plans/economics ; State Health Plans/organization & administration ; United States
Language	English
Publishing date	2002-02-28
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	632712-6
ISSN	1544-5208 ; 0278-2715
ISSN (online)	1544-5208
ISSN	0278-2715
DOI	10.1377/hlthaff.21.4.255
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Article: Tracking Medicaid managed care in rural communinities: a fifty-state follow-up

James, Kerry / Poley, Stephanie / Silberman, Pam / Slifkin, Rebecca

Health affairs Vol. 21, No. 4 , p. 255-263

the recent exodus of Medicaid managed care plans from rural areas has forced states and counties to radically change the remaining plans to ensure their survival

2002 Volume 21, Issue 4, Page(s) 255–263

Author's details	by Pam Silberman
Keywords	Integrierte Versorgung ; Gesetzliche Krankenversicherung ; Sozialleistungsempfänger ; Ländlicher Raum ; USA
Language	English
Publisher	Project Hope
Publishing place	Bethesda, Md.
Document type	Article
ZDB-ID	632712-6
Database	ECONomics Information System

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Article: Migration and remittances

James, Kerry E

Pacific viewpoint : change, conflict, continuity 32 ,1, S. 1-23

a Tongan village perspective

1991

Author's details	K. E. James
Keywords	Arbeitsmigranten ; Rücküberweisungen ; Tonga
Language	English
Size	Graph. Darst
Publishing place	Wellington
Document type	Article
ZDB-ID	417554-2
ISSN	0030-8978
Database	ECONomics Information System

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