Article ; Online: Response to infections in patients with asthma and atopic disease: an epiphenomenon or reflection of host susceptibility?
The Journal of allergy and clinical immunology
2012 Volume 130, Issue 2, Page(s) 343–351
Abstract: Associations between respiratory tract infections and asthma inception and exacerbations are well established. Infant respiratory syncytial virus and rhinovirus infections are known to be associated with an increased risk of asthma development, and among ...
| Abstract | Associations between respiratory tract infections and asthma inception and exacerbations are well established. Infant respiratory syncytial virus and rhinovirus infections are known to be associated with an increased risk of asthma development, and among children with prevalent asthma, 85% of asthma exacerbations are associated with viral infections. However, the exact nature of this relationship remains unclear. Is the increase in severity of infections an epiphenomenon, meaning respiratory tract infections just appear to be more severe in patients with underlying respiratory disease, or instead a reflection of altered host susceptibility among persons with asthma and atopic disease? The main focus of this review is to summarize the available levels of evidence supporting or refuting the notion that patients with asthma or atopic disease have an altered susceptibility to selected pathogens, as well as discussing the biological mechanism or mechanisms that might explain such associations. Finally, we will outline areas in need of further research because understanding the relationships between infections and asthma has important implications for asthma prevention and treatment, including potential new pathways that might target the host immune response to select pathogens. |
|---|---|
| MeSH term(s) | Asthma/complications ; Asthma/immunology ; Asthma/physiopathology ; Child ; Cytokines/immunology ; Disease Susceptibility ; Humans ; Infant ; Picornaviridae Infections/complications ; Picornaviridae Infections/immunology ; Picornaviridae Infections/physiopathology ; Respiratory Syncytial Virus Infections/complications ; Respiratory Syncytial Virus Infections/immunology ; Respiratory Syncytial Virus Infections/physiopathology ; Respiratory Syncytial Viruses/immunology ; Respiratory Tract Infections/complications ; Respiratory Tract Infections/immunology ; Respiratory Tract Infections/physiopathology ; Rhinovirus/immunology ; Severity of Illness Index ; Th2 Cells/immunology |
| Chemical Substances | Cytokines |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2012-07-14 |
| Publishing country | United States |
| Document type | Journal Article ; Review |
| ZDB-ID | 121011-7 |
| ISSN | 1097-6825 ; 1085-8725 ; 0091-6749 |
| ISSN (online) | 1097-6825 ; 1085-8725 |
| ISSN | 0091-6749 |
| DOI | 10.1016/j.jaci.2012.05.056 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
Full text online
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Uh III Zs.92: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.