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  1. Article ; Online: Primary left ventricular leiomyosarcoma: a case report.

    Balachandran, Vipin / Young, Vanessa / Baillie, Tina / James, Allen

    Journal of cardiothoracic surgery

    2024  Volume 19, Issue 1, Page(s) 168

    Abstract: Cardiac leiomyosarcomas are a rare subset of the already infrequent, primary malignant cardiac neoplasia spectrum. The most common site for a primary leiomyosarcoma of the ventricle is on the right with fewer than five globally reported cases in the left ...

    Abstract Cardiac leiomyosarcomas are a rare subset of the already infrequent, primary malignant cardiac neoplasia spectrum. The most common site for a primary leiomyosarcoma of the ventricle is on the right with fewer than five globally reported cases in the left ventricle. Most present with non-specific symptoms but attention is usually sought after the appearance of compressive symptoms or arrhythmias. We present a case of a left ventricular leiomyosarcoma in a 50-year old female patient that had a delayed diagnosis and its subsequent surgical resection and oncological management with docetaxel and gemcitabine. This case highlights the need for a high index of suspicion for cardiac masses especially if there are competing chronic diseases with similar symptomatology. Given the rare presentation of left ventricular leiomyosarcomas, case reports may provide valuable information that is otherwise unavailable.
    MeSH term(s) Female ; Humans ; Middle Aged ; Heart Ventricles/pathology ; Leiomyosarcoma/diagnosis ; Leiomyosarcoma/surgery ; Leiomyosarcoma/pathology ; Heart Neoplasms/diagnosis ; Heart Neoplasms/surgery ; Heart Neoplasms/pathology
    Language English
    Publishing date 2024-04-02
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2227224-0
    ISSN 1749-8090 ; 1749-8090
    ISSN (online) 1749-8090
    ISSN 1749-8090
    DOI 10.1186/s13019-024-02680-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online: Mechanisms of Persistence, Survival, and Transmission of Bacterial Foodborne Pathogens in Production Animals

    Kogut, Michael H. / Jr, James Allen Byrd / He, Haiqi / Genovese, Kenneth J. / Swaggerty, Christina L.

    2018  

    Abstract: Foodborne illness resulting from food production animals is a global health concern, and the Centers for Disease Control estimate that one in six Americans will become sick with a foodborne illness each year. Of course there are numerous causes for these ...

    Abstract Foodborne illness resulting from food production animals is a global health concern, and the Centers for Disease Control estimate that one in six Americans will become sick with a foodborne illness each year. Of course there are numerous causes for these outbreaks, but contamination from a food production animal is certainly one source. Understanding the host-pathogen interaction and how foodborne bacterial pathogens establish a persistent infection and evade host immune responses will be pivotal in reducing the instance of foodborne illness traced back to a food production animal source.In this volume, we bring together original research and review articles covering some of the key issues surrounding the mechanisms of persistence, survival, and transmission of bacterial foodborne pathogens in production animals. The research focused on poultry and specifically addressed antibiotic resistance, Salmonella colonization, pathogen reduction strategies using pre- or probiotics, pathogen evasion, and post-harvest intervention and pathogen testing. The following 11 articles are fine examples of the multidisciplinary approaches that will be required to address and understand the complex interplay between food safety and animal production
    Keywords Medicine (General) ; Veterinary medicine
    Size 1 electronic resource (130 p.)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020101859
    ISBN 9782889455454 ; 2889455459
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Thesis: Schmerz und entzündliche Hyperalgesie ausgelöst durch intradermale Injektionen humaner Thrombozyten und Leukozyten

    Blunk, James Allen

    2000  

    Author's details vorgelegt von James Allen Blunk
    Language German
    Size 24 S. , graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Erlangen, Nürnberg, Univ., Diss., 2000
    Note Aus: European journal of pain ; 3
    HBZ-ID HT013101408
    Database Catalogue ZB MED Medicine, Health

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  4. Article ; Online: The public health impact of loneliness during the COVID-19 pandemic

    James Allen / Oliver Darlington / Karen Hughes / Mark A. Bellis

    BMC Public Health, Vol 22, Iss 1, Pp 1-

    2022  Volume 9

    Abstract: Abstract Background Social distancing measures have been effective in mitigating the spread of COVID-19; however, they have imposed a significant burden on population mental health and well-being. This study aimed to identify factors associated with ... ...

    Abstract Abstract Background Social distancing measures have been effective in mitigating the spread of COVID-19; however, they have imposed a significant burden on population mental health and well-being. This study aimed to identify factors associated with loneliness during the COVID-19 pandemic, and to describe the relationship between loneliness and the risk of worsening health outcomes and behaviours. Methods Data for 8,960 adults were drawn from a national cross-sectional survey undertaken in Wales between January and June 2021. Participants self-reported changes to health and behaviour since the start of the pandemic. Logistic regression was used to identify factors associated with loneliness, and the impact of loneliness on self-reported changes in physical health, physical fitness, mental health, weight, alcohol consumption and social relations in comparison with pre-pandemic experiences. Results Groups most at risk of loneliness were those aged < 35 years, women (odds ratio [95% confidence interval]: 1.86 [1.70–2.05]), those with chronic health conditions (1.43 [1.29–1.58]) and the unemployed (2.18 [1.76–2.70]). Loneliness was a strong predictor of worsening health outcomes and behaviours, with those reporting often feeling lonely being at increased odds of worsening physical health (3.29 [2.80–3.86]), physical fitness (2.22 [1.90–2.60]), mental health (8.33 [6.95–9.99]), weight (1.39 [1.19–1.62]), alcohol consumption (1.37 [1.12,-1.66]) and social relations (2.45 [2.07–2.89]) during the pandemic. Conclusion This study established an association between loneliness and self-reported worsening health during the pandemic, and identified factors increasing the risk of loneliness. The effect that social control measures have on loneliness should influence the design of future public health policy.
    Keywords COVID-19 ; Loneliness ; Public health ; Mental health ; Physical health ; Public aspects of medicine ; RA1-1270
    Subject code 300 ; 796
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Distribution of Coronavirus Receptors in the Swine Respiratory and Intestinal Tract.

    Nelli, Rahul Kumar / Roth, James Allen / Gimenez-Lirola, Luis Gabriel

    Veterinary sciences

    2022  Volume 9, Issue 9

    Abstract: Coronaviruses use a broad range of host receptors for binding and cell entry, essential steps in establishing viral infections. This pilot study evaluated the overall distribution of angiotensin-converting enzyme 2 (ACE2), aminopeptidase N (APN), ... ...

    Abstract Coronaviruses use a broad range of host receptors for binding and cell entry, essential steps in establishing viral infections. This pilot study evaluated the overall distribution of angiotensin-converting enzyme 2 (ACE2), aminopeptidase N (APN), carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), and dipeptidyl peptidase 4 (DPP4) receptors in the pig respiratory and intestinal tract. All the receptors evaluated in this study were expressed and differentially distributed through the respiratory and intestinal tract. The presence and expression levels of these receptors could determine susceptibility to coronavirus infections. This study may have important implications for the development of research models and the assessment of the potential risk and introduction of novel coronaviruses into the swine population.
    Language English
    Publishing date 2022-09-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2768971-2
    ISSN 2306-7381 ; 2306-7381
    ISSN (online) 2306-7381
    ISSN 2306-7381
    DOI 10.3390/vetsci9090500
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Designing azobenzene-based tools for controlling neurotransmission.

    Leippe, Philipp / Frank, James Allen

    Current opinion in structural biology

    2019  Volume 57, Page(s) 23–30

    Abstract: Chemical and electrical signaling at the synapse is a dynamic process that is crucial to neurotransmission and pathology. Traditional pharmacotherapy has found countless applications in both academic labs and the clinic; however, diffusible drugs lack ... ...

    Abstract Chemical and electrical signaling at the synapse is a dynamic process that is crucial to neurotransmission and pathology. Traditional pharmacotherapy has found countless applications in both academic labs and the clinic; however, diffusible drugs lack spatial and temporal precision when employed in heterogeneous tissues such as the brain. In the field of photopharmacology, chemical attachment of a synthetic photoswitch to a bioactive ligand allows cellular signaling to be controlled with light. Azobenzenes have remained the go-to photoswitch for biological applications due to their tunable photophysical properties, and can be leveraged to achieve reversible optical control of numerous receptors and ion channels. Here, we discuss the most recent advances in photopharmacology which will improve the use of azobenzene-based probes for neuroscience applications.
    MeSH term(s) Azo Compounds/metabolism ; Drug Design ; Light ; Molecular Probes/metabolism ; Signal Transduction/radiation effects ; Synaptic Transmission/radiation effects
    Chemical Substances Azo Compounds ; Molecular Probes ; azobenzene (F0U1H6UG5C)
    Language English
    Publishing date 2019-02-28
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1068353-7
    ISSN 1879-033X ; 0959-440X
    ISSN (online) 1879-033X
    ISSN 0959-440X
    DOI 10.1016/j.sbi.2019.01.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: The Effectiveness of Cognitive Behavioral Therapy-Based Intervention on Improving Sleep-Related Outcomes for People with Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

    Wang, Hongjuan / Li, Rongzhi / Ge, Lin / Xu, Fan / Wiley, James Allen / Tang, Siyuan / Sun, Mei

    Psychology research and behavior management

    2024  Volume 17, Page(s) 957–972

    Abstract: Background: Sleep-related outcomes in people with diabetes are poor, which is closely linked to reducing the development of diabetes. Cognitive behavioral therapy (CBT) based intervention presents innovative solutions that can help improve sleep-related ...

    Abstract Background: Sleep-related outcomes in people with diabetes are poor, which is closely linked to reducing the development of diabetes. Cognitive behavioral therapy (CBT) based intervention presents innovative solutions that can help improve sleep-related outcomes.
    Aim: This synthesis aims to assess the effectiveness of CBT-based intervention compared to controls in Randomized Controlled Trials (RCTs) for sleep-related outcomes among people with diabetes.
    Methods: Eight electronic databases were systematically searched: PubMed, EMBASE, Cochrane library, Web of Science, PsycINFO, CINAHL, China National Knowledge Infrastructure (CNKI), and Wan Fang database. We examined CBT-based intervention's effectiveness on sleep-related outcomes in people with diabetes in RCTs identified in these databases from their inception to 1st November 2023, and updated on 15 January 2024. The risk of bias was assessed using the Cochrane Risk of Bias tool by two reviewers. The meta-analysis of included studies was conducted by RevMan 5.3 software.
    Results: Seven studies in total (n = 2633 participants) were included in this systematic review based on our inclusion criteria. The systematic review found CBT-based intervention significantly improved sleep quality (Pittsburgh Sleep Quality Index, PSQI scores) at immediate post-intervention [95% CI=(-1.31 to -0.32), p = 0.001], six months [95% CI=(-0.75 to -0.22), p = 0.0003], and 12 months [95% CI=(-0.72 to -0.24), <0.0001], compared to control groups. Furthermore, our findings demonstrated that six sessions [95% CI= (-0.38 to -0.13), p < 0.0001] or more than six sessions [95% CI=(-1.76 to -0.02), p = 0.05] of CBT-based intervention could improve sleep quality compared to controls (I
    Conclusion: CBT-based intervention appears to have a beneficial effect on improving sleep quality and total sleep time among people with diabetes. CBT-based intervention could be considered a strategy among healthcare providers to enhance sleep quality and total sleep time for people with diabetes. More RCTs with rigorous designs and long-term follow-up are warranted to provide conclusive evidence of the CBT-based intervention on sleep-related outcomes and to explore the mechanisms by which the CBT-based interventions improve sleep-related outcomes.
    Language English
    Publishing date 2024-03-09
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2495093-2
    ISSN 1179-1578
    ISSN 1179-1578
    DOI 10.2147/PRBM.S449577
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book ; Online: Density functions for QuickQuant and QuickVal

    Fill, James Allen / Hung, Wei-Chun

    2021  

    Abstract: We prove that, for every $0 \leq t \leq 1$, the limiting distribution of the scale-normalized number of key comparisons used by the celebrated algorithm QuickQuant to find the $t$th quantile in a randomly ordered list has a Lipschitz continuous density ... ...

    Abstract We prove that, for every $0 \leq t \leq 1$, the limiting distribution of the scale-normalized number of key comparisons used by the celebrated algorithm QuickQuant to find the $t$th quantile in a randomly ordered list has a Lipschitz continuous density function $f_t$ that is bounded above by $10$. Furthermore, this density $f_t(x)$ is positive for every $x > \min\{t, 1 - t\}$ and, uniformly in $t$, enjoys superexponential decay in the right tail. We also prove that the survival function $1 - F_t(x) = \int_x^{\infty}\!f_t(y)\,\mathrm{d}y$ and the density function $f_t(x)$ both have the right tail asymptotics $\exp [-x \ln x - x \ln \ln x + O(x)]$. We use the right-tail asymptotics to bound large deviations for the scale-normalized number of key comparisons used by QuickQuant.

    Comment: 72 pages; submitted for publication in September, 2021
    Keywords Mathematics - Probability ; Computer Science - Data Structures and Algorithms ; 68P10 (Primary) 60E05 ; 60C05 (Secondary)
    Subject code 519
    Publishing date 2021-09-29
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Understanding health inequalities in Wales using the Blinder-Oaxaca decomposition method

    James Allen / Andrew Cotter-Roberts / Oliver Darlington / Mariana Dyakova / Rebecca Masters / Luke Munford

    Frontiers in Public Health, Vol

    2022  Volume 10

    Abstract: BackgroundThroughout Wales and the world, health inequality remains a problem that is interconnected with a wider and complex social, economic and environmental dynamic. Subsequently, action to tackle inequality in health needs to take place at a ... ...

    Abstract BackgroundThroughout Wales and the world, health inequality remains a problem that is interconnected with a wider and complex social, economic and environmental dynamic. Subsequently, action to tackle inequality in health needs to take place at a structural level, acknowledging the constraints affecting an individual's (or community's) capability and opportunity to enable change. While the ‘social determinants of health' is an established concept, fully understanding the composition of the health gap is dependent on capturing the relative contributions of a myriad of social, economic and environmental factors within a quantitative analysis.MethodThe decomposition analysis sought to explain the differences in the prevalence of these outcomes in groups stratified by their ability to save at least £10 a month, whether they were in material deprivation, and the presence of a limiting long-standing illness, disability of infirmity. Responses to over 4,200 questions within the National Survey for Wales (n = 46,189; 2016–17 to 2019–20) were considered for analysis. Variables were included based on (1) their alignment to a World Health Organization (WHO) health equity framework (“Health Equity Status Report initiative”) and (2) their ability to allow for stratification of the survey sample into distinct groups where considerable gaps in health outcomes existed. A pooled Blinder-Oaxaca model was used to analyse inequalities in self-reported health (fair/poor health, low mental well-being and low life satisfaction) and were stratified by the variables relating to financial security, material deprivation and disability status.ResultsThe prevalence of fair/poor health was 75% higher in those who were financially insecure and 95% higher in those who are materially deprived. Decomposition of the outcome revealed that just under half of the health gap was “explained” i.e., 45.5% when stratifying by the respondent's ability to save and 46% when stratifying by material deprivation status. Further analysis of the explained ...
    Keywords health inequality ; health equity ; health gap ; mental well-being ; life satisfaction ; decompositions methods ; Public aspects of medicine ; RA1-1270
    Subject code 360
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Psilocybin and Obsessive Compulsive Disorder.

    Wilcox, James Allen

    Journal of psychoactive drugs

    2014  Volume 46, Issue 5, Page(s) 393–395

    Abstract: Obsessive Compulsive Disorder (OCD) is a psychiatric disorder with considerable morbidity and mortality. This condition disables many individuals and is often refractory to treatment. Research suggests that serotonin plays a role in OCD symptom reduction. ...

    Abstract Obsessive Compulsive Disorder (OCD) is a psychiatric disorder with considerable morbidity and mortality. This condition disables many individuals and is often refractory to treatment. Research suggests that serotonin plays a role in OCD symptom reduction. We present a case of an individual who successfully used psilocybin, a serotonergic agent, to reduce the core symptoms of OCD for several years. Although not endorsing this form of treatment, we feel that the successful use of this agent highlights the role of serotonergic factors in OCD and the need for further, legitimate research into the value of psilocybin in the treatment of anxiety disorders.
    MeSH term(s) Adult ; Humans ; Male ; Obsessive-Compulsive Disorder/drug therapy ; Psilocybin/therapeutic use
    Chemical Substances Psilocybin (2RV7212BP0)
    Language English
    Publishing date 2014-11
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 392405-1
    ISSN 2159-9777 ; 0279-1072
    ISSN (online) 2159-9777
    ISSN 0279-1072
    DOI 10.1080/02791072.2014.963754
    Database MEDical Literature Analysis and Retrieval System OnLINE

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