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  1. Article ; Online: The use of gas chromatography combined with chemical and sensory analysis to evaluate nuisance odours in the air and water environment

    James E. Hayes / Radosław J. Barczak / Irwin “Mel” Suffet / Richard M. Stuetz

    Environment International, Vol 180, Iss , Pp 108214- (2023)

    2023  

    Abstract: Varieties of gas chromatography (GC) combined with chemical detection (CD) and sensory analysis at the odour detection port (ODP) for the evaluation of environmental odorants has steadily increased in application and sophistication; this has given rise ... ...

    Abstract Varieties of gas chromatography (GC) combined with chemical detection (CD) and sensory analysis at the odour detection port (ODP) for the evaluation of environmental odorants has steadily increased in application and sophistication; this has given rise to a plethora of techniques that cater to specific tasks. With this diversity of approaches in mind, there is a need to assess the critical points at which these approaches differ, as well as likely risks and factors that may affect them. These critical points explained within this review include sample preparation, GC separation techniques (with associated co-elution risks), how the elute is separated between CD and sensory analysis, the type of CD, the type of sensory analysis (with particular attention paid to its factors and guidelines), integrative data techniques, as well as how that data may be used. Additionally, this review provides commentary on the current state of the research space and makes recommendations based on how these analyses should be reported, the standardisation of nomenclature, as well as the impediments to the future goals of this research area. By careful consideration of the critical points of varying analytical processes and how best to communicate these findings, the quality of output within this area will improve. This review provides a benchmark for how GC-CD/sensory analysis should be undertaken and reported.
    Keywords Odorants ; Olfactory analysis ; GC–MS/ODP ; Mass spectrometry ; Environmental odour ; Environmental sciences ; GE1-350
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Framework for the use of odour wheels to manage odours throughout wastewater biosolids processing

    Fisher, Ruth M / Radoslaw J. Barczak / I.H. “Mel” Suffet / James E. Hayes / Richard M. Stuetz

    Science of the total environment. 2018 Sept. 01, v. 634

    2018  

    Abstract: Odorous emissions from wastewater biosolids processing can cause nuisance impacts to the surrounding community. Odour Wheels are an effective tool for environmental odour management, but have yet to be provided for wastewater biosolids processing. ... ...

    Abstract Odorous emissions from wastewater biosolids processing can cause nuisance impacts to the surrounding community. Odour Wheels are an effective tool for environmental odour management, but have yet to be provided for wastewater biosolids processing. Emissions throughout the biosolids processing from eight wastewater treatment plants, each with different unit operation configurations, were surveyed to identify odorants present and their olfactory properties. Chemical and olfactory methods identified a range of odorants and odours emitted throughout biosolids processing. Within the biosolids processing locations studied Sulfur type odours, described as rotten eggs or cabbage, were typically encountered. However, there was also a varying presence of Rancid/putrid and Faecal/manure type odours. Odour Wheels were generated to communicate both the olfactory and chemical components of emissions which were measured throughout biosolids processing. Examples based on the operation of the eight wastewater treatment plants were used to demonstrate how the Odour Wheels can be used as an onsite odour management aid. The paper demonstrates how Odour Wheels can be prepared using chemical and olfactory measurements and then used to communicate olfactory properties, as well as identify the causes of nuisance emissions throughout biosolids processing at wastewater treatment plants. The linking of odours and odorants to process conditions throughout biosolids processing facilitates effective abatement and management practices.
    Keywords biosolids ; cabbage ; eggs ; emissions ; odor compounds ; odors ; sulfur ; wastewater ; wastewater treatment ; wheels
    Language English
    Dates of publication 2018-0901
    Size p. 214-223.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2018.03.352
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Tissue-Specific Enrichment of Lymphoma Risk Loci in Regulatory Elements.

    James E Hayes / Gosia Trynka / Joseph Vijai / Kenneth Offit / Soumya Raychaudhuri / Robert J Klein

    PLoS ONE, Vol 10, Iss 9, p e

    2015  Volume 0139360

    Abstract: Though numerous polymorphisms have been associated with risk of developing lymphoma, how these variants function to promote tumorigenesis is poorly understood. Here, we report that lymphoma risk SNPs, especially in the non-Hodgkin's lymphoma subtype ... ...

    Abstract Though numerous polymorphisms have been associated with risk of developing lymphoma, how these variants function to promote tumorigenesis is poorly understood. Here, we report that lymphoma risk SNPs, especially in the non-Hodgkin's lymphoma subtype chronic lymphocytic leukemia, are significantly enriched for co-localization with epigenetic marks of active gene regulation. These enrichments were seen in a lymphoid-specific manner for numerous ENCODE datasets, including DNase-hypersensitivity as well as multiple segmentation-defined enhancer regions. Furthermore, we identify putatively functional SNPs that are both in regulatory elements in lymphocytes and are associated with gene expression changes in blood. We developed an algorithm, UES, that uses a Monte Carlo simulation approach to calculate the enrichment of previously identified risk SNPs in various functional elements. This multiscale approach integrating multiple datasets helps disentangle the underlying biology of lymphoma, and more broadly, is generally applicable to GWAS results from other diseases as well.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2015-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels

    Tuomas O. Kilpeläinen / Jayne F. Martin Carli / Alicja A. Skowronski / Qi Sun / Jennifer Kriebel / Mary F Feitosa / Åsa K. Hedman / Alexander W. Drong / James E. Hayes / Jinghua Zhao / Tune H. Pers / Ursula Schick / Niels Grarup / Zoltán Kutalik / Stella Trompet / Massimo Mangino / Kati Kristiansson / Marian Beekman / Leo-Pekka Lyytikäinen /
    Joel Eriksson / Peter Henneman / Jari Lahti / Toshiko Tanaka / Jian’an Luan / Fabiola Del Greco M / Dorota Pasko / Frida Renström / Sara M. Willems / Anubha Mahajan / Lynda M. Rose / Xiuqing Guo / Yongmei Liu / Marcus E. Kleber / Louis Pérusse / Tom Gaunt / Tarunveer S. Ahluwalia / Yun Ju Sung / Yolande F. Ramos / Najaf Amin / Antoinette Amuzu / Inês Barroso / Claire Bellis / John Blangero / Brendan M. Buckley / Stefan Böhringer / Yii-Der I Chen / Anton J. N. de Craen / David R. Crosslin / Caroline E. Dale / Zari Dastani

    Nature Communications, Vol 7, Iss 1, Pp 1-

    2016  Volume 14

    Abstract: This meta-analysis of genome-wide association studies identifies four genetic loci associated with circulating leptin levels independent of adiposity. Examination in mouse adipose tissue explants provides functional support for the leptin-associated loci. ...

    Abstract This meta-analysis of genome-wide association studies identifies four genetic loci associated with circulating leptin levels independent of adiposity. Examination in mouse adipose tissue explants provides functional support for the leptin-associated loci.
    Keywords Science ; Q
    Language English
    Publishing date 2016-02-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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