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  1. Article ; Online: Genome-wide association study of early-onset and late-onset postpartum depression: the IGEDEPP prospective study.

    Tebeka, Sarah / Gloaguen, Emilie / Mullaert, Jimmy / He, Qin / Boland, Anne / Deleuze, Jean-Francois / Jamet, Camille / Ramoz, Nicolas / Dubertret, Caroline

    European psychiatry : the journal of the Association of European Psychiatrists

    2024  , Page(s) 1–36

    Language English
    Publishing date 2024-04-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 1074337-6
    ISSN 1778-3585 ; 0767-399X ; 0924-9338
    ISSN (online) 1778-3585
    ISSN 0767-399X ; 0924-9338
    DOI 10.1192/j.eurpsy.2024.26
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2369: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 558: Show issues

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  2. Article ; Online: Divergent local and systemic antitumor response in primary uveal melanomas.

    Lucibello, Francesca / Lalanne, Ana I / Le Gac, Anne-Laure / Soumare, Abdoulaye / Aflaki, Setareh / Cyrta, Joanna / Dubreuil, Lea / Mestdagh, Martin / Salou, Marion / Houy, Alexandre / Ekwegbara, Christina / Jamet, Camille / Gardrat, Sophie / Le Ven, Anais / Bernardeau, Karine / Cassoux, Nathalie / Matet, Alexandre / Malaise, Denis / Pierron, Gaelle /
    Piperno-Neumann, Sophie / Stern, Marc-Henri / Rodrigues, Manuel / Lantz, Olivier

    The Journal of experimental medicine

    2024  Volume 221, Issue 6

    Abstract: Uveal melanoma (UM) is the most common cancer of the eye. The loss of chromosome 3 (M3) is associated with a high risk of metastases. M3 tumors are more infiltrated by T-lymphocytes than low-risk disomic-3 (D3) tumors, contrasting with other tumor types ... ...

    Abstract Uveal melanoma (UM) is the most common cancer of the eye. The loss of chromosome 3 (M3) is associated with a high risk of metastases. M3 tumors are more infiltrated by T-lymphocytes than low-risk disomic-3 (D3) tumors, contrasting with other tumor types in which T cell infiltration correlates with better prognosis. Whether these T cells represent an antitumor response and how these T cells would be primed in the eye are both unknown. Herein, we characterized the T cells infiltrating primary UMs. CD8+ and Treg cells were more abundant in M3 than in D3 tumors. CD39+PD-1+CD8+ T cells were enriched in M3 tumors, suggesting specific responses to tumor antigen (Ag) as confirmed using HLA-A2:Melan-A tetramers. scRNAseq-VDJ analysis of T cells evidenced high numbers of proliferating CD39+PD1+CD8+ clonal expansions, suggesting in situ antitumor Ag responses. TCRseq and tumor-Ag tetramer staining characterized the recirculation pattern of the antitumor responses in M3 and D3 tumors. Thus, tumor-Ag responses occur in localized UMs, raising the question of the priming mechanisms in the absence of known lymphatic drainage.
    MeSH term(s) Humans ; Melanoma/therapy ; Uveal Neoplasms ; CD8-Positive T-Lymphocytes ; Drainage
    Language English
    Publishing date 2024-04-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20232094
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.107: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 45: Show issues

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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