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  1. AU="Jamil N. Kanji"
  2. AU="Altintas, Sibel"
  3. AU=Menne Jan
  4. AU=Fadavi Pedram
  5. AU="Caravita, R."
  6. AU="Ruppert, David"
  7. AU="Ochoa, Ayako Miyashita"
  8. AU=Hemphill H E
  9. AU="Piton, Yasmin Vendruscolo"
  10. AU="Thadani, Nicole N"
  11. AU="Allison E. Norlander" AU="Allison E. Norlander"
  12. AU="Wei, Peifa"
  13. AU="Colak, Errol"
  14. AU="Hassan, Hosni M"
  15. AU="Becker, D T"
  16. AU="Lewis-Lloyd, Christopher A"
  17. AU=Doshi Rupali Kotwal AU=Doshi Rupali Kotwal
  18. AU="Kore Schlottau"
  19. AU="Jamjoom, Mona"
  20. AU="Bergmann, P."
  21. AU="Li, Congju"
  22. AU="Christenson, Robert"
  23. AU="O'Neill, Hugh M"
  24. AU="Vaccaro, Daniel H."
  25. AU=Panchin Yuri V
  26. AU=McIlvennan Colleen K
  27. AU="Khan, Mohammad Afsar"
  28. AU="Zhuang, Hua-Lu"
  29. AU="Lopez, Omar M"
  30. AU=Asfaw Abay
  31. AU="Santana, Ricardo Costa de"
  32. AU="Ortega, Johis"
  33. AU="Sogaolu, Moyosore"
  34. AU="Duchesne, Gabriela"
  35. AU="Sander, Klaus"
  36. AU="Wiegersma, Aline Marileen"
  37. AU=Mehta Yatin
  38. AU="Ki Hwan Kim"
  39. AU="Gulati, Rajiv"
  40. AU="Sullivan, Christopher"
  41. AU="Meier-Stephenson, Vanessa C"
  42. AU=Kim Joo Seop
  43. AU="Mortensen, Jennifer L"
  44. AU="Manthey, Helga D"
  45. AU="Baker, Susan"
  46. AU="Gunasegaram, James R"
  47. AU="Jung, Steffen"
  48. AU="Cairns, Anita"
  49. AU="Fox, Lindsay"

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  1. Artikel ; Online: Autochthonous North American Leprosy

    Prenilla Naidu / Rahul Sharma / Jamil N. Kanji / Vilma Marks / Arienne King

    Infectious Disease Reports, Vol 13, Iss 83, Pp 917-

    A Second Case in Canada

    2021  Band 923

    Abstract: Autochthonous leprosy was reported in the Southern USA in 2011 and has comprised an average of 34% of new cases from 2015 to 2020 in that country. We report a similar case in a patient from Western Canada. A 50-year old male patient presented with a four- ...

    Abstract Autochthonous leprosy was reported in the Southern USA in 2011 and has comprised an average of 34% of new cases from 2015 to 2020 in that country. We report a similar case in a patient from Western Canada. A 50-year old male patient presented with a four-year history of a chronic rash. Pathology stains revealed acid-fast bacilli prompting specialist referral. Examination was suspicious for leprosy, which was confirmed on slit skin smears and molecular testing. The patient responded well to treatment. Genotypic testing mapped the organism to the 3I-2 SNP type, which is of European origin and is the type found in implicated armadillo species in North America.
    Schlagwörter leprosy ; Hansen’s disease ; leprosy in North America ; autochthonous leprosy ; Mycobacterium leprae ; leprosy genotyping ; Other systems of medicine ; RZ201-999
    Sprache Englisch
    Erscheinungsdatum 2021-10-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: A gold nanoparticle-protein G electrochemical affinity biosensor for the detection of SARS-CoV-2 antibodies

    Yeganeh Khaniani / Yuhao Ma / Mahdi Ghadiri / Jie Zeng / David Wishart / Shawn Babiuk / Carmen Charlton / Jamil N. Kanji / Jie Chen

    Scientific Reports, Vol 12, Iss 1, Pp 1-

    a surface modification approach

    2022  Band 12

    Abstract: Abstract As COVID-19 waves continue to spread worldwide, demand for a portable, inexpensive and convenient biosensor to determine community immune/infection status is increasing. Here we describe an impedance-based affinity biosensor using Interdigitated ...

    Abstract Abstract As COVID-19 waves continue to spread worldwide, demand for a portable, inexpensive and convenient biosensor to determine community immune/infection status is increasing. Here we describe an impedance-based affinity biosensor using Interdigitated Electrode (IDE) arrays to detect antibodies to SARS-CoV-2 in serum. We created the biosensor by functionalizing the IDEs’ surface with abaculaovirus-expressed and purified Spike (S) protein to bind anti-SARS CoV-2antibodies. Gold nanoparticles (GNP) fused to protein G were used to probe for bound antibodies. An ELISA assay using horseradish peroxidase-protein G to probe for bound IgG confirmed that the purified S protein bound a commercial source of anti-SARS-CoV-2 antibodies specifically and bound anti-SARS-CoV-2 antibodies in COVID-19 positive serum. Then we demonstrated that our biosensor could detect anti-SARS-CoV-2 antibodies with 72% sensitivity in 2 h. Using GNP-protein G, the affinity biosensor had increased impedance changes with COVID-19positive serum and minimal or decreased impedance changes with negative serum. This demonstrated that our biosensor could discriminate between COVID-19 positive and negative sera, which were further improved using poly(vinyl alcohol)as a blocking agent.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 570
    Sprache Englisch
    Erscheinungsdatum 2022-07-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: A longitudinal seroepidemiology study to evaluate antibody response to SARS-CoV-2 virus infection and vaccination in children in Calgary, Canada from July 2020 to April 2022

    Emily J Doucette / Joslyn Gray / Kevin Fonseca / Carmen Charlton / Jamil N Kanji / Graham Tipples / Susan Kuhn / Jessica Dunn / Payton Sayers / Nicola Symonds / Guosong Wu / Stephen B Freedman / James D Kellner

    PLoS ONE, Vol 18, Iss 4, p e

    Alberta COVID-19 Childhood Cohort (AB3C) Study.

    2023  Band 0284046

    Abstract: Background Measurement of SARS-CoV-2 antibody seropositivity is important to accurately understand exposure to infection and/or vaccination in specific populations. This study aimed to estimate the serologic response to SARS-CoV-2 virus infection and ... ...

    Abstract Background Measurement of SARS-CoV-2 antibody seropositivity is important to accurately understand exposure to infection and/or vaccination in specific populations. This study aimed to estimate the serologic response to SARS-CoV-2 virus infection and vaccination in children in Calgary, Alberta over a two-year period. Methods Children with or without prior SARS-CoV-2 infections, were enrolled in Calgary, Canada in 2020. Venous blood was sampled 4 times from July 2020 to April 2022 for SARS-CoV-2 nucleocapsid and spike antibodies. Demographic and clinical information was obtained including SARS-CoV-2 testing results and vaccination records. Results 1035 children were enrolled and 88.9% completed all 4 visits; median age 9 years (IQR: 5,13); 519 (50.1%) female; and 815 (78.7%) Caucasian. Before enrolment, 118 (11.4%) had confirmed or probable SARS-CoV-2. By April 2022, 39.5% of previously uninfected participants had a SARS-CoV-2 infection. Nucleocapsid antibody seropositivity declined to 16.4% of all infected children after more than 200 days post diagnosis. Spike antibodies remained elevated in 93.6% of unvaccinated infected children after more than 200 days post diagnosis. By April 2022, 408 (95.6%) children 12 years and older had received 2 or more vaccine doses, and 241 (61.6%) 5 to 11 year-old children had received 2 vaccine doses. At that time, all 685 vaccinated children had spike antibodies, compared with 94/176 (53.4%) of unvaccinated children. Conclusions In our population, after the first peak of Omicron variant infections and introduction of COVID-19 vaccines for children, all vaccinated children, but just over one-half of unvaccinated children, had SARS-CoV-2 spike antibodies indicating infection and/or vaccination, highlighting the benefit of vaccination. It is not yet known whether a high proportion of seropositivity at the present time predicts sustained population-level protection against future SARS-CoV-2 transmission, infection or severe COVID-19 outcomes in children.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 360
    Sprache Englisch
    Erscheinungsdatum 2023-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: A longitudinal seroepidemiology study to evaluate antibody response to SARS-CoV-2 virus infection and vaccination in children in Calgary, Canada from July 2020 to April 2022

    Emily J. Doucette / Joslyn Gray / Kevin Fonseca / Carmen Charlton / Jamil N. Kanji / Graham Tipples / Susan Kuhn / Jessica Dunn / Payton Sayers / Nicola Symonds / Guosong Wu / Stephen B. Freedman / James D. Kellner

    PLoS ONE, Vol 18, Iss

    Alberta COVID-19 Childhood Cohort (AB3C) Study

    2023  Band 4

    Abstract: Background Measurement of SARS-CoV-2 antibody seropositivity is important to accurately understand exposure to infection and/or vaccination in specific populations. This study aimed to estimate the serologic response to SARS-CoV-2 virus infection and ... ...

    Abstract Background Measurement of SARS-CoV-2 antibody seropositivity is important to accurately understand exposure to infection and/or vaccination in specific populations. This study aimed to estimate the serologic response to SARS-CoV-2 virus infection and vaccination in children in Calgary, Alberta over a two-year period. Methods Children with or without prior SARS-CoV-2 infections, were enrolled in Calgary, Canada in 2020. Venous blood was sampled 4 times from July 2020 to April 2022 for SARS-CoV-2 nucleocapsid and spike antibodies. Demographic and clinical information was obtained including SARS-CoV-2 testing results and vaccination records. Results 1035 children were enrolled and 88.9% completed all 4 visits; median age 9 years (IQR: 5,13); 519 (50.1%) female; and 815 (78.7%) Caucasian. Before enrolment, 118 (11.4%) had confirmed or probable SARS-CoV-2. By April 2022, 39.5% of previously uninfected participants had a SARS-CoV-2 infection. Nucleocapsid antibody seropositivity declined to 16.4% of all infected children after more than 200 days post diagnosis. Spike antibodies remained elevated in 93.6% of unvaccinated infected children after more than 200 days post diagnosis. By April 2022, 408 (95.6%) children 12 years and older had received 2 or more vaccine doses, and 241 (61.6%) 5 to 11 year-old children had received 2 vaccine doses. At that time, all 685 vaccinated children had spike antibodies, compared with 94/176 (53.4%) of unvaccinated children. Conclusions In our population, after the first peak of Omicron variant infections and introduction of COVID-19 vaccines for children, all vaccinated children, but just over one-half of unvaccinated children, had SARS-CoV-2 spike antibodies indicating infection and/or vaccination, highlighting the benefit of vaccination. It is not yet known whether a high proportion of seropositivity at the present time predicts sustained population-level protection against future SARS-CoV-2 transmission, infection or severe COVID-19 outcomes in children.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 360
    Sprache Englisch
    Erscheinungsdatum 2023-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Tracking SARS-CoV-2 Omicron lineages using real-time reverse transcriptase PCR assays and prospective comparison with genome sequencing

    Nathan Zelyas / Kanti Pabbaraju / Matthew A. Croxen / Tarah Lynch / Emily McCullough / Stephanie A. Murphy / Sandy Shokoples / Anita Wong / Jamil N. Kanji / Graham Tipples

    Scientific Reports, Vol 13, Iss 1, Pp 1-

    2023  Band 9

    Abstract: Abstract Omicron has become the dominant SARS-CoV-2 variant globally since December 2021, with distinct waves being associated with separate Omicron sublineages. Rapid detection of BA.1, BA.2, BA.4, and BA.5 was accomplished in the province of Alberta, ... ...

    Abstract Abstract Omicron has become the dominant SARS-CoV-2 variant globally since December 2021, with distinct waves being associated with separate Omicron sublineages. Rapid detection of BA.1, BA.2, BA.4, and BA.5 was accomplished in the province of Alberta, Canada, through the design and implementation of real-time reverse transcriptase PCR assays targeting S:N501Y, S:ins214EPE, S:H69/V70, ORF7b:L11F, and M:D3N. Using the combination of results for each of these markers, samples could be designated as belonging to sublineages within BA.1, BA.2, BA.4, or BA.5. The analytical sensitivity of these markers ranged from 132 to 2229 copies/mL and in-laboratory accuracy was 98.9–100%. A 97.3% agreement using 12,592 specimens was demonstrated for the assays compared to genome sequencing. The use of these assays, combined with genome sequencing, facilitated the surveillance of SARS-CoV-2 lineages throughout a BA.5-dominated period.
    Schlagwörter Medicine ; R ; Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2023-10-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Characterization of Swine Influenza A(H1N2) Variant, Alberta, Canada, 2020

    Jamil N. Kanji / Kanti Pabbaraju / Matthew Croxen / Susan Detmer / Nathalie Bastien / Yan Li / Anna Majer / Hussein Keshwani / Nathan Zelyas / Ifeoma Achebe / Corinne Jones / Maureen Rutz / Angela Jacobs / Keith Lehman / Deena Hinshaw / Graham Tipples

    Emerging Infectious Diseases, Vol 27, Iss 12, Pp 3045-

    2021  Band 3051

    Abstract: Influenza strains circulating among swine populations can cause outbreaks in humans. In October 2020, we detected a variant influenza A subtype H1N2 of swine origin in a person in Alberta, Canada. We initiated a public health, veterinary, and laboratory ... ...

    Abstract Influenza strains circulating among swine populations can cause outbreaks in humans. In October 2020, we detected a variant influenza A subtype H1N2 of swine origin in a person in Alberta, Canada. We initiated a public health, veterinary, and laboratory investigation to identify the source of the infection and determine whether it had spread. We identified the probable source as a local pig farm where a household contact of the index patient worked. Phylogenetic analysis revealed that the isolate closely resembled strains found at that farm in 2017. Retrospective and prospective surveillance using molecular testing did not identify any secondary cases among 1,532 persons tested in the surrounding area. Quick collaboration between human and veterinary public health practitioners in this case enabled a rapid response to a potential outbreak.
    Schlagwörter influenza A ; swine ; variants ; H1N2 ; pandemic potential ; influenza ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
    Sprache Englisch
    Erscheinungsdatum 2021-12-01T00:00:00Z
    Verlag Centers for Disease Control and Prevention
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Early warning and rapid public health response to prevent COVID-19 outbreaks in long-term care facilities (LTCF) by monitoring SARS-CoV-2 RNA in LTCF site-specific sewage samples and assessment of antibodies response in this population

    John Kim / Carole A Estabrooks / Arto Ohinmaa / Carmen Charlton / Jamil N Kanji / Bonita E Lee / Christopher Sikora / Douglas Faulder / Eleanor Risling / Lorie A Little / Yuanyuan Qiu / Tiejun Gao / Ross Bulat / Stephen Craik / Steve E Hrudey / Anne-Claude Gingras / Heidi Wood / Alyssia Robinson / Nathan Zelyas /
    Sheila F O’Brien / Steven Drews / Xiao-Li Pang

    BMJ Open, Vol 11, Iss

    prospective study protocol

    2021  Band 8

    Abstract: Introduction The COVID-19 pandemic has an excessive impact on residents in long-term care facilities (LTCF), causing high morbidity and mortality. Early detection of presymptomatic and asymptomatic COVID-19 cases supports the timely implementation of ... ...

    Abstract Introduction The COVID-19 pandemic has an excessive impact on residents in long-term care facilities (LTCF), causing high morbidity and mortality. Early detection of presymptomatic and asymptomatic COVID-19 cases supports the timely implementation of effective outbreak control measures but repetitive screening of residents and staff incurs costs and discomfort. Administration of vaccines is key to controlling the pandemic but the robustness and longevity of the antibody response, correlation of neutralising antibodies with commercial antibody assays, and the efficacy of current vaccines for emerging COVID-19 variants require further study. We propose to monitor SARS-CoV-2 in site-specific sewage as an early warning system for COVID-19 in LTCF and to study the immune response of the staff and residents in LTCF to COVID-19 vaccines.Methods and analysis The study includes two parts: (1) detection and quantification of SARS-CoV-2 in LTCF site-specific sewage samples using a molecular assay followed by notification of Public Health within 24 hours as an early warning system for appropriate outbreak investigation and control measures and cost–benefit analyses of the system and (2) testing for SARS-CoV-2 antibodies among staff and residents in LTCF at various time points before and after COVID-19 vaccination using commercial assays and neutralising antibody testing performed at a reference laboratory.Ethics and dissemination Ethics approval was obtained from the University of Alberta Health Research Ethics Board with considerations to minimise risk and discomforts for the participants. Early recognition of a COVID-19 case in an LTCF might prevent further transmission in residents and staff. There was no direct benefit identified to the participants of the immunity study. Anticipated dissemination of information includes a summary report to the immunity study participants, sharing of study data with the scientific community through the Canadian COVID-19 Immunity Task Force, and prompt dissemination of study results in ...
    Schlagwörter Medicine ; R
    Thema/Rubrik (Code) 360
    Sprache Englisch
    Erscheinungsdatum 2021-08-01T00:00:00Z
    Verlag BMJ Publishing Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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