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  1. AU="Jamjoom, Maan"
  2. AU="Benjamin K. Harley"
  3. AU="Redpath, Stephanie"
  4. AU="Costa Oliveira, Diogo"
  5. AU="Ibarra-Meneses, Ana Victoria"
  6. AU=Ozgenel Guzin Yesim
  7. AU="Shu-Ying Li"
  8. AU="Umemura, Yutaka"
  9. AU=Eiring A M
  10. AU="Eunhee Ha"
  11. AU="Espíndola, Otávio M"
  12. AU=Shahbazian Heshmatollah
  13. AU="Esmaeel Panahi kokhdan"
  14. AU=Peekhaus N
  15. AU="Ferrari-Toniolo, Simone"
  16. AU="Oleg M. Mikhailenok"

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  1. Artikel: Vascular Involvement of Immunoglobulin G4-Related Disease: A Case Report.

    Jamjoom, Maan / Altirkistani, Bsaim A / Alghamdi, Yasir A / Alansari, Ammar Y

    Cureus

    2023  Band 15, Heft 4, Seite(n) e37893

    Abstract: Immunoglobulin-G4-related disease (IgG4-RD) is a fibro-inflammatory condition that can impact any organs/tissues, including the vascular systems, resulting in aortitis/periaortitis/periarteritis (PAO/PA). The complex nature of this disease and limited ... ...

    Abstract Immunoglobulin-G4-related disease (IgG4-RD) is a fibro-inflammatory condition that can impact any organs/tissues, including the vascular systems, resulting in aortitis/periaortitis/periarteritis (PAO/PA). The complex nature of this disease and limited understanding have led to potential delays in identifying and managing irreversible organ damage. Herein, we report a 17-year-old female with hyper IgG4 disease, sclerosing mesenteritis, short stature, and insulin resistance who presented with symptoms of fever, epigastric pain, left flank pain, vomiting, dizziness, decreased urine output, and diarrhea. Imaging studies revealed an arterial wall thickening of the ascending aorta and aortic arch, splenic abscesses, and enlarged lymph nodes, consistent with IgG4-related aortitis. Treatment with steroids and antifungal agents was initiated. However, the patient developed septic shock and multi-organ failure requiring inotropes and mechanical ventilation. Ascending aortic aneurysm rupture, in this case, probably led to the patient's demise, but unfortunately, no autopsy was done to confirm it. This case highlights the importance of identifying and addressing vascular involvement in IgG4-RD to prevent irreversible organ damage and mortality.
    Sprache Englisch
    Erscheinungsdatum 2023-04-20
    Erscheinungsland United States
    Dokumenttyp Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.37893
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Comparison of acetaminophen, ketamine, or ketorolac versus morphine in the treatment of acute renal colic: A network meta-analysis.

    Alghamdi, Yasir A / Morya, Roaa E / Bahathiq, Dena M / Bokhari, Abdullah F / Alaboud, Ahmad K / Abdulhamid, Ahmed S / Ghaddaf, Abdullah A / Jamjoom, Maan

    The American journal of emergency medicine

    2023  Band 73, Seite(n) 187–196

    Abstract: Background: Renal colic is a disease in which a calculus obstructs the urinary tract, resulting in severe pain do ureteric peristaltic movements. Other symptoms, such as hematuria, nausea, and vomiting, may accompany the pain. This network meta-analysis ...

    Abstract Background: Renal colic is a disease in which a calculus obstructs the urinary tract, resulting in severe pain do ureteric peristaltic movements. Other symptoms, such as hematuria, nausea, and vomiting, may accompany the pain. This network meta-analysis aimed to compare the efficacy and safety of different analgesic agents for the treatment of acute renal colic.
    Methods: Medline, Embase, and CENTRAL databases were searched. Randomized controlled trials (RCTs) that compared different analgesic agents, either alone or in combination were included. For the management of acute renal colic, analgesic agents were selected based on the current standard medical practice. The medications included intravenous acetaminophen, ketamine, ketorolac, and morphine. This study sought to evaluate the pain score on the visual analog scale (VAS) at 15, 30, and 60 min; adverse events; and the utilization of rescue therapy. The efficacy of different analgesic agents was explored through a frequentist network meta-analysis using the Netmeta statistical package in R software. All treatments were ranked using the Netrank function, yielding P-scores.
    Results: Twelve RCTs were deemed eligible. As per the P-scores, acetaminophen was the most effective in reducing pain score at 15 min (P-score = 0.74). Ketorolac was the most effective in reducing the pain score at 30 and 60 min (P-score = 0.84) (P-score = 0.99), whereas morphine was the least effective (P-score = 0.07). Moreover, morphine was correlated with the highest odds of adverse events after treatment (P-score = 0.89). Morphine was the most frequently required rescue therapy in cases of suboptimal pain relief (P-score = 0.96).
    Conclusion: This network meta-analysis demonstrated that ketorolac and acetaminophen were the most effective analgesic agents according to the pain score. Morphine showed the highest adverse event profile and the highest rate at which rescue therapy was required for the management of acute renal colic.
    Sprache Englisch
    Erscheinungsdatum 2023-08-19
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 605890-5
    ISSN 1532-8171 ; 0735-6757
    ISSN (online) 1532-8171
    ISSN 0735-6757
    DOI 10.1016/j.ajem.2023.08.029
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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