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  1. Article ; Online: Sustainability in Public Pension Funds? A Longitudinal Study of the Council on Ethics of the Swedish AP Funds

    Joel Boudin / Jan Olsson

    Sustainability, Vol 13, Iss 429, p

    2021  Volume 429

    Abstract: Are public pension funds taking sustainability values into serious consideration? This question is addressed by analyzing annual reports of The Council on Ethics in the Swedish public pension system, which has a clear mission from The Swedish Government ... ...

    Abstract Are public pension funds taking sustainability values into serious consideration? This question is addressed by analyzing annual reports of The Council on Ethics in the Swedish public pension system, which has a clear mission from The Swedish Government to consider sustainability values. The council was established in 2007 and supports four funds with advice. This article studies empirically how the council’s expression of words connected to different values has changed over time as well as how it practically reasons in situations of value conflicts. The quantitative data shows that words indicative of “sustainability values” have considerably increased. As a contrast, the critical discourse analysis shows that the council often reasons in a general, loose way about preferable solutions, while more practical claims for action are largely lacking or are vague in relation to sustainable development. The underlying rationale is very much in line with the discourse of economic rationalism. Thus, the quantitative findings suggest an emerging sustainability discourse, while the qualitative analysis clearly indicates that an economic rationale continues to underpin the council’s practical reasoning. However, it is concluded that this is not a simple case of green washing documents but rather a slow train moving towards green institutional change.
    Keywords sustainability ; public pension funds ; Council on Ethics ; critical discourse analysis ; economic rationalism ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Subject code 710
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: PILRA polymorphism modifies the effect of APOE4 and GM17 on Alzheimer’s disease risk

    Karin Lopatko Lindman / Caroline Jonsson / Bodil Weidung / Jan Olsson / Janardan P. Pandey / Dmitry Prokopenko / Rudolph E. Tanzi / Göran Hallmans / Sture Eriksson / Fredrik Elgh / Hugo Lövheim

    Scientific Reports, Vol 12, Iss 1, Pp 1-

    2022  Volume 8

    Abstract: Abstract PILRA (rs1859788 A > G) has been suggested to be a protective variant for Alzheimer’s disease (AD) and is an entry co-receptor for herpes simplex virus-1. We conducted a nested case–control study of 360 1:1-matched AD subjects. Interactions ... ...

    Abstract Abstract PILRA (rs1859788 A > G) has been suggested to be a protective variant for Alzheimer’s disease (AD) and is an entry co-receptor for herpes simplex virus-1. We conducted a nested case–control study of 360 1:1-matched AD subjects. Interactions between the PILRA-A allele, APOE risk variants (ε3/ε4 or ε4/ε4) and GM17 for AD risk were modelled. The associations were cross-validated using two independent whole-genome sequencing datasets. We found negative interactions between PILRA-A and GM17 (OR 0.72, 95% CI 0.52–1.00) and between PILRA-A and APOE risk variants (OR 0.56, 95% CI 0.32–0.98) in the discovery dataset. In the replication cohort, a joint effect of PILRA and PILRA × GM 17/17 was observed for the risk of developing AD (p .02). Here, we report a negative effect modification by PILRA on APOE and GM17 high-risk variants for future AD risk in two independent datasets. This highlights the complex genetics of AD.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: HSV presence in brains of individuals without dementia

    Jan Olsson / Hugo Lövheim / Emma Honkala / Pekka J. Karhunen / Fredrik Elgh / Eloise H. Kok

    Disease Models & Mechanisms, Vol 9, Iss 11, Pp 1349-

    the TASTY brain series

    2016  Volume 1355

    Abstract: Herpes simplex virus (HSV) type 1 affects a majority of the population and recent evidence suggests involvement in Alzheimer's disease aetiology. We investigated the prevalence of HSV type 1 and 2 in the Tampere Autopsy Study (TASTY) brain samples using ... ...

    Abstract Herpes simplex virus (HSV) type 1 affects a majority of the population and recent evidence suggests involvement in Alzheimer's disease aetiology. We investigated the prevalence of HSV type 1 and 2 in the Tampere Autopsy Study (TASTY) brain samples using PCR and sero-positivity in plasma, and associations with Alzheimer's disease neuropathology. HSV was shown to be present in human brain tissue in 11/584 (1.9%) of samples in the TASTY cohort, of which six had Alzheimer's disease neuropathological amyloid beta (Aβ) aggregations. Additionally, serological data revealed 86% of serum samples tested were IgG-positive for HSV. In conclusion, we report epidemiological evidence of the presence of HSV in brain tissue free from encephalitis symptoms in a cohort most closely representing the general population (a minimum prevalence of 1.9%). Whereas 6/11 samples with HSV DNA in the brain tissue had Aβ aggregations, most of those with Aβ aggregations did not have HSV present in the brain tissue.
    Keywords Herpes simplex virus ; Amyloid beta aggregations ; Alzheimer's disease ; PCR detection ; Human brain tissue ; Paraffin-embedded samples ; Medicine ; R ; Pathology ; RB1-214
    Language English
    Publishing date 2016-11-01T00:00:00Z
    Publisher The Company of Biologists
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Correction

    Jan Olsson / Johanna Bergh Drott / Lovisa Laurantzon / Oscar Laurantzon / Anders Bergh / Fredrik Elgh

    PLoS ONE, Vol 8, Iss

    Chronic Prostatic Infection and Inflammation by Propionibacterium acnes in a Rat Prostate Infection Model

    2013  Volume 7

    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2013-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Correction

    Jan Olsson / Johanna Bergh Drott / Lovisa Laurantzon / Oscar Laurantzon / Anders Bergh / Fredrik Elgh

    PLoS ONE, Vol 8, Iss

    Chronic Prostatic Infection and Inflammation by in a Rat Prostate Infection Model.

    2013  Volume 7

    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2013-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Conditions for Transformative Learning for Sustainable Development

    Magnus Boström / Erik Andersson / Monika Berg / Karin Gustafsson / Eva Gustavsson / Erik Hysing / Rolf Lidskog / Erik Löfmarck / Maria Ojala / Jan Olsson / Benedict E. Singleton / Sebastian Svenberg / Ylva Uggla / Johan Öhman

    Sustainability, Vol 10, Iss 12, p

    A Theoretical Review and Approach

    2018  Volume 4479

    Abstract: Continued unsustainability and surpassed planetary boundaries require not only scientific and technological advances, but deep and enduring social and cultural changes. The purpose of this article is to contribute a theoretical approach to understand ... ...

    Abstract Continued unsustainability and surpassed planetary boundaries require not only scientific and technological advances, but deep and enduring social and cultural changes. The purpose of this article is to contribute a theoretical approach to understand conditions and constraints for societal change towards sustainable development. In order to break with unsustainable norms, habits, practices, and structures, there is a need for learning for transformation, not only adaption. Based on a critical literature review within the field of learning for sustainable development, our approach is a development of the concept of transformative learning, by integrating three additional dimensions—Institutional Structures, Social Practices, and Conflict Perspectives. This approach acknowledges conflicts on macro, meso, and micro levels, as well as structural and cultural constraints. It contends that transformative learning is processual, interactional, long-term, and cumbersome. It takes place within existing institutions and social practices, while also transcending them. The article adopts an interdisciplinary social science perspective that acknowledges the importance of transformative learning in order for communities, organizations, and individuals to be able to deal with global sustainability problems, acknowledging the societal and personal conflicts involved in such transformation.
    Keywords conflict ; institutional ; learning ; social change ; social practice ; structure ; transformative ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Subject code 300
    Language English
    Publishing date 2018-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Chronic prostatic infection and inflammation by Propionibacterium acnes in a rat prostate infection model.

    Jan Olsson / Johanna Bergh Drott / Lovisa Laurantzon / Oscar Laurantzon / Anders Bergh / Fredrik Elgh

    PLoS ONE, Vol 7, Iss 12, p e

    2012  Volume 51434

    Abstract: Chronic inflammation in the prostate, seen as infiltration of inflammatory cells into the prostate gland in histological samples, affects approximately half the male population without indication of prostate disease, and is almost ubiquitous in patients ... ...

    Abstract Chronic inflammation in the prostate, seen as infiltration of inflammatory cells into the prostate gland in histological samples, affects approximately half the male population without indication of prostate disease, and is almost ubiquitous in patients diagnosed with benign prostate hyperplasia and cancer. Several studies have demonstrated the gram-positive bacterium Propionibacterium acnes to be frequently present in prostate tissue from men suffering from prostate disease. P. acnes has been shown to be associated with histological inflammation in human prostatectomy specimens, and also to induce strong inflammatory response in prostate-derived tissue culture models. The present paper describes a rat model for assessment of the pathogenic potential of P. acnes in prostate. Prostate glands of Sprague Dawley rats (n = 98) were exposed via an abdominal incision and live P. acnes or, in control rats, saline were injected into the ventral and dorso-lateral lobes. Rats were sacrificed 5 days, 3 weeks, 3 months and 6 months post infection, and prostate tissue was analyzed for bacterial content and histological inflammation. Rat sera were assessed for levels of CRP and anti-P. acnes IgG. Live P. acnes could be recovered from the dorso-lateral lobes up to 3 months post infection, while the ventral lobes were cleared from bacteria at that time. In samples up to 3 months post infection, the dorso-lateral lobes exhibited intense focal inflammation. CRP and IgG levels were elevated throughout the span of the experiment, and reached maximum levels 3 weeks and 3 months post infection, respectively. We show that P. acnes have the potential to cause chronic infection in previously healthy prostate, and that the infection has potential to cause chronic histological inflammation in the infected tissue. The high prevalence of P. acnes in human prostate tissue calls for resolution of pathogenic details. The present rat model suggests that complications such as chronic inflammation may be induced by P. acnes infection.
    Keywords Medicine ; R ; Science ; Q
    Subject code 570
    Language English
    Publishing date 2012-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Amyloid formation by the pro-inflammatory S100A8/A9 proteins in the ageing prostate.

    Kiran Yanamandra / Oleg Alexeyev / Vladimir Zamotin / Vaibhav Srivastava / Andrei Shchukarev / Ann-Christin Brorsson / Gian Gaetano Tartaglia / Thomas Vogl / Rakez Kayed / Gunnar Wingsle / Jan Olsson / Christopher M Dobson / Anders Bergh / Fredrik Elgh / Ludmilla A Morozova-Roche

    PLoS ONE, Vol 4, Iss 5, p e

    2009  Volume 5562

    Abstract: BACKGROUND:The conversion of soluble peptides and proteins into polymeric amyloid structures is a hallmark of many age-related degenerative disorders, including Alzheimer's disease, type II diabetes and a variety of systemic amyloidoses. We report here ... ...

    Abstract BACKGROUND:The conversion of soluble peptides and proteins into polymeric amyloid structures is a hallmark of many age-related degenerative disorders, including Alzheimer's disease, type II diabetes and a variety of systemic amyloidoses. We report here that amyloid formation is linked to another major age-related phenomenon--prostate tissue remodelling in middle-aged and elderly men. METHODOLOGY/PRINCIPAL FINDINGS:By using multidisciplinary analysis of corpora amylacea inclusions in prostate glands of patients diagnosed with prostate cancer we have revealed that their major components are the amyloid forms of S100A8 and S100A9 proteins associated with numerous inflammatory conditions and types of cancer. In prostate protease rich environment the amyloids are stabilized by dystrophic calcification and lateral thickening. We have demonstrated that material closely resembling CA can be produced from S100A8/A9 in vitro under native and acidic conditions and shows the characters of amyloids. This process is facilitated by calcium or zinc, both of which are abundant in ex vivo inclusions. These observations were supported by computational analysis of the S100A8/A9 calcium-dependent aggregation propensity profiles. We found DNA and proteins from Escherichia coli in CA bodies, suggesting that their formation is likely to be associated with bacterial infection. CA inclusions were also accompanied by the activation of macrophages and by an increase in the concentration of S100A8/A9 in the surrounding tissues, indicating inflammatory reactions. CONCLUSIONS/SIGNIFICANCE:These findings, taken together, suggest a link between bacterial infection, inflammation and amyloid deposition of pro-inflammatory proteins S100A8/A9 in the prostate gland, such that a self-perpetuating cycle can be triggered and may increase the risk of malignancy in the ageing prostate. The results provide strong support for the prediction that the generic ability of polypeptide chains to convert into amyloids could lead to their involvement in an ...
    Keywords Medicine ; R ; Science ; Q
    Subject code 570
    Language English
    Publishing date 2009-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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