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  1. Article ; Online: Comparison of Risk Factors During First and Second Wave of COVID-19 in Patients with Autoimmune Rheumatic Diseases (AIRD): Results from KRACC Subset.

    Jain, Vikramraj / Shobha, Vineeta / Kumar, Sharath / Janardana, Ramya / Selvam, Sumithra

    Mediterranean journal of rheumatology

    2023  Volume 34, Issue 3, Page(s) 342–348

    Abstract: Background: The differential influence and outcome of various risk factors on occurrence of COVID-19 among patients with autoimmune rheumatic diseases (AIRD) during different COVID-19 peaks is underreported.: Aim: To assess the impact and outcome of ... ...

    Abstract Background: The differential influence and outcome of various risk factors on occurrence of COVID-19 among patients with autoimmune rheumatic diseases (AIRD) during different COVID-19 peaks is underreported.
    Aim: To assess the impact and outcome of conventional risk factors, immunosuppressants, and comorbidities on the risk of COVID-19 among AIRD patients during the first two COVID-19 peaks.
    Design: Prospective, non-interventional longitudinal cohort study.
    Methods: This is a subset of the KRA COVID19 cohort undertaken during the initial wave of COVID-19 (W1) (Apr-Dec2021); and the 2nd-wave (W2) (Jan-Aug2021). Data collected included description of AIRD subsets, treatment characteristics, comorbidities, and COVID-19 occurrence. Risk factors associated with mortality were analysed. The incidence rate was compared with that of the general population in the same geographic region.
    Results: AIRD patients (n=2969) had a higher incidence of COVID-19 in the W2 (7.1%) than in the W1 (1.7%) as compared to the general population (Government bulletin). Age (p<0.01) and duration of AIRD (p<0.001) influenced COVID-19 occurrence in W2 while major disease subsets and immunosuppressants including glucocorticoids did not. The W2 had lower HCQ usage (Adjusted Odds Ratio [AOR]-0.81) and comorbidities like hypertension (AOR -0.54) and pre-existing lung disease (AOR -0.38;0.19-0.75) compared to W1. Older age (1.11) and coexistent diabetes mellitus (AOR 6.74) were independent risk factors associated with mortality in W2.
    Conclusions: We report 1.7 times higher occurrence, and no influence of major disease subsets or immunosuppressants including glucocorticoids on COVID-19. Age and diabetes were independent risk factors for mortality.
    Language English
    Publishing date 2023-08-27
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 3019943-8
    ISSN 2529-198X ; 2459-3516
    ISSN (online) 2529-198X
    ISSN 2459-3516
    DOI 10.31138/mjr.20230827.co
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: 'Outside the box' genes, transcriptions and translations in Rheumatoid arthritis.

    Janardana, Ramya / Danda, Debashish

    International journal of rheumatic diseases

    2016  Volume 19, Issue 2, Page(s) 114–115

    MeSH term(s) Arthritis, Rheumatoid/genetics ; Humans ; Protein Biosynthesis
    Language English
    Publishing date 2016-02
    Publishing country England
    Document type Editorial
    ZDB-ID 2426924-4
    ISSN 1756-185X ; 1756-1841
    ISSN (online) 1756-185X
    ISSN 1756-1841
    DOI 10.1111/1756-185X.12846
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Low-dose rituximab is efficacious in refractory idiopathic inflammatory myopathies.

    Janardana, Ramya / Amin, S N / Rajasekhar, Liza / Pinto, Benzeeta / Kodishala, Chanakya / Selvam, Sumithra / Shobha, Vineeta

    Rheumatology (Oxford, England)

    2022  Volume 62, Issue 3, Page(s) 1243–1247

    Abstract: Objectives: Rituximab (RTX) use early in the course of refractory idiopathic inflammatory myopathy (IIM) is not well studied. This study sought to determine the short-term efficacy of RTX in a registry-based cohort of refractory IIM.: Methods: ... ...

    Abstract Objectives: Rituximab (RTX) use early in the course of refractory idiopathic inflammatory myopathy (IIM) is not well studied. This study sought to determine the short-term efficacy of RTX in a registry-based cohort of refractory IIM.
    Methods: Registry-based observational data about IIM patients receiving RTX between 2018 and 2021 were included. Total improvement score was calculated from the core set measures as per International Myositis Assessment and Clinical Studies group (IMACS) at baseline, 6 months and 12 months of follow-up.
    Results: Forty-two patients (F:M, 29:13), with a mean (s.d.) age of 39.5 (11.5) years were studied. Majority of patients received RTX for refractory myositis, after a median (interquartile range) duration of 8 (4,18) months. Twenty-eight received RTX at a dosage of 1 g × two doses, while 14 received 500 mg × two doses with an interval of 15 days. At 6 months and 12 months post-RTX, the improvement was recorded in manual muscle testing (MMT-8) scores, physician global assessment (PGA), patient global assessment (PtGA) and median steroid dosage as compared with the baseline (P < 0.01 for all). A mean (s.d.) improvement of 44.5 (16) and 48.7 (19.2) in total improvement score was recorded at 6 and 12 months, respectively. The change in MMT-8, PGA and PtGA scores from baseline between the two dosage regimens of RTX were comparable at 6 and 12 months. Severe lower respiratory tract infections requiring hospitalization occurred in three patients of the cohort.
    Conclusion: RTX improved IMACS core set measures and had steroid sparing efficacy at 6 and 12 months in patients with IIM in this registry-based study. Rituximab as an induction regimen of two doses of 500 mg can be as efficacious as 1 g at 6 months and 12 months of follow-up.
    MeSH term(s) Humans ; Adult ; Rituximab ; Treatment Outcome ; Myositis ; Retrospective Studies
    Chemical Substances Rituximab (4F4X42SYQ6)
    Language English
    Publishing date 2022-08-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/keac438
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Exploratory clinical subgroup clustering in systemic sclerosis: Results from the Indian Progressive Systemic Sclerosis Registry.

    Philip, Shery Susan / Janardana, Ramya / Shenoy, Padmanabha / Kavadichanda, Chengappa / Bairwa, Devender / Sircar, Geetabali / Ghosh, Parasar / Wakhlu, Anupam / Selvam, Sumithra / Khanna, Dinesh / Shobha, Vineeta

    Journal of scleroderma and related disorders

    2023  Volume 9, Issue 1, Page(s) 29–37

    Abstract: Objective: To conduct an exploratory cluster analysis of systemic sclerosis patients from the baseline data of the Indian systemic sclerosis registry.: Methods: Patients satisfying American College of Rheumatology-European League Against Rheumatism ... ...

    Abstract Objective: To conduct an exploratory cluster analysis of systemic sclerosis patients from the baseline data of the Indian systemic sclerosis registry.
    Methods: Patients satisfying American College of Rheumatology-European League Against Rheumatism classification criteria for systemic sclerosis were included. The clusters formed using clinical and immunological parameters were compared.
    Results: Of the 564 systemic sclerosis registry participants, 404 patients were included. We derived four clusters of which three were anti-topoisomerase I predominant and one was anti-centromere antibody 2 dominant.
    Conclusion: With exploratory cluster analysis, we confirmed the possibility of subclassification of systemic sclerosis along a spectrum based on clinical and immunological characteristics. We also corroborated the presence of anti-topoisomerase I in limited cutaneous systemic sclerosis and the association of interstitial lung disease with anti-topoisomerase I.
    Language English
    Publishing date 2023-12-14
    Publishing country England
    Document type Journal Article
    ISSN 2397-1991
    ISSN (online) 2397-1991
    DOI 10.1177/23971983231215470
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Occurrence and outcome of COVID-19 in AIRD patients on concomitant treatment with Tofacitinib- results from KRA COVID COHORT (KRACC) subset.

    Chebbi, Pramod / Shobha, Vineeta / Rao, Vijay K / Haridas, Vikram / Janardana, Ramya / Pinto, Benzeeta / Kumar, Sharath / Patil, Abhishek / Tekkatte, Roopa / Salanke, Manasa / Mahendranath, K M

    BMC rheumatology

    2023  Volume 7, Issue 1, Page(s) 22

    Abstract: Introduction: We assessed the risk factors and outcome of COVID-19 in patients with autoimmune rheumatic diseases(AIRD) who contracted infection while on background treatment with tofacitinib.: Methods: This is a non-interventional, cross-sectional, ... ...

    Abstract Introduction: We assessed the risk factors and outcome of COVID-19 in patients with autoimmune rheumatic diseases(AIRD) who contracted infection while on background treatment with tofacitinib.
    Methods: This is a non-interventional, cross-sectional, questionnaire based telephonic study which included consecutive AIRD patients on tofacitinib co-treatment. Data related to the AIRD subset, disease modifying anti rheumatic drugs(DMARDs) including glucocorticoids and comorbidities, was collected from 7 rheumatology centers across Karnataka during the second wave of COVID-19 pandemic. The information about COVID-19 occurrence and COVID-19 vaccination was recorded.
    Results: During the study period (Jun-July 2021), 335 AIRD patients (80.6% female) on treatment with tofacitinib were included. The mean duration of tofacitinib use was 3.4+/-3.1months. Thirty-six(10.75%) patients developed COVID-19. Diabetes mellitus (p = 0.04 (OR 2.60 (1.13-5.99)) was identified as a risk factor for COVID-19 in our cohort. Almost half of our cohort was COVID-19 vaccinated with at least one dose, with resultant decline in incidence of COVID-19(OR 0.15 (0.06-0.39) among the vaccinated. Recovery amongst COVID-19 infection group was 91.2%.
    Conclusions: The subset of AIRD patients who were on treatment with tofacitinib were found to have a higher rate of COVID-19 infection as compared to our KRACC cohort. Pre-existing comorbidity of diabetes mellitus was the significant risk factor in our cohort. This subset of the KRACC cohort shows RA patients had a lesser infection and PsA patients had a higher infection.
    Language English
    Publishing date 2023-07-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2918121-5
    ISSN 2520-1026 ; 2520-1026
    ISSN (online) 2520-1026
    ISSN 2520-1026
    DOI 10.1186/s41927-023-00345-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Long Term Outcomes in Idiopathic Inflammatory Myositis: An Observational Epidemiologic Study over 15 Years.

    Janardana, Ramya / Kn, Sangeetha / Bhat, Vasudha / Balakrishnan, Divya / Raj, John Michael / Pinto, Benzeeta / K, Chanakya / Nadig, Raghunandan / Mahadevan, Anita / Shobha, Vineeta

    Mediterranean journal of rheumatology

    2023  Volume 34, Issue 4, Page(s) 513–524

    Abstract: Background: We report a longitudinal observational cohort of idiopathic inflammatory myositis (IIM) focusing on the long-term clinical outcome and associated parameters.: Methods: IIM patients were classified as per Bohan and Peter criteria. In those ...

    Abstract Background: We report a longitudinal observational cohort of idiopathic inflammatory myositis (IIM) focusing on the long-term clinical outcome and associated parameters.
    Methods: IIM patients were classified as per Bohan and Peter criteria. In those with ≥ 24 months of follow-up; the treatment response, functional outcomes, and damage at last follow-up were recorded. Complete clinical response and clinical remission as defined by Oddis et al., was used to define outcomes at last follow-up.
    Results: The cohort consists of 175 patients, mean age 40.9 (+12.6) years, M:F 1:3.3; and the major subsets were dermatomyositis (44.6%), overlap myositis (25.7%), antisynthetase syndrome (6.3%), polymyositis (14.3%), and juvenile DM/OM (8.6%). Ninety-four patients have followed up for 24 months or more, with the median (IQR) of 65(35,100.7) months. Of them, 74.1% and 11.8% had complete and partial clinical responses respectively at the last follow-up. In our cohort 40.2% were off-steroids and 13.8% were in clinical remission at the last follow-up. Complete clinical response was associated with better functional outcomes and lesser damage as determined by HAQ-DI of 0[OR10.9; 95%CI (3.3,160)], MRS [OR 3.2; 95%CI (1.4,7.3)] and lesser MDI [OR 1.7; 95% CI (1.1,2.7)] respectively as compared to partial response (unadjusted analysis). Baseline parameters and IIM subsets did not significantly influence the functional outcome and damage. The mortality rate in our cohort is 24/175 (13.7%), the disease-specific mortality rate being 9.1%. Large majority of deaths were early, associated with active disease.
    Conclusion: We report good long-term outcomes in all major myositis subsets. Partial clinical response to treatment is associated with worse functional outcomes and damage accrual. Death occurs early in association with active disease.
    Language English
    Publishing date 2023-08-28
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 3019943-8
    ISSN 2529-198X ; 2459-3516
    ISSN (online) 2529-198X
    ISSN 2459-3516
    DOI 10.31138/mjr.280823.lto
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Determinants of diagnosis and disease course in primary Sjögren's syndrome: Results from datamining of electronic health records.

    Sandhya, Pulukool / Janardana, Ramya / Sudarsanam, Thambu / Mahasampath, Gowri / Prakash, John Antony Jude / Danda, Debashish

    International journal of rheumatic diseases

    2019  Volume 22, Issue 9, Page(s) 1768–1774

    Abstract: Background: Determinants of diagnosis in primary Sjögren's syndrome (pSS) in tertiary care settings is not well understood.: Methods: Patients were screened by tracing reports of anti-SSA (anti-Ro) antibody assays between January 2008 and October ... ...

    Abstract Background: Determinants of diagnosis in primary Sjögren's syndrome (pSS) in tertiary care settings is not well understood.
    Methods: Patients were screened by tracing reports of anti-SSA (anti-Ro) antibody assays between January 2008 and October 2015. Electronic health records (EHR) were reviewed. Patients fulfilling the 2016 American College of Rheumatology/European League Against Rheumatism (EULAR) classification criteria were included. Variables including the specialties of first consultation, initial clinical presentations, investigations ordered at first consultation, number of hospital visits prior to reaching the final diagnosis of pSS and the baseline EULAR SS Disease Activity Index (ESSDAI) were noted.
    Results: A total of 275 patients with pSS consulted 24 different specialties at first visit. Rheumatology accounted for 128 (46.55%) patients. At first consultation, initial suspicion for pSS was 48.4% for all specialties together and 64.84% for the rheumatologist. Median number of visits prior to arriving at the final diagnosis was 1 (1-6), when the initial impression was pSS and 3 (1-14), if the initial clinical impression was a non-SS differential (P < 0.001). A first impression of pSS, enquiry about sicca symptoms and ordering anti-SSA (anti-Ro) antibody test at first consultation were strong predictors of early diagnosis with odds (95% CI) of 5.01 (1.72-14.55) P < 0.001, 4.79 (1.16-19.84) P = 0.03 and 9.60 (3.0-30.67) P < 0.0001, respectively. None of the clinical variables proved to be useful predictors of early diagnosis.
    Conclusions: Diagnosis of pSS is challenging even in tertiary care centers as patients present with myriad features to several specialties. Initial suspicion was limited to 48.4% for all specialties together and 64.84% for the rheumatologist. High suspicion of pSS along with ordering anti-SSA (anti-Ro) antibody could hasten diagnosis.
    MeSH term(s) Adult ; Antibodies, Antinuclear/blood ; Biomarkers/blood ; Data Mining ; Early Diagnosis ; Electronic Health Records ; Female ; Humans ; Immunologic Tests ; Male ; Middle Aged ; Predictive Value of Tests ; Reproducibility of Results ; Retrospective Studies ; Sjogren's Syndrome/blood ; Sjogren's Syndrome/diagnosis ; Sjogren's Syndrome/immunology ; Tertiary Care Centers
    Chemical Substances Antibodies, Antinuclear ; Biomarkers ; SS-A antibodies
    Language English
    Publishing date 2019-07-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2426924-4
    ISSN 1756-185X ; 1756-1841
    ISSN (online) 1756-185X
    ISSN 1756-1841
    DOI 10.1111/1756-185X.13641
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Unique clinical and autoantibody profile of a large Asian Indian cohort of scleroderma-do South Asians have a more aggressive disease?

    Janardana, Ramya / Nair, Aswin M / Surin, Ajit K / Prakash, John Anthony Jude / Gowri, Mahasampath / Danda, Debashish

    Clinical rheumatology

    2019  Volume 38, Issue 11, Page(s) 3179–3187

    Abstract: Aim and methods: A single-centre retrospective study was conducted using electronic medical records (EMR) of inpatients and outpatients with the diagnosis of "scleroderma" or "systemic sclerosis" visiting our clinic over the preceding 5 years.: ... ...

    Abstract Aim and methods: A single-centre retrospective study was conducted using electronic medical records (EMR) of inpatients and outpatients with the diagnosis of "scleroderma" or "systemic sclerosis" visiting our clinic over the preceding 5 years.
    Results: A total of 327 patients' charts met our selection criteria; 301 were females. The median (IQR (inter quartile range)) age at onset of first non-Raynaud's symptom was 34.67 (27-43) years and median (IQR) disease duration prior to presentation to our department was 2.5 (1-5) years. Of these, 310 (94.8%) belonged to diffuse systemic sclerosis variety, 13 (4%) had limited systemic sclerosis, and 4 (1.2%) were of sine scleroderma type. A total of 289/302 (95.7%) patients were positive for ANA; of them, 245/327 (74.9%) were Scl-70 antibody-positive and 4% were CENP antibody-positive. Interstitial lung disease (ILD) was present in 288/327 (88.1%) patients. Among patients with available baseline forced vital capacity (FVC) data, 20% had a normal lung function and 28.4% had severe restriction. Pulmonary hypertension as assessed by echocardiography was present in 8.1% of patients. A significant association of Scl-70 antibody positivity with the presence of interstitial lung disease (ILD) (p = 0.000) and pulmonary hypertension (p = 0.035) was seen. On the other hand, presence of CENP antibody showed a protective trend against muscle weakness and/or muscle enzyme elevation (p = 0.052). Presence of arthritis was protective against development of digital ulceration (p = 0.021) and PAH (0.004). Patients younger than 40 years of age had significantly higher frequency of Scl-70 positivity (p = 0.038), whereas CENP antibody positivity was more likely in those aged > 40 years (p = 0.002).
    Conclusion: Younger age of onset and high prevalence of Scl-70 antibody are unique South Asian features common with large Indian, Thai, and Chinese series. High prevalence of ILD is a feature common to Indian and Chinese series. Strong correlation of Scl-70 antibody with younger age and pulmonary hypertension were unique features of our cohort.
    Key points: • Asian Indian scleroderma patients are younger by 2 decades compared to Caucasian series. • Higher prevalence of Scl-70 antibody, its association with young age, interstitial lung disease and pulmonary hypertension are features of our cohort. • High prevalence of interstitial lung disease (88.1%) was noted

    among those with baseline spirometry data (141/327), two thirds(66%) had moderate to severe restriction. • Younger age at onset, higher prevalence of Scl-70 antibody are features common to other Indian, Thai and Chinese series.
    MeSH term(s) Adult ; Autoantibodies ; Female ; Humans ; India/epidemiology ; Lung Diseases, Interstitial/diagnostic imaging ; Lung Diseases, Interstitial/epidemiology ; Lung Diseases, Interstitial/etiology ; Male ; Middle Aged ; Respiratory Function Tests ; Retrospective Studies ; Scleroderma, Systemic/complications ; Scleroderma, Systemic/epidemiology ; Scleroderma, Systemic/immunology ; Scleroderma, Systemic/therapy ; Tomography, X-Ray Computed ; Vascular Diseases/epidemiology ; Vascular Diseases/etiology ; Young Adult
    Chemical Substances Autoantibodies
    Language English
    Publishing date 2019-07-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 604755-5
    ISSN 1434-9949 ; 0770-3198
    ISSN (online) 1434-9949
    ISSN 0770-3198
    DOI 10.1007/s10067-019-04659-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Neuropsychiatric manifestations are associated with increased mortality in Indian patients with lupus: A single centre retrospective observational study.

    Pinto, Benzeeta / Suresh, Sumatha C / Ramyasri, Kodali / Narayan, Girish / Susan, Deepa / Manuel, Sandra / Wodeyar, Aishwarya / Shivanna, Archana / Janardana, Ramya / Chanakya, Kodishala / Charles, B Sheba / Nanjundaswamy, Sangeetha K / Desai, Anu M / Nadig, Raghunandan / Shobha, Vineeta

    Lupus

    2022  Volume 31, Issue 13, Page(s) 1563–1571

    Abstract: Objective: To study the prevalence of different NPSLE manifestations in our cohort and to compare clinical and immunological features and outcomes including mortality of patients with NPSLE and SLE controls without NP involvement.: Methods: This was ... ...

    Abstract Objective: To study the prevalence of different NPSLE manifestations in our cohort and to compare clinical and immunological features and outcomes including mortality of patients with NPSLE and SLE controls without NP involvement.
    Methods: This was a retrospective study in a tertiary care referral centre. All patients of SLE seen in the last 10 years and fulfilling the SLICC criteria with neuropsychiatric manifestations as per the ACR definitions were included. Patients of SLE without NP involvement were sequentially assigned as controls in a ratio of 1:2.
    Results: Of the 769 patients diagnosed with SLE from Jan 2011 to December 2020, 128 (16.6%) had NPSLE manifestations as per the ACR definitions. The commonest NPSLE manifestation was seizures (6.5%) followed by cerebrovascular accident (3.9%). NPSLE manifestation occurred at the first presentation of SLE in 99/128 (77.3%) patients and 58 (45.3%) patients had more than one NPSLE manifestation. Lupus anticoagulant and anticardiolipin antibody were tested in 120 patients and were positive in 16 (13.3%) and 12 (10%), respectively. No difference was found in anti-ribosomal
    Conclusions: Seizures and cerebrovascular accidents are the commonest NPSLE syndromes in our patients. The presence of NPSLE was associated with high mortality in Indian patients with lupus.
    MeSH term(s) Humans ; Retrospective Studies ; Lupus Vasculitis, Central Nervous System/diagnosis ; Lupus Coagulation Inhibitor ; Lupus Erythematosus, Systemic/complications ; Antibodies, Anticardiolipin ; Antiphospholipid Syndrome/complications ; Seizures/epidemiology ; Stroke
    Chemical Substances Lupus Coagulation Inhibitor ; Antibodies, Anticardiolipin
    Language English
    Publishing date 2022-09-22
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 1154407-7
    ISSN 1477-0962 ; 0961-2033
    ISSN (online) 1477-0962
    ISSN 0961-2033
    DOI 10.1177/09612033221127898
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Comparison of the 2017 EULAR/ACR criteria with Bohan and Peter criteria for the classification of idiopathic inflammatory myopathies.

    Pinto, Benzeeta / Janardana, Ramya / Nadig, Raghunanadan / Mahadevan, Anita / Bhatt, Anusha S / Raj, John Michael / Shobha, Vineeta

    Clinical rheumatology

    2019  Volume 38, Issue 7, Page(s) 1931–1934

    Abstract: Bohan and Peter is the oldest criteria for the classification of idiopathic inflammatory myopathies (IIM). Recently, 2017 EULAR/ACR criteria were introduced which were validated against a control group. The objective of this study was to assess the ... ...

    Abstract Bohan and Peter is the oldest criteria for the classification of idiopathic inflammatory myopathies (IIM). Recently, 2017 EULAR/ACR criteria were introduced which were validated against a control group. The objective of this study was to assess the performance of the 2017 EULAR/ACR criteria in retrospective cohort of adult and juvenile idiopathic inflammatory myopathies and compare with Bohan and Peter criteria. This was a retrospective study of patients clinically diagnosed to have IIM in a tertiary care center in the last 10 years. Only patients with a minimum follow-up of 6 months and response to steroids and immunosuppression were included in the study. Performance of both the criteria in the cohort was assessed and compared with clinical diagnosis. Hundred and eleven patients (87 females) were included in the study. Eleven patients had juvenile onset. Ninety-three patients (83.8%) were classified as probable/definite myositis using the Bohan and Peter criteria. Eighty-nine (80.2%) patients were classified as having probable/definite inflammatory myositis using the new criteria. Agreement between the two criteria was weak in our cohort (κ-0.331). Complete details of muscle biopsy were available in 52 patients. In this subgroup, 96% were classified by Bohan and Peter and 80.8% by EULAR/ACR criteria. Bohan and Peter classified 73% and EULAR/ACR 82% of patients when biopsy was excluded (n = 111). Both criteria classified over 90% of the patients with dermatomyositis. Forty-two patients were clinically diagnosed as polymyositis, of these 32 patients had myositis overlap syndrome. Bohan and Peter classified 66.7% and EULAR/ACR classified 64.3% in this subset. Bohan and Peter criteria had high sensitivity in the presence of muscle biopsy compared with EULAR/ACR. The performance of the EULAR/ACR criteria was similar to Bohan and Peter in the absence of muscle biopsy. Both criteria had poor sensitivity in polymyositis.
    MeSH term(s) Adult ; Female ; Humans ; Male ; Myositis/classification ; Myositis/diagnosis ; Retrospective Studies
    Language English
    Publishing date 2019-03-22
    Publishing country Germany
    Document type Comparative Study ; Journal Article
    ZDB-ID 604755-5
    ISSN 1434-9949 ; 0770-3198
    ISSN (online) 1434-9949
    ISSN 0770-3198
    DOI 10.1007/s10067-019-04512-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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