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  1. AU="Jane Ru Choi"
  2. AU="Nepal, Gaurav"
  3. AU=Pietrobelli Angelo AU=Pietrobelli Angelo
  4. AU="Lopeztello-Santillan, Adriana L"
  5. AU="Iaquinta, Angela"
  6. AU="Layne, Diana M"
  7. AU=Nadesalingam Ajantha
  8. AU=Kieser D C
  9. AU=Borthwick L. A.
  10. AU="Ding, Yiming"
  11. AU="Sid Ahmed, Mazen A"
  12. AU="Bermudez-Lekerika, Paola"
  13. AU="Ter Hoeve, Natalie D"
  14. AU="Yang, X-D"
  15. AU="Jerry J Shih"
  16. AU=Kapil Vikas
  17. AU="Sanda Cosarca"
  18. AU=Murthy J M K
  19. AU="Ward Chiasson, Stephanie"
  20. AU="Kinsella, Paul"
  21. AU="Alyaqout, Khaled"
  22. AU="J Joshua Smith"
  23. AU="Kotak, Dinesh"
  24. AU="Michael Holland"
  25. AU="Pauline, Staelen"
  26. AU="Mouna Esmaeilzadeh"
  27. AU=Congreve Miles
  28. AU="Li, Yunfeng" AU="Li, Yunfeng"
  29. AU="Shankar, Ganesh"
  30. AU="Ruginsk, Silvia G"
  31. AU="Aquilante, Francesco"
  32. AU="Dillon, Robert C"
  33. AU="Yuan Qu"
  34. AU="Dufour, A"
  35. AU="Hannus, Jill"
  36. AU="Rieber, Julia"
  37. AU="Gulmuradov, Tashpulat"
  38. AU="Romeu Fontanillas, Teresa"
  39. AU="Fleming, Renée"
  40. AU="Cao, Fang"
  41. AU="Sally J L Moore"
  42. AU="Moreno, Yolanda"
  43. AU="Vasiliy Ya. Kolyuchkin"

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  1. Artikel ; Online: Development of Point-of-Care Biosensors for COVID-19

    Jane Ru Choi

    Frontiers in Chemistry, Vol

    2020  Band 8

    Abstract: Coronavirus disease 2019 (COVID-19) outbreak has become a global pandemic. The deleterious effects of coronavirus have prompted the development of diagnostic tools to manage the spread of disease. While conventional technologies such as quantitative real ...

    Abstract Coronavirus disease 2019 (COVID-19) outbreak has become a global pandemic. The deleterious effects of coronavirus have prompted the development of diagnostic tools to manage the spread of disease. While conventional technologies such as quantitative real time polymerase chain reaction (qRT-PCR) have been broadly used to detect COVID-19, they are time-consuming, labor-intensive and are unavailable in remote settings. Point-of-care (POC) biosensors, including chip-based and paper-based biosensors are typically low-cost and user-friendly, which offer tremendous potential for rapid medical diagnosis. This mini review article discusses the recent advances in POC biosensors for COVID-19. First, the development of POC biosensors which are made of polydimethylsiloxane (PDMS), papers, and other flexible materials such as textile, film, and carbon nanosheets are reviewed. The advantages of each biosensors along with the commercially available COVID-19 biosensors are highlighted. Lastly, the existing challenges and future perspectives of developing robust POC biosensors to rapidly identify and manage the spread of COVID-19 are briefly discussed.
    Schlagwörter POC biosensors ; PDMS ; paper ; flexible materials ; COVID-19 ; Chemistry ; QD1-999
    Sprache Englisch
    Erscheinungsdatum 2020-05-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Current Status and Perspectives of Human Mesenchymal Stem Cell Therapy 2020

    Jane Ru Choi / Kar Wey Yong / Hui Yin Nam

    Stem Cells International, Vol

    2022  Band 2022

    Schlagwörter Internal medicine ; RC31-1245
    Sprache Englisch
    Erscheinungsdatum 2022-01-01T00:00:00Z
    Verlag Hindawi Limited
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Recent Progress in Nanotechnology for COVID-19 Prevention, Diagnostics and Treatment

    Yousef Rasmi / Kouass Sahbani Saloua / Mahdieh Nemati / Jane Ru Choi

    Nanomaterials, Vol 11, Iss 1788, p

    2021  Band 1788

    Abstract: The COVID-19 pandemic is currently an unprecedented public health threat. The rapid spread of infections has led to calls for alternative approaches to combat the virus. Nanotechnology is taking root against SARS-CoV-2 through prevention, diagnostics and ...

    Abstract The COVID-19 pandemic is currently an unprecedented public health threat. The rapid spread of infections has led to calls for alternative approaches to combat the virus. Nanotechnology is taking root against SARS-CoV-2 through prevention, diagnostics and treatment of infections. In light of the escalating demand for managing the pandemic, a comprehensive review that highlights the role of nanomaterials in the response to the pandemic is highly desirable. This review article comprehensively discusses the use of nanotechnology for COVID-19 based on three main categories: prevention, diagnostics and treatment. We first highlight the use of various nanomaterials including metal nanoparticles, carbon-based nanoparticles and magnetic nanoparticles for COVID-19. We critically review the benefits of nanomaterials along with their applications in personal protective equipment, vaccine development, diagnostic device fabrication and therapeutic approaches. The remaining key challenges and future directions of nanomaterials for COVID-19 are briefly discussed. This review is very informative and helpful in providing guidance for developing nanomaterial-based products to fight against COVID-19.
    Schlagwörter COVID-19 ; nanomaterials ; prevention ; diagnostics ; treatment ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 360
    Sprache Englisch
    Erscheinungsdatum 2021-07-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: In Vitro Human Cancer Models for Biomedical Applications

    Jane Ru Choi / Gül Kozalak / Ighli di Bari / Quratulain Babar / Zahra Niknam / Yousef Rasmi / Kar Wey Yong

    Cancers, Vol 14, Iss 2284, p

    2022  Band 2284

    Abstract: Cancer is one of the leading causes of death worldwide, and its incidence is steadily increasing. Although years of research have been conducted on cancer treatment, clinical treatment options for cancers are still limited. Animal cancer models have been ...

    Abstract Cancer is one of the leading causes of death worldwide, and its incidence is steadily increasing. Although years of research have been conducted on cancer treatment, clinical treatment options for cancers are still limited. Animal cancer models have been widely used for studies of cancer therapeutics, but these models have been associated with many concerns, including inaccuracy in the representation of human cancers, high cost and ethical issues. Therefore, in vitro human cancer models are being developed quickly to fulfill the increasing demand for more relevant models in order to get a better knowledge of human cancers and to find novel treatments. This review summarizes the development of in vitro human cancer models for biomedical applications. We first review the latest development in the field by detailing various types of in vitro human cancer models, including transwell-based models, tumor spheroids, microfluidic tumor-microvascular systems and scaffold-based models. The advantages and limitations of each model, as well as their biomedical applications, are summarized, including therapeutic development, assessment of tumor cell migration, metastasis and invasion and discovery of key cancer markers. Finally, the existing challenges and future perspectives are briefly discussed.
    Schlagwörter in vitro model ; human cancers ; biomedical applications ; therapeutic development ; tumor biology ; cancer markers ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282
    Thema/Rubrik (Code) 170
    Sprache Englisch
    Erscheinungsdatum 2022-05-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Editorial

    Jane Ru Choi / Mithran Somasundrum / Muhammad J.A. Shiddiky / Werasak Surareungchai / Yufang Hu / Zhihe Qing

    Frontiers in Chemistry, Vol

    Advances in Nucleic Acid-Based Biosensors and Imaging

    2022  Band 10

    Schlagwörter nucleic acid ; DNA/RNA ; sensing ; diagnostics ; imaging ; detection ; Chemistry ; QD1-999
    Sprache Englisch
    Erscheinungsdatum 2022-05-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Current Status and Perspectives of Human Mesenchymal Stem Cell Therapy

    Jane Ru Choi / Kar Wey Yong / Hui Yin Nam

    Stem Cells International, Vol

    2019  Band 2019

    Schlagwörter Internal medicine ; RC31-1245
    Sprache Englisch
    Erscheinungsdatum 2019-01-01T00:00:00Z
    Verlag Hindawi Limited
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Single-Cell RNA Sequencing and Its Combination with Protein and DNA Analyses

    Jane Ru Choi / Kar Wey Yong / Jean Yu Choi / Alistair C. Cowie

    Cells, Vol 9, Iss 1130, p

    2020  Band 1130

    Abstract: Heterogeneity in cell populations poses a significant challenge for understanding complex cell biological processes. The analysis of cells at the single-cell level, especially single-cell RNA sequencing (scRNA-seq), has made it possible to ... ...

    Abstract Heterogeneity in cell populations poses a significant challenge for understanding complex cell biological processes. The analysis of cells at the single-cell level, especially single-cell RNA sequencing (scRNA-seq), has made it possible to comprehensively dissect cellular heterogeneity and access unobtainable biological information from bulk analysis. Recent efforts have combined scRNA-seq profiles with genomic or proteomic data, and show added value in describing complex cellular heterogeneity than transcriptome measurements alone. With the rising demand for scRNA-seq for biomedical and clinical applications, there is a strong need for a timely and comprehensive review on the scRNA-seq technologies and their potential biomedical applications. In this review, we first discuss the latest state of development by detailing each scRNA-seq technology, including both conventional and microfluidic technologies. We then summarize their advantages and limitations along with their biomedical applications. The efforts of integrating the transcriptome profile with highly multiplexed proteomic and genomic data are thoroughly reviewed with results showing the integrated data being more informative than transcriptome data alone. Lastly, the latest progress toward commercialization, the remaining challenges, and future perspectives on the development of scRNA-seq technologies are briefly discussed.
    Schlagwörter single-cell RNA sequencing ; protein ; genome ; biomedical applications ; commercialization ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 612
    Sprache Englisch
    Erscheinungsdatum 2020-05-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Recent Advances in Mechanically Loaded Human Mesenchymal Stem Cells for Bone Tissue Engineering

    Kar Wey Yong / Jane Ru Choi / Jean Yu Choi / Alistair C. Cowie

    International Journal of Molecular Sciences, Vol 21, Iss 5816, p

    2020  Band 5816

    Abstract: Large bone defects are a major health concern worldwide. The conventional bone repair techniques (e.g., bone-grafting and Masquelet techniques) have numerous drawbacks, which negatively impact their therapeutic outcomes. Therefore, there is a demand to ... ...

    Abstract Large bone defects are a major health concern worldwide. The conventional bone repair techniques (e.g., bone-grafting and Masquelet techniques) have numerous drawbacks, which negatively impact their therapeutic outcomes. Therefore, there is a demand to develop an alternative bone repair approach that can address the existing drawbacks. Bone tissue engineering involving the utilization of human mesenchymal stem cells (hMSCs) has recently emerged as a key strategy for the regeneration of damaged bone tissues. However, the use of tissue-engineered bone graft for the clinical treatment of bone defects remains challenging. While the role of mechanical loading in creating a bone graft has been well explored, the effects of mechanical loading factors (e.g., loading types and regime) on clinical outcomes are poorly understood. This review summarizes the effects of mechanical loading on hMSCs for bone tissue engineering applications. First, we discuss the key assays for assessing the quality of tissue-engineered bone grafts, including specific staining, as well as gene and protein expression of osteogenic markers. Recent studies of the impact of mechanical loading on hMSCs, including compression, perfusion, vibration and stretching, along with the potential mechanotransduction signalling pathways, are subsequently reviewed. Lastly, we discuss the challenges and prospects of bone tissue engineering applications.
    Schlagwörter bone repair ; mechanical loading ; human mesenchymal stem cells ; bone tissue engineering ; mechanotransduction ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2020-08-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: Recent advances in photo-crosslinkable hydrogels for biomedical applications

    Jane Ru Choi / Kar Wey Yong / Jean Yu Choi / Alistair C Cowie

    BioTechniques, Vol 66, Iss 1, Pp 40-

    2019  Band 53

    Abstract: Photo-crosslinkable hydrogels have recently attracted significant scientific interest. Their properties can be manipulated in a spatiotemporal manner through exposure to light to achieve the desirable functionality for various biomedical applications. ... ...

    Abstract Photo-crosslinkable hydrogels have recently attracted significant scientific interest. Their properties can be manipulated in a spatiotemporal manner through exposure to light to achieve the desirable functionality for various biomedical applications. This review article discusses the recent advances of the most common photo-crosslinkable hydrogels, including poly(ethylene glycol) diacrylate, gelatin methacryloyl and methacrylated hyaluronic acid, for various biomedical applications. We first highlight the advantages of photopolymerization and discuss diverse photosensitive systems used for the synthesis of photo-crosslinkable hydrogels. We then introduce their synthesis methods and review their latest state of development in biomedical applications, including tissue engineering and regenerative medicine, drug delivery, cancer therapies and biosensing. Lastly, the existing challenges and future perspectives of engineering photo-crosslinkable hydrogels for biomedical applications are briefly discussed.
    Schlagwörter biosensing ; cancer therapies ; drug delivery ; photo-crosslinkable hydrogels ; tissue engineering ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 620
    Sprache Englisch
    Erscheinungsdatum 2019-01-01T00:00:00Z
    Verlag Future Science Ltd
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel ; Online: See-N-Seq

    Jeong Hyun Lee / Emily S. Park / Jane Ru Choi / Kerryn Matthews / Alice V. Lam / Xiaoyan Deng / Simon P. Duffy / Hongshen Ma

    Communications Biology, Vol 5, Iss 1, Pp 1-

    RNA sequencing of target single cells identified by microscopy via micropatterning of hydrogel porosity

    2022  Band 10

    Abstract: A selective sequencing method, termed SeeN-Seq, is presented to link morphological phenotypes to single-cell RNAseq using UV laser patterning of hydrogel porosity. ...

    Abstract A selective sequencing method, termed SeeN-Seq, is presented to link morphological phenotypes to single-cell RNAseq using UV laser patterning of hydrogel porosity.
    Schlagwörter Biology (General) ; QH301-705.5
    Sprache Englisch
    Erscheinungsdatum 2022-07-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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