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Article ; Online: Economic and Cardiometabolic Risk Factors Are Predictors of Lower Thyroid Stimulating Hormone (TSH) Levels in Hispanic/Latinx Adults with Euthyroidism—A Community-Based Study

Sabrina Sales Martinez / Margaret Gutierrez / Ivan Delgado-Enciso / Jezabel Maisonet / Aydevis Jean Pierre / Adriana Campa / Laura Kallus / Janet Diaz Martinez

International Journal of Environmental Research and Public Health, Vol 19, Iss 8142, p

2022 Volume 8142

Abstract: Thyroid hormone abnormalities are among the most common endocrine disorders comorbidly suffered alongside metabolic syndrome and type 2 diabetes mellitus (T2DM), and within the euthyroid range they may also impact other outcomes, such as mood disorders. ... ...

Abstract	Thyroid hormone abnormalities are among the most common endocrine disorders comorbidly suffered alongside metabolic syndrome and type 2 diabetes mellitus (T2DM), and within the euthyroid range they may also impact other outcomes, such as mood disorders. This study aimed to observationally examine the relationship between TSH and social determinants of health and clinical measures in a euthyroid Hispanic/Latinx patient sample with a diagnosis of anxiety and/or depression disorders from a community health clinic. A needs assessment was completed using a random sample of 100 de-identified medical records of individuals who received free medical care, including mental health, at a community-based clinic. Those with low normal TSH (<2 mIU/L) compared with high normal TSH (≥2 mIU/L) had a greater odds of food insecurity ( p = 0.016) and being at 100% of the federal poverty level ( p = 0.015). The low normal TSH group had significantly higher fasting glucose ( p = 0.046), hemoglobin A1c ( p = 0.018), and total cholesterol ( p = 0.034) compared with the high normal TSH group. In those with T2DM, individuals with low normal TSH had six-times greater odds of having high fasting glucose ( p = 0.022) and high hemoglobin A1c ( p = 0.029). These relationships warrant further study, to inform future public health policies and follow-up care for underserved and vulnerable communities.
Keywords	thyroid-stimulating hormone ; income ; food insecurity ; Hispanic ; cardiometabolic risk factors ; Medicine ; R
Subject code	360
Language	English
Publishing date	2022-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Severity and outcomes of Omicron variant of SARS-CoV-2 compared to Delta variant and severity of Omicron sublineages

Lisa Askie / Maria D Van Kerkhove / Janet Diaz / Olivier Le Polain de Waroux / Nkengafac Villyen Motaze / Pryanka Relan / Bharath Kumar Tirupakuzhi Vijayaraghavan / Kavita Kothari

BMJ Global Health, Vol 8, Iss

a systematic review and metanalysis

2023 Volume 7

Abstract: Objectives To compare severity and clinical outcomes from Omicron as compared with the Delta variant and to compare outcomes between Omicron sublineages.Methods We searched the WHO COVID-19 Research database for studies that compared clinical outcomes ... ...

Abstract	Objectives To compare severity and clinical outcomes from Omicron as compared with the Delta variant and to compare outcomes between Omicron sublineages.Methods We searched the WHO COVID-19 Research database for studies that compared clinical outcomes for patients with Omicron variant and the Delta variant, and separately Omicron sublineages BA.1 and BA.2. A random-effects meta-analysis was used to pool estimates of relative risk (RR) between variants and sublineages. Heterogeneity between studies was assessed using the I2 index. Risk of bias was assessed using the tool developed by the Clinical Advances through Research and Information Translation team.Results Our search identified 1494 studies and 42 met the inclusion criteria. Eleven studies were published as preprints. Of the 42 studies, 29 adjusted for vaccination status; 12 had no adjustment; and for 1, the adjustment was unclear. Three of the included studies compared the sublineages of Omicron BA.1 versus BA.2. As compared with Delta, individuals infected with Omicron had 61% lower risk of death (RR 0.39, 95% CI 0.33 to 0.46) and 56% lower risk of hospitalisation (RR 0.44, 95% CI 0.34 to 0.56). Omicron was similarly associated with lower risk of intensive care unit (ICU) admission, oxygen therapy, and non-invasive and invasive ventilation. The pooled risk ratio for the outcome of hospitalisation when comparing sublineages BA.1 versus BA.2 was 0.55 (95% 0.23 to 1.30).Discussion Omicron variant was associated with lower risk of hospitalisation, ICU admission, oxygen therapy, ventilation and death as compared with Delta. There was no difference in the risk of hospitalisation between Omicron sublineages BA.1 and BA.2.PROSPERO registration number CRD42022310880.
Keywords	Medicine (General) ; R5-920 ; Infectious and parasitic diseases ; RC109-216
Subject code	610
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Stress Increases the Association between Cigarette Smoking and Mental Disorders, as Measured by the COVID-19-Related Worry Scale, in the Miami Adult Studies on HIV (MASH) Cohort during the Pandemic

Janet Diaz-Martinez / Ivan Delgado-Enciso / Adriana Campa / Javier A. Tamargo / Haley R. Martin / Angelique Johnson / Suzanne Siminski / Pamina M. Gorbach / Marianna K. Baum

International Journal of Environmental Research and Public Health, Vol 19, Iss 8207, p

2022 Volume 8207

Abstract: Background: Smoking has been associated with mental disorders (MD). People who smoke are at a higher risk of contracting COVID-19 and experiencing more severe symptoms of the illness. This study aimed to investigate the relationship between cigarette ... ...

Abstract	Background: Smoking has been associated with mental disorders (MD). People who smoke are at a higher risk of contracting COVID-19 and experiencing more severe symptoms of the illness. This study aimed to investigate the relationship between cigarette smoking and MD before and during the COVID-19 pandemic and whether it was influenced by COVID-19-related stress in the MASH cohort. Methods: An ambispective design was used with data collected during the pandemic (July/August 2020) by the COVID-19-Related Worry Scale, a parameter for stress, and data collected at the participants’ last cohort visit before the pandemic (December 2019). Results: In our sample of 314 participants, 58.6% were living with HIV, 39.2% had MD, 52.5% smoked before, and 47.8% smoked during the pandemic. Participants with MD were twice as likely to smoke cigarettes both before (aOR = 2.02, 95% CI: 1.21–3.37, p = 0.007) and during the pandemic (aOR = 2.10, 95% CI: 1.24–3.56, p = 0.006); and experienced higher levels of stress measured by the COVID-19-Related Worry Scale (8.59 [5.0–10.0] vs. 7.65 [5.0–10.0]; p = 0.026) compared to those without MD. Participants with MD and high levels of stress smoked more days per month (20.1 [0–30] days) than those with lower levels of stress (9.2 [0–30] days, p = 0.021), and more than those with high levels of stress, but no MD (2.6 [0–30] days, p < 0.001). Conclusions: Cigarette smoking decreased in the MASH cohort during the pandemic, but increased in participants with MD and higher levels of stress.
Keywords	smoking ; COVID-19 stress ; HIV ; Medicine ; R
Subject code	150
Language	English
Publishing date	2022-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Risk of dispersion or aerosol generation and infection transmission with nasopharyngeal and oropharyngeal swabs for detection of COVID-19

Karen EA Burns / Janet Diaz / Dipayan Chaudhuri / John Basmaji / David S Hui / Neill K J Adhikari / Fiona Muttalib / Samira Mubareka / Layla Bakaa / Sonia Brar / David Granton / Devin Chetan / Malini Hu / Charles D Gomersall

BMJ Open, Vol 11, Iss

a systematic review

2021 Volume 3

Abstract: Objectives SARS-CoV-2-related disease, referred to as COVID-19, has emerged as a global pandemic since December 2019. While there is growing recognition regarding possible airborne transmission, particularly in the setting of aerosol-generating ... ...

Abstract	Objectives SARS-CoV-2-related disease, referred to as COVID-19, has emerged as a global pandemic since December 2019. While there is growing recognition regarding possible airborne transmission, particularly in the setting of aerosol-generating procedures and treatments, whether nasopharyngeal and oropharyngeal swabs for SARS-CoV-2 generate aerosols remains unclear.Design Systematic review.Data sources We searched Ovid MEDLINE and EMBASE up to 3 November 2020. We also searched the China National Knowledge Infrastructure, Chinese Medical Journal Network, medRxiv and ClinicalTrials.gov up to 29 March 2020.Eligibility criteria All comparative and non-comparative studies that evaluated dispersion or aerosolisation of viable airborne organisms, or transmission of infection associated with nasopharyngeal or oropharyngeal swab testing.Results Of 7702 citations, only one study was deemed eligible. Using a dedicated sampling room with negative pressure isolation room, personal protective equipment including N95 or higher masks, strict sterilisation protocols, structured training with standardised collection methods and a structured collection and delivery system, a tertiary care hospital proved a 0% healthcare worker infection rate among eight nurses conducting over 11 000 nasopharyngeal swabs. No studies examining transmissibility with other safety protocols, nor any studies quantifying the risk of aerosol generation with nasopharyngeal or oropharyngeal swabs for detection of SARS-CoV-2, were identified.Conclusions There is limited to no published data regarding aerosol generation and risk of transmission with nasopharyngeal and oropharyngeal swabs for the detection of SARS-CoV-2. Field experiments to quantify this risk are warranted. Vigilance in adhering to current standards for infection control is suggested.
Keywords	Medicine ; R
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Virus kinetics and biochemical derangements among children with Ebolavirus disease

Lindsey Kjaldgaard / Kasereka Masumbuko Claude / Daniel Mukadi-Bamuleka / Richard Kitenge-Omasumbu / Devika Dixit / François Edidi-Atani / Meris Matondo Kuamfumu / Junior Bulabula-Penge / Fabrice Mambu-Mbika / Olivier Tshiani-Mbaya / Janet Diaz / Sabue Mulangu / Anais Legand / Placide Mbala-Kingebeni / Pierre Formenty / Steve Ahuka-Mundeke / Jean-Jacques Muyembe-Tamfum / Michael T. Hawkes

EClinicalMedicine, Vol 53, Iss , Pp 101638- (2022)

2022

Abstract: Summary: Background: A paucity of data is available on virologic and biochemical characteristics of paediatric Ebolavirus disease (EVD), compared to adults. Methods: We conducted a retrospective chart review of children (<16 years old) and a comparator ... ...

Abstract	Summary: Background: A paucity of data is available on virologic and biochemical characteristics of paediatric Ebolavirus disease (EVD), compared to adults. Methods: We conducted a retrospective chart review of children (<16 years old) and a comparator group of young adults (16–44 years) from two treatment centres during the 2018–2020 EVD epidemic in Eastern Democratic Republic of the Congo. Statistical methods included chi-squared and Fisher's exact tests (dichotomous and categorical variables), Mann-Whitney U-test (continuous variables), multivariable linear regression (for determinants of admission viral load), linear mixed-effects models (for analysis of longitudinal viral load), and Cox proportional hazard models (to examine risk factors for mortality). Findings: We included 73 children and 234 adults admitted from April to October 2019. Paediatric patients commonly had electrolytes imbalances: hypokalaemia in 26/73 (36%), hyperkalaemia in 38/73 (52%), and hyponatraemia in 54/73 (74%). Hypoglycaemia occurred in 20/73 (27%), acute kidney injury in 43/73 (59%), and rhabdomyolysis in 35/73 (48%). Biochemical abnormalities were detected in a similar proportion of children and adults. The viral load (VL, log10 copies/mL) at admission (7.2 versus 6.5, p=0.0001), the peak viral load (7.5 versus 6.7, p=<0.0001), and the time for viraemia clearance (16 days versus 12 days, p=<0.0001) were significantly different in children. The duration of hospital stay was prolonged in children (20 versus 16 days, p=<0.0001). Risk factors for mortality in children were: VL >7.6 log10copies/mL, alanine transaminase >525 U/L, C-reactive protein >100 mg/L, blood urea nitrogen >7.5 mmol/L, rhabdomyolysis, and.acute kidney injury. Interpretation: Paediatric EVD patients, like adults, experience multiorgan dysfunction with life-threatening electrolyte imbalances, hypoglycaemia, kidney injury, liver injury, and rhabdomyolysis. Paediatric patients have significantly higher VLs throughout the course of EVD than ...
Keywords	Ebolavirus disease ; Child ; Viral load ; Mortality ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Epidemiological, clinical, and public health response characteristics of a large outbreak of diphtheria among the Rohingya population in Cox's Bazar, Bangladesh, 2017 to 2019

PLoS Medicine, Vol 18, Iss 4, p e

A retrospective study.

2021 Volume 1003587

Abstract: Background Unrest in Myanmar in August 2017 resulted in the movement of over 700,000 Rohingya refugees to overcrowded camps in Cox's Bazar, Bangladesh. A large outbreak of diphtheria subsequently began in this population. Methods and findings Data were ... ...

Abstract	Background Unrest in Myanmar in August 2017 resulted in the movement of over 700,000 Rohingya refugees to overcrowded camps in Cox's Bazar, Bangladesh. A large outbreak of diphtheria subsequently began in this population. Methods and findings Data were collected during mass vaccination campaigns (MVCs), contact tracing activities, and from 9 Diphtheria Treatment Centers (DTCs) operated by national and international organizations. These data were used to describe the epidemiological and clinical features and the control measures to prevent transmission, during the first 2 years of the outbreak. Between November 10, 2017 and November 9, 2019, 7,064 cases were reported: 285 (4.0%) laboratory-confirmed, 3,610 (51.1%) probable, and 3,169 (44.9%) suspected cases. The crude attack rate was 51.5 cases per 10,000 person-years, and epidemic doubling time was 4.4 days (95% confidence interval [CI] 4.2-4.7) during the exponential growth phase. The median age was 10 years (range 0-85), and 3,126 (44.3%) were male. The typical symptoms were sore throat (93.5%), fever (86.0%), pseudomembrane (34.7%), and gross cervical lymphadenopathy (GCL; 30.6%). Diphtheria antitoxin (DAT) was administered to 1,062 (89.0%) out of 1,193 eligible patients, with adverse reactions following among 229 (21.6%). There were 45 deaths (case fatality ratio [CFR] 0.6%). Household contacts for 5,702 (80.7%) of 7,064 cases were successfully traced. A total of 41,452 contacts were identified, of whom 40,364 (97.4%) consented to begin chemoprophylaxis; adherence was 55.0% (N = 22,218) at 3-day follow-up. Unvaccinated household contacts were vaccinated with 3 doses (with 4-week interval), while a booster dose was administered if the primary vaccination schedule had been completed. The proportion of contacts vaccinated was 64.7% overall. Three MVC rounds were conducted, with administrative coverage varying between 88.5% and 110.4%. Pentavalent vaccine was administered to those aged 6 weeks to 6 years, while tetanus and diphtheria (Td) vaccine was ...
Keywords	Medicine ; R
Subject code	630
Language	English
Publishing date	2021-04-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Corticosteroid therapy for critically ill patients with COVID-19

Jonathan A. C. Sterne / Janet Diaz / Jesús Villar / Srinivas Murthy / Arthur S. Slutsky / Anders Perner / Peter Jüni / Derek C. Angus / Djillali Annane / Luciano Cesar Pontes Azevedo / Bin Du / Pierre-Francois Dequin / Anthony C. Gordon / Cameron Green / Julian P. T. Higgins / Peter Horby / Martin J. Landray / Giuseppe Lapadula / Amelie Le Gouge /

Marie Leclerc / Jelena Savović / Bruno Tomazini / Balasubramanian Venkatesh / Steve Webb / John C. Marshall / for the WHO COVID-19 Clinical Management and Characterization Working Group

Trials, Vol 21, Iss 1, Pp 1-

A structured summary of a study protocol for a prospective meta-analysis of randomized trials

2020 Volume 3

Abstract: Abstract Objectives Primary objective: To estimate the effect of corticosteroids compared with usual care or placebo on mortality up to 28 days after randomization. Secondary objectives: To examine whether the effect of corticosteroids compared with ... ...

Abstract	Abstract Objectives Primary objective: To estimate the effect of corticosteroids compared with usual care or placebo on mortality up to 28 days after randomization. Secondary objectives: To examine whether the effect of corticosteroids compared with usual care or placebo on mortality up to 28 days after randomization varies between subgroups related to treatment characteristics, disease severity at the time of randomization, patient characteristics, or risk of bias. To examine the effect of corticosteroids compared with usual care or placebo on serious adverse events. Study design Prospective meta-analysis of randomized controlled trials. Both placebo-controlled and open-label trials are eligible. Participants Hospitalised, critically ill patients with suspected or confirmed COVID-19. Intervention and comparator Intervention groups will have received therapeutic doses of a steroid (dexamethasone, hydrocortisone or methylprednisolone) with IV or oral administration immediately after randomization. The comparator groups will have received standard of care or usual care or placebo. Main outcome All-cause mortality up to 28 days after randomization. Search methods Systematic searching of clinicaltrials.gov , EudraCT, the WHO ISRCTN registry, and the Chinese clinical trials registry. Additionally, research and WHO networks will be asked for relevant trials. Risk of bias assessments These will be based on the Cochrane RoB 2 tool, and will use structured information provided by the trial investigators on a form designed for this prospective meta-analysis. Summary of findings We will use GRADE to assess the certainty of the evidence. Statistical analyses Trial investigators will provide data on the numbers of participants who did and did not experience each outcome according to intervention group, overall and in specified subgroups. We will conduct fixed-effect (primary analysis) and random-effects (Paule-Mandel estimate of heterogeneity and Hartung-Knapp adjustment) meta-analyses. We will quantify inconsistency in ...
Keywords	COVID-19 ; Randomised controlled trial ; Systematic Review ; Corticosteroid ; Dexamethasone ; Hydrocortisone ; Medicine (General) ; R5-920 ; covid19
Subject code	310
Language	English
Publishing date	2020-08-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Effect of GSTM1-Polymorphism on Disease Progression and Oxidative Stress in HIV Infection: Modulation by HIV/HCV Co-Infection and Alcohol Consumption.

Parsons, Mary / Campa, Adriana / Lai, Shenghan / Li, Yinghui / Martinez, Janet Diaz / Murillo, Jorge / Greer, Pedro / Martinez, Sabrina Sales / Baum, Marianna K

Journal of AIDS & clinical research

2013 Volume 4, Issue 9

Abstract: Objective: To examine the effects of GSTM1 null-allele polymorphism on oxidative stress and disease progression in HIV infected and HIV/hepatitis C (HCV) co-infected adults.: Methods: HIV-infected and HIV/HCV co-infected participants aged 40-60 years ...

Abstract	Objective: To examine the effects of GSTM1 null-allele polymorphism on oxidative stress and disease progression in HIV infected and HIV/hepatitis C (HCV) co-infected adults. Methods: HIV-infected and HIV/HCV co-infected participants aged 40-60 years old with CD4 cell count >350 cells/ µl, were recruited. GSTM1 genotype was determined by quantitative PCR. Oxidative stress (mitochondrial 8-oxo-2'-deoxyguanosine [8-oxo-dG], malondialdehyde [MDA], oxidized glutathione and Complexes I and IV), apoptosis and HIV disease (CD4 count and viral load) markers were measured. Gene copies were not quantified, thus the Hardy-Weinberg formula was not applicable. Results: Of the 129 HIV-infected participants, 58 were HIV/HCV co-infected. GSTM1 occurred in 66% (62/94) in those of African descent, and 33% (11/33) of the Caucasians. Those with GSTM1 coding for the functional antioxidant enzyme Glutathione S-transferase (GST), had higher CD4 cell count (β=3.48, p=0.034), lower HIV viral load (β=-0.536, p=0.018), and lower mitochondrial 8-oxo-dG (β=-0.28, p=0.03). ART reduced oxidative stress in the participants with the GSTM1 coding for the functional antioxidant enzyme. HIV/HCV co-infected participants with the GSTM1 coding for the functional antioxidant enzyme also had lower HIV viral load, lower 8-oxo-dG and lower rate of apoptosis, but also higher oxidized glutathione. Alcohol consumption was associated with lower HIV viral load but higher oxidized glutathione in those with the GSTM1 genotype coding for the functional antioxidant enzyme. Conclusion: The GSTM1 genotype coding for the functional antioxidant enzyme is associated with lower HIV disease severity, and with lower oxidative stress, compared to GSTM1 null-allele polymorphism. HCV co-infection and alcohol use may be associated with increased oxidative stress even in the presence of the GSTM1 coding for the functional antioxidant enzyme. The null-gene, on the contrary, appears to have a detrimental effect on immune function, viral load control, and antioxidant status, suggesting a potential benefit from antioxidants in HIV infected patients with the defective gene.
Language	English
Publishing date	2013-12-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2601227-3
ISSN	2155-6113
ISSN	2155-6113
DOI	10.4172/2155-6113.1000237
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Presentación de caso radiológico

Desi Pozo Alonso / Lino Aboy Sarduy / Julio Smith García-Menocal / Jorge Oller Gómez / Orlando del Valle Alonso / Janet Díaz Pérez

Revista Habanera de Ciencias Médicas , Vol 9, Pp 673-

Esclerosis tuberosa Radiologic case presentation: Tuberous sclerosis

2010 Volume 679

Abstract: Se presenta un caso de una mujer de 27 años, quien acude al Cuerpo de Guardia con dolor abdominal moderado de reciente comienzo. Al examen físico, se constata una masa abdominal que ocupaba ambos flancos. Luego de los estudios clínicos e imagenológicos, ... ...

Abstract	Se presenta un caso de una mujer de 27 años, quien acude al Cuerpo de Guardia con dolor abdominal moderado de reciente comienzo. Al examen físico, se constata una masa abdominal que ocupaba ambos flancos. Luego de los estudios clínicos e imagenológicos, se comprobó la presencia de angiomiolipomas renales bilaterales, nódulos subependimarios y lesiones en piel por lo que se diagnosticó esclerosis tuberosa. La esclerosis tuberosa es una enfermedad neurocutánea caracterizada por cambios hamartomatosos en los pulmones, cerebro, riñones, piel, corazón y otros órganos. Para el diagnóstico se aplican criterios basados en el hallazgo de manifestaciones mayores y menores. En esto, la Imagenología tiene un importante papel. A 27 year old woman was given to the emergency department with mild, acute onset of right side abdominal pain. Clinical examination revealed firm masses bilaterally occupying almost the entire abdomen. Because the presence of bilateral angiomyolipomas, subependymal tuberous and adenoma sebaceum of the skin the patient was diagnosed as having a case of tuberous sclerosis . TS is a neurocutaneous disease characterized by hamartomatous changes in the lungs, brain, kidneys, skin, heart and others organs. The diagnostic criteria consisted of a set of major and minor diagnostic features. The imagenology plays a very important role.
Keywords	Esclerosis tuberosa ; angiomiolipomas bilaterales ; nódulos subependimarios ; Tuberous sclerosis ; bilateral angiomyolipomas ; subependymal tubers ; Medicine (General) ; R5-920 ; Medicine ; R ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Language	Spanish
Publishing date	2010-12-01T00:00:00Z
Publisher	Universidad de Ciencias Médicas de la Habana
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Presentación de caso radiológico. Esclerosis tuberosa

Desi Pozo Alonso / Lino Aboy Sarduy / Julio Smith García- Menocal / Jorge Oller Gómez / Orlando del Valle Alonso / Janet Díaz Pérez

Revista Habanera de Ciencias Médicas, Vol 9, Iss

2010 Volume 5

Abstract	Se presenta un caso de una mujer de 27 años, quien acude al Cuerpo de Guardia con dolor abdominal moderado de reciente comienzo. Al examen físico, se constata una masa abdominal que ocupaba ambos flancos. Luego de los estudios clínicos e imagenológicos, se comprobó la presencia de angiomiolipomas renales bilaterales, nódulos subependimarios y lesiones en piel por lo que se diagnosticó esclerosis tuberosa. La esclerosis tuberosa es una enfermedad neurocutánea caracterizada por cambios hamartomatosos en los pulmones, cerebro, riñones, piel, corazón y otros órganos. Para el diagnóstico se aplican criterios basados en el hallazgo de manifestaciones mayores y menores. En esto, la Imagenología tiene un importante papel. Palabras clave: Esclerosis tuberosa, angiomiolipomas bilaterales, nódulos subependimarios.
Keywords	Medicine (General) ; R5-920 ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2010-02-01T00:00:00Z
Publisher	Universidad de Ciencias Médicas de La Habana
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