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  1. Article ; Online: The association between antibody responses and prolonged viable SARS-CoV-2 shedding in immunocompromised patients: a prospective cohort study.

    Lim, So Yun / Kim, Jun-Won / Kim, Ji Yeun / Kang, Sung-Woon / Jang, Choi-Young / Chang, Euijin / Yang, Jeong-Sun / Kim, Kyung-Chang / Jang, Hee-Chang / Kim, Da Sol / Shin, Younmin / Lee, Joo-Yeon / Kim, Sung-Han

    The Journal of infectious diseases

    2023  

    Abstract: Immunocompromised COVID-19 patients were prospectively enrolled from March to November 2022 to understand the association between antibody responses and SARS-CoV-2 shedding. A total of 62 patients were analyzed and the results indicated a faster decline ... ...

    Abstract Immunocompromised COVID-19 patients were prospectively enrolled from March to November 2022 to understand the association between antibody responses and SARS-CoV-2 shedding. A total of 62 patients were analyzed and the results indicated a faster decline in genomic and subgenomic viral RNA in patients with higher neutralizing and S1-specific IgG antibodies (both P < 0.001). Notably, high neutralizing antibody levels were associated with a significantly faster decrease in viable virus cultures (P = 0.04). Our observations suggest the role of neutralizing antibodies in prolonged virus shedding in immunocompromised patients, highlighting the potential benefits of enhancing their humoral immune response through vaccination or monoclonal antibody treatments.
    Language English
    Publishing date 2023-12-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiad579
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh II Zs.50: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 445: Show issues

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  2. Article ; Online: Characteristics and risk factors of prolonged viable virus shedding in immunocompromised patients with COVID-19: a prospective cohort study.

    Kang, Sung-Woon / Kim, Jun-Won / Kim, Ji Yeun / Lim, So Yun / Jang, Choi-Young / Chang, Euijin / Yang, Jeong-Sun / Kim, Kyung-Chang / Jang, Hee-Chang / Kim, Dasol / Shin, Younmin / Lee, Joo-Yeon / Kim, Sung-Han

    The Journal of infection

    2023  Volume 86, Issue 4, Page(s) 412–414

    MeSH term(s) Humans ; COVID-19 ; Prospective Studies ; Virus Shedding ; Risk Factors ; Immunocompromised Host ; RNA, Viral
    Chemical Substances RNA, Viral
    Language English
    Publishing date 2023-01-20
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2023.01.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1501: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 48: Show issues

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  3. Article ; Online: Virological characteristics and the rapid antigen test as deisolation criteria in immunocompromised patients with COVID-19: A prospective cohort study.

    Kang, Sung-Woon / Kim, Jun-Won / Kim, Ji Yeun / Lim, So Yun / Jang, Choi-Young / Chang, Euijin / Yang, Jeong-Sun / Kim, Kyung-Chang / Jang, Hee-Chang / Kim, Dasol / Shin, Younmin / Lee, Joo-Yeon / Kim, Sung-Han

    Journal of medical virology

    2023  Volume 95, Issue 11, Page(s) e29228

    Abstract: There are limited data supporting current Centers for Disease Control and Prevention guidelines for the isolation period in moderate to severely immunocompromised patients with coronavirus disease 2019 (COVID-19). Adult COVID-19 patients who underwent ... ...

    Abstract There are limited data supporting current Centers for Disease Control and Prevention guidelines for the isolation period in moderate to severely immunocompromised patients with coronavirus disease 2019 (COVID-19). Adult COVID-19 patients who underwent solid organ transplantation (SOT) or received active chemotherapy against hematologic malignancy were enrolled and weekly respiratory samples were collected. Samples with positive genomic real-time polymerase chain reaction results underwent virus culture and rapid antigen testing (RAT). A total of 65 patients (40 with hematologic malignancy and 25 SOT) were enrolled. The median duration of viable virus shedding was 4 weeks (interquartile range: 3-7). Multivariable analysis revealed that B-cell depletion (hazard ratio [HR]: 4.76) was associated with prolonged viral shedding, and COVID-19 vaccination (≥3 doses) was negatively associated with prolonged viral shedding (HR: 0.22). The sensitivity, specificity, positive predictive value, and negative predictive value of RAT for viable virus shedding were 79%, 76%, 74%, and 81%, respectively. The negative predictive value of RAT was only 48% (95% confidence interval [CI]: 33-65) in the samples from those with symptom onset ≤20 days, but it was as high as 92% (95% CI: 85-96) in the samples from those with symptom onset >20 days. About half of immunocompromised COVID-19 patients shed viable virus for ≥4 weeks from the diagnosis, and virus shedding was prolonged especially in unvaccinated patients with B-cell-depleting therapy treatment. RAT beyond 20 days in immunocompromised patients had a relatively high negative predictive value for viable virus shedding.
    MeSH term(s) Adult ; Humans ; COVID-19/diagnosis ; SARS-CoV-2 ; Prospective Studies ; COVID-19 Vaccines ; Hematologic Neoplasms/complications ; Virus Shedding ; RNA, Viral/analysis
    Chemical Substances COVID-19 Vaccines ; RNA, Viral
    Language English
    Publishing date 2023-11-27
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.29228
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1320: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Mutational analysis of severe acute respiratory syndrome coronavirus 2 in immunocompromised patients with persistent viral detection using whole genome sequencing.

    Chang, Euijin / Lee, Jungmin / Kim, Jun-Won / Seok, Jong Hyeon / Bae, Joon-Yong / Kim, Jeonghun / Park, Heedo / Jang, Choi-Young / Kang, Sung-Woon / Lim, So Yun / Kim, Ji Yeun / Yang, Jeong-Sun / Kim, Kyung-Chang / Lee, Joo-Yeon / Park, Man-Seong / Kim, Sung-Han

    Clinical and translational medicine

    2023  Volume 13, Issue 11, Page(s) e1462

    MeSH term(s) Humans ; SARS-CoV-2/genetics ; COVID-19/diagnosis ; COVID-19/genetics ; Whole Genome Sequencing ; Immunocompromised Host
    Language English
    Publishing date 2023-11-06
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2697013-2
    ISSN 2001-1326 ; 2001-1326
    ISSN (online) 2001-1326
    ISSN 2001-1326
    DOI 10.1002/ctm2.1462
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Letter to the Editor with # CTM2-2023-10-2488 entitled 'Antibody responses as correlates of protection against SARS-CoV-2 in the Omicron era: A 5-month prospective cohort study in Korean healthcare workers'.

    Lim, So Yun / Kim, Jineui / Kwon, Ji-Soo / Kang, Sung-Woon / Kim, Seung-Beom / Kim, Woori / Son, Ju Yeon / Jang, Choi Young / Park, Heedo / Kim, Jeonghun / Lee, Sohyun / Kim, Kyung Taek / Choi, Jaeuk / Kim, Ji Yeun / Lim, Joon Seo / Chang, Euijin / Bae, Seongman / Jung, Jiwon / Kim, Min Jae /
    Chong, Yong Pil / Lee, Sang-Oh / Choi, Sang-Ho / Kim, Yang Soo / Park, Man-Seong / Kim, Sung-Han

    Clinical and translational medicine

    2024  Volume 14, Issue 1, Page(s) e1551

    MeSH term(s) Humans ; SARS-CoV-2 ; Antibody Formation ; Prospective Studies ; COVID-19 ; Republic of Korea/epidemiology
    Language English
    Publishing date 2024-01-27
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2697013-2
    ISSN 2001-1326 ; 2001-1326
    ISSN (online) 2001-1326
    ISSN 2001-1326
    DOI 10.1002/ctm2.1551
    Database MEDical Literature Analysis and Retrieval System OnLINE

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