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Article ; Conference proceedings: Clinical usefulness of AI-assisted small bowel localization and lesion detection in capsule endoscopy

Yang, Y. J. / Cho, B. J. / Jang, H. J.

2024 Volume 56, Issue S 02

Event/congress	ESGE Days 2024, Berlin, Germany, 2024-04-25
Language	English
Publishing date	2024-04-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	80120-3
ISSN	1438-8812 ; 0013-726X
ISSN (online)	1438-8812
ISSN	0013-726X
DOI	10.1055/s-0044-1782956
Database	Thieme publisher's database

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Zs.A 669: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Quercetin Enhances the Function and Reduces Apoptosis of Mouse Islets.

Kim, S S / Jang, H J / Oh, M Y

Transplantation proceedings

2019 Volume 51, Issue 5, Page(s) 1451–1457

Abstract: Background: Quercetin (QE) is an antioxidant, anti-inflammatory, flavonoid compound. It was shown that islets are susceptible to oxidative stress due to their inherent low antioxidant capacity. In the present study, we investigated whether treatment of ... ...

Abstract	Background: Quercetin (QE) is an antioxidant, anti-inflammatory, flavonoid compound. It was shown that islets are susceptible to oxidative stress due to their inherent low antioxidant capacity. In the present study, we investigated whether treatment of mouse islets with QE could enhance their function before transplantation. Methods: Balb/c mouse islets were treated with various concentrations of QE and their viability, function, and nitric oxide (NO) and the expression of inducible NO synthase (iNOS) were determined before and after cytokine treatment. The expression of antioxidant genes was determined. Apoptosis and apoptosis-associated gene expression was measured using INS-1 cells with or without QE treatment before and after cytokine treatment. Results: The QE-treated islets and INS-1 cells showed higher cell function compared to untreated control. The expression of heme oxygenase-1, manganese-dependent superoxide dismutase, and B-cell lymphoma-2 (Bcl-2) were enhanced, and the expression of NO, iNOS, and Bcl-2-associated X protein were reduced before and after cytokine treatment. Conclusions: Our results show that QE could enhance the viability and reduce apoptosis of mouse islets and improve their function before transplantation.
MeSH term(s)	Animals ; Antioxidants/pharmacology ; Apoptosis/drug effects ; Islets of Langerhans/drug effects ; Islets of Langerhans/metabolism ; Islets of Langerhans/pathology ; Islets of Langerhans Transplantation ; Mice ; Mice, Inbred BALB C ; Oxidative Stress/drug effects ; Quercetin/pharmacology
Chemical Substances	Antioxidants ; Quercetin (9IKM0I5T1E)
Language	English
Publishing date	2019-05-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	82046-5
ISSN	1873-2623 ; 0041-1345
ISSN (online)	1873-2623
ISSN	0041-1345
DOI	10.1016/j.transproceed.2019.03.022
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Article: Evaluation of the probiotic characteristics and prophylactic potential of Weissella cibaria strains isolated from kimchi

Yu, H.-S. / Jang, H. J. / Lee, N.-K. / Paik, H.-D.

LWT - food science and technology

2019 Volume 112, Issue -, Page(s) 108229

Language	English
Document type	Article
ZDB-ID	2169058-3
ISSN	0023-6438
Database	Current Contents Nutrition, Environment, Agriculture

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Article ; Online: Tetrahydrocurcumin Enhances Islet Cell Function and Attenuates Apoptosis in Mouse Islets.

Kim, S S / Jang, H J / Oh, M Y / Lee, J H / Kang, K S

Transplantation proceedings

2018 Volume 50, Issue 9, Page(s) 2847–2853

Abstract: Background: The transplantation of isolated pancreatic islets is a promising treatment for diabetes. Curcumin has been used for its pharmacologic effects, such as antidiabetic and anti-inflammatory activities. Tetrahydrocurcumin (THC), one of the major ... ...

Abstract	Background: The transplantation of isolated pancreatic islets is a promising treatment for diabetes. Curcumin has been used for its pharmacologic effects, such as antidiabetic and anti-inflammatory activities. Tetrahydrocurcumin (THC), one of the major metabolites of curcumin, has been reported to have antioxidant and anti-inflammatory activities. This study examines the hypothesis that preoperative THC treatment can attenuate ischemic damage and apoptosis before islet transplantation. Methods: Islets isolated from Balb/c mice were randomly divided into 2 groups and cultured in medium supplemented with or without THC. In vitro islet viability and function were assessed. After treatment with a cytokine cocktail consisting of tumor necrosis factor-α, interferon-β, and interleukin-1β, islet cell viability, function, and apoptotic status were determined. Proteins related to apoptosis were analyzed using INS-1 cell after streptozocin treatment. Results: There was no difference in cell viability between the 2 groups. Islets cultured in the medium supplemented with THC showed 1.3-fold higher glucose-induced insulin secretion than the islets cultured in the medium without THC. After treatment with a cytokine cocktail, glucose-induced insulin release, and NO of the islets were significantly improved in THC-treated islets compared with islets not treated with THC. Apoptosis was significantly decreased, and B-cell lymphoma-2 was elevated in the THC-treated group. The streptozocin-treated INS-1 cell produced significantly higher levels of and B-cell lymphoma-2-associated X protein, caspase-3, and caspase-9 than INS-1 treated with THC. Conclusions: These results suggest that preoperative THC administration enhances islet function before transplantation and attenuates the cytokine-induced damage associated with apoptosis.
MeSH term(s)	Animals ; Antioxidants/pharmacology ; Apoptosis/drug effects ; Curcumin/analogs & derivatives ; Curcumin/pharmacology ; Cytokines/biosynthesis ; Cytokines/drug effects ; Ischemia/prevention & control ; Islets of Langerhans/drug effects ; Islets of Langerhans Transplantation/methods ; Mice ; Mice, Inbred BALB C
Chemical Substances	Antioxidants ; Cytokines ; tetrahydrocurcumin (00U0645U03) ; Curcumin (IT942ZTH98)
Language	English
Publishing date	2018-03-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	82046-5
ISSN	1873-2623 ; 0041-1345
ISSN (online)	1873-2623
ISSN	0041-1345
DOI	10.1016/j.transproceed.2018.03.033
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Article ; Online: Tetrahydrocurcumin Ameliorates Tacrolimus-Induced Nephrotoxicity Via Inhibiting Apoptosis.

Park, C S / Jang, H J / Lee, J H / Oh, M Y / Kim, H J

Transplantation proceedings

2018 Volume 50, Issue 9, Page(s) 2854–2859

Abstract: Background: Calcineurin inhibitors are effective immunosuppressive agents, but associated adverse effects such as nephrotoxicity may limit efficacy. Tacrolimus (FK506) is an immunosuppressive drug used mainly to lower the risk of organ rejection after ... ...

Abstract	Background: Calcineurin inhibitors are effective immunosuppressive agents, but associated adverse effects such as nephrotoxicity may limit efficacy. Tacrolimus (FK506) is an immunosuppressive drug used mainly to lower the risk of organ rejection after allogeneic organ transplant. Adverse effects of FK-506 can prompt patients to end treatment despite the efficacy. In the present study, we investigated the protective effect and mechanism of tetrahydrocurcumin (THC) on FK506-induced renal damage, apoptosis, and oxidative stress to evaluate its possible use for kidney protection. Materials and methods: The effect of THC on FK506-induced kidney cell damage was investigated in LLC-PK1 cells. LLC-PK1 cells were pretreated with THC at concentrations of dose for 2 hours followed by addition of FK506 for 24 hours. LLC-PK1 cells were treated with FK506 and THC, and cell viability and glutathione was measured. The number of apoptotic cells was measured using an annexin V/propidium iodide staining with flow cytometry. The effect of apoptosis by THC in LLC-PK1 cells was determined by measuring the caspase-9, caspase-3, B-cell lymphoma-2 (Bcl-2), and Bcl-2-associated X protein levels using Western blotting analyses. Results: FK506-induced LLC-PK1 renal cell damage was markedly ameliorated by THC treatment. THC protected LLC-PK1 cells by preventing FK506-induced glutathione decrease. THC protects against FK506-induced apoptosis in LLC-PK1 cells. Apoptosis was significantly decreased, and Bcl-2 was elevated in the THC-treated group. Bcl-2-associated X protein, caspase-3, and caspase-9 were decreased in the THC-treated group. Conclusion: These results collectively provide therapeutic evidence that THC ameliorates the FK506-induced renal damage via antioxidant effect and apoptosis inhibition.
MeSH term(s)	Animals ; Antioxidants/pharmacology ; Apoptosis/drug effects ; Cell Survival/drug effects ; Curcumin/analogs & derivatives ; Curcumin/pharmacology ; Immunosuppressive Agents/toxicity ; Kidney/drug effects ; LLC-PK1 Cells/drug effects ; Oxidative Stress/drug effects ; Swine ; Tacrolimus/toxicity
Chemical Substances	Antioxidants ; Immunosuppressive Agents ; tetrahydrocurcumin (00U0645U03) ; Curcumin (IT942ZTH98) ; Tacrolimus (WM0HAQ4WNM)
Language	English
Publishing date	2018-03-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	82046-5
ISSN	1873-2623 ; 0041-1345
ISSN (online)	1873-2623
ISSN	0041-1345
DOI	10.1016/j.transproceed.2018.03.031
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Article ; Online: A cost-effective cell- and matrix-based minimally invasive single-stage chondroregenerative technique developed with validated vertical translation methodology.

Shetty, A A / Kim, S J / Ahmed, S / Trattnig, S / Kim, S A / Jang, H J

Annals of the Royal College of Surgeons of England

2018 Volume 100, Issue 3, Page(s) 240–246

Abstract: Introduction The morbidity and significant health economic impact associated with the chondral lesion has led to a large number of strategies for therapeutic neochondrogenesis. The challenge has been to develop techniques that are cost effective single- ... ...

Abstract	Introduction The morbidity and significant health economic impact associated with the chondral lesion has led to a large number of strategies for therapeutic neochondrogenesis. The challenge has been to develop techniques that are cost effective single-stage procedures with minimal surgical trauma that have undergone rigorous preclinical scrutiny and robust reproducible assessment of effectiveness. A biological repair requires the generation of a cellular and matrix composite with appropriate signalling for chondrogenic differentiation. Methods and results A technique was developed that allowed chondrogenic primary (uncultured) cells from bone marrow aspirate concentrate, combined with a composite hydrophilic and fibrillar matrix to be applied arthroscopically to a site of a chondral lesion. The construct was tested in vitro and in animal experiments before clinical trials. Clinical trials involved 60 patients in a prospective study. Symptomatic International Cartilage Repair Society grade 3 and 4a lesions were mapped and treated. Pre- and postoperative clinical assessments showed statistically significant improved outcomes; Lysholm Knee Scoring Scale (mean 52.8 to > 76.4; P < 0.05) International Knee Documentation Committee (mean 39 to > 79 P < 0.05) and Knee injury and Osteoarthritis Outcome Score (64.5 to >89.2 P < 0.05). Postoperative magnetic resonance imaging was evaluated morphologically (magnetic resonance observation of cartilage repair tissue, average MOCART score 72) and qualitatively; the regenerate was comparable to native cartilage. Conclusions This technique is effective, affordable, requires no complex tools and delivers a single-stage treatment that is potentially accessible to any centre capable of performing arthroscopic surgery. Good clinical results were found to be sustained at five years of follow-up with a regenerate that appears hyaline like using multiple magnetic resonance measures.
MeSH term(s)	Adult ; Animals ; Arthroscopy/economics ; Arthroscopy/methods ; Cartilage Diseases/economics ; Cartilage Diseases/surgery ; Cartilage, Articular/pathology ; Cartilage, Articular/physiology ; Cartilage, Articular/surgery ; Chondrogenesis ; Cost-Benefit Analysis ; Female ; Follow-Up Studies ; Guided Tissue Regeneration/economics ; Guided Tissue Regeneration/methods ; Humans ; Knee Joint/surgery ; Male ; Mesenchymal Stem Cell Transplantation/economics ; Mesenchymal Stem Cell Transplantation/methods ; Middle Aged ; Prospective Studies ; Rabbits ; Translational Medical Research ; Treatment Outcome ; United Kingdom
Language	English
Publishing date	2018-03-14
Publishing country	England
Document type	Clinical Trial ; Journal Article
ZDB-ID	80044-2
ISSN	1478-7083 ; 0035-8843
ISSN (online)	1478-7083
ISSN	0035-8843
DOI	10.1308/rcsann.2017.0223
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Article ; Online: A self-amplified transistor immunosensor under dual gate operation: highly sensitive detection of hepatitis B surface antigen.

Lee, I-K / Jeun, M / Jang, H-J / Cho, W-J / Lee, K H

Nanoscale

2015 Volume 7, Issue 40, Page(s) 16789–16797

Abstract: Ion-sensitive field-effect transistors (ISFETs), although they have attracted considerable attention as effective immunosensors, have still not been adopted for practical applications owing to several problems: (1) the poor sensitivity caused by the ... ...

Abstract	Ion-sensitive field-effect transistors (ISFETs), although they have attracted considerable attention as effective immunosensors, have still not been adopted for practical applications owing to several problems: (1) the poor sensitivity caused by the short Debye screening length in media with high ion concentration, (2) time-consuming preconditioning processes for achieving the highly-diluted media, and (3) the low durability caused by undesirable ions such as sodium chloride in the media. Here, we propose a highly sensitive immunosensor based on a self-amplified transistor under dual gate operation (immuno-DG ISFET) for the detection of hepatitis B surface antigen. To address the challenges in current ISFET-based immunosensors, we have enhanced the sensitivity of an immunosensor by precisely tailoring the nanostructure of the transistor. In the pH sensing test, the immuno-DG ISFET showed superior sensitivity (2085.53 mV per pH) to both standard ISFET under single gate operation (58.88 mV per pH) and DG ISFET with a non-tailored transistor (381.14 mV per pH). Moreover, concerning the detection of hepatitis B surface antigens (HBsAg) using the immuno-DG ISFET, we have successfully detected trace amounts of HBsAg (22.5 fg mL(-1)) in a non-diluted 1× PBS medium with a high sensitivity of 690 mV. Our results demonstrate that the proposed immuno-DG ISFET can be a biosensor platform for practical use in the diagnosis of various diseases.
MeSH term(s)	Biosensing Techniques/instrumentation ; Biosensing Techniques/methods ; Hepatitis B/diagnosis ; Hepatitis B/immunology ; Hepatitis B Surface Antigens/analysis ; Hepatitis B Surface Antigens/immunology ; Hepatitis B virus/chemistry ; Hepatitis B virus/immunology ; Transistors, Electronic
Chemical Substances	Hepatitis B Surface Antigens
Language	English
Publishing date	2015-10-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2515664-0
ISSN	2040-3372 ; 2040-3364
ISSN (online)	2040-3372
ISSN	2040-3364
DOI	10.1039/c5nr03146j
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Article ; Online: Differential modulation of phasic and tonic inhibition underlies serotonergic suppression of long-term potentiation in the rat visual cortex.

Jang, H-J / Cho, K-H / Joo, K / Kim, M-J / Rhie, D-J

Neuroscience

2015 Volume 301, Page(s) 351–362

Abstract: GABA receptor type A (GABA(A)R)-mediated inhibition is divided into phasic and tonic inhibition. GABA(A)Rs mediating the two inhibitory modalities exhibit differences in subcellular localization and subunit composition. We previously demonstrated that ... ...

Abstract	GABA receptor type A (GABA(A)R)-mediated inhibition is divided into phasic and tonic inhibition. GABA(A)Rs mediating the two inhibitory modalities exhibit differences in subcellular localization and subunit composition. We previously demonstrated that phasic and tonic inhibition are independently regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and protein kinase A (PKA), respectively. Since modulation of GABA(A)Rs by phosphorylation differs depending on subunit composition and protein kinases, phasic and tonic inhibition might be differentially regulated by a single neuromodulator activating multiple protein kinases. However, the neuromodulatory control for phasic and tonic inhibition is largely unknown. Thus, in the present study, we concurrently investigated the serotonin (5-HT) regulation of phasic and tonic inhibition and its functional implication in the pyramidal neurons of the rat visual cortex. Interestingly, 5-HT enhanced phasic inhibition but suppressed tonic inhibition. Increase in phasic inhibition was mediated by 5-HT2 receptor and CaMKII, whereas decrease in tonic inhibition depended on 5-HT1A receptor and PKA. Thus, phasic and tonic inhibition might be independently regulated even by a single neuromodulator. Functionally, the opposite modulation of phasic and tonic inhibition decreased the summation of consecutive excitatory postsynaptic potentials (EPSPs) without affecting the shape of single EPSPs, which might underlie the suppression of the induction of long-term potentiation by 5-HT. These results suggest that the integrative regulation of phasic and tonic inhibition provides mechanisms for elaborate modulation of shape and summation of EPSPs and long-term synaptic plasticity.
MeSH term(s)	Animals ; Drug Interactions ; Electric Stimulation ; Excitatory Amino Acid Agents/pharmacology ; GABA Agents/pharmacology ; In Vitro Techniques ; Inhibitory Postsynaptic Potentials/drug effects ; Intracellular Signaling Peptides and Proteins/pharmacology ; Long-Term Potentiation/drug effects ; Long-Term Potentiation/physiology ; Neural Inhibition/drug effects ; Neural Inhibition/physiology ; Patch-Clamp Techniques ; Rats ; Rats, Sprague-Dawley ; Serotonergic Neurons/drug effects ; Serotonergic Neurons/physiology ; Serotonin Agents/pharmacology ; Visual Cortex/cytology
Chemical Substances	Excitatory Amino Acid Agents ; GABA Agents ; Intracellular Signaling Peptides and Proteins ; Serotonin Agents ; protein kinase modulator
Language	English
Publishing date	2015-08-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	196739-3
ISSN	1873-7544 ; 0306-4522
ISSN (online)	1873-7544
ISSN	0306-4522
DOI	10.1016/j.neuroscience.2015.06.018
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Article ; Online: Effortful swallow enhances vertical hyolaryngeal movement and prolongs duration after maximal excursion.

Jang, H J / Leigh, J H / Seo, H G / Han, T R / Oh, B M

Journal of oral rehabilitation

2015 Volume 42, Issue 10, Page(s) 765–773

Abstract: Effortful swallowing (EFS) is a common compensatory swallowing manoeuver for dysphagia patients. We investigated the influence of EFS on temporal and spatial characteristics of the movements of the hyoid bone, larynx and epiglottis in healthy subjects. A ...

Abstract	Effortful swallowing (EFS) is a common compensatory swallowing manoeuver for dysphagia patients. We investigated the influence of EFS on temporal and spatial characteristics of the movements of the hyoid bone, larynx and epiglottis in healthy subjects. A total of 41 volunteers swallowed 10 mL of diluted barium solution using two swallowing strategies: usual and effortful swallowing (USS and EFS). The motions of the hyoid bone, larynx and epiglottis were tracked using frame-by-frame kinematic motion analysis of videofluoroscopic images. Maximal velocities and maximal displacements of hyoid and larynx, the maximal angle of the epiglottic tilt, and the durations of hyoid excursion, laryngeal elevation and epiglottic tilt were measured. Compared to USS, EFS was associated with significantly greater vertical displacement of the hyoid (P < 0.001), vertical and horizontal displacement of the larynx (P = 0.003, P = 0.019), and maximal angle of the epiglottic tilt (P = 0.001). In addition, the durations of the vertical and horizontal excursions of the hyoid, vertical excursion of the larynx and the epiglottic tilt were greater in EFS, compared with USS. Effortful swallowing was also associated with significantly greater maximum velocities of the hyoid and larynx during swallowing. In conclusion, the EFS manoeuver facilitates vertical speed and distance of hyolaryngeal excursion and epiglottic tilt and extends the duration of excursion and the epiglottic tilt, especially after reaching maximal excursion in healthy subjects. These results confirm the temporal and kinematic benefits of airway protection induced by the EFS manoeuver.
MeSH term(s)	Adult ; Aged ; Biomechanical Phenomena ; Deglutition/physiology ; Epiglottis/physiology ; Female ; Fluoroscopy/methods ; Humans ; Hyoid Bone/physiology ; Larynx/physiology ; Male ; Middle Aged ; Movement/physiology ; Video Recording ; Young Adult
Language	English
Publishing date	2015-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	187079-8
ISSN	1365-2842 ; 0305-182X
ISSN (online)	1365-2842
ISSN	0305-182X
DOI	10.1111/joor.12312
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Article ; Online: Outcomes of En Bloc Kidney Transplantation From Pediatric Donors: A Single-Center Experience.

Choi, J Y / Jung, J H / Kwon, J G / Shin, S / Kim, Y H / Jang, H J / Han, D J

Transplantation proceedings

2017 Volume 49, Issue 5, Page(s) 977–981

Abstract: Background: To overcome a shortage of donors, cadaveric pediatric en bloc kidneys can be used to expand the donor pool. Recent evidence shows that en bloc kidney transplantation (EBKT) has better outcomes than standard-criteria deceased adult donor ... ...

Abstract	Background: To overcome a shortage of donors, cadaveric pediatric en bloc kidneys can be used to expand the donor pool. Recent evidence shows that en bloc kidney transplantation (EBKT) has better outcomes than standard-criteria deceased adult donor kidney transplantation. We reviewed our experiences of EBKT and their outcomes. Methods: From September 1996 to January 2016, 15 EBKTs were performed in Asan Medical Center. The characteristics of donors and recipients were analyzed. Graft survival was analyzed by means of serum creatinine levels. Results: Nine male and 6 female donors were used. The mean age and body weight of donors was 2.79 years (range, 0.25-14) and 13.14 kg (range, 5.5-35). The mean weight of en bloc kidneys was 117.43 g (range, 36-146). Recipient median age was 39.13 years and body weight was 49.47 kg. Ureteral anastomosis was performed by means of side-to-side anastomosis and then bladder anastomosis in 9 patients and by bladder patch anastomosis in 4 patients. Serum creatinine levels at discharge and latest follow-up were 0.97 mg/dL (range, 0.7-1.54) and 0.89 mg/dL (range, 0.44-2.58). Delayed graft function developed in 3 patients and clinical rejection developed in 2 patients. We performed graftectomy on post-operative day 1 because of graft thrombosis. The rest maintained their graft function well. Graft survival was comparable with that of kidney transplantation from standard donors. Conclusions: EBKT showed excellent graft function and outcomes at our center. As an approach to expand the donor pool and improve graft utilization, EBKT is acceptable and should be more widely used.
Language	English
Publishing date	2017-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	82046-5
ISSN	1873-2623 ; 0041-1345
ISSN (online)	1873-2623
ISSN	0041-1345
DOI	10.1016/j.transproceed.2017.03.028
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