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Article ; Online: Residual pure intralymphatic carcinoma component only (lymphovascular tumor emboli without invasive carcinoma) after neoadjuvant chemotherapy is associated with poor outcome: Not pathologic complete response.

Lee, Hyunwoo / Jang, Yunjeong / Cho, Yoon Ah / Cho, Eun Yoon

2024 Volume 145, Page(s) 1–8

Abstract: Residual pure intralymphatic carcinoma (PIC) component only after neoadjuvant chemotherapy (NAC) is lymphovascular tumor emboli without invasive carcinoma and extremely rare form of residual tumor after NAC. Although several studies have been published, ... ...

Abstract	Residual pure intralymphatic carcinoma (PIC) component only after neoadjuvant chemotherapy (NAC) is lymphovascular tumor emboli without invasive carcinoma and extremely rare form of residual tumor after NAC. Although several studies have been published, the prognostic influence of residual PIC component only had not been fully evaluated. This study aims to evaluate the clinicopathologic features and the prognostic value of residual PIC component only. We reviewed the 251 patients with no residual invasive carcinoma in breast after NAC and found 12 patients with residual PIC component only after NAC. Five cases were triple negative, 6 were HER2 positive, and 1 was estrogen receptor positive and HER2 negative. The extent of PIC component ranged from 0.18 to 50.00 mm. The detailed microscopic PIC component findings did not significantly correlate with regional lymph node metastasis, local recurrence, or distant metastasis (p > 0.05). In multivariate survival analysis, the presence of lymph node metastasis and pretreatment ki-67 labeling index more than 50 % was statistically associated with greater risk of relapse [Cox proportional hazards ratio (HR) = 3.236, 95 % confidence interval (CI), 1.461-7.280, p = 0.004; HR = 3.046, 95 % CI, 1.421-6.529, p = 0.004, respectively) and residual PIC component only tended to be associated with greater risk of relapse (HR = 2.378, 95 % CI, 0.853-6.631; p = 0.098), but not reached to statistically significance. In patients without lymph node metastasis, the presence of residual PIC component only was associated with worse disease-free survival (p = 0.004). Although the number of published studies still limited, residual residual PIC component only after NAC is associated with poor outcome, and it should not be considered as pathological complete response.
MeSH term(s)	Humans ; Female ; Lymphatic Metastasis ; Neoadjuvant Therapy ; Neoplasm Recurrence, Local ; Prognosis ; Carcinoma ; Pathologic Complete Response ; Recurrence ; Breast Neoplasms/drug therapy ; Chemotherapy, Adjuvant ; Neoplasm, Residual ; Retrospective Studies
Language	English
Publishing date	2024-02-02
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	207657-3
ISSN	1532-8392 ; 0046-8177
ISSN (online)	1532-8392
ISSN	0046-8177
DOI	10.1016/j.humpath.2024.02.002
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Article: Comparison of participant and non-participant perceptions on healthy restaurant for sodium reduction: a qualitative study.

Pyo, Jeehee / Lee, Mina / Jang, Yunjeong / Ock, Minsu

Nutrition research and practice

2023 Volume 17, Issue 3, Page(s) 503–515

Abstract: Background/objectives: In the Republic of Korea, "Healthy Restaurant for Sodium Reduction (HRSR)" project have been designated as one of the representative policies for sodium intake reduction. However, as of 2021, only 879 restaurants, less than 0.1% ... ...

Abstract	Background/objectives: In the Republic of Korea, "Healthy Restaurant for Sodium Reduction (HRSR)" project have been designated as one of the representative policies for sodium intake reduction. However, as of 2021, only 879 restaurants, less than 0.1% of all restaurants, had been designated. Therefore, to increase the participation of restaurants in this policy, it is necessary to examine the in-depth perception and experience of participants and non-participants in the HRSR. Materials/methods: Two focus group discussions were conducted for HRSR project participants and non-participants. Results: A total of 260 semantic units were derived from the 2 groups. The units were further classified into 5 upper categories and 11 subcategories. All the study participants knew the importance of low sodium intake, but they had little information on HRSR project. Various attempts have been made to encourage low sodium practice in restaurants, and the participants reported that the amount of salt used in their restaurants currently is reduced compared to that used in the past. However, they were worried about customers' complaints about the low sodium in their diet and the insignificant beneficent associated with the policy, which makes restaurant owners reluctant to participate in this policy. All the participants agreed on the urgent need for the improvement of public awareness of low-sodium diets and for substantive government support for HRSR. Conclusion: This study concluded that strategies such as more active publicity for the practice of sodium reduction in restaurants, identification of approaches to dispel the perception that low-salt diet is not tasty, and development of plans to increase the sale of food in of HRSR, are needed.
Language	English
Publishing date	2023-02-20
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2387946-4
ISSN	2005-6168 ; 1976-1457
ISSN (online)	2005-6168
ISSN	1976-1457
DOI	10.4162/nrp.2023.17.3.503
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Article ; Online: Effects of preoperative personal education on shoulder function and lymphedema in patients with breast cancer: A consort.

Byun, Hayoung / Jang, Yunjeong / Kim, Ju-Yeon / Kim, Jae-Myung / Lee, Chang Han

Medicine

2022 Volume 101, Issue 38, Page(s) e30810

Abstract: Background: To compare the incidence and severity of ipsilateral shoulder dysfunction and lymphedema of 2 groups of patients needing to undergo unilateral breast cancer surgery, one of which had only received printed education materials and the other ... ...

Abstract	Background: To compare the incidence and severity of ipsilateral shoulder dysfunction and lymphedema of 2 groups of patients needing to undergo unilateral breast cancer surgery, one of which had only received printed education materials and the other group which had received educational materials plus preoperative education. Methods: We selected 61 patients who had been diagnosed with unilateral breast cancer and planned to undergo surgery. Before surgery, patients were randomly assigned, either to a control group that only received printed education materials about exercise for shoulder pain relief and lymphatic edema prevention following breast cancer surgery, or to an experimental group that received the printed education material with personal education. Participants were evaluated at 1, 3, 6, and 12 months after the surgery. To evaluate the impairment of shoulder function, we measured the passive shoulder range of motion (ROM), the degree of pain as visual analog scale (VAS), the short version of the disability of arm, shoulder, and hand (short DASH) scores, and the shoulder pain and disability index (SPADI). We checked arm circumferences to evaluate lymphedema. Results: There was no significant difference in demographic or clinical variables between the control and experimental groups. The experimental group showed significantly less limitation in abduction (P = .042) and forward flexion (P = .039) in the 6 months following surgery. Change in the VAS, short DASH, and SPADI scores were 1.633 (P < .001), 2.167 (P < .001), and 4.1 (P = .003) at 1 month following surgery, respectively. These then decreased with time. These changes started before shoulder ROM and arm circumference changes had occurred, which had started 3 months following surgery. Conclusions: Preoperative education might be helpful for the prevention of a shoulder ROM limitation, and we need to focus on pain and disability in patients immediately following breast cancer surgery, and then on ROM and lymphedema.
MeSH term(s)	Breast Neoplasms/complications ; Female ; Humans ; Lymphedema/etiology ; Lymphedema/prevention & control ; Range of Motion, Articular ; Shoulder/surgery ; Shoulder Pain/complications ; Shoulder Pain/prevention & control ; Unilateral Breast Neoplasms
Language	English
Publishing date	2022-10-05
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000030810
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Article ; Online: Malnutrition and Associated Factors in Acute and Subacute Stroke Patients with Dysphagia.

Yoon, Jiyong / Baek, Soyeong / Jang, Yunjeong / Lee, Chang Han / Lee, Eun Shin / Byun, Hayoung / Oh, Min-Kyun

Nutrients

2023 Volume 15, Issue 17

Abstract: Most patients with stroke suffer from complications and these include dysphagia. Dysphagia can cause malnutrition, and malnutrition affects prognosis and recovery. However, there is a lack of accurate studies on the nutritional status of stroke patients ... ...

Abstract	Most patients with stroke suffer from complications and these include dysphagia. Dysphagia can cause malnutrition, and malnutrition affects prognosis and recovery. However, there is a lack of accurate studies on the nutritional status of stroke patients with dysphagia and its associated factors in different phases of stroke. This study retrospectively investigated 620 stroke patients who underwent a videofluoroscopic swallowing study (VFSS) due to dysphagia, from March 2018 to February 2021. The study aimed to evaluate the nutritional state and associated factors of malnutrition in acute and subacute stroke patients with dysphagia. Serum albumin and percentage of current weight to ideal weight were used to determine nutritional status. Malnutrition was observed in 58.9 and 78.9% of acute and subacute stroke patients. Exact logistic regression analysis revealed that old age and high penetration-aspiration scale score were significantly associated factors for malnutrition in patients with acute stroke. Old age, stroke history, bilateral hemiplegia, high modified Rankin score, low Korean Mini-Mental State Examination, pneumonia, and high functional dysphagia score were significantly associated factors for malnutrition in patients with subacute stroke. Patients with these associated factors in each phase of stroke require active nutritional assessment and care to decrease the risk of malnutrition.
MeSH term(s)	Humans ; Deglutition Disorders/diagnosis ; Deglutition Disorders/epidemiology ; Deglutition Disorders/etiology ; Retrospective Studies ; Malnutrition/complications ; Malnutrition/diagnosis ; Nutritional Status ; Stroke/complications
Language	English
Publishing date	2023-08-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15173739
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Article: Human Epidermal Growth Factor Receptor 2-positive Mucinous Carcinoma with Signet Ring Cell Differentiation, Which Showed Complete Response after Neoadjuvant Chemotherapy.

Jang, Yunjeong / Cho, Eun Yoon / Cho, Soo Youn

Journal of breast cancer

2019 Volume 22, Issue 2, Page(s) 336–340

Abstract: Mucinous carcinoma (MC) is a rare subtype of breast cancer, which is composed of tumor cells floating in the abundant extracellular mucin. This form of cancer is usually estrogen receptor/progesterone receptor positive and human epidermal growth factor ... ...

Abstract	Mucinous carcinoma (MC) is a rare subtype of breast cancer, which is composed of tumor cells floating in the abundant extracellular mucin. This form of cancer is usually estrogen receptor/progesterone receptor positive and human epidermal growth factor receptor 2 (HER2) negative. Here, we present a case of HER2-positive MC with an unusual signet ring cell differentiation. It is very rare that a breast tumor consists entirely of signet ring cells. The tumor showed pathologic complete response (pCR) after neoadjuvant chemotherapy with trastuzumab and pertuzumab. pCR of HER2-positive MC has rarely been described in literature. It is important to consider the biological heterogeneity of MCs for effective management.
Language	English
Publishing date	2019-06-28
Publishing country	Korea (South)
Document type	Case Reports
ZDB-ID	2559753-X
ISSN	2092-9900 ; 1738-6756
ISSN (online)	2092-9900
ISSN	1738-6756
DOI	10.4048/jbc.2019.22.e17
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Article ; Online: Musculoskeletal Pain, Physical Activity, Muscle Mass, and Mortality in Older Adults: Results from the Korean Longitudinal Study on Health and Aging (KLoSHA).

Hwang, Sun-Woo / Kim, Chang-Woo / Jang, Yun-Jeong / Lee, Chang-Han / Oh, Min-Kyun / Kim, Ki-Woong / Jang, Hak-Chul / Lim, Jae-Young / Chun, Se-Woong / Lim, Seung-Kyu

Medicina (Kaunas, Lithuania)

2024 Volume 60, Issue 3

Abstract: Background and objectives: ...

Abstract	Background and objectives:
MeSH term(s)	Humans ; Aged ; Musculoskeletal Pain ; Longitudinal Studies ; Cohort Studies ; Quality of Life ; Prospective Studies ; Aging/physiology ; Low Back Pain ; Exercise ; Republic of Korea/epidemiology ; Muscles
Language	English
Publishing date	2024-03-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina60030462
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Article ; Online: Association between dyslipidemia and the risk of incident chronic kidney disease affected by genetic susceptibility: Polygenic risk score analysis.

Weon, Boram / Jang, Yunjeong / Jo, Jinyeon / Jin, Wencheng / Ha, Seounguk / Ko, Ara / Oh, Yun Kyu / Lim, Chun Soo / Lee, Jung Pyo / Won, Sungho / Lee, Jeonghwan

PloS one

2024 Volume 19, Issue 4, Page(s) e0299605

Abstract: Background: The effect of dyslipidemia on kidney disease outcomes has been inconclusive, and it requires further clarification. Therefore, we aimed to investigate the effects of genetic factors on the association between dyslipidemia and the risk of ... ...

Abstract	Background: The effect of dyslipidemia on kidney disease outcomes has been inconclusive, and it requires further clarification. Therefore, we aimed to investigate the effects of genetic factors on the association between dyslipidemia and the risk of chronic kidney disease (CKD) using polygenic risk score (PRS). Methods: We analyzed data from 373,523 participants from the UK Biobank aged 40-69 years with no history of CKD. Baseline data included plasma levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride, as well as genome-wide genotype data for PRS. Our primary outcome, incident CKD, was defined as a composite of estimated glomerular filtration rate < 60 ml/min/1.73 m2 and CKD diagnosis according to International Classification of Disease-10 codes. The effects of the association between lipid levels and PRS on incident CKD were assessed using the Cox proportional hazards model. To investigate the effect of this association, we introduced multiplicative interaction terms into a multivariate analysis model and performed subgroup analysis stratified by PRS tertiles. Results: In total, 4,424 participants developed CKD. In the multivariable analysis, PRS was significantly predictive of the risk of incident CKD as both a continuous variable and a categorized variable. In addition, lower total cholesterol, LDL-C, HDL-C, and higher triglyceride levels were significantly associated with the risk of incident CKD. There were interactions between triglycerides and intermediate and high PRS, and the interactions were inversely associated with the risk of incident CKD. Conclusions: This study showed that PRS presented significant predictive power for incident CKD and individuals in the low-PRS group had a higher risk of triglyceride-related incident CKD.
MeSH term(s)	Humans ; Genetic Risk Score ; Renal Insufficiency, Chronic/epidemiology ; Renal Insufficiency, Chronic/genetics ; Triglycerides ; Cholesterol, HDL ; Dyslipidemias/complications ; Dyslipidemias/genetics ; Genetic Predisposition to Disease ; Risk Factors
Chemical Substances	Triglycerides ; Cholesterol, HDL
Language	English
Publishing date	2024-04-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0299605
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Article ; Online: Medication Adherence and Persistence of Open-Angle Glaucoma Patients in Korea: A Retrospective Study Using National Health Insurance Claims Data.

Jang, Yunjeong / Jee, Donghyun / Lee, Donghwan / Choi, Nam-Kyong / Bae, SeungJin

International journal of environmental research and public health

2021 Volume 18, Issue 8

Abstract: This study aimed to analyze medication adherence and persistence among open-angle glaucoma patients in Korea. A retrospective study was conducted using the Korean National Health Insurance (NHI) claims database from 2016 to 2019. Newly diagnosed open- ... ...

Abstract	This study aimed to analyze medication adherence and persistence among open-angle glaucoma patients in Korea. A retrospective study was conducted using the Korean National Health Insurance (NHI) claims database from 2016 to 2019. Newly diagnosed open-angle glaucoma patients who were prescribed with the intraocular pressure (IOP)-lowering eyedrops were included. Adherence was measured using the medication possession ratio (MPR), and persistence was measured using the duration of therapy during the 24 month follow-up period. During the study period, 14,648 open-angle glaucoma patients were identified, and 3118 (21.3%) and 4481 patients (30.6%) were adherent to and persistent with their glaucoma treatment, respectively. The mean MPR was 48.8%, and the mean duration of therapy was 357.2 days. Logistic regression analysis showed that patients who are older, female, using prostaglandins as the index medication, and visiting secondary or tertiary hospitals were significantly associated with greater rates of adherence (odds ratio (OR) = 1.21, 1.12, 1.27, and 1.73, respectively) and persistence (OR = 1.11, 1.17, 1.16, 1.17, and 1.36, respectively) during the study period. Patients with open-angle glaucoma in Korea had substandard medication adherence and discontinued their treatment. Ophthalmologists should pay more attention to younger, male patients to improve adherence.
MeSH term(s)	Antihypertensive Agents/therapeutic use ; Female ; Glaucoma, Open-Angle/drug therapy ; Glaucoma, Open-Angle/epidemiology ; Humans ; Male ; Medication Adherence ; National Health Programs ; Republic of Korea ; Retrospective Studies
Chemical Substances	Antihypertensive Agents
Language	English
Publishing date	2021-04-13
Publishing country	Switzerland
Document type	Journal Article
ISSN	1660-4601
ISSN (online)	1660-4601
DOI	10.3390/ijerph18084106
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Article ; Online: Factors Contributing to Successful Transvenous Retrograde Thoracic Duct Cannulation.

Kim, Hyeongchun / Hyun, Dongho / Shin, Sung Wook / Jeong, Guseong / Kim, Jungon / Cho, Jong Ho / Lee, Ho Yun / Jang, Yunjeong

Journal of vascular and interventional radiology : JVIR

2022 Volume 34, Issue 2, Page(s) 205–211

Abstract: Purpose: To identify key factors for successful transvenous retrograde cannulation (TVRC) of the thoracic duct.: Materials and methods: A total of 47 consecutive patients (62.1 ± 13.2 years; 32 men) who underwent attempted TVRC between July 2016 and ... ...

Abstract	Purpose: To identify key factors for successful transvenous retrograde cannulation (TVRC) of the thoracic duct. Materials and methods: A total of 47 consecutive patients (62.1 ± 13.2 years; 32 men) who underwent attempted TVRC between July 2016 and July 2021 were included. Reasons for interventions were chylous leakage from the chest (n = 36), abdomen (n = 6), and other sites (n = 5). Patient age, sex, access vein (femoral vs brachial), anatomic classification (presence of dominant channel vs plexiform) of the terminal thoracic duct, and engagement of a diagnostic catheter into the jugulovenous junction were included in the analyses. Anatomic details were evaluated according to catheter-based high-pressure lymphangiography and conventional intranodal lymphangiography. The Firth bias-reduced penalized-likelihood logistic regression model was used to analyze prognostic factors. Results: TVRC was successful in 33 of the 47 patients (70%). In univariate analysis, femoral access, diagnostic catheter engagement, and presence of dominant channel were significant positive prognostic factors (P <.05). In multivariate analysis, diagnostic catheter engagement and presence of dominant channel were significant prognostic factors (P <.05). Diagnostic catheter engagement showed the highest prognostic performance (accuracy = 0.872), followed by presence of a dominant channel. High-pressure catheter-based lymphangiographic findings showed better performance (accuracy, 0.844 vs 0.727) than intranodal lymphangiography to delineate the anatomy of the terminal thoracic duct. Conclusions: A secure selection of the jugulovenous junction and the presence of a dominant channel in the terminal portion of the thoracic duct were significant prognostic factors for successful TVRC.
MeSH term(s)	Male ; Humans ; Chylothorax/diagnostic imaging ; Chylothorax/therapy ; Thoracic Duct/diagnostic imaging ; Catheterization ; Lymphography ; Catheters ; Embolization, Therapeutic
Language	English
Publishing date	2022-10-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	1137756-2
ISSN	1535-7732 ; 1051-0443
ISSN (online)	1535-7732
ISSN	1051-0443
DOI	10.1016/j.jvir.2022.10.037
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Article ; Online: Hepatic Angiosarcoma: Clinicopathologic Study With an Investigation of ROS1 Gene Rearrangements.

Jung, Hera / Kim, Han-Na / Jang, Yunjeong / Park, Cheol-Keun / Shin, So-Hyun / Ha, Sang Yun

In vivo (Athens, Greece)

2020 Volume 34, Issue 3, Page(s) 1463–1467

Abstract: Background/aim: Primary hepatic angiosarcoma (PHA) is a rare disease entity with variable morphologic features. Recent findings regarding ROS1 gene rearrangements in PHA may lead to new targeted therapies.: Patients and methods: Thirteen cases (4 ... ...

Abstract	Background/aim: Primary hepatic angiosarcoma (PHA) is a rare disease entity with variable morphologic features. Recent findings regarding ROS1 gene rearrangements in PHA may lead to new targeted therapies. Patients and methods: Thirteen cases (4 resected specimens and 9 biopsy samples) underwent histologic review and morphologic patterns were classified according to a previous study as 1) sinusoidal, 2) peliotic, 3) vasoformative, and 4) solid (epithelioid/spindled). ROS1 immunohistochemistry and investigation of the presence of a ROS1 fusion gene by reverse transcription-polymerase chain reaction were performed in available cases. Results: Eight of 13 cases (62%) showed vasoformative patterns. Three cases (23%) were classified as sinusoidal and two (15%) as solid patterns. Mortality rate was 90% (9/10) except for three patients lost in follow up. Only one patient is still alive and has survived for 8 months with the disease. All cases tested did not have ROS1 expression (0/9) or a ROS1 fusion gene (0/4). Conclusion: We report 13 cases of PHA with 90% mortality. Vasoformative PHA is the most common histologic type. New findings on ROS1 fusion gene rearrangements could lead to the development of novel targeted therapeutics for PHA patients with dismal prognosis.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Child, Preschool ; Female ; Gene Rearrangement ; Hemangiosarcoma/diagnosis ; Hemangiosarcoma/genetics ; Hemangiosarcoma/metabolism ; Hemangiosarcoma/mortality ; Humans ; Immunohistochemistry ; Korea ; Liver Neoplasms/diagnosis ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism ; Liver Neoplasms/mortality ; Male ; Middle Aged ; Neoplasm Grading ; Neoplasm Staging ; Prognosis ; Protein-Tyrosine Kinases/genetics ; Protein-Tyrosine Kinases/metabolism ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins/metabolism ; Young Adult
Chemical Substances	Proto-Oncogene Proteins ; Protein-Tyrosine Kinases (EC 2.7.10.1) ; ROS1 protein, human (EC 2.7.10.1)
Language	English
Publishing date	2020-04-27
Publishing country	Greece
Document type	Journal Article
ZDB-ID	807031-3
ISSN	1791-7549 ; 0258-851X
ISSN (online)	1791-7549
ISSN	0258-851X
DOI	10.21873/invivo.11930
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