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  1. AU="Jang Hoon Kim"
  2. AU="Person, Maria D"
  3. AU="Maricato, Juliana"
  4. AU="Mallo, Federico"
  5. AU="Chatterjee, G.C"
  6. AU="Charrier, Alicia"
  7. AU="Pearson, Amelia"
  8. AU="Yang, Zhiqi"
  9. AU="Chen, John"
  10. AU="Yildirim, Sinan"
  11. AU="Percopo, Caroline"
  12. AU="Nevian, Thomas"
  13. AU="Matthias Arnold"
  14. AU="Abbonante, Francesco"
  15. AU=Cao Yongsen
  16. AU="Mei, Guoliang"
  17. AU="G.Kang, "
  18. AU="Djimdé, Abdoulaye"
  19. AU="Bone, Nathaniel"
  20. AU="Zhou, Yuewen"
  21. AU="Lynch, Stephen M"
  22. AU=Collins Jannette
  23. AU=Kim Soo-Kyoung
  24. AU=Atkinson Sarah H.
  25. AU=Ma Chunlong
  26. AU="Park, Youngjin"
  27. AU="Lakbita, Omar"
  28. AU=ElGokhy Sherin M
  29. AU="Stegmaier, Sabine"
  30. AU="Simons, Gemma N"
  31. AU="Domínguez-Zorita, Sonia"
  32. AU="Nakashima, Ayaka"
  33. AU="Skorecki, Karl"
  34. AU=Ibrahim Salwa
  35. AU=Geocadin Romergryko G
  36. AU="Leroy, J"
  37. AU="Wilson, Peter H"
  38. AU="Cunha, Carla Baroni"

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  1. Artikel ; Online: Anti-inflammatory of disenecionyl cis-khellactone in LPS-stimulated RAW264.7 cells and the its inhibitory activity on soluble epoxide hydrolase

    Ji Hyeon Park / Jang Hoon Kim / Seon Il Jang / Byoung Ok Cho

    Heliyon, Vol 9, Iss 10, Pp e21032- (2023)

    2023  

    Abstract: The objective of the present study was to investigate anti-inflammatory effects of disenecionyl cis-khellactone (DK) isolated from Peucedanum japonicum Thunberg, a traditional edible plant, in RAW264.7 cells stimulated with lipopolysaccharide (LPS). Anti- ...

    Abstract The objective of the present study was to investigate anti-inflammatory effects of disenecionyl cis-khellactone (DK) isolated from Peucedanum japonicum Thunberg, a traditional edible plant, in RAW264.7 cells stimulated with lipopolysaccharide (LPS). Anti-inflammatory effects of DK were analyzed using various techniques, including NO assay, Western blot analysis, enzyme-linked immunosorbent assay (ELISA), real-time PCR, and immunofluorescence staining. It was revealed that DK reduced the production of pro-inflammatory cytokines including Monocyte chemoattractant protein-1 (MCP-1), Tumor necrosis factor-α (TNF-α), Interleukin 1β (IL-1β), and Interleukin 6 (IL-6) in RAW264.7 cells stimulated with LPS. It was revealed that DK effectively downregulated expression levels of iNOS and COX-2 due to inhibition of NF-κB activation and suppressing the phosphorylation of p38 and jun N-terminal kinase (JNK) mitogen-activated protein kinase (MAPK) phosphorylation. Also, soluble epoxide hydrolase activity and expression were decreased by the proinflammatory inhibitor, DK. Finally, findings of this study suggest that DK isolated from P. japonicum might have potential as a therapeutic candidate for inflammatory diseases.
    Schlagwörter Peucedanum japonicum thunberg ; Disenecionyl cis-khellactone ; Anti-inflammation ; NF-κB ; MAPK ; Soluble epoxide hydrolase ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2023-10-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Eupatin, a Flavonoid, Inhibits Coronavirus 3CL Protease and Replication

    Yea-In Park / Jang Hoon Kim / Siyun Lee / Ik Soo Lee / Junsoo Park

    International Journal of Molecular Sciences, Vol 24, Iss 9211, p

    2023  Band 9211

    Abstract: The coronavirus disease 2019 (COVID-19) pandemic has caused more than six million deaths worldwide since 2019. Although vaccines are available, novel variants of coronavirus are expected to appear continuously, and there is a need for a more effective ... ...

    Abstract The coronavirus disease 2019 (COVID-19) pandemic has caused more than six million deaths worldwide since 2019. Although vaccines are available, novel variants of coronavirus are expected to appear continuously, and there is a need for a more effective remedy for coronavirus disease. In this report, we isolated eupatin from Inula japonica flowers and showed that it inhibits the coronavirus 3 chymotrypsin-like (3CL) protease as well as viral replication. We showed that eupatin treatment inhibits SARS-CoV-2 3CL-protease, and computational modeling demonstrated that it interacts with key residues of 3CL-protease. Further, the treatment decreased the number of plaques formed by human coronavirus OC43 (HCoV-OC43) infection and decreased viral protein and RNA levels in the media. These results indicate that eupatin inhibits coronavirus replication.
    Schlagwörter SARS-CoV-2 ; flavonoid ; 3CL protease ; Inula japonica ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 572
    Sprache Englisch
    Erscheinungsdatum 2023-05-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: The Luteolinidin and Petunidin 3- O -Glucoside

    Seo Young Yang / Jang Hoon Kim / Xiangdong Su / Jeong Ah Kim

    Molecules, Vol 27, Iss 5703, p

    A Competitive Inhibitor of Tyrosinase

    2022  Band 5703

    Abstract: The enzyme tyrosinase plays a key role in the early stages of melanin biosynthesis. This study evaluated the inhibitory activity of anthocyanidin ( 1 ) and anthocyanins ( 2 – 6 ) on the catalytic reaction. Of the six derivatives examined, 1 – 3 showed ... ...

    Abstract The enzyme tyrosinase plays a key role in the early stages of melanin biosynthesis. This study evaluated the inhibitory activity of anthocyanidin ( 1 ) and anthocyanins ( 2 – 6 ) on the catalytic reaction. Of the six derivatives examined, 1 – 3 showed inhibitory activity with IC 50 values of 3.7 ± 0.1, 10.3 ± 1.0, and 41.3 ± 3.2 μM, respectively. Based on enzyme kinetics, 1 – 3 were confirmed to be competitive inhibitors with K i values of 2.8, 9.0, and 51.9 μM, respectively. Molecular docking analysis revealed the formation of a binary encounter complex between 1 – 3 and the tyrosinase catalytic site. Luteolinidin ( 1 ) and petunidin 3- O -glucoside ( 2 ) may serve as tyrosinase inhibitors to block melanin production.
    Schlagwörter tyrosinase ; melanin ; anthocyanins ; competitive inhibitor ; molecular docking ; Organic chemistry ; QD241-441
    Sprache Englisch
    Erscheinungsdatum 2022-09-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Kushenol C from Sophora flavescens protects against UVB-induced skin damage in mice through suppression of inflammation and oxidative stress

    Feng Wang / Jae Young Shin / Eun Seo Kang / Jang Hoon Kim / Seon Il Jang / Byoung Ok Cho

    Heliyon, Vol 9, Iss 12, Pp e22804- (2023)

    2023  

    Abstract: Sophora flavescens has been used in traditional medicine for the treatment of various diseases such as viral hepatitis, fever, cancer, and pain. It is known to contain many bioactive compounds including prenylated flavonoids such as kurarinone, ... ...

    Abstract Sophora flavescens has been used in traditional medicine for the treatment of various diseases such as viral hepatitis, fever, cancer, and pain. It is known to contain many bioactive compounds including prenylated flavonoids such as kurarinone, sophoraflavanone G, kuraridine and isoxanthohumol. These flavonoids have been confirmed to have anti-inflammatory, α-glucosidase inhibitory and antioxidant performances. However, the protective activities against UV-induced skin damage of kushenol C from S. flavescens have not yet been elucidated. In this study, we explored the protective effect of kushenol C against the skin damage induced by UVB in mice. Our results showed that kushenol C treatment significantly recovered UVB-induced skin damage, the degradation of collagen, mast cell infiltration, together with epidermal hyperplasia in mice. Furthermore, the treatment of kushenol C remarkably suppressed the generation of pro-inflammatory mediators in the mice irradiated by UVB. More so, treatment with kushenol C suppressed the oxidative stress in mice irradiated by UVB. In conclusion, these results showed that kushenol C from S. flavescens has potentialities to treat skin injury via suppressing skin damage induced by UVB and oxidative stress.
    Schlagwörter Kushenol C ; Sophora flavescens ; Ultraviolet-B radiation ; Skin damage ; Oxidative stress ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
    Thema/Rubrik (Code) 571
    Sprache Englisch
    Erscheinungsdatum 2023-12-01T00:00:00Z
    Verlag Elsevier
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    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Association between longitudinal blood pressure and prognosis after treatment of cerebral aneurysm

    Jinkwon Kim / Jang Hoon Kim / Hye Sun Lee / Sang Hyun Suh / Kyung-Yul Lee

    PLoS ONE, Vol 16, Iss 5, p e

    A nationwide population-based cohort study.

    2021  Band 0252042

    Abstract: Background High blood pressure is a major risk factor for the development and rupture of cerebral aneurysm. Endovascular coil embolization and surgical clipping are established procedures to treat cerebral aneurysm. However, longitudinal data of blood ... ...

    Abstract Background High blood pressure is a major risk factor for the development and rupture of cerebral aneurysm. Endovascular coil embolization and surgical clipping are established procedures to treat cerebral aneurysm. However, longitudinal data of blood pressure after the treatment of cerebral aneurysm and its impact on long-term prognosis are not well known. Methods This retrospective cohort study included 1275 patients who underwent endovascular coil embolization (n = 558) or surgical clipping (n = 717) of cerebral aneurysm in 2002-2015 using the nationwide health screening database of Korea. Systolic and diastolic blood pressure of patients were repeatedly obtained from the nationwide health screening program. We performed a multivariate time-dependent Cox regression analysis of the primary composite outcome of stroke, myocardial infarction, and all-cause death. Results During the mean follow-up period of 6.13 ± 3.41 years, 89 patients suffered the primary outcome. Among the total 3546 times of blood pressure measurement, uncontrolled high blood pressure (systolic ≥140 mmHg or diastolic ≥90 mmHg) was 22.9%. There was a significantly increased risk of primary outcome with high systolic (adjusted HR [95% CI] per 10 mmHg, 1.16 [1.01-1.35]) and diastolic (adjusted HR [95% CI] per 10 mmHg, 1.32 [1.06-1.64]) blood pressure. Conclusions High blood pressure is prevalent even in patients who received treatment for cerebral aneurysm, which is significantly associated with poor outcome. Strict control of high blood pressure may further improve the prognosis of patients with cerebral aneurysm.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2021-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Inhibition of Soluble Epoxide Hydrolase Activity by Components of Glycyrrhiza uralensis

    Jang Hoon Kim / Yun-Chan Huh / Mok Hur / Woo Tae Park / Youn-Ho Moon / Tae Il Kim / Yong Il Kim / Seon Mi Kim / Jeonghoon Lee / Ik Soo Lee

    International Journal of Molecular Sciences, Vol 24, Iss 6485, p

    2023  Band 6485

    Abstract: Soluble epoxide hydrolase (sEH) is a target enzyme for the treatment of inflammation and cardiovascular disease. A Glycyrrhiza uralensis extract exhibited ~50% inhibition of sEH at 100 μg/mL, and column chromatography yielded compounds 1 – 11 . ... ...

    Abstract Soluble epoxide hydrolase (sEH) is a target enzyme for the treatment of inflammation and cardiovascular disease. A Glycyrrhiza uralensis extract exhibited ~50% inhibition of sEH at 100 μg/mL, and column chromatography yielded compounds 1 – 11 . Inhibitors 1 , 4 – 6 , 9 , and 11 were non-competitive; inhibitors 3, 7 , 8 , and 10 were competitive. The IC 50 value of inhibitor 10 was below 2 μM. Molecular simulation was used to identify the sEH binding site. Glycycoumarin ( 10 ) requires further evaluation in cells and animals.
    Schlagwörter Glycyrrhiza uralensis ; soluble epoxide hydrolase ; competitive inhibitor ; noncompetitive inhibitor ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Sprache Englisch
    Erscheinungsdatum 2023-03-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Discovery and Characterization of Chemical Compounds That Inhibit the Function of Bacterial Neuraminidase from Codonopsis ussuriensis

    Sung Cheol Koo / Hyun Sim Woo / Jae Woo Kim / Yeong-Su Kim / Jeong Yoon Kim / Jang Hoon Kim / Jin Yu / Young Chang Kim / Dae Wook Kim

    Applied Sciences, Vol 12, Iss 6254, p

    2022  Band 6254

    Abstract: Codonopsis ussuriensis (Rupr. and Maxim.) Hemsl is a medicinal herb commonly found in Korea, Japan, and the Russian Far East. However, its chemical composition and bioactivity have not been extensively studied. Thus, in this study, we aimed to examine ... ...

    Abstract Codonopsis ussuriensis (Rupr. and Maxim.) Hemsl is a medicinal herb commonly found in Korea, Japan, and the Russian Far East. However, its chemical composition and bioactivity have not been extensively studied. Thus, in this study, we aimed to examine and characterize the major components of the plant’s roots. Liquid chromatography with high-resolution mass spectrometry (LC-HRMS) was used to identify the components of the crude extracts. The compounds that were identified were named ussurienoside I ( 1 ) and tangshenoside I ( 2 ). The identified compounds were tested in vitro for inhibitory action against bacterial neuraminidase, and the mechanisms of inhibition were revealed. Compound 1 significantly inhibited bacterial neuraminidase activity in a dose-dependent manner (IC 50 = 56.0 μM). The neuraminidase inhibitor (compound 1 ) exhibited mixed type-I kinetic characteristics. The LC-HRMS data showed that the root extracts contained eight compounds. The findings of this study may aid in the development of bacterial neuraminidase inhibitors with medicinal potential.
    Schlagwörter Codonopsis ussuriensis ; ussurienoside I ; tangshenoside I ; bacterial neuraminidase ; mixed type-I inhibition ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 540
    Sprache Englisch
    Erscheinungsdatum 2022-06-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Inhibitory Activity of Quercetin 3- O -Arabinofuranoside and 2-Oxopomolic Acid Derived from Malus domestica on Soluble Epoxide Hydrolase

    In Sook Cho / Jang Hoon Kim / Yunjia Lin / Xiang Dong Su / Jong Seong Kang / Seo Young Yang / Young Ho Kim

    Molecules, Vol 25, Iss 4352, p

    2020  Band 4352

    Abstract: Flavonoids and triterpenoids were revealed to be the potential inhibitors on soluble epoxide hydrolase (sEH). The aim of this study is to reveal sEH inhibitors from Fuji apples. A flavonoid and three triterpenoids derived from the fruit of Malus ... ...

    Abstract Flavonoids and triterpenoids were revealed to be the potential inhibitors on soluble epoxide hydrolase (sEH). The aim of this study is to reveal sEH inhibitors from Fuji apples. A flavonoid and three triterpenoids derived from the fruit of Malus domestica were identified as quercetin-3- O -arabinoside ( 1 ), ursolic acid ( 2 ), corosolic acid ( 3 ), and 2-oxopomolic acid ( 4 ). They had half-maximal inhibitory concentration of the inhibitors (IC 50 ) values of 39.3 ± 3.4, 84.5 ± 9.5, 51.3 ± 4.9, and 11.4 ± 2.7 μM, respectively, on sEH. The inhibitors bound to allosteric sites of enzymes in mixed ( 1 ) and noncompetitive modes ( 2 – 4 ). Molecular simulations were carried out for inhibitors 1 and 4 to calculate the binding force of ligands to receptors. The inhibitors bound to the left ( 1 ) and right ( 4 ) pockets next to the enzyme’s active site. Based on analyses of their molecular docking and dynamics, it was shown that inhibitors 1 and 4 can stably bind sEH at 1 bar and 300 K. Finally, inhibitors 1 and 4 are promising candidates for further studies using cell-based assays and in vivo cardiovascular tests.
    Schlagwörter Malus domestica ; soluble epoxide hydrolase ; mixed inhibitor ; noncompetitive inhibitor ; binding pocket ; Organic chemistry ; QD241-441
    Thema/Rubrik (Code) 540
    Sprache Englisch
    Erscheinungsdatum 2020-09-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: Kushenol C Prevents Tert-Butyl Hydroperoxide and Acetaminophen-Induced Liver Injury

    Byoung Ok Cho / Jang Hoon Kim / Denis Nchang Che / Hyun Ju Kang / Jae Young Shin / Hao Suping / Ji Hyeon Park / Wang Feng / Yun Ji Lee / Seon Il Jang

    Molecules, Vol 26, Iss 1635, p

    2021  Band 1635

    Abstract: Sophora flavescens , also known as Kushen, has traditionally been used as a herbal medicine. In the present study we evaluated the ameliorative effects of kushenol C (KC) from S. flavescens against tBHP (tert-Butyl hydroperoxide)-induced oxidative stress ...

    Abstract Sophora flavescens , also known as Kushen, has traditionally been used as a herbal medicine. In the present study we evaluated the ameliorative effects of kushenol C (KC) from S. flavescens against tBHP (tert-Butyl hydroperoxide)-induced oxidative stress in hepatocellular carcinoma (HEPG2) cells and acetaminophen (APAP)-induced hepatotoxicity in mice. KC pretreatment protected the HEPG2 cells against oxidative stress by reducing cell death, apoptosis and reactive oxygen species (ROS) generation. KC pretreatment also upregulated pro-caspase 3 and GSH (glutathione) as well as expression of 8-Oxoguanine DNA Glycosylase (OGG1) in the HEPG2 cells. The mechanism of action was partly related by KC’s activation of Akt (Protein kinase B (PKB)) and Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) in the HepG2 cells. In in vivo investigations, coadministration of mice with KC and APAP significantly attenuated APAP-induced hepatotoxicity and liver damage, as the serum enzymatic activity of aspartate aminotransferase and alanine aminotransferase, as well as liver lipid peroxidation and cleaved caspase 3 expression, were reduced in APAP-treated mice. Coadministration with KC also up-regulated antioxidant enzyme expression and prevented the production of proinflammatory mediators in APAP-treated mice. Taken together, these results showed that KC treatment has potential as a therapeutic agent against liver injury through the suppression of oxidative stress.
    Schlagwörter kushenol C ; Nrf2 ; Akt ; antioxidant ; OGG1 ; liver injury ; Organic chemistry ; QD241-441
    Thema/Rubrik (Code) 500
    Sprache Englisch
    Erscheinungsdatum 2021-03-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel ; Online: Inhibitory Effects of Cucurbitane-Type Triterpenoids from Momordica charantia Fruit on Lipopolysaccharide-Stimulated Pro-Inflammatory Cytokine Production in Bone Marrow-Derived Dendritic Cells

    Thao Quyen Cao / Nguyen Viet Phong / Jang Hoon Kim / Dan Gao / Hoang Le Tuan Anh / Viet-Duc Ngo / Le Ba Vinh / Young Sang Koh / Seo Young Yang

    Molecules, Vol 26, Iss 4444, p

    2021  Band 4444

    Abstract: The bitter melon, Momordica charantia L., was once an important food and medicinal herb. Various studies have focused on the potential treatment of stomach disease with M . charantia and on its anti-diabetic properties. However, very little is known ... ...

    Abstract The bitter melon, Momordica charantia L., was once an important food and medicinal herb. Various studies have focused on the potential treatment of stomach disease with M . charantia and on its anti-diabetic properties. However, very little is known about the specific compounds responsible for its anti-inflammatory activities. In addition, the in vitro inhibitory effect of M . charantia on pro-inflammatory cytokine production by lipopolysaccharide (LPS)-stimulated bone marrow-derived dendritic cells (BMDCs) has not been reported. Phytochemical investigation of M . charantia fruit led to the isolation of 15 compounds ( 1 − 15 ). Their chemical structures were elucidated spectroscopically (one- and two-dimensional nuclear magnetic resonance) and with electrospray ionization mass spectrometry. The anti-inflammatory effects of the isolated compounds were evaluated by measuring the production of the pro-inflammatory cytokines interleukin IL-6, IL-12 p40, and tumor necrosis factor α (TNF-α) in LPS-stimulated BMDCs. The cucurbitanes were potent inhibitors of the cytokines TNF-α, IL-6, and IL-12 p40, indicating promising anti-inflammatory effects. Based on these studies and in silico simulations, we determined that the ligand likely docked in the receptors. These results suggest that cucurbitanes from M . charantia are potential candidates for treating inflammatory diseases.
    Schlagwörter Momordica charantia ; bioactive compound ; anti-inflammatory effect ; triterpenoid ; Organic chemistry ; QD241-441
    Thema/Rubrik (Code) 540
    Sprache Englisch
    Erscheinungsdatum 2021-07-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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