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Article ; Online: Development and validation of a prediction model for iron status in a large U.S. cohort of women.

Von Holle, Ann / O'Brien, Katie M / Janicek, Robert / Weinberg, Clarice R

2023 Volume 13, Issue 1, Page(s) 17309

Abstract: Serum iron levels can be important contributors to health outcomes, but it is not often feasible to rely on blood-based measures for a large epidemiologic study. Predictive models that use questionnaire-based factors such as diet, supplement use, recency ...

Abstract	Serum iron levels can be important contributors to health outcomes, but it is not often feasible to rely on blood-based measures for a large epidemiologic study. Predictive models that use questionnaire-based factors such as diet, supplement use, recency of blood donation, and medical conditions could potentially provide a noninvasive alternative for studying health effects associated with iron status. We hypothesized that a model based on questionnaire data could predict blood-based measures of iron status biomarkers. Using iron (mcg/dL), ferritin (mcg/dL), and transferrin saturation (%) based on blood collected at study entry, in a subsample from the U.S.-wide Sister Study (n = 3171), we developed and validated a prediction model for iron with multivariable linear regression models. Model performance based on these cross-sectional data was weak, with R
MeSH term(s)	Humans ; Female ; Iron/metabolism ; Cross-Sectional Studies ; Hemoglobins/metabolism ; Ferritins ; Transferrins ; Transferrin
Chemical Substances	Iron (E1UOL152H7) ; Hemoglobins ; Ferritins (9007-73-2) ; Transferrins ; Transferrin
Language	English
Publishing date	2023-10-12
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-42993-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: XPM estimation and compensation in the WDM system based on a low-complexity inner FEC.

Nassaji, Ehsan / Truhachev, Dmitri / Najafi, Hossein / Ebrahimzad, Hamid / Mitra, Jeebak / Janicek, Rene

Optics letters

2023 Volume 48, Issue 21, Page(s) 5663–5666

Abstract: In this work, we focus on compensation of inter-channel nonlinearity in optical wavelength division multiplexed (WDM) systems. We consider pre-coding with a high-rate forward error correction (FEC) code and a low-complexity and low-latency decoding and ... ...

Abstract	In this work, we focus on compensation of inter-channel nonlinearity in optical wavelength division multiplexed (WDM) systems. We consider pre-coding with a high-rate forward error correction (FEC) code and a low-complexity and low-latency decoding and equalization scheme at the receiver. The 2 × 2 multiple-input multiple-output (MIMO) recursive least square (RLS) equalizer is applied to reduce the inter-symbol interference (ISI) caused by the inter-channel nonlinearity, while the decoder improves the quality of the data feedback. Decisions based on feedback reliability have been implemented to prevent error propagation. We demonstrate that our system can readily utilize the inner FEC part of a mainstream concatenated optical FEC designs such as the 400ZR standard FEC. We evaluate the proposed algorithm for the dual-polarization 16QAM and 256QAM optical links. Based on our simulation results, the Q-factor has been increased by 0.36 and 0.67 dB for the 16QAM and 256QAM, respectively. The optimum launch power has been increased by 0.4 dB for both cases.
Language	English
Publishing date	2023-10-31
Publishing country	United States
Document type	Journal Article
ISSN	1539-4794
ISSN (online)	1539-4794
DOI	10.1364/OL.499294
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Article ; Online: Dual mode of action of IP

Egger, Caroline / Fernandez-Tenorio, Miguel / Blanch, Joaquim / Janicek, Radoslav / Egger, Marcel

Journal of molecular and cellular cardiology

2023 Volume 186, Page(s) 107–110

Abstract: In heart muscle, the physiological function of ... ...

Abstract	In heart muscle, the physiological function of IP
MeSH term(s)	Humans ; Myocytes, Cardiac/metabolism ; Sarcoplasmic Reticulum/metabolism ; Calcium/metabolism ; Calcium Signaling ; Excitation Contraction Coupling ; Arrhythmias, Cardiac/metabolism ; Ryanodine Receptor Calcium Release Channel/metabolism
Chemical Substances	Calcium (SY7Q814VUP) ; Ryanodine Receptor Calcium Release Channel
Language	English
Publishing date	2023-11-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80157-4
ISSN	1095-8584 ; 0022-2828
ISSN (online)	1095-8584
ISSN	0022-2828
DOI	10.1016/j.yjmcc.2023.11.009
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Article ; Online: A deep learning-based approach for efficient detection and classification of local Ca²⁺ release events in Full-Frame confocal imaging.

Dotti, Prisca / Fernandez-Tenorio, Miguel / Janicek, Radoslav / Márquez-Neila, Pablo / Wullschleger, Marcel / Sznitman, Raphael / Egger, Marcel

Cell calcium

2024 Volume 121, Page(s) 102893

Abstract: The release of ... ...

Abstract	The release of Ca
Language	English
Publishing date	2024-04-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	757687-0
ISSN	1532-1991 ; 0143-4160
ISSN (online)	1532-1991
ISSN	0143-4160
DOI	10.1016/j.ceca.2024.102893
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Zs.A 1596: Show issues

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Book: Mit Patienten richtig reden

Janicek, Robert

Gesprächsführung im Krankenhaus

1985

Author's details	Robert Janicek
Keywords	Communication ; Physician-Patient Relations ; Krankenhaus ; Gespräch ; Arzt ; Patient ; Kommunikative Kompetenz ; Pflegepersonal
Subject	Patienten ; Klinik ; Klinikum ; Krankenanstalt ; Krankenhauswesen ; Spital ; Gesprächssammlung ; Gespräche ; Pflegekraft ; Pflegefachkraft ; Krankenpflegepersonal ; Kommunikationskompetenz ; Kommunikative Fähigkeit ; Mediziner ; Ärzte
Language	German
Size	144 S.
Publisher	Bibliomed
Publishing place	Melsungen
Document type	Book
HBZ-ID	HT002122222
ISBN	3-921958-38-5 ; 978-3-921958-38-4
Database	Catalogue ZB MED Medicine, Health

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Shelf mark	Loan status	Location
1985 B 1127	order for loan	Magazin

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Article ; Online: Toenail and serum levels as biomarkers of iron status in pre- and postmenopausal women: correlations and stability over eight-year follow-up.

Von Holle, Ann / O'Brien, Katie M / Sandler, Dale P / Janicek, Robert / Karagas, Margaret R / White, Alexandra J / Niehoff, Nicole M / Levine, Keith E / Jackson, Brian P / Weinberg, Clarice R

Scientific reports

2024 Volume 14, Issue 1, Page(s) 1682

Abstract: Iron status is often assessed in epidemiologic studies, and toenails offer a convenient alternative to serum because of ease of collection, transport, and storage, and the potential to reflect a longer exposure window. Very few studies have examined the ... ...

Abstract	Iron status is often assessed in epidemiologic studies, and toenails offer a convenient alternative to serum because of ease of collection, transport, and storage, and the potential to reflect a longer exposure window. Very few studies have examined the correlation between serum and toenail levels for trace metals. Our aim was to compare iron measures using serum and toenails on both a cross-sectional and longitudinal basis. Using a subset of the US-wide prospective Sister Study cohort, we compared toenail iron measures to serum concentrations for iron, ferritin and percent transferrin saturation. Among 146 women who donated both blood and toenails at baseline, a subsample (59%, n = 86) provided specimens about 8 years later. Cross-sectional analyses included nonparametric Spearman's rank correlations between toenail and serum biomarker levels. We assessed within-woman maintenance of rank across time for the toenail and serum measures and fit mixed effects models to measure change across time in relation to change in menopause status. Spearman correlations at baseline (follow-up) were 0.08 (0.09) for serum iron, 0.08 (0.07) for transferrin saturation, and - 0.09 (- 0.17) for ferritin. The within-woman Spearman correlation for toenail iron between the two time points was higher (0.47, 95% CI 0.30, 0.64) than for serum iron (0.30, 95% CI 0.09, 0.51) and transferrin saturation (0.34, 95% CI 0.15, 0.54), but lower than that for ferritin (0.58, 95% CI 0.43, 0.73). Serum ferritin increased over time while nail iron decreased over time for women who experienced menopause during the 8-years interval. Based on cross-sectional and repeated assessments, our evidence does not support an association between serum biomarkers and toenail iron levels. Toenail iron concentrations did appear to be moderately stable over time but cannot be taken as a proxy for serum iron biomarkers and they may reflect physiologically distinct fates for iron.
MeSH term(s)	Humans ; Female ; Iron/metabolism ; Nails/metabolism ; Follow-Up Studies ; Prospective Studies ; Postmenopause ; Cross-Sectional Studies ; Ferritins ; Biomarkers ; Transferrins ; Transferrin
Chemical Substances	Iron (E1UOL152H7) ; Ferritins (9007-73-2) ; Biomarkers ; Transferrins ; Transferrin
Language	English
Publishing date	2024-01-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-50506-5
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Article ; Online: Activation of endogenous protein phosphatase 1 enhances the calcium sensitivity of the ryanodine receptor type 2 in murine ventricular cardiomyocytes.

Potenza, Duilio Michele / Janicek, Radoslav / Fernandez-Tenorio, Miguel / Niggli, Ernst

The Journal of physiology

2020 Volume 598, Issue 6, Page(s) 1131–1150

Abstract: Key points: Increased protein phosphatase 1 (PP-1) activity has been found in end stage human heart failure. Although PP-1 has been extensively studied, a detailed understanding of its role in the excitation-contraction coupling mechanism, in normal and ...

Abstract	Key points: Increased protein phosphatase 1 (PP-1) activity has been found in end stage human heart failure. Although PP-1 has been extensively studied, a detailed understanding of its role in the excitation-contraction coupling mechanism, in normal and diseased hearts, remains elusive. The present study investigates the functional effect of the PP-1 activity on local Ca Abstract: Changes in cardiac ryanodine receptor (RyR2) phosphorylation are considered to be important regulatory and disease related post-translational protein modifications. The extent of RyR2 phosphorylation is mainly determined by the balance of the activities of protein kinases and phosphatases, respectively. Increased protein phosphatase-1 (PP-1) activity has been observed in heart failure, although the regulatory role of this enzyme on intracellular Ca
MeSH term(s)	Animals ; Calcium/metabolism ; Calcium Signaling ; Mice ; Mice, Transgenic ; Myocytes, Cardiac/metabolism ; Phosphorylation ; Protein Phosphatase 1/metabolism ; Ryanodine Receptor Calcium Release Channel/metabolism ; Sarcoplasmic Reticulum/metabolism
Chemical Substances	Ryanodine Receptor Calcium Release Channel ; Protein Phosphatase 1 (EC 3.1.3.16) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2020-02-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3115-x
ISSN	1469-7793 ; 0022-3751
ISSN (online)	1469-7793
ISSN	0022-3751
DOI	10.1113/JP278951
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Article ; Online: The yin and yang of intracellular delivery of amphipathic optical probes using

Agarwal, Hitesh K / Janicek, Radoslav / Zhao, Jun / Sambath, Karthik / Egger, Marcel / Niggli, Ernst / Ellis-Davies, Graham C R

Chemical communications (Cambridge, England)

2022 Volume 58, Issue 17, Page(s) 2826–2829

Abstract: Monitoring and manipulation of ionized intracellular calcium concentrations within intact, living cells using optical probes with organic chromophores is a core method for cell physiology. Since all these probes have multiple negative charges, they must ... ...

Abstract	Monitoring and manipulation of ionized intracellular calcium concentrations within intact, living cells using optical probes with organic chromophores is a core method for cell physiology. Since all these probes have multiple negative charges, they must be smuggled through the plasma membrane in a transiently neutral form, with intracellular esterases used to deprotect the masked anions. Here we explore the ability of the synthetically easily accessible
MeSH term(s)	Calcium/chemistry ; Calcium/metabolism ; Cell Membrane/chemistry ; Cell Membrane/metabolism ; Cytosol/chemistry ; Cytosol/metabolism ; Esterases/chemistry ; Esterases/metabolism ; Fluorescent Dyes/chemistry ; Fluorescent Dyes/metabolism ; Humans ; Molecular Structure ; Myocytes, Cardiac/chemistry ; Myocytes, Cardiac/metabolism ; Particle Size
Chemical Substances	Fluorescent Dyes ; Esterases (EC 3.1.-) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2022-02-24
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d1cc06792c
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Article ; Online: Uptake-leak balance of SR Ca

Lopez, Ruben / Janicek, Radoslav / Fernandez-Tenorio, Miguel / Courtehoux, Marianne / Matas, Lluis / Gerbaud, Pascale / Gomez, Ana M / Egger, Marcel / Niggli, Ernst

Journal of molecular and cellular cardiology

2022 Volume 170, Page(s) 1–14

Abstract: Mutations of the RyR2 are channelopathies that can predispose to life threatening catecholaminergic polymorphic ventricular tachycardias (CPVTs) during exercise or stress. However, the cellular and molecular mechanisms that are causal for the arrhythmias ...

Abstract	Mutations of the RyR2 are channelopathies that can predispose to life threatening catecholaminergic polymorphic ventricular tachycardias (CPVTs) during exercise or stress. However, the cellular and molecular mechanisms that are causal for the arrhythmias downstream of the β-adrenergic receptor (β-AR) activation are not defined. They may be specific and different for each particular RyR2 mutation. Obvious possibilities are the phosphorylation of the mutated RyR2s or the stimulation of the SR Ca
MeSH term(s)	Animals ; Arrhythmias, Cardiac/metabolism ; Calcium/metabolism ; Calcium Signaling ; Isoproterenol/pharmacology ; Mice ; Myocytes, Cardiac/metabolism ; Ryanodine Receptor Calcium Release Channel/metabolism ; Sarcoplasmic Reticulum/metabolism
Chemical Substances	Ryanodine Receptor Calcium Release Channel ; Isoproterenol (L628TT009W) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2022-05-26
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80157-4
ISSN	1095-8584 ; 0022-2828
ISSN (online)	1095-8584
ISSN	0022-2828
DOI	10.1016/j.yjmcc.2022.05.011
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Zs.A 426: Show issues

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Article ; Online: Association Between Serum Iron Biomarkers and Breast Cancer.

Von Holle, Ann / O'Brien, Katie M / Sandler, Dale P / Janicek, Robert / Weinberg, Clarice R

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

2020 Volume 30, Issue 2, Page(s) 422–425

Abstract: Background: Iron is both essential to life and potentially toxic at higher levels. Epidemiologic studies of iron and breast cancer are sparse, with substantial heterogeneity found in a recent meta-analysis. Evidence based on a comprehensive set of iron ... ...

Abstract	Background: Iron is both essential to life and potentially toxic at higher levels. Epidemiologic studies of iron and breast cancer are sparse, with substantial heterogeneity found in a recent meta-analysis. Evidence based on a comprehensive set of iron biomarkers and a large sample size could help clarify relationships between iron body stores and breast cancer risk. Methods: A case-cohort sample of 6,008 women, including 3,011 incident cases, has been followed for a median of 7.9 years. We estimated breast cancer HRs with Cox models, including age as the primary time scale and including in turn iron, ferritin, percent transferrin saturation, and their first principal component (PC) both as categorical (quartiles) and continuous measures. Results: Adjusted HRs for the highest versus lowest quartiles of iron, ferritin, and transferrin saturation (95% confidence interval) were 1.06 (0.90-1.25), 1.03 (0.87-1.23), and 0.94 (0.80-1.12), respectively, and 1.06 (0.90-1.25) for the first principal component (PC). Associations were similar when follow-up time was restricted to ≤4 or >2 years. Conclusions: A study with one of the largest sample sizes to date and with all three measures of circulating iron, ferritin, and transferrin saturation does not support a strong association between elevated iron stores and breast cancer risk. Further investigation of low iron may be warranted. Impact: These results do not support a strong association between iron overload and breast cancer incidence.
MeSH term(s)	Biomarkers/blood ; Breast Neoplasms/blood ; Breast Neoplasms/epidemiology ; Female ; Humans ; Incidence ; Iron/blood ; Middle Aged ; Negative Results ; Risk Factors
Chemical Substances	Biomarkers ; Iron (E1UOL152H7)
Language	English
Publishing date	2020-12-08
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Intramural
ZDB-ID	1153420-5
ISSN	1538-7755 ; 1055-9965
ISSN (online)	1538-7755
ISSN	1055-9965
DOI	10.1158/1055-9965.EPI-20-0715
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