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  1. Article: Plurifocal cutaneous leishmaniasis during treatment with ustekinumab.

    Rakotonarivo, Louva / Lons-Danic, Dominique / Janier, Michel

    JAAD case reports

    2018  Volume 4, Issue 4, Page(s) 298–300

    Language English
    Publishing date 2018-03-31
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2834220-3
    ISSN 2352-5126
    ISSN 2352-5126
    DOI 10.1016/j.jdcr.2017.09.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Syphilis: aspects cliniques, diagnostiques et thérapeutiques.

    Janier, Michel

    La Revue du praticien

    2004  Volume 54, Issue 4, Page(s) 376–382

    Abstract: Syphilis is a STI. The present epidemic is related to the relapse into unsafe sexual behaviour. HIV has not modified clinical aspects and the great simulator implies to perform TPHA and VDRL in various circumstances. Treatment is simple and consensual in ...

    Title translation Syphilis: clinical, biological and therapeutical aspects.
    Abstract Syphilis is a STI. The present epidemic is related to the relapse into unsafe sexual behaviour. HIV has not modified clinical aspects and the great simulator implies to perform TPHA and VDRL in various circumstances. Treatment is simple and consensual in early syphilis. Treatment of late syphilis is dependent upon indications of CSF control, to be discussed by specialists, particularly in HIV+ patients.
    MeSH term(s) HIV Infections/complications ; Humans ; Prognosis ; Risk-Taking ; Syphilis/drug therapy ; Syphilis/transmission
    Language French
    Publishing date 2004-02-29
    Publishing country France
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: First case of chancroid in 14 years at the largest STI clinic in Paris, France.

    Fouéré, Sébastien / Lassau, François / Rousseau, Clotilde / Bagot, Martine / Janier, Michel

    International journal of STD & AIDS

    2016  Volume 27, Issue 9, Page(s) 805–807

    Abstract: We report the first case of chancroid seen at our clinic in 14 years. It was diagnosed by nuclear acid amplification test in a male patient returning from Madagascar. Although the disease is considered on the verge of disappearance even in tropical ... ...

    Abstract We report the first case of chancroid seen at our clinic in 14 years. It was diagnosed by nuclear acid amplification test in a male patient returning from Madagascar. Although the disease is considered on the verge of disappearance even in tropical countries, its real potential for reemergence - due to new strains of Haemophilus ducreyi, underreporting and a lack of widespread use of molecular testing - could be underestimated.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Chancroid/diagnosis ; Chancroid/drug therapy ; Chancroid/microbiology ; France ; Haemophilus ducreyi/genetics ; Haemophilus ducreyi/isolation & purification ; Humans ; Madagascar ; Male ; Middle Aged ; Polymerase Chain Reaction/methods ; Treatment Outcome ; Ulcer/diagnosis ; Ulcer/etiology
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2016-08
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1018089-8
    ISSN 1758-1052 ; 0956-4624
    ISSN (online) 1758-1052
    ISSN 0956-4624
    DOI 10.1177/0956462415598252
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Lymphogranuloma Venereum-Serovar L2b Presenting With Painful Genital Ulceration: An Emerging Clinical Presentation?

    Haber, Roger / Maatouk, Ismaël / de Barbeyrac, Bertille / Bagot, Martine / Janier, Michel / Fouéré, Sébastien

    Sexually transmitted diseases

    2017  Volume 44, Issue 5, Page(s) 310–312

    Abstract: These 5 cases of atypical inflammatory lymphogranula venereum (LGV) serovar L2b presenting initially with edema and persistent painful ulceration illustrate that clinical manifestations of LGV in the current outbreak in men who have sex with men reflect ... ...

    Abstract These 5 cases of atypical inflammatory lymphogranula venereum (LGV) serovar L2b presenting initially with edema and persistent painful ulceration illustrate that clinical manifestations of LGV in the current outbreak in men who have sex with men reflect the influence of both the serovars virulence and the host immune system and are not confined to proctitis. L2b serovar could have a particular high virulence profile, and the need for awareness of LGV as a cause of genital ulceration is crucial.
    MeSH term(s) Adult ; Chlamydia trachomatis/immunology ; Chlamydia trachomatis/pathogenicity ; Edema/diagnosis ; Edema/immunology ; Edema/microbiology ; Genitalia, Male/microbiology ; Genitalia, Male/pathology ; Homosexuality, Male/statistics & numerical data ; Humans ; Immune System ; Lymphogranuloma Venereum/diagnosis ; Lymphogranuloma Venereum/microbiology ; Lymphogranuloma Venereum/pathology ; Male ; Middle Aged ; Proctitis/diagnosis ; Proctitis/microbiology ; Proctitis/pathology ; Serogroup ; Ulcer/diagnosis ; Ulcer/microbiology ; Ulcer/pathology ; Virulence
    Language English
    Publishing date 2017-05
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 435191-5
    ISSN 1537-4521 ; 0148-5717
    ISSN (online) 1537-4521
    ISSN 0148-5717
    DOI 10.1097/OLQ.0000000000000597
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Infections génitales de l'homme ecoulement urétral.

    Chaine, Bénédicte / Janier, Michel

    La Revue du praticien

    2007  Volume 57, Issue 9, Page(s) 1027–1032

    Title translation Genital infections in men. Urethral discharge.
    MeSH term(s) Decision Trees ; Genital Diseases, Male/diagnosis ; Genital Diseases, Male/drug therapy ; Genital Diseases, Male/microbiology ; Humans ; Male ; Suppuration ; Urethra
    Language French
    Publishing date 2007-05-15
    Publishing country France
    Document type Journal Article
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Syphilitic balanitis of Follmann: three case reports.

    Abdennader, Sami / Janier, Michel / Morel, Patrice

    Acta dermato-venereologica

    2011  Volume 91, Issue 2, Page(s) 191–192

    MeSH term(s) Adult ; Anti-Bacterial Agents/therapeutic use ; Balanitis/diagnosis ; Balanitis/drug therapy ; Balanitis/etiology ; Diagnosis, Differential ; Humans ; Male ; Penicillin G Benzathine/therapeutic use ; Syphilis/complications ; Syphilis/diagnosis ; Syphilis/drug therapy ; Young Adult
    Chemical Substances Anti-Bacterial Agents ; Penicillin G Benzathine (RIT82F58GK)
    Language English
    Publishing date 2011-03
    Publishing country Sweden
    Document type Case Reports ; Letter
    ZDB-ID 80007-7
    ISSN 1651-2057 ; 0001-5555
    ISSN (online) 1651-2057
    ISSN 0001-5555
    DOI 10.2340/00015555-0983
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Actualités diagnostique et thérapeutique des infections à Neisseria gonorrhoeae.

    Chanal, Johan / Lassau, François / Morand, Philippe / Janier, Michel / Dupin, Nicolas

    Presse medicale (Paris, France : 1983)

    2013  Volume 42, Issue 4 Pt 1, Page(s) 454–458

    Abstract: Bacterial culture remains the gold standard for symptomatic infection. Nucleic Acid Amplification Tests (NAATs) have better sensitivity and specificity for rectal and pharyngeal specimens. A bacterial culture with antibiogram must be done for all NAAT ... ...

    Title translation What's new in the diagnosis and treatment of Neisseria gonorrhoeae.
    Abstract Bacterial culture remains the gold standard for symptomatic infection. Nucleic Acid Amplification Tests (NAATs) have better sensitivity and specificity for rectal and pharyngeal specimens. A bacterial culture with antibiogram must be done for all NAAT positive specimens in order to modify antibiotics prescription if needed. We must fear a diffusion of extensively drug-resistant Neisseria gonorrhoeae in the future. Nevertheless, ceftriaxone 500 mg intramuscular with 1 g of azithromycin against Chlamydia trachomatis remains the treatment of N. gonorrhoeae infections. Screening of partners of identified cases and other STDs is the main measure to add to the treatment of gonorrhea.
    MeSH term(s) Adult ; Azithromycin/therapeutic use ; Bacteriological Techniques ; Ceftriaxone/therapeutic use ; Chlamydia Infections/diagnosis ; Chlamydia Infections/drug therapy ; Chlamydia Infections/epidemiology ; Chlamydia Infections/transmission ; Chlamydia trachomatis ; Comorbidity ; Drug Resistance, Multiple, Bacterial ; Drug Therapy, Combination ; Female ; Gonorrhea/diagnosis ; Gonorrhea/drug therapy ; Gonorrhea/epidemiology ; Gonorrhea/transmission ; Humans ; Injections, Intramuscular ; Male ; Mass Screening ; Microbial Sensitivity Tests ; Nucleic Acid Amplification Techniques ; Predictive Value of Tests
    Chemical Substances Ceftriaxone (75J73V1629) ; Azithromycin (83905-01-5)
    Language French
    Publishing date 2013-04
    Publishing country France
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 120943-7
    ISSN 2213-0276 ; 0032-7867 ; 0755-4982 ; 0301-1518
    ISSN (online) 2213-0276
    ISSN 0032-7867 ; 0755-4982 ; 0301-1518
    DOI 10.1016/j.lpm.2012.09.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Infections à gonocoques.

    Chaine, Bénédicte / Lassau, François / Janier, Michel

    La Revue du praticien

    2010  Volume 60, Issue 4, Page(s) 533–538

    Abstract: Gonococcal infections as well as other sexually transmited diseases have been increasing for several years. Short incubation period and rich symptomatology of gonococcal urethritis in man, make it an epidemiological indicator of high-risk sexual behavior. ...

    Title translation Gonococcal infections.
    Abstract Gonococcal infections as well as other sexually transmited diseases have been increasing for several years. Short incubation period and rich symptomatology of gonococcal urethritis in man, make it an epidemiological indicator of high-risk sexual behavior. In women, cervicitis is often asymptomatic. Anorectitis is a classical form of gonococcal infection especially in men who have sex with men. Sepsis and conjunctivitis, while rare, are to be diagnosed as quickly as possible because of their severity. To limit the spread of gonococcal infections, prevention of sexually transmitted diseases must be strengthened, the screening of asymptomatic subjects can be improved by using the polymerase chain reaction technique and finally the latest therapeutic guidelines taking into account gonococcal antibiotic resistances must be applied.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Female ; Gonorrhea/diagnosis ; Gonorrhea/drug therapy ; Gonorrhea/physiopathology ; Humans ; Male
    Chemical Substances Anti-Bacterial Agents
    Language French
    Publishing date 2010-04-20
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Human Treponema pallidum 11q/j isolate belongs to subsp. endemicum but contains two loci with a sequence in TP0548 and TP0488 similar to subsp. pertenue and subsp. pallidum, respectively.

    Mikalová, Lenka / Strouhal, Michal / Oppelt, Jan / Grange, Philippe Alain / Janier, Michel / Benhaddou, Nadjet / Dupin, Nicolas / Šmajs, David

    PLoS neglected tropical diseases

    2017  Volume 11, Issue 3, Page(s) e0005434

    Abstract: Background: Treponema pallidum subsp. endemicum (TEN) is the causative agent of endemic syphilis (bejel). An unusual human TEN 11q/j isolate was obtained from a syphilis-like primary genital lesion from a patient that returned to France from Pakistan.!## ...

    Abstract Background: Treponema pallidum subsp. endemicum (TEN) is the causative agent of endemic syphilis (bejel). An unusual human TEN 11q/j isolate was obtained from a syphilis-like primary genital lesion from a patient that returned to France from Pakistan.
    Methodology/principal findings: The TEN 11q/j isolate was characterized using nested PCR followed by Sanger sequencing and/or direct Illumina sequencing. Altogether, 44 chromosomal regions were analyzed. Overall, the 11q/j isolate clustered with TEN strains Bosnia A and Iraq B as expected from previous TEN classification of the 11q/j isolate. However, the 11q/j sequence in a 505 bp-long region at the TP0488 locus was similar to Treponema pallidum subsp. pallidum (TPA) strains, but not to TEN Bosnia A and Iraq B sequences, suggesting a recombination event at this locus. Similarly, the 11q/j sequence in a 613 bp-long region at the TP0548 locus was similar to Treponema pallidum subsp. pertenue (TPE) strains, but not to TEN sequences.
    Conclusions/significance: A detailed analysis of two recombinant loci found in the 11q/j clinical isolate revealed that the recombination event occurred just once, in the TP0488, with the donor sequence originating from a TPA strain. Since TEN Bosnia A and Iraq B were found to contain TPA-like sequences at the TP0548 locus, the recombination at TP0548 took place in a treponeme that was an ancestor to both TEN Bosnia A and Iraq B. The sequence of 11q/j isolate in TP0548 represents an ancestral TEN sequence that is similar to yaws-causing treponemes. In addition to the importance of the 11q/j isolate for reconstruction of the TEN phylogeny, this case emphasizes the possible role of TEN strains in development of syphilis-like lesions.
    MeSH term(s) Adult ; Cluster Analysis ; Evolution, Molecular ; France ; Genetic Loci ; Genetic Variation ; Genotype ; Humans ; Male ; Pakistan ; Phylogeny ; Polymerase Chain Reaction ; Recombination, Genetic ; Sequence Analysis, DNA ; Sequence Homology ; Syphilis/microbiology ; Travel ; Treponema pallidum/genetics ; Treponema pallidum/isolation & purification
    Language English
    Publishing date 2017-03-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2429704-5
    ISSN 1935-2735 ; 1935-2727
    ISSN (online) 1935-2735
    ISSN 1935-2727
    DOI 10.1371/journal.pntd.0005434
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Surveillance of Antibiotic Resistance Genes in Treponema Pallidum Subspecies Pallidum from Patients with Early Syphilis in France.

    Sanchez, Adrien / Mayslich, Constance / Malet, Isabelle / Grange, Philippe Alain / Janier, Michel / Saule, Julie / Martinet, Pervenche / Robert, Jean-Luc / Moulene, Dominique / Truchetet, François / Pinault, Anne-Lise / Vermersch-Langlin, Annie / Benhaddou, Nadjet / Chanal, Johan / Dupin, Nicolas

    Acta dermato-venereologica

    2020  Volume 100, Issue 14, Page(s) adv00221

    Abstract: Benzathine penicillin G (BPG) is the reference treatment for early syphilis, but shortages have recently been reported, highlighting a need for the validation of alternative treatments. The aim of this study was to evaluate the genomic resistance of ... ...

    Abstract Benzathine penicillin G (BPG) is the reference treatment for early syphilis, but shortages have recently been reported, highlighting a need for the validation of alternative treatments. The aim of this study was to evaluate the genomic resistance of Treponema pallidum subspecies pallidum (TPA) to macrolides and doxycycline in France. Swabs from genital, anal, oral and cutaneous lesions were obtained from 146 patients with early syphilis in France. They were screened for mutations conferring resistance to macrolides and doxycycline by nested PCR and sequencing. Resistance to macrolides was detected in 85% of the isolates, but no point mutations conferring doxycycline resistance were detected. These findings confirm that, in France, resistance to macrolides is widespread. Moreover, we confirmed the absence of genomic resistance to doxycycline in the TPA strains. Therefore, doxycycline could be safely recommended as an alternative to BPG for the treatment of early syphilis.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Drug Resistance, Bacterial/genetics ; France/epidemiology ; Globus Pallidus ; Humans ; Syphilis/diagnosis ; Syphilis/drug therapy ; Syphilis/epidemiology ; Treponema pallidum/genetics
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2020-07-28
    Publishing country Sweden
    Document type Journal Article
    ZDB-ID 80007-7
    ISSN 1651-2057 ; 0001-5555
    ISSN (online) 1651-2057
    ISSN 0001-5555
    DOI 10.2340/00015555-3589
    Database MEDical Literature Analysis and Retrieval System OnLINE

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