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  1. Artikel: COVID-19 and Parkinson's Disease: Shared Inflammatory Pathways Under Oxidative Stress.

    Chaudhry, Zahara L / Klenja, Donika / Janjua, Najma / Cami-Kobeci, Gerta / Ahmed, Bushra Y

    Brain sciences

    2020  Band 10, Heft 11

    Abstract: The current coronavirus pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in a serious global health crisis. It is a major concern for individuals living with chronic disorders such as Parkinson's disease ( ... ...

    Abstract The current coronavirus pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in a serious global health crisis. It is a major concern for individuals living with chronic disorders such as Parkinson's disease (PD). Increasing evidence suggests an involvement of oxidative stress and contribution of NFκB in the development of both COVID-19 and PD. Although, it is early to identify if SARS-CoV-2 led infection enhances PD complications, it is likely that oxidative stress may exacerbate PD progression in COVID-19 affected individuals and/or vice versa. In the current study, we sought to investigate whether NFκB-associated inflammatory pathways following oxidative stress in SARS-CoV-2 and PD patients are correlated. Toward this goal, we have integrated bioinformatics analysis obtained from Basic Local Alignment Search Tool of Protein Database (BLASTP) search for similarities of SARS-CoV-2 proteins against human proteome, literature review, and laboratory data obtained in a human cell model of PD. A Parkinson's like state was created in 6-hydroxydopamine (6OHDA)-induced differentiated dopamine-containing neurons (dDCNs) obtained from an immortalized human neural progenitor cell line derived from the ventral mesencephalon region of the brain (ReNVM). The results indicated that SARS-CoV-2 infection and 6OHDA-induced toxicity triggered stimulation of caspases-2, -3 and -8 via the NFκB pathway resulting in the death of dDCNs. Furthermore, specific inhibitors for NFκB and studied caspases reduced the death of stressed dDCNs. The findings suggest that knowledge of the selective inhibition of caspases and NFκB activation may contribute to the development of potential therapeutic approaches for the treatment of COVID-19 and PD.
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-10-31
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci10110807
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: COVID-19 and Parkinson’s Disease: Shared Inflammatory Pathways Under Oxidative Stress

    Chaudhry, Zahara L. / Klenja, Donika Janjua Najma Cami-Kobeci Gerta Ahmed Bushra Y.

    Brain Sciences

    Abstract: The current coronavirus pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in a serious global health crisis It is a major concern for individuals living with chronic disorders such as Parkinson’s disease (PD) ...

    Abstract The current coronavirus pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in a serious global health crisis It is a major concern for individuals living with chronic disorders such as Parkinson’s disease (PD) Increasing evidence suggests an involvement of oxidative stress and contribution of NFκB in the development of both COVID-19 and PD Although, it is early to identify if SARS-CoV-2 led infection enhances PD complications, it is likely that oxidative stress may exacerbate PD progression in COVID-19 affected individuals and/or vice versa In the current study, we sought to investigate whether NFκB-associated inflammatory pathways following oxidative stress in SARS-CoV-2 and PD patients are correlated Toward this goal, we have integrated bioinformatics analysis obtained from Basic Local Alignment Search Tool of Protein Database (BLASTP) search for similarities of SARS-CoV-2 proteins against human proteome, literature review, and laboratory data obtained in a human cell model of PD A Parkinson’s like state was created in 6-hydroxydopamine (6OHDA)-induced differentiated dopamine-containing neurons (dDCNs) obtained from an immortalized human neural progenitor cell line derived from the ventral mesencephalon region of the brain (ReNVM) The results indicated that SARS-CoV-2 infection and 6OHDA-induced toxicity triggered stimulation of caspases-2, -3 and -8 via the NFκB pathway resulting in the death of dDCNs Furthermore, specific inhibitors for NFκB and studied caspases reduced the death of stressed dDCNs The findings suggest that knowledge of the selective inhibition of caspases and NFκB activation may contribute to the development of potential therapeutic approaches for the treatment of COVID-19 and PD
    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #896243
    Datenquelle COVID19

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  3. Artikel ; Online: COVID-19 and Parkinson’s disease

    Chaudhry, Zahara Latif / Klenja, Donika / Janjua, Najma / Cami-Kobeci, Gerta / Ahmed, Bushra Y.

    shared inflammatory pathways under oxidative stress

    2020  

    Abstract: The current coronavirus pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in a serious global health crisis. It is a major concern for individuals living with chronic disorders such as Parkinson’s disease ( ... ...

    Abstract The current coronavirus pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in a serious global health crisis. It is a major concern for individuals living with chronic disorders such as Parkinson’s disease (PD). Increasing evidence suggests an involvement of oxidative stress and contribution of NFκB in the development of both COVID-19 and PD. Though, it is early to identify if SARS-CoV-2 led infection enhances PD complications, it is likely that oxidative stress may exacerbate PD progression in COVID-19 affected individuals and/or vice versa. In the current study, we sought to investigate whether NFκB-associated inflammatory pathways following oxidative stress in SARS-CoV-2 and PD patients are correlated. Toward this goal, we have integrated bioinformatics analysis obtained from BLASTP search for similarities between SARS-CoV-2 proteins and human proteome, literature review, and laboratory data obtained in a human cell model of PD. A Parkinson’s like state was created in 6OHDA-induced differentiated dopaminergic neurons (dDCNs) obtained from ReNVM cell line. The results indicated that SARS-CoV-2 infection and 6OHDA-induced toxicity triggered stimulation of caspases -2, -3 and -8 via the NFκB pathway resulting in death of dDCNs. Furthermore, specific inhibitors for NFκB and studied caspases reduced the death of stressed dDCNs. The findings suggest that knowledge of the selective inhibition of caspases and NFκB activation may contribute to development of potential therapeutic approaches for the treatment of COVID-19 and PD.

    No external funding; partially funded by RiT grant RES 07339, University of Bedfordshire, UK.

    open access
    Schlagwörter COVID-19 ; COVID-19 pandemic ; coronavirus ; Parkinson’s disease ; SARS-CoV-2 ; caspase ; inhibitors ; oxidative stress ; Subject Categories::B140 Neuroscience ; covid19
    Thema/Rubrik (Code) 572
    Sprache Englisch
    Erscheinungsdatum 2020-11-09T12:31:51Z
    Verlag MDPI
    Erscheinungsland uk
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: In vivo tissue uptake of intravenously injected water soluble all- trans β-carotene used as a food colorant

    Janjua Najma / Torii Midori I / Yamanushi Tomoko T / Kabuto Hideaki

    Nutrition Journal, Vol 8, Iss 1, p

    2009  Band 56

    Abstract: Abstract Water soluble β-carotene (WS-BC) is a carotenoid form that has been developed as a food colorant. WS-BC is known to contain 10% of all- trans β-carotene (AT-BC). The aim of the present study was to investigate in vivo tissue uptake of AT-BC ... ...

    Abstract Abstract Water soluble β-carotene (WS-BC) is a carotenoid form that has been developed as a food colorant. WS-BC is known to contain 10% of all- trans β-carotene (AT-BC). The aim of the present study was to investigate in vivo tissue uptake of AT-BC after the administration of WS-BC into rats. Seven-week-old male rats were administered 20 mg of WS-BC dissolved in saline by intravenous injection into the tail vein. At 0, 6, 24, 72, 120 and 168 hours (n = 7/time), blood was drawn and liver, lungs, adrenal glands, kidneys and testes were dissected. The levels of AT-BC in the plasma and dissected tissues were quantified with HPLC. After intravenous administration, AT-BC level in plasma first increased up to 6 h and returned to normal at 72 h. In the testes, the AT-BC level first increased up to 24 h and then did not decrease but was retained up to 168 h. In the other tissues, the level first increased up to 6 h and then decreased from 6 to 120 or 168 h but did not return to normal. The accumulation of WS-BC in testes but not in the other 5 tissues examined may suggest that AT-BC was excreted or metabolized in these tissues but not in testes. Although WS-BC is commonly used as a food colorant, its effects on body tissues are still not clarified. Results of the present study suggest that further investigations are required to elucidate effects of WS-BC on various body tissues.
    Schlagwörter Nutrition. Foods and food supply ; TX341-641 ; Home economics ; TX1-1110 ; Technology ; T ; DOAJ:Nutrition and Food Sciences ; DOAJ:Agriculture and Food Sciences
    Thema/Rubrik (Code) 590 ; 630
    Sprache Englisch
    Erscheinungsdatum 2009-12-01T00:00:00Z
    Verlag BioMed Central
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Oral administration of eicosapentaenoic acid or docosahexaenoic acid modifies cardiac function and ameliorates congestive heart failure in male rats.

    Yamanushi, Tomoko T / Kabuto, Hideaki / Hirakawa, Eiichiro / Janjua, Najma / Takayama, Fusako / Mankura, Mitsumasa

    The Journal of nutrition

    2014  Band 144, Heft 4, Seite(n) 467–474

    Abstract: This study assessed the effects of eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) on normal cardiac function (part 1) and congestive heart failure (CHF) (part 2) through electrocardiogram analysis and determination of EPA, DHA, and arachidonic ...

    Abstract This study assessed the effects of eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) on normal cardiac function (part 1) and congestive heart failure (CHF) (part 2) through electrocardiogram analysis and determination of EPA, DHA, and arachidonic acid (AA) concentrations in rat hearts. In part 2, pathologic assessments were also performed. For part 1 of this study, 4-wk-old male rats were divided into a control group and 2 experimental groups. The rats daily were orally administered (1 g/kg body weight) saline, EPA-ethyl ester (EPA-Et; E group), or DHA-ethyl ester (DHA-Et; D group), respectively, for 28 d. ECGs revealed that QT intervals were significantly shorter for groups E and D compared with the control group (P ≤ 0.05). Relative to the control group, the concentration of EPA was higher in the E group and concentrations of EPA and DHA were higher in the D group, although AA concentrations were lower (P ≤ 0.05). In part 2, CHF was produced by subcutaneous injection of monocrotaline into 5-wk-old rats. At 3 d before monocrotaline injection, rats were administered either saline, EPA-Et, or DHA-Et as mentioned above and then killed at 21 d. The study groups were as follows: normal + saline (control), CHF + saline (H group), CHF + EPA-Et (HE group), and CHF + DHA-Et (HD group). QT intervals were significantly shorter (P ≤ 0.05) in the control and HD groups compared with the H and HE groups. Relative to the H group, concentrations of EPA were higher in the HE group and those of DHA were higher in the control and HD groups (P ≤ 0.05). There was less mononuclear cell infiltration in the myocytes of the HD group than in the H group (P = 0.06). The right ventricles in the H, HE, and HD groups showed significantly increased weights (P ≤ 0.05) compared with controls. The administration of EPA-Et or DHA-Et may affect cardiac function by modification of heart fatty acid composition, and the administration of DHA-Et may ameliorate CHF.
    Mesh-Begriff(e) Animals ; Anti-Inflammatory Agents, Non-Steroidal/metabolism ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Dietary Supplements ; Disease Models, Animal ; Docosahexaenoic Acids/administration & dosage ; Docosahexaenoic Acids/metabolism ; Docosahexaenoic Acids/therapeutic use ; Eicosapentaenoic Acid/administration & dosage ; Eicosapentaenoic Acid/analogs & derivatives ; Eicosapentaenoic Acid/metabolism ; Eicosapentaenoic Acid/therapeutic use ; Electrocardiography ; Heart Failure/immunology ; Heart Failure/pathology ; Heart Failure/physiopathology ; Heart Failure/prevention & control ; Heart Ventricles/immunology ; Heart Ventricles/metabolism ; Heart Ventricles/pathology ; Heart Ventricles/physiopathology ; Leukocytes, Mononuclear/immunology ; Leukocytes, Mononuclear/pathology ; Male ; Organ Size ; Rats ; Rats, Sprague-Dawley ; Survival Analysis ; Ventricular Dysfunction, Right/etiology ; Ventricular Dysfunction, Right/prevention & control
    Chemische Substanzen Anti-Inflammatory Agents, Non-Steroidal ; Docosahexaenoic Acids (25167-62-8) ; eicosapentaenoic acid ethyl ester (6GC8A4PAYH) ; 4,7,10,13,16,19-docosahexaenoic acid ethyl ester (7PO7G8PA8M) ; Eicosapentaenoic Acid (AAN7QOV9EA)
    Sprache Englisch
    Erscheinungsdatum 2014-02-12
    Erscheinungsland United States
    Dokumenttyp Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218373-0
    ISSN 1541-6100 ; 0022-3166
    ISSN (online) 1541-6100
    ISSN 0022-3166
    DOI 10.3945/jn.113.175125
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Effects of squalene/squalane on dopamine levels, antioxidant enzyme activity, and fatty acid composition in the striatum of Parkinson's disease mouse model.

    Kabuto, Hideaki / Yamanushi, Tomoko T / Janjua, Najma / Takayama, Fusako / Mankura, Mitsumasa

    Journal of oleo science

    2013  Band 62, Heft 1, Seite(n) 21–28

    Abstract: Active oxygen has been implicated in the pathogenesis of Parkinson's disease (PD); therefore, antioxidants have attracted attention as a potential way to prevent this disease. Squalene, a natural triterpene and an intermediate in the biosynthesis of ... ...

    Abstract Active oxygen has been implicated in the pathogenesis of Parkinson's disease (PD); therefore, antioxidants have attracted attention as a potential way to prevent this disease. Squalene, a natural triterpene and an intermediate in the biosynthesis of cholesterol, is known to have active oxygen scavenging activities. Squalane, synthesized by complete hydrogenation of squalene, does not have active oxygen scavenging activities. We examined the effects of oral administration of squalene or squalane on a PD mouse model, which was developed by intracerebroventricular injection of 6-hydroxydopamine (6-OHDA). Squalene administration 7 days before and 7 days after one 6-OHDA injection prevented a reduction in striatal dopamine (DA) levels, while the same administration of squalane enhanced the levels. Neither squalene nor squalane administration for 7 days changed the levels of catalase, glutathione peroxidase, or superoxide dismutase activities in the striatum. Squalane increased thiobarbituric acid reactive substances, a marker of lipid peroxidation, in the striatum. Both squalane and squalene increased the ratio of linoleic acid/linolenic acid in the striatum. These results suggest that the administration of squalene or squalane induces similar changes in the composition of fatty acids and has no effect on the activities of active oxygen scavenging enzymes in the striatum. However, squalane increases oxidative damage in the striatum and exacerbates the toxicity of 6-OHDA, while squalene prevents it. The effects of squalene or squalane treatment in this model suggest their possible uses and risks in the treatment of PD.
    Mesh-Begriff(e) Administration, Oral ; Animals ; Catalase/metabolism ; Corpus Striatum/metabolism ; Disease Models, Animal ; Dopamine/metabolism ; Fatty Acids/metabolism ; Free Radical Scavengers/administration & dosage ; Free Radical Scavengers/pharmacology ; Lipid Peroxidation/drug effects ; Male ; Mice ; Mice, Inbred ICR ; Oxidopamine/toxicity ; Parkinson Disease/etiology ; Parkinson Disease/metabolism ; Parkinson Disease/prevention & control ; Squalene/administration & dosage ; Squalene/adverse effects ; Squalene/analogs & derivatives ; Squalene/pharmacology ; Superoxide Dismutase/metabolism ; Thiobarbituric Acid Reactive Substances/metabolism
    Chemische Substanzen Fatty Acids ; Free Radical Scavengers ; Thiobarbituric Acid Reactive Substances ; Squalene (7QWM220FJH) ; Oxidopamine (8HW4YBZ748) ; Catalase (EC 1.11.1.6) ; Superoxide Dismutase (EC 1.15.1.1) ; squalane (GW89575KF9) ; Dopamine (VTD58H1Z2X)
    Sprache Englisch
    Erscheinungsdatum 2013-01-14
    Erscheinungsland Japan
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1347-3352
    ISSN (online) 1347-3352
    DOI 10.5650/jos.62.21
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: In vivo tissue uptake of intravenously injected water soluble all-trans beta-carotene used as a food colorant.

    Yamanushi, Tomoko T / Torii, Midori I / Janjua, Najma / Kabuto, Hideaki

    Nutrition journal

    2009  Band 8, Seite(n) 56

    Abstract: Water soluble beta-carotene (WS-BC) is a carotenoid form that has been developed as a food colorant. WS-BC is known to contain 10% of all-trans beta-carotene (AT-BC). The aim of the present study was to investigate in vivo tissue uptake of AT-BC after ... ...

    Abstract Water soluble beta-carotene (WS-BC) is a carotenoid form that has been developed as a food colorant. WS-BC is known to contain 10% of all-trans beta-carotene (AT-BC). The aim of the present study was to investigate in vivo tissue uptake of AT-BC after the administration of WS-BC into rats. Seven-week-old male rats were administered 20 mg of WS-BC dissolved in saline by intravenous injection into the tail vein. At 0, 6, 24, 72, 120 and 168 hours (n = 7/time), blood was drawn and liver, lungs, adrenal glands, kidneys and testes were dissected. The levels of AT-BC in the plasma and dissected tissues were quantified with HPLC. After intravenous administration, AT-BC level in plasma first increased up to 6 h and returned to normal at 72 h. In the testes, the AT-BC level first increased up to 24 h and then did not decrease but was retained up to 168 h. In the other tissues, the level first increased up to 6 h and then decreased from 6 to 120 or 168 h but did not return to normal. The accumulation of WS-BC in testes but not in the other 5 tissues examined may suggest that AT-BC was excreted or metabolized in these tissues but not in testes. Although WS-BC is commonly used as a food colorant, its effects on body tissues are still not clarified. Results of the present study suggest that further investigations are required to elucidate effects of WS-BC on various body tissues.
    Mesh-Begriff(e) Animals ; Food Coloring Agents/analysis ; Food Coloring Agents/pharmacokinetics ; Male ; Rats ; Rats, Sprague-Dawley ; Solubility ; Testis/chemistry ; Tissue Distribution ; beta Carotene/analysis ; beta Carotene/blood ; beta Carotene/pharmacokinetics
    Chemische Substanzen Food Coloring Agents ; beta Carotene (01YAE03M7J)
    Sprache Englisch
    Erscheinungsdatum 2009-12-01
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 1475-2891
    ISSN (online) 1475-2891
    DOI 10.1186/1475-2891-8-56
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: Localization of nestin in amygdaloid kindled rat: an immunoelectron microscopic study.

    Nakagawa, Toshitaka / Miyamoto, Osamu / Janjua, Najma A / Auer, Roland N / Nagao, Seigo / Itano, Toshifumi

    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

    2005  Band 31, Heft 4, Seite(n) 514–519

    Abstract: Background: Nestin is a class VI intermediate filament protein, expressed during early embryonic development in mammals. Postnatally, nestin and its mRNA are down-regulated and gradually disappear. Recently, nestin expression has been detected in the ... ...

    Abstract Background: Nestin is a class VI intermediate filament protein, expressed during early embryonic development in mammals. Postnatally, nestin and its mRNA are down-regulated and gradually disappear. Recently, nestin expression has been detected in the adult nervous system, and it has been suggested that this protein may be related to neurogenesis, although, its role in the mechanism of neurogenesis is not known.
    Methods: The present study examined the localization of nestin in CNS tissue of the amygdaloid kindled rat by light and electron microscopy.
    Results: Kindled animals showed nestin expression mainly in the piriform cortex and the perirhinal cortex. By light microscopy, nestin was shown to be expressed in astrocytes, neurons, and endothelial cells. Electron microscopy demonstrated nestin expression in endothelial cells, astrocytic perivascular end feet, the rare pericyte, neurons and oligodendrocytes.
    Conclusion: We conclude that epilepsy causes widespread nestin expression in many cell types in the CNS, including non-neural cells.
    Mesh-Begriff(e) Amygdala/cytology ; Amygdala/metabolism ; Animals ; Astrocytes/metabolism ; Electric Stimulation ; Endothelial Cells/metabolism ; Glial Fibrillary Acidic Protein/metabolism ; Immunohistochemistry ; Intermediate Filament Proteins/metabolism ; Kindling, Neurologic/metabolism ; Male ; Nerve Tissue Proteins/metabolism ; Nestin ; Parahippocampal Gyrus/cytology ; Parahippocampal Gyrus/metabolism ; Rats ; Rats, Sprague-Dawley ; Temporal Lobe/cytology ; Temporal Lobe/metabolism ; Tissue Distribution
    Chemische Substanzen Glial Fibrillary Acidic Protein ; Intermediate Filament Proteins ; Nerve Tissue Proteins ; Nes protein, rat ; Nestin
    Sprache Englisch
    Erscheinungsdatum 2005-01-01
    Erscheinungsland England
    Dokumenttyp Comparative Study ; Journal Article
    ZDB-ID 197622-9
    ISSN 0317-1671
    ISSN 0317-1671
    DOI 10.1017/s0317167100003747
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: Analysis of the inhibitory mechanism of d-allose on MOLT-4F leukemia cell proliferation

    Hirata, Yuko / Saito, Madoka / Tsukamoto, Ikuko / Yamaguchi, Fuminori / Sui, Li / Kamitori, Kazuyo / Dong, Youyi / Uehara, Eisuke / Konishi, Ryoji / Janjua, Najma / Tokuda, Masaaki

    Journal of bioscience and bioengineering. 2009 May, v. 107, no. 5

    2009  

    Abstract: d-Allose, the C-3 epimer of d-glucose, is one of the rare sugars found in nature. In the present study, we have elucidated for the first time that various leukemia cell lines have different susceptibility to anti-proliferative activity of d-allose, and ... ...

    Abstract d-Allose, the C-3 epimer of d-glucose, is one of the rare sugars found in nature. In the present study, we have elucidated for the first time that various leukemia cell lines have different susceptibility to anti-proliferative activity of d-allose, and that this difference is related to the difference in induction of thioredoxin interacting protein (TXNIP) expression. We examined 5 leukemia cell lines (MOLT-4F, IM-9, HL-60, BALL-1 and Daudi), and found that MOLT-4F (T-cell lymphoblastic leukemia) had the highest susceptibility to d-allose, and that Daudi (Burkitt's lymphoma) had the lowest. d-Allose significantly slowed the cell cycle progression without causing apoptosis of MOLT-4F cells. Intracellular TXNIP expression was specifically and markedly enhanced in MOLT-4F cells by d-allose treatment, and subsequent increase of p27kip¹, a cell cycle inhibitor, was observed. On the other hand, d-allose did not increase TXNIP and p27kip¹ levels at all in Daudi cells. These results indicate that d-allose suppresses MOLT-4F cell proliferation possibly by the inhibition of cell cycle progression via induction of TXNIP expression.
    Sprache Englisch
    Erscheinungsverlauf 2009-05
    Umfang p. 562-568.
    Erscheinungsort Osaka, Japan: Society for Bioscience and Bioengineering, Japan; Amsterdam, the Netherlands: Distributed outside Japan by Elsevier Science
    Dokumenttyp Artikel
    ZDB-ID 1465387-4
    ISSN 1347-4421 ; 1389-1723
    ISSN (online) 1347-4421
    ISSN 1389-1723
    DOI 10.1016/j.jbiosc.2008.12.021
    Datenquelle NAL Katalog (AGRICOLA)

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  10. Artikel: Regional expression of the radial glial marker vimentin at different stages of the kindling process.

    Nakagawa, Toshitaka / Miyazaki, Tetsuji / Miyamoto, Osamu / Janjua, Najma A / Hata, Toshiyuki / Itano, Toshifumi

    Epilepsy research

    2004  Band 61, Heft 1-3, Seite(n) 141–151

    Abstract: The classical view of the function of radial glia in brain development is a supporting function guiding radial neural migration. However, recent evidence indicates that they may play key roles in neurogenesis and gliogenesis, as ubiquitous precursors ... ...

    Abstract The classical view of the function of radial glia in brain development is a supporting function guiding radial neural migration. However, recent evidence indicates that they may play key roles in neurogenesis and gliogenesis, as ubiquitous precursors that generate neurons and glia. Although we previously reported the emergence of radial glia after spinal cord injury in adult rats, their precise function in this process is still unknown. In the present study, we examined emergence of radial glia in rat brain during progression of kindling, by performing immunohistochemical staining for vimentin which is a specific marker of radial glia. Vimentin immunoreactivity was found to be highest at clonus 3 and then decreased at clonus 5 in the hippocampal formation, regions around the third ventricle, caudate putamen and lateral habenular nucleus. Contrast, vimentin immunoreactivity consistently increased with progression of kindling in the cingulum and parietal cortex. These findings indicate dynamic changes in vimentin expression dependent on the kindling stage of seizure-prone state, and suggest that these changes play roles in formation of new circuits following kindling.
    Mesh-Begriff(e) Animals ; Biomarkers ; Brain Chemistry/physiology ; Hippocampus/metabolism ; Hippocampus/pathology ; Immunohistochemistry ; Kindling, Neurologic/physiology ; Male ; Neuroglia/metabolism ; Parietal Lobe/metabolism ; Pyramidal Cells/metabolism ; Rats ; Rats, Sprague-Dawley ; Third Ventricle/metabolism ; Vimentin/biosynthesis
    Chemische Substanzen Biomarkers ; Vimentin
    Sprache Englisch
    Erscheinungsdatum 2004-09
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632939-1
    ISSN 1872-6844 ; 0920-1211
    ISSN (online) 1872-6844
    ISSN 0920-1211
    DOI 10.1016/j.eplepsyres.2004.07.007
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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