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Article ; Online: Molecular epidemiology and HIV-1 variant evolution in Poland between 2015 and 2019.

Serwin, Karol / Urbańska, Anna / Scheibe, Kaja / Witak-Jędra, Magdalena / Jankowska, Maria / Hlebowicz, Maria / Bociąga-Jasik, Monika / Kalinowska-Nowak, Anna / Biała, Martyna / Ciepłucha, Hubert / Łojewski, Władysław / Olczak, Anita / Jabłonowska, Elżbieta / Kowalczuk-Kot, Aldona / Rozpłochowski, Błażej / Witor, Adam / Parczewski, Miłosz

Scientific reports

2021 Volume 11, Issue 1, Page(s) 16609

Abstract: The occurrence of HIV-1 subtypes differs worldwide and within Europe, with non-B variants mainly found across different exposure groups. In this study, we investigated the distribution and temporal trends in HIV-1 subtype variability across Poland ... ...

Abstract	The occurrence of HIV-1 subtypes differs worldwide and within Europe, with non-B variants mainly found across different exposure groups. In this study, we investigated the distribution and temporal trends in HIV-1 subtype variability across Poland between 2015 and 2019. Sequences of the pol gene fragment from 2518 individuals were used for the analysis of subtype prevalence. Subtype B was dominant (n = 2163, 85.90%). The proportion of subtype B-infected individuals decreased significantly, from 89.3% in 2015 to 80.3% in 2019. This was related to the increasing number of subtype A infections. In 355 (14.10%) sequences, non-B variants were identified. In 65 (2.58%) samples, recombinant forms (RFs) were noted. Unique recombinant forms (URFs) were found in 30 (1.19%) sequences. Three A/B recombinant clusters were identified of which two were A6/B mosaic viruses not previously described. Non-B clades were significantly more common among females (n = 81, 22.8%, p = 0.001) and heterosexually infected individuals (n = 45, 32.4%, p = 0.0031). The predominance of subtype B is evident, but the variability of HIV-1 in Poland is notable. Almost half of RFs (n = 65, 2.58%) was comprised of URFs (n = 30, 1.19%); thus those forms were common in the analyzed population. Hence, molecular surveillance of identified variants ensures recognition of HIV-1 evolution in Poland.
MeSH term(s)	Adult ; Female ; Genes, pol ; Geography, Medical ; HIV Infections/epidemiology ; HIV Infections/transmission ; HIV Infections/virology ; HIV-1/classification ; HIV-1/genetics ; HIV-1/isolation & purification ; Humans ; Male ; Middle Aged ; Molecular Epidemiology ; Morbidity/trends ; Phylogeny ; Poland/epidemiology ; Prevalence
Language	English
Publishing date	2021-08-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-96125-w
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Article ; Online: Assessing complexity of heart rate variability in people with spinal cord injury using local scale exponents.

Liao, Fuyuan / Brooks, Ian / Hsieh, Chang-Wei / Rice, Ian M / Jankowska, Maria M / Jan, Yih-Kuen

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

2015 Volume 2014, Page(s) 6381–6384

Abstract: Detrended fluctuation analysis (DFA) has been widely used to study dynamics of heart rate variability (HRV), which provides a quantitative parameter, the scaling exponent a, to represent the correlation properties of RR interval series. However, it has ... ...

Abstract	Detrended fluctuation analysis (DFA) has been widely used to study dynamics of heart rate variability (HRV), which provides a quantitative parameter, the scaling exponent a, to represent the correlation properties of RR interval series. However, it has been demonstrated that HRV exhibits complex behavior that cannot be fully described by a single exponent. This study aimed to investigate whether local scale exponent α(t) with t being the time scale can reveal new features of HRV that cannot be reflected by DFA coefficients. To accurately estimate α(t), we developed an approach for correcting a(t) at small scales and verified the approach using simulated signals. We studied HRV in 12 subjects with spinal cord injury and 14 able-bodied controls during sitting and prone postures. The results showed that α(t) provides complementary views of HRV, suggesting that it may be used to evaluate the effects of SCI-induced autonomic damage on HRV.
MeSH term(s)	Adult ; Algorithms ; Case-Control Studies ; Demography ; Electrocardiography ; Female ; Heart Rate/physiology ; Humans ; Male ; Posture ; Spinal Cord Injuries/physiopathology
Language	English
Publishing date	2015-01-06
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	2694-0604
ISSN (online)	2694-0604
DOI	10.1109/EMBC.2014.6945088
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Article ; Online: Public spirometry campaign in chronic obstructive pulmonary disease screening - hope or hype?

Korczyński, Piotr / Górska, Katarzyna / Jankowski, Piotr / Kosiński, Jakub / Kudas, Agata / Sułek, Katarzyna / Jankowska, Maria / Jaśkiewicz, Kaja / Krenke, Rafał

Advances in respiratory medicine

2017 Volume 85, Issue 3, Page(s) 143–150

Abstract: Introduction: Underdiagnosis of COPD seems to be a relevant clinical and social problem. We hypothesized that active public spirometry campaign may help identify subjects with airflow limitation consistent with COPD. The aim of the study was (1) to ... ...

Abstract	Introduction: Underdiagnosis of COPD seems to be a relevant clinical and social problem. We hypothesized that active public spirometry campaign may help identify subjects with airflow limitation consistent with COPD. The aim of the study was (1) to evaluate the willingness of random smokers to undergo public spirometry, (2) to assess the ability to obtain an acceptable quality spirometry during a public campaign, and (3) to assess the relationships between the presence and severity of respiratory symptoms and readiness to undergo spirometry. Material and methods: Pedestrians aged > 40 years and a smoking history >10 pack-years were recruited by medical students to fill a questionnaire and perform spirometry. Those with obstructive or borderline ventilatory insuffciency were invited and encouraged to undergo stationary spirometry in a pulmonary outpatient department. Results: Nine hundred and five subjects meeting the inclusion criteria were invited to the study. Only 178 subjects agreed to complete the questionnaire and undergo spirometry. Airway obstruction and borderline spirometry result (classified as possible airway obstruction) were found in 22 and 37 subjects, respectively. Of these, only 15 patients attended follow-up visit to verify public spirometry results. Extrapolation of the limited data showed the incidence of newly diagnosed airway obstruction as 10.7%. Conclusion: Public spirometry campaign does not seem to be an effective way of COPD screening. Smokers are reluctant to undergo complimentary spirometry even in the presence of pronounced respiratory symptoms. Our observations may be helpful in elaborating future screening programs for COPD.
MeSH term(s)	Female ; Follow-Up Studies ; Forced Expiratory Volume ; Humans ; Male ; Mass Screening/methods ; Mass Screening/psychology ; Middle Aged ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/psychology ; Risk Assessment/methods ; Smoking/epidemiology ; Smoking/psychology ; Spirometry/methods ; Spirometry/psychology
Language	English
Publishing date	2017-06-30
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2893877-X
ISSN	2543-6031 ; 2451-4934
ISSN (online)	2543-6031
ISSN	2451-4934
DOI	10.5603/ARM.2017.0024
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Article: Ocena wartości energetycznej całodziennych racji pokarmowych osób dorosłych HIV-pozytywnych.

Lebiedzińska, Anna / Bierzyńska, Natalia / Lemańska, Małgorzata / Jankowska, Maria / Trocha, Hanna / Smiatacz, Tomasz / Szefer, Piotr

Roczniki Panstwowego Zakladu Higieny

2009 Volume 60, Issue 2, Page(s) 191–194

Abstract: The purpose of this study was to determine energy intake in HIV-positive adults. In the study participated 150 adults. Energy intake and percentage of energy from protein, carbohydrate and fat were measured using 24-hour dietary recalls and computer ... ...

Title translation	Assessment of energy intake in HIV--positive adults.
Abstract	The purpose of this study was to determine energy intake in HIV-positive adults. In the study participated 150 adults. Energy intake and percentage of energy from protein, carbohydrate and fat were measured using 24-hour dietary recalls and computer program Wikt 1.3. The results of the study showed that energy intakes were below the dietary reference values for HIV-positive. Moreover the analyzed diets contained too small protein and carbohydrate contents but too high level of fat. Despite of this fact, the majority of respondents had correct BMI value.
MeSH term(s)	Adult ; Body Mass Index ; Case-Control Studies ; Diet Surveys ; Dietary Carbohydrates/metabolism ; Dietary Fats/metabolism ; Dietary Proteins/metabolism ; Energy Intake ; Female ; HIV Seropositivity/physiopathology ; Humans ; Male ; Nutrition Assessment
Chemical Substances	Dietary Carbohydrates ; Dietary Fats ; Dietary Proteins
Language	Polish
Publishing date	2009
Publishing country	Poland
Document type	English Abstract ; Journal Article
ZDB-ID	421739-1
ISSN	0035-7715
ISSN	0035-7715
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Article ; Online: Expanding HIV-1 subtype B transmission networks among men who have sex with men in Poland.

Parczewski, Miłosz / Leszczyszyn-Pynka, Magdalena / Witak-Jędra, Magdalena / Szetela, Bartosz / Gąsiorowski, Jacek / Knysz, Brygida / Bociąga-Jasik, Monika / Skwara, Paweł / Grzeszczuk, Anna / Jankowska, Maria / Barałkiewicz, Grażyna / Mozer-Lisewska, Iwona / Łojewski, Władysław / Kozieł, Katarzyna / Grąbczewska, Edyta / Jabłonowska, Elżbieta / Urbańska, Anna

PloS one

2017 Volume 12, Issue 2, Page(s) e0172473

Abstract: Introduction: Reconstruction of HIV transmission links allows to trace the spread and dynamics of infection and guide epidemiological interventions. The aim of this study was to characterize transmission networks among subtype B infected patients from ... ...

Abstract	Introduction: Reconstruction of HIV transmission links allows to trace the spread and dynamics of infection and guide epidemiological interventions. The aim of this study was to characterize transmission networks among subtype B infected patients from Poland. Material and methods: Maximum likelihood phylogenenetic trees were inferred from 966 HIV-1 subtype B protease/reverse transcriptase sequences from patients followed up in nine Polish HIV centers. Monophyletic clusters were identified using 3% within-cluster distance and 0.9 bootstrap values. Interregional links for the clusters were investigated and time from infection to onward transmission estimated using Bayesian dated MCMC phylogeny. Results: Three hundred twenty one (33.2%) sequences formed 109 clusters, including ten clusters of ≥5 sequences (n = 81, 8.4%). Transmission networks were more common among MSM (234 sequences, 68.6%) compared to other infection routes (injection drug use: 28 (8.2%) and heterosexual transmissions: 59 (17.3%) cases, respectively [OR:3.5 (95%CI:2.6-4.6),p<0.001]. Frequency of clustering increased from 26.92% in 2009 to 50.6% in 2014 [OR:1.18 (95%CI:1.06-1.31),p = 0.0026; slope +2.8%/year] with median time to onward transmission within clusters of 1.38 (IQR:0.59-2.52) years. In multivariate models clustering was associated with both MSM transmission route [OR:2.24 (95%CI:1.38-3.65),p<0.001] and asymptomatic stage of HIV infection [OR:1.93 (95%CI:1.4-2.64),p<0.0001]. Additionally, interregional networks were linked to MSM transmissions [OR:4.7 (95%CI:2.55-8.96),p<0.001]. Conclusions: Reconstruction of the HIV-1 subtype B transmission patterns reveals increasing degree of clustering and existence of interregional networks among Polish MSM. Dated phylogeny confirms the association between onward transmission and recent infections. High transmission dynamics among Polish MSM emphasizes the necessity for active testing and early treatment in this group.
MeSH term(s)	Adult ; Bayes Theorem ; Cluster Analysis ; Contact Tracing/statistics & numerical data ; Female ; Genotype ; HIV Infections/epidemiology ; HIV Infections/transmission ; HIV Infections/virology ; HIV Protease/genetics ; HIV-1/classification ; HIV-1/genetics ; HIV-1/isolation & purification ; Heterosexuality ; Homosexuality, Male ; Humans ; Male ; Phylogeny ; Poland/epidemiology ; Public Health Surveillance ; Substance Abuse, Intravenous/epidemiology ; Substance Abuse, Intravenous/virology
Chemical Substances	HIV Protease (EC 3.4.23.-) ; p16 protease, Human immunodeficiency virus 1 (EC 3.4.23.-)
Language	English
Publishing date	2017-02-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0172473
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Article: Technological progress in relation to changes in behavior patterns among blue collar workers in Poland

Jankowska, Maria A

Osteuropa / Osteuropa-Wirtschaft 34 ,3, S. 201-223

1989

Author's details	Maria A. Jankowska
Keywords	Technischer Fortschritt ; Arbeitskräfte ; Polen
Language	English
Size	Graph. Darst
Publisher	Berliner Wissenschafts-Verl
Publishing place	Berlin
Document type	Article
Note	Sprache der Zusammenfassung: Deutsch
ZDB-ID	123413-4
ISSN	0030-6460
ISSN	0030-6460
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Article: The Spectrum of Malignancies among Adult HIV Cohort in Poland between 1995 and 2012: A Retrospective Analysis of 288 Cases.

Kowalski, Jacek / Cholewińska, Grażyna / Pyziak-Kowalska, Karolina / Jabłonowska, Elżbieta / Barałkiewicz, Grażyna / Grzeszczuk, Anna / Leszczyszyn-Pynka, Magdalena / Olczak, Anita / Jankowska, Maria / Mikuła, Tomasz / Bociąga-Jasik, Monika / Firląg-Burkacka, Ewa / Horban, Andrzej

Contemporary oncology (Poznan, Poland)

2015 Volume 19, Issue 3, Page(s) 226–235

Abstract: The aim of the study: The aim of the study was to evaluate the spectrum of AIDS-defining malignancies (ADMs) and non-AIDS-defining malignancies (NADMs) in HIV-infected patients in Poland.: Material and methods: A retrospective observational study was ...

Abstract	The aim of the study: The aim of the study was to evaluate the spectrum of AIDS-defining malignancies (ADMs) and non-AIDS-defining malignancies (NADMs) in HIV-infected patients in Poland. Material and methods: A retrospective observational study was conducted among HIV-infected adult patients who developed a malignancy between 1995 and 2012 in a Polish cohort. Malignancies were divided into ADMs and NADMs. Non-AIDS-defining malignancies were further categorised as virus-related (NADMs-VR) and unrelated (NADMs-VUR). Epidemiological data was analysed according to demographic data, medical history, and HIV-related information. Results were analysed by OR, EPITools package parameters and Fisher's exact test. Results: In this study 288 malignancies were discovered. The mean age at diagnosis was 41.25 years (IQR20-81); for ADMs 38.05 years, and for NADMs-VURs 46.42 years; 72.22% were male, 40.28% were co-infected with HCV. The risk behaviours were: 37.85% IDU, 33.33% MSM, and 24.31% heterosexual. Mean CD4+ at the diagnosis was 282 cells/mm(3) (for ADMs 232 and for NADMs-VUR 395). Average duration of HIV infection at diagnosis was 5.69 years. There were 159 (55.2%) ADMs and 129 (44.8%) NADMs, among whom 58 (44.96%) NADMs-VR and 71 (55.04%) NADMs-VUR. The most frequent malignancies were: NHL (n = 76; 26.39%), KS (n = 49; 17.01%), ICC (n = 34; 11.81%), HD (n = 23; 7.99%), lung cancer (n = 18; 6.25%) and HCC (n = 14; 4.86%). The amount of NADMs, NADMs-VURs in particular, is increasing at present. Male gender (OR = 1.889; 95% CI: 1.104-3.233; p = 0.024), advanced age: 50-60 years (OR = 3.022; 95% CI: 1.359-6.720; p = 0.01) and ≥ 60 years (OR = 15.111; 95% CI: 3.122-73.151; p < 0.001), longer duration of HIV-infection and successful HAART (OR = 2.769; 95% CI: 1.675-4.577; p = 0) were independent predictors of NADMs overall, respectively. Conclusions: In a Polish cohort NHL was the most frequent malignancy among ADMs, whereas HD was the most frequent among NADMs. Increased incidence of NADMs appearing in elderly men with longer duration of HIV-infection and with better virological and immunological control was confirmed. As HIV-infected individuals live longer, better screening strategies, especially for NADMs-VUR, are needed. The spectrum of cancer diagnoses in Poland currently does not appear dissimilar to that observed in other European populations.
Language	English
Publishing date	2015-07-08
Publishing country	Poland
Document type	Journal Article
ISSN	1428-2526
ISSN	1428-2526
DOI	10.5114/wo.2015.52658
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Article ; Online: Distribution and time trends of HIV-1 variants in Poland: Characteristics of non-B clades and recombinant viruses.

Parczewski, Miłosz / Leszczyszyn-Pynka, Magdalena / Witak-Jędra, Magdalena / Rymer, Weronika / Zalewska, Małgorzata / Gąsiorowski, Jacek / Bociąga-Jasik, Monika / Kalinowska-Nowak, Anna / Garlicki, Aleksander / Grzeszczuk, Anna / Jankowska, Maria / Lemańska, Małgorzata / Barałkiewicz, Grażyna / Mozer-Lisewska, Iwona / Łojewski, Władysław / Grąbczewska, Edyta / Olczak, Anita / Jabłonowska, Elżbieta / Urbańska, Anna

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases

2016 Volume 39, Page(s) 232–240

Abstract: The spread of HIV-1 subtypes varies considerably both worldwide and within Europe, with non-B variants commonly found across various exposure groups. This study aimed to analyse the distribution and temporal trends in HIV-1 subtype variability across ... ...

Abstract	The spread of HIV-1 subtypes varies considerably both worldwide and within Europe, with non-B variants commonly found across various exposure groups. This study aimed to analyse the distribution and temporal trends in HIV-1 subtype variability across Poland. For analysis of the subtype distribution, 1219 partial pol sequences obtained from patients followed up in 9 of 17 Polish HIV treatment centres were used. Subtyping was inferred using the maximum likelihood method; recombination was assessed using the bootscanning and jumping profile hidden Markov model methods. Subtype B dominated in the studied group (n=1059, 86.9%); in 160 (13.1%) sequences, non-B variants were present [A1 (n=63, 5.2%), D (n=43, 3.5%), C (n=22, 1.8%), and F1 (n=2, 0.2%)]. In 25 (2.1%) cases circulating recombinant forms (CRFs) were found. Five A1 variants (0.4%) were unique AB recombinant forms (URF) not previously identified in Poland. Non-B clades were notably more common among females (n=73, 45.6%, p<0.001) and heterosexual individuals (n=103, 66.5%, p<0.001) and less frequent among men who have sex with men (MSM) (n=27, 17.42%, p<0.001). HIV-1 viral load at diagnosis was higher among non-B cases [median: 5.0 (IQR: 4.4-5.6)] vs. [median: 4.8 (IQR: 4.3-5.4) log copies/ml for subtype B (p<0.001)] with a lower CD4(+) lymphocyte count at baseline [median: 248 (IQR: 75-503) for non-B vs. median: 320 (IQR: 125-497) cells/μl for subtype B; p<0.001]. The frequency of the non-B subtypes proved stable from 2008 (11.5%) to 2014 (8.0%) [OR: 0.95 (95% CI: 0.84-1.07), p=0.4], with no temporal differences for exposure groups, gender, age and AIDS. Despite the predominance of subtype B, the variability of HIV in Poland is notable; both CRFs and URFs are present in the analysed population. Non-B variants are associated with heterosexual transmission, more advanced HIV disease and have stable temporal frequencies.
MeSH term(s)	Adult ; CD4 Lymphocyte Count ; Female ; Genetic Variation ; Genotype ; HIV Infections/epidemiology ; HIV Infections/immunology ; HIV Infections/virology ; HIV-1/genetics ; Humans ; Male ; Middle Aged ; Odds Ratio ; Phylogeny ; Poland/epidemiology ; Recombination, Genetic ; Viral Load
Language	English
Publishing date	2016-04
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2037068-4
ISSN	1567-7257 ; 1567-1348
ISSN (online)	1567-7257
ISSN	1567-1348
DOI	10.1016/j.meegid.2016.02.001
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Article ; Online: Transmitted HIV drug resistance in antiretroviral-treatment-naive patients from Poland differs by transmission category and subtype.

Parczewski, Miłosz / Leszczyszyn-Pynka, Magdalena / Witak-Jędra, Magdalena / Maciejewska, Katarzyna / Rymer, Weronika / Szymczak, Aleksandra / Szetela, Bartosz / Gąsiorowski, Jacek / Bociąga-Jasik, Monika / Skwara, Paweł / Garlicki, Aleksander / Grzeszczuk, Anna / Rogalska, Magdalena / Jankowska, Maria / Lemańska, Małgorzata / Hlebowicz, Maria / Barałkiewicz, Grażyna / Mozer-Lisewska, Iwona / Mazurek, Renata /

Lojewski, Władyslaw / Grąbczewska, Edyta / Olczak, Anita / Jabłonowska, Elżbieta / Clark, Jeremy / Urbańska, Anna

The Journal of antimicrobial chemotherapy

2015 Volume 70, Issue 1, Page(s) 233–242

Abstract: Objectives: The surveillance of HIV-transmitted drug resistance mutations (t-DRMs), including temporal trends across subtypes and exposure groups, remains a priority in the current management of the epidemic worldwide.: Methods: A cross-sectional ... ...

Abstract	Objectives: The surveillance of HIV-transmitted drug resistance mutations (t-DRMs), including temporal trends across subtypes and exposure groups, remains a priority in the current management of the epidemic worldwide. Methods: A cross-sectional analysis of 833 treatment-naive patients from 9 of 17 Polish HIV treatment centres. Partial pol sequences were used to analyse drug resistance with a general time reversible (GTR)-based maximum likelihood algorithm used for cluster/pair identification. Mutation frequencies and temporal trends were investigated. Results: t-DRMs were observed in 9% of cases (5.8% for NRTI, 1.2% NNRTI and 2.0% PI mutations) and were more common among heterosexually infected (HET) individuals (13.4%) compared with MSM (8.3%, P = 0.03) or injection drug users (IDUs; 2.9%, P = 0.001) and in MSM compared with IDUs (P = 0.046). t-DRMs were more frequent in cases infected with the non-B variant (21.6%) compared with subtype B (6.6%, P < 0.001). With subtype B a higher mutation frequency was found in MSM compared with non-MSM cases (8.3% versus 1.8% for IDU + HET, P = 0.038), while non-B variants were associated with heterosexual exposure (30.4% for HET versus 4.8% for MSM, P = 0.019; versus 0 for IDU, P = 0.016). Trends in t-DRM frequencies were stable over time except for a decrease in NNRTI t-DRMs among MSM (P = 0.0662) and an NRTI t-DRM decrease in HET individuals (P = 0.077). With subtype B a higher frequency of sequence pairs/clusters in MSM (50.4%) was found compared with HET (P < 0.001) and IDUs (P = 0.015). Conclusions: Despite stable trends over time, patterns of t-DRMs differed notably between transmission categories and subtypes: subtype B was associated with MSM transmission and clustering while in non-B clades t-DRMs were more common and were associated with heterosexual infections.
MeSH term(s)	Adult ; Anti-HIV Agents/pharmacology ; Cross-Sectional Studies ; Drug Resistance, Viral ; Female ; Genotype ; HIV/classification ; HIV/drug effects ; HIV/genetics ; HIV Infections/epidemiology ; HIV Infections/transmission ; HIV Infections/virology ; Humans ; Male ; Middle Aged ; Mutation Rate ; Poland/epidemiology ; Prevalence ; Sequence Analysis, DNA ; pol Gene Products, Human Immunodeficiency Virus/genetics
Chemical Substances	Anti-HIV Agents ; pol Gene Products, Human Immunodeficiency Virus
Language	English
Publishing date	2015-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	191709-2
ISSN	1460-2091 ; 0305-7453
ISSN (online)	1460-2091
ISSN	0305-7453
DOI	10.1093/jac/dku372
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Article ; Online: Meeting the WHO 90% target: antiretroviral treatment efficacy in Poland is associated with baseline clinical patient characteristics.

Parczewski, Milosz / Siwak, Ewa / Leszczyszyn-Pynka, Magdalena / Cielniak, Iwona / Burkacka, Ewa / Pulik, Piotr / Witor, Adam / Muller, Karolina / Zasik, Ewelina / Grzeszczuk, Anna / Jankowska, Maria / Lemańska, Małgorzata / Olczak, Anita / Grąbczewska, Edyta / Szymczak, Aleksandra / Gąsiorowski, Jacek / Szetela, Bartosz / Bociąga-Jasik, Monika / Skwara, Paweł /

Witak-Jędra, Magdalena / Jabłonowska, Elżbieta / Wójcik-Cichy, Kamila / Kamerys, Juliusz / Janczarek, Małgorzata / Krankowska, Dagny / Mikuła, Tomasz / Kozieł, Katarzyna / Bielec, Dariusz / Stempkowska, Justyna / Kocbach, Aleksandra / Błudzin, Wiesława / Horban, Andrzej

Journal of the International AIDS Society

2017 Volume 20, Issue 1, Page(s) 21847

Abstract: Introduction: Modern combined antiretroviral therapies (cART) allow to effectively suppress HIV-1 viral load, with the 90% virologic success rate, meeting the WHO target in most clinical settings. The aim of this study was to analyse antiretroviral ... ...

Abstract	Introduction: Modern combined antiretroviral therapies (cART) allow to effectively suppress HIV-1 viral load, with the 90% virologic success rate, meeting the WHO target in most clinical settings. The aim of this study was to analyse antiretroviral treatment efficacy in Poland and to identify variables associated with virologic suppression. M: ethods Results: Virologic suppression rates of <50 copies/mL were observed in 4672 (90.68%) and <200 copies/mL in 4934 (95.77%) individuals. In univariate analyses, for the suppression threshold <50 copies/mL higher efficacy was noted for 2NRTI+NNRTI-based combinations (94.73%) compared to 2NRTI+PI (89.93%), 2NRTI+InI (90.61%), nucleos(t)ide sparing PI/r+InI (82.02%) and three drug class regimens (74.49%) ( Conclusions: Proportion of virologically suppressed patients is in line with WHO treatment target confirming successful application of antiretroviral treatment strategy in Poland. Virological suppression rates depend on baseline patient characteristics, which should guide individualized antiretroviral tre0atment decisions.
MeSH term(s)	Adult ; Age Factors ; Anti-HIV Agents/therapeutic use ; CD4 Lymphocyte Count ; Cross-Sectional Studies ; Drug Therapy, Combination ; Female ; HIV Infections/drug therapy ; HIV-1 ; Health Planning ; Humans ; Male ; Middle Aged ; Poland ; Treatment Outcome ; Viral Load ; World Health Organization ; Young Adult
Chemical Substances	Anti-HIV Agents
Language	English
Publishing date	2017-07-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2467110-1
ISSN	1758-2652 ; 1758-2652
ISSN (online)	1758-2652
ISSN	1758-2652
DOI	10.7448/IAS.20.1.21847
Database	MEDical Literature Analysis and Retrieval System OnLINE

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