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  1. Article ; Online: Frozen water NMR lineshape analysis enables absolute polarization quantification.

    Koptyug, Igor V / Stern, Quentin / Jannin, Sami / Elliott, Stuart J

    Physical chemistry chemical physics : PCCP

    2022  Volume 24, Issue 10, Page(s) 5956–5964

    Abstract: Typical magnetic resonance experiments are routinely limited by weak signal responses. In some cases, the low intrinsic sensitivity can be alleviated by the implementation of hyperpolarization technologies. Dissolution-dynamic nuclear polarization offers ...

    Abstract Typical magnetic resonance experiments are routinely limited by weak signal responses. In some cases, the low intrinsic sensitivity can be alleviated by the implementation of hyperpolarization technologies. Dissolution-dynamic nuclear polarization offers a means of hyperpolarizing small molecules. Hyperpolarized water is employed in several dynamic nuclear polarization studies, and hence accurate and rapid quantification of the
    MeSH term(s) Ice ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy/methods ; Water
    Chemical Substances Ice ; Water (059QF0KO0R)
    Language English
    Publishing date 2022-03-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d1cp05127j
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  2. Article ; Online: Solid-state

    Elliott, Stuart J / Stern, Quentin / Jannin, Sami

    Magnetic resonance (Gottingen, Germany)

    2021  Volume 2, Issue 2, Page(s) 643–652

    Abstract: Dissolution dynamic nuclear polarization is used to prepare nuclear spin polarizations approaching unity. At present, ...

    Abstract Dissolution dynamic nuclear polarization is used to prepare nuclear spin polarizations approaching unity. At present,
    Language English
    Publishing date 2021-08-20
    Publishing country Germany
    Document type Journal Article
    ISSN 2699-0016
    ISSN (online) 2699-0016
    DOI 10.5194/mr-2-643-2021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Protonation tuned dipolar order mediated

    Elliott, Stuart J / Stern, Quentin / Cala, Olivier / Jannin, Sami

    Solid state nuclear magnetic resonance

    2021  Volume 116, Page(s) 101762

    Abstract: A strategy of dipolar order mediated nuclear spin polarization transfer has recently been combined with dissolution-dynamic nuclear polarization (dDNP) and improved by employing optimized shaped radiofrequency pulses and suitable molecular modifications. ...

    Abstract A strategy of dipolar order mediated nuclear spin polarization transfer has recently been combined with dissolution-dynamic nuclear polarization (dDNP) and improved by employing optimized shaped radiofrequency pulses and suitable molecular modifications. In the context of dDNP experiments, this offers a promising means of transferring polarization from high-gamma
    MeSH term(s) Magnetic Resonance Spectroscopy ; Protons ; Radio Waves ; Solubility ; Solvents
    Chemical Substances Protons ; Solvents
    Language English
    Publishing date 2021-10-16
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1122088-0
    ISSN 1527-3326 ; 0926-2040
    ISSN (online) 1527-3326
    ISSN 0926-2040
    DOI 10.1016/j.ssnmr.2021.101762
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  4. Article ; Online: Frémy's Salt as a Low-Persistence Hyperpolarization Agent: Efficient Dynamic Nuclear Polarization Plus Rapid Radical Scavenging.

    Negroni, Mattia / Turhan, Ertan / Kress, Thomas / Ceillier, Morgan / Jannin, Sami / Kurzbach, Dennis

    Journal of the American Chemical Society

    2022  Volume 144, Issue 45, Page(s) 20680–20686

    Abstract: Nuclear magnetic resonance (NMR) spectroscopy is a key technique for molecular structure determination in solution. However, due to its low sensitivity, many efforts have been made to improve signal strengths and reduce the required substrate amounts. In ...

    Abstract Nuclear magnetic resonance (NMR) spectroscopy is a key technique for molecular structure determination in solution. However, due to its low sensitivity, many efforts have been made to improve signal strengths and reduce the required substrate amounts. In this regard, dissolution dynamic nuclear polarization (DDNP) is a versatile approach as signal enhancements of over 10 000-fold are achievable. Samples are signal-enhanced
    MeSH term(s) Nitroso Compounds/chemistry ; Magnetic Resonance Spectroscopy/methods ; Magnetic Resonance Imaging
    Chemical Substances Fremy's salt (14293-70-0) ; 2-(1,1-dicyanopropenyl-2-)-6-dimethylaminonaphthaleney ; Nitroso Compounds
    Language English
    Publishing date 2022-11-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.2c07960
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Rapid and Simple

    Stern, Quentin / Reynard-Feytis, Quentin / Elliott, Stuart J / Ceillier, Morgan / Cala, Olivier / Ivanov, Konstantin / Jannin, Sami

    Journal of the American Chemical Society

    2023  Volume 145, Issue 50, Page(s) 27576–27586

    Abstract: Dissolution dynamic nuclear polarization (dDNP) is a method of choice for preparing ... ...

    Abstract Dissolution dynamic nuclear polarization (dDNP) is a method of choice for preparing hyperpolarized
    Language English
    Publishing date 2023-12-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.3c09209
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  6. Book ; Online: Solid-state 1H spin polarimetry by 13CH3 nuclear magnetic resonance

    Elliott, Stuart J. / Stern, Quentin / Jannin, Sami

    eISSN: 2699-0016

    2021  

    Abstract: Dissolution dynamic nuclear polarization is used to prepare nuclear spin polarizations approaching unity. At present, 1 H polarization quantification in the solid state remains fastidious due to the requirement of measuring thermal equilibrium signals. ... ...

    Abstract Dissolution dynamic nuclear polarization is used to prepare nuclear spin polarizations approaching unity. At present, 1 H polarization quantification in the solid state remains fastidious due to the requirement of measuring thermal equilibrium signals. Line shape polarimetry of solid-state nuclear magnetic resonance spectra is used to determine several useful properties regarding the spin system under investigation. In the case of highly polarized nuclear spins, such as those prepared under the conditions of dissolution dynamic nuclear polarization experiments, the absolute polarization of a particular isotopic species within the sample may be directly inferred from the characteristics of the corresponding resonance line shape. In situations where direct measurements of polarization are complicated by deleterious phenomena, indirect estimates of polarization using coupled heteronuclear spins prove informative. We present a simple analysis of the 13 C spectral line shape of [2- 13 C]sodium acetate based on the normalized deviation of the centre of gravity of the 13 C peaks, which can be used to indirectly evaluate the proton polarization of the methyl group moiety and very likely the entire sample in the case of rapid and homogeneous 1 H– 1 H spin diffusion. For the case of positive microwave irradiation, 1 H polarization was found to increase with an increasing normalized centre of gravity deviation. These results suggest that, as a dopant, [2- 13 C]sodium acetate could be used to indirectly gauge 1 H polarizations in standard sample formulations, which is potentially advantageous for (i) samples polarized in commercial dissolution dynamic nuclear polarization devices that lack 1 H radiofrequency hardware, (ii) measurements that are deleteriously influenced by radiation damping or complicated by the presence of large background signals and (iii) situations where the acquisition of a thermal equilibrium spectrum is not feasible.
    Subject code 333
    Language English
    Publishing date 2021-08-20
    Publishing country de
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Book ; Online: Solid-State 1H Spin Polarimetry by 13CH3 Nuclear Magnetic Resonance

    Elliott, Stuart J. / Stern, Quentin / Jannin, Sami

    eISSN: 2699-0016

    2021  

    Abstract: Dissolution-dynamic nuclear polarization is emerging as a promising means to prepare proton polarizations approaching unity. At present, 1 H polarization quantification remains fastidious due to the requirement of measuring thermal equilibrium signals. ... ...

    Abstract Dissolution-dynamic nuclear polarization is emerging as a promising means to prepare proton polarizations approaching unity. At present, 1 H polarization quantification remains fastidious due to the requirement of measuring thermal equilibrium signals. Lineshape polarimetry of solid-state nuclear magnetic resonance spectra is used to determine a number of useful properties regarding the spin system under investigation. In the case of highly polarized nuclear spins, such as those prepared under the conditions of dissolution-dynamic nuclear polarization experiments, the absolute polarization of a particular isotopic species within the sample can be directly inferred from the characteristics of the corresponding resonance lineshape. In situations where direct measurements of polarization are complicated by deleterious phenomena, indirect estimates of polarization using coupled heteronuclear spins prove informative. We present a simple analysis of the 13 C spectral lineshape asymmetry of [2- 13 C]sodium acetate based on relative peak intensities, which can be used to indirectly evaluate the proton polarization of the methyl group moiety, and very likely the entire sample in the case of rapid and homogeneous 1 H- 1 H spin diffusion. 1 H polarizations greater than ~10–25 % (depending on the sign of the microwave irradiation) were found to be linearly proportional to the 13 C peak asymmetry, which responds differently to positive or negative microwave irradiation. These results suggest that, as a dopant, [2- 13 C]sodium acetate could be used to indirectly gauge 1 H polarizations in standard sample formulations, which is potentially advantageous for: samples polarized in commercial dissolution-dynamic nuclear polarization devices that lack 1 H radiofrequency hardware, measurements which are deleteriously influenced by radiation damping or complicated by the presence of large background signals, and situations where the acquisition of a thermal equilibrium spectrum is not feasible.
    Subject code 333
    Language English
    Publishing date 2021-03-15
    Publishing country de
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Optimizing dissolution dynamic nuclear polarization.

    Bornet, Aurélien / Jannin, Sami

    Journal of magnetic resonance (San Diego, Calif. : 1997)

    2016  Volume 264, Page(s) 13–21

    Abstract: This article is a short review of some of our recent developments in dissolution dynamic nuclear polarization (d-DNP). We present the basic principles of d-DNP, and motivate our choice to step away from conventional approaches. We then introduce a ... ...

    Abstract This article is a short review of some of our recent developments in dissolution dynamic nuclear polarization (d-DNP). We present the basic principles of d-DNP, and motivate our choice to step away from conventional approaches. We then introduce a modified d-DNP recipe that can be summed up as follows. (i) Using broad line polarizing agents to efficiently polarize 1H spins. (ii) Increasing the magnetic field to 6.7 T and above. (iii) Applying microwave frequency modulation. (iv) Applying (1)H-(13)C cross polarization. (v) Transferring hyperpolarized solution through a magnetic tunnel.
    MeSH term(s) Electromagnetic Fields ; Indicators and Reagents ; Magnetic Resonance Spectroscopy/instrumentation ; Magnetic Resonance Spectroscopy/methods ; Microwaves ; Solubility
    Chemical Substances Indicators and Reagents
    Language English
    Publishing date 2016-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1469665-4
    ISSN 1096-0856 ; 1557-8968 ; 1090-7807 ; 0022-2364
    ISSN (online) 1096-0856 ; 1557-8968
    ISSN 1090-7807 ; 0022-2364
    DOI 10.1016/j.jmr.2015.12.007
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  9. Article ; Online: Zero- to Ultralow-Field Nuclear Magnetic Resonance Enhanced with Dissolution Dynamic Nuclear Polarization

    Picazo-Frutos, Román / Stern, Quentin / Blanchard, John W. / Cala, Olivier / Ceillier, Morgan / Cousin, Samuel F. / Eills, James / Elliott, Stuart J. / Jannin, Sami / Budker, Dmitry

    Analytical Chemistry. 2022 Dec. 23, v. 95, no. 2 p.720-729

    2022  

    Abstract: Zero- to ultralow-field nuclear magnetic resonance is a modality of magnetic resonance experiment which does not require strong superconducting magnets. Contrary to conventional high-field nuclear magnetic resonance, it has the advantage of allowing high- ...

    Abstract Zero- to ultralow-field nuclear magnetic resonance is a modality of magnetic resonance experiment which does not require strong superconducting magnets. Contrary to conventional high-field nuclear magnetic resonance, it has the advantage of allowing high-resolution detection of nuclear magnetism through metal as well as within heterogeneous media. To achieve high sensitivity, it is common to couple zero-field nuclear magnetic resonance with hyperpolarization techniques. To date, the most common technique is parahydrogen-induced polarization, which is only compatible with a small number of compounds. In this article, we establish dissolution dynamic nuclear polarization as a versatile method to enhance signals in zero-field nuclear magnetic resonance experiments on sample mixtures of [¹³C]sodium formate, [1-¹³C]­glycine, and [2-¹³C]sodium acetate, and our technique is immediately extendable to a broad range of molecules with >1 s relaxation times. We find signal enhancements of up to 11,000 compared with thermal prepolarization in a 2 T permanent magnet. To increase the signal in future experiments, we investigate the relaxation effects of the TEMPOL radicals used for the hyperpolarization process at zero- and ultralow-fields.
    Keywords analytical chemistry ; magnetic materials ; magnetism ; nuclear magnetic resonance spectroscopy ; sodium acetate ; sodium formate
    Language English
    Dates of publication 2022-1223
    Size p. 720-729.
    Publishing place American Chemical Society
    Document type Article ; Online
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.2c02649
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Application and methodology of dissolution dynamic nuclear polarization in physical, chemical and biological contexts.

    Jannin, Sami / Dumez, Jean-Nicolas / Giraudeau, Patrick / Kurzbach, Dennis

    Journal of magnetic resonance (San Diego, Calif. : 1997)

    2019  Volume 305, Page(s) 41–50

    Abstract: Dissolution dynamic nuclear polarization (d-DNP) is a versatile method to enhance nuclear magnetic resonance (NMR) spectroscopy. It boosts signal intensities by four to five orders of magnitude thereby providing the potential to improve and enable a ... ...

    Abstract Dissolution dynamic nuclear polarization (d-DNP) is a versatile method to enhance nuclear magnetic resonance (NMR) spectroscopy. It boosts signal intensities by four to five orders of magnitude thereby providing the potential to improve and enable a plethora of applications ranging from the real-time monitoring of chemical or biological processes to metabolomics and in-cell investigations. This perspectives article highlights possible avenues for developments and applications of d-DNP in biochemical and physicochemical studies. It outlines how chemists, biologists and physicists with various fields of interest can transform and employ d-DNP as a powerful characterization method for their research.
    MeSH term(s) Biochemistry/instrumentation ; Chemistry, Physical/instrumentation ; Equipment Design ; Image Enhancement ; Nuclear Magnetic Resonance, Biomolecular/methods ; Nuclear Physics/instrumentation
    Language English
    Publishing date 2019-06-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1469665-4
    ISSN 1096-0856 ; 1557-8968 ; 1090-7807 ; 0022-2364
    ISSN (online) 1096-0856 ; 1557-8968
    ISSN 1090-7807 ; 0022-2364
    DOI 10.1016/j.jmr.2019.06.001
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