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Article ; Online: Haemodynamic effects of the flavonoid quercetin in rats revisited.

Vrolijk, Misha F / van Essen, Helma / Opperhuizen, Antoon / Bast, Aalt / Janssen, Ben J

2020 Volume 177, Issue 8, Page(s) 1841–1852

Abstract: Background and purpose: The flavonoid quercetin increased the in vitro potency of the α: Experimental approach: First, in rats pretreated with quercetin or its vehicle, responses to phenylephrine and tamsulosin were examined. Second, tamsulosin- ... ...

Abstract	Background and purpose: The flavonoid quercetin increased the in vitro potency of the α Experimental approach: First, in rats pretreated with quercetin or its vehicle, responses to phenylephrine and tamsulosin were examined. Second, tamsulosin-induced changes in renal, mesenteric, hindquarter and carotid conductance were compared in quercetin- and vehicle-treated rats instrumented with Doppler flow probes. Animals were also placed on a tilt table to record regional haemodynamic changes to orthostatic challenges. Third, adult SHR were instrumented with telemeters to measure 24-hr patterns of BP. Recordings were made before and during a 5-week oral treatment of quercetin. Finally, pre-hypertensive SHR were treated with quercetin from 4 to 8 weeks of age and arterial pressure was measured at 8 and 12 weeks. Key results: Pretreatment with quercetin did not influence the responses to phenylephrine and tamsulosin, in neither WKY nor SHR. While tamsulosin treatment and tilting lowered BP and increased conductance in all vascular beds, effect size was not influenced by pretreatment with quercetin. Prolonged treatment with quercetin, in either prehypertensive SHR or adult SHR with established hypertension did not lower BP. Conclusions and implications: Cumulatively, these data demonstrate that quercetin does not amplify haemodynamic effects of tamsulosin or tilting in vivo in rats and has no effect on BP development in SHR.
MeSH term(s)	Animals ; Blood Pressure ; Flavonoids ; Hemodynamics ; Hypertension/drug therapy ; Quercetin/pharmacology ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY
Chemical Substances	Flavonoids ; Quercetin (9IKM0I5T1E)
Language	English
Publishing date	2020-02-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80081-8
ISSN	1476-5381 ; 0007-1188
ISSN (online)	1476-5381
ISSN	0007-1188
DOI	10.1111/bph.14955
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Article ; Online: Letter to the editor: Ketamine-only versus isoflurane effects on murine cardiac function: comparison at similar depths of anesthesia?

Zuurbier, Coert J / Koeman, Anneke / Janssen, Ben J

American journal of physiology. Heart and circulatory physiology

2015 Volume 309, Issue 12, Page(s) H2160

MeSH term(s)	Anesthetics/pharmacology ; Animals ; Ethanol/analogs & derivatives ; Female ; Heart Ventricles/diagnostic imaging ; Heart Ventricles/drug effects ; Ketamine/pharmacology ; Male ; Ultrasonography ; Ventricular Function, Left/drug effects
Chemical Substances	Anesthetics ; Ethanol (3K9958V90M) ; Ketamine (690G0D6V8H)
Language	English
Publishing date	2015-12-16
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	603838-4
ISSN	1522-1539 ; 0363-6135
ISSN (online)	1522-1539
ISSN	0363-6135
DOI	10.1152/ajpheart.00792.2015
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Article ; Online: Nitric Oxide Synthase Inhibition Induces Renal Medullary Hypoxia in Conscious Rats.

Emans, Tonja W / Janssen, Ben J / Joles, Jaap A / Krediet, C T Paul

Journal of the American Heart Association

2018 Volume 7, Issue 15, Page(s) e009501

Abstract: Background Renal hypoxia, implicated as crucial factor in onset and progression of chronic kidney disease, may be attributed to reduced nitric oxide because nitric oxide dilates vasculature and inhibits mitochondrial oxygen consumption. We hypothesized ... ...

Abstract	Background Renal hypoxia, implicated as crucial factor in onset and progression of chronic kidney disease, may be attributed to reduced nitric oxide because nitric oxide dilates vasculature and inhibits mitochondrial oxygen consumption. We hypothesized that chronic nitric oxide synthase inhibition would induce renal hypoxia. Methods and Results Oxygen-sensitive electrodes, attached to telemeters, were implanted in either renal cortex (n=6) or medulla (n=7) in rats. After recovery and stabilization, baseline oxygenation ( pO
MeSH term(s)	Animals ; Blood Pressure/drug effects ; Blood Pressure/physiology ; Enzyme Inhibitors/pharmacology ; Glomerular Filtration Rate/drug effects ; Glomerular Filtration Rate/physiology ; Hypertension ; Hypoxia ; Kidney Cortex/drug effects ; Kidney Cortex/metabolism ; Kidney Medulla/drug effects ; Kidney Medulla/metabolism ; Male ; Nitric Oxide Synthase/antagonists & inhibitors ; Nitroarginine/pharmacology ; Oxygen/metabolism ; Proteinuria ; Rats ; Renal Circulation/drug effects ; Renal Circulation/physiology ; Sodium/metabolism
Chemical Substances	Enzyme Inhibitors ; Nitroarginine (2149-70-4) ; Sodium (9NEZ333N27) ; Nitric Oxide Synthase (EC 1.14.13.39) ; Oxygen (S88TT14065)
Language	English
Publishing date	2018-07-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.118.009501
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Article ; Online: The Dutch list of essential drugs for undergraduate medical education: A modified Delphi study.

Donker, Erik M / Pandit, Rahul / Poleij, Merel C S / Brinkman, David J / van Agtmael, Michiel A / van Rosse, Floor / Dumont, Glenn / Kramers, Cornelis / Atiqi, Roya / Richir, Milan C / van Smeden, Jeroen / Hessel, Marleen H M / Janssen, Ben J / Knol, Wilma / Tichelaar, Jelle

British journal of clinical pharmacology

2022 Volume 89, Issue 4, Page(s) 1431–1451

Abstract: Aims: Prescribing errors among junior doctors are common in clinical practice because many lack prescribing competence after graduation. This is in part due to inadequate education in clinical pharmacology and therapeutics (CP&T) in the undergraduate ... ...

Abstract	Aims: Prescribing errors among junior doctors are common in clinical practice because many lack prescribing competence after graduation. This is in part due to inadequate education in clinical pharmacology and therapeutics (CP&T) in the undergraduate medical curriculum. To support CP&T education, it is important to determine which drugs medical undergraduates should be able to prescribe safely and effectively without direct supervision by the time they graduate. Currently, there is no such list with broad-based consensus. Therefore, the aim was to reach consensus on a list of essential drugs for undergraduate medical education in the Netherlands. Methods: A two-round modified Delphi study was conducted among pharmacists, medical specialists, junior doctors and pharmacotherapy teachers from all eight Dutch academic hospitals. Participants were asked to indicate whether it was essential that medical graduates could prescribe specific drugs included on a preliminary list. Drugs for which ≥80% of all respondents agreed or strongly agreed were included in the final list. Results: In all, 42 (65%) participants completed the two Delphi rounds. A total of 132 drugs (39%) from the preliminary list and two (3%) newly proposed drugs were included. Conclusions: This is the first Delphi consensus study to identify the drugs that Dutch junior doctors should be able to prescribe safely and effectively without direct supervision. This list can be used to harmonize and support the teaching and assessment of CP&T. Moreover, this study shows that a Delphi method is suitable to reach consensus on such a list, and could be used for a European list.
MeSH term(s)	Humans ; Education, Medical, Undergraduate/methods ; Drugs, Essential ; Delphi Technique ; Clinical Competence ; Curriculum
Chemical Substances	Drugs, Essential
Language	English
Publishing date	2022-12-08
Publishing country	England
Document type	Journal Article
ZDB-ID	188974-6
ISSN	1365-2125 ; 0306-5251 ; 0264-3774
ISSN (online)	1365-2125
ISSN	0306-5251 ; 0264-3774
DOI	10.1111/bcp.15606
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Article: The Beneficial Effects of UM206 on Wound Healing After Myocardial Infarction in Mice Are Lost in Follow-Up Experiments.

Daskalopoulos, Evangelos P / Hermans, Kevin C M / Debets, Jacques / Strzelecka, Agnieszka / Leenders, Peter / Vervoort-Peters, Lily / Janssen, Ben J A / Blankesteijn, W Matthijs

Frontiers in cardiovascular medicine

2019 Volume 6, Page(s) 118

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2019-09-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2019.00118
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Article ; Online: Targeting Wnt signaling to improve wound healing after myocardial infarction.

Daskalopoulos, Evangelos P / Janssen, Ben J A / Blankesteijn, W Matthijs

Methods in molecular biology (Clifton, N.J.)

2013 Volume 1037, Page(s) 355–380

Abstract: Myocardial infarction is one of the major causes of left ventricular dilatation, frequently leading to heart failure. In the last decade, the wound healing process that takes place in the infarct area after infarction has been recognized as a novel ... ...

Abstract	Myocardial infarction is one of the major causes of left ventricular dilatation, frequently leading to heart failure. In the last decade, the wound healing process that takes place in the infarct area after infarction has been recognized as a novel therapeutic target to attenuate left ventricular dilatation and preserve an adequate cardiac function. In this chapter, we discuss the role of Wnt signaling in the wound healing process after infarction, with a specific focus on its modulating effect on myofibroblast characteristics.
MeSH term(s)	Adrenergic beta-Antagonists/pharmacology ; Adrenergic beta-Antagonists/therapeutic use ; Angiotensin-Converting Enzyme Inhibitors/pharmacology ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Animals ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Frizzled Receptors/antagonists & inhibitors ; Frizzled Receptors/metabolism ; Heart Failure/etiology ; Heart Failure/metabolism ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Molecular Targeted Therapy ; Myocardial Infarction/drug therapy ; Myocardial Infarction/metabolism ; Myofibroblasts/drug effects ; Myofibroblasts/metabolism ; Renin-Angiotensin System/drug effects ; Signal Transduction/drug effects ; Ventricular Remodeling/drug effects ; Wnt Proteins/metabolism ; Wound Healing/drug effects
Chemical Substances	Adrenergic beta-Antagonists ; Angiotensin-Converting Enzyme Inhibitors ; Frizzled Receptors ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Wnt Proteins
Language	English
Publishing date	2013
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-62703-505-7_21
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Article: Circadian Rhythm in Kidney Tissue Oxygenation in the Rat.

Emans, Tonja W / Janssen, Ben J / Joles, Jaap A / Krediet, C T Paul

Frontiers in physiology

2017 Volume 8, Page(s) 205

Abstract: Blood pressure, renal hemodynamics, electrolyte, and water excretion all display diurnal oscillation. Disturbance of these patterns is associated with hypertension and chronic kidney disease. Kidney oxygenation is dependent on oxygen delivery and ... ...

Abstract	Blood pressure, renal hemodynamics, electrolyte, and water excretion all display diurnal oscillation. Disturbance of these patterns is associated with hypertension and chronic kidney disease. Kidney oxygenation is dependent on oxygen delivery and consumption that in turn are determined by renal hemodynamics and metabolism. We hypothesized that kidney oxygenation also demonstrates 24-h periodicity. Telemetric oxygen-sensitive carbon paste electrodes were implanted in Sprague-Dawley rats (250-300 g), either in renal medulla (
Language	English
Publishing date	2017-04-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2017.00205
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Article ; Online: The impact of a summative national prescribing assessment and curriculum type on the development of the prescribing competence of junior doctors.

European journal of clinical pharmacology

2023 Volume 79, Issue 12, Page(s) 1613–1621

Abstract: Purpose: The primary aim of this study was to investigate the effect of including the Dutch National Pharmacotherapy Assessment (DNPA) in the medical curriculum on the level and development of prescribing knowledge and skills of junior doctors. The ... ...

Abstract	Purpose: The primary aim of this study was to investigate the effect of including the Dutch National Pharmacotherapy Assessment (DNPA) in the medical curriculum on the level and development of prescribing knowledge and skills of junior doctors. The secondary aim was to evaluate the relationship between the curriculum type and the prescribing competence of junior doctors. Methods: We re-analysed the data of a longitudinal study conducted in 2016 involving recently graduated junior doctors from 11 medical schools across the Netherlands and Belgium. Participants completed three assessments during the first year after graduation (around graduation (+ / - 4 weeks), and 6 months, and 1 year after graduation), each of which contained 35 multiple choice questions (MCQs) assessing knowledge and three clinical case scenarios assessing skills. Only one medical school used the DNPA in its medical curriculum; the other medical schools used conventional means to assess prescribing knowledge and skills. Five medical schools were classified as providing solely theoretical clinical pharmacology and therapeutics (CPT) education; the others provided both theoretical and practical CPT education (mixed curriculum). Results: Of the 1584 invited junior doctors, 556 (35.1%) participated, 326 (58.6%) completed the MCQs and 325 (58.5%) the clinical case scenarios in all three assessments. Junior doctors whose medical curriculum included the DNPA had higher knowledge scores than other junior doctors (76.7% [SD 12.5] vs. 67.8% [SD 12.6], 81.8% [SD 11.1] vs. 76.1% [SD 11.1], 77.0% [12.1] vs. 70.6% [SD 14.0], p < 0.05 for all three assessments, respectively). There was no difference in skills scores at the moment of graduation (p = 0.110), but after 6 and 12 months junior doctors whose medical curriculum included the DNPA had higher skills scores (both p < 0.001). Junior doctors educated with a mixed curriculum had significantly higher scores for both knowledge and skills than did junior doctors educated with a theoretical curriculum (p < 0.05 in all assessments). Conclusion: Our findings suggest that the inclusion of the knowledge focused DNPA in the medical curriculum improves the prescribing knowledge, but not the skills, of junior doctors at the moment of graduation. However, after 6 and 12 months, both the knowledge and skills were higher in the junior doctors whose medical curriculum included the DNPA. A curriculum that provides both theoretical and practical education seems to improve both prescribing knowledge and skills relative to a solely theoretical curriculum.
MeSH term(s)	Humans ; Longitudinal Studies ; Curriculum ; Education, Medical ; Netherlands ; Medical Staff, Hospital/education ; Clinical Competence
Language	English
Publishing date	2023-09-22
Publishing country	Germany
Document type	Journal Article
ZDB-ID	121960-1
ISSN	1432-1041 ; 0031-6970
ISSN (online)	1432-1041
ISSN	0031-6970
DOI	10.1007/s00228-023-03567-4
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Article ; Online: Myofibroblasts in the infarct area: concepts and challenges.

Daskalopoulos, Evangelos P / Janssen, Ben J A / Blankesteijn, W Matthijs

Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada

2012 Volume 18, Issue 1, Page(s) 35–49

Abstract: Myofibroblasts are differentiated fibroblasts that hold a key role in wound healing and remodeling following myocardial infarction (MI). A large repertoire of stimuli, such as mechanical stretch, growth factors, cytokines, and vasoactive peptides, ... ...

Abstract	Myofibroblasts are differentiated fibroblasts that hold a key role in wound healing and remodeling following myocardial infarction (MI). A large repertoire of stimuli, such as mechanical stretch, growth factors, cytokines, and vasoactive peptides, induces myofibroblast differentiation. Myofibroblasts are responsible for the production and deposition of collagen, leading to the establishment of a dense extracellular matrix that strengthens the infarcted tissue and minimizes dilatation of the infarct area. In addition, cells contributing to fibrosis act on sites distal from the infarct area and promote collagen deposition in noninfarcted tissue, thus contributing to adverse remodeling and consequently to the development of congestive heart failure (CHF). Current drugs that are used to treat post-MI CHF do influence fibroblasts and myofibroblasts; however, their therapeutic efficacy is far from being regarded as ideal. Novel therapeutic agents targeting (myo)fibroblasts are being developed to successfully prevent the cardiac remodeling of sites remote from the infarct area and therefore hinder the establishment of CHF. The purpose of this review article is to discuss the basic concepts of the myofibroblasts' actions in cardiac wound healing processes, factors that influence them, currently available pharmacological agents, and future challenges in this area.
MeSH term(s)	Animals ; Collagen/metabolism ; Extracellular Matrix/metabolism ; Fibroblasts/metabolism ; Fibroblasts/physiology ; Fibrosis/pathology ; Fibrosis/physiopathology ; Heart Failure/pathology ; Heart Failure/physiopathology ; Humans ; Mice ; Myocardial Infarction/pathology ; Myocardial Infarction/physiopathology ; Myofibroblasts/metabolism ; Myofibroblasts/physiology ; Rats ; Wound Healing
Chemical Substances	Collagen (9007-34-5)
Language	English
Publishing date	2012-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1385710-1
ISSN	1435-8115 ; 1431-9276
ISSN (online)	1435-8115
ISSN	1431-9276
DOI	10.1017/S143192761101227X
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Article ; Online: Angiotensin II-induced hypertension in rats is only transiently accompanied by lower renal oxygenation.

Emans, Tonja W / Patinha, Daniela / Joles, Jaap A / Koeners, Maarten P / Janssen, Ben J / Krediet, C T Paul

Scientific reports

2018 Volume 8, Issue 1, Page(s) 16342

Abstract: Activation of the renin-angiotensin system may initiate chronic kidney disease. We hypothesised that renal hypoxia is a consequence of hemodynamic changes induced by angiotensin II and occurs prior to development of severe renal damage. Male Sprague- ... ...

Abstract	Activation of the renin-angiotensin system may initiate chronic kidney disease. We hypothesised that renal hypoxia is a consequence of hemodynamic changes induced by angiotensin II and occurs prior to development of severe renal damage. Male Sprague-Dawley rats were infused continuously with angiotensin II (350 ng/kg/min) for 8 days. Mean arterial pressure (n = 5), cortical (n = 6) and medullary (n = 7) oxygenation (pO
MeSH term(s)	Angiotensin II/pharmacology ; Angiotensin II Type 1 Receptor Blockers/pharmacology ; Animals ; Arterial Pressure/drug effects ; Circadian Rhythm/drug effects ; Dose-Response Relationship, Drug ; Hypertension/chemically induced ; Hypertension/metabolism ; Hypertension/physiopathology ; Kidney/drug effects ; Kidney/metabolism ; Kinetics ; Male ; Rats ; Rats, Sprague-Dawley ; Receptor, Angiotensin, Type 1/metabolism ; Renin-Angiotensin System/drug effects
Chemical Substances	Angiotensin II Type 1 Receptor Blockers ; Receptor, Angiotensin, Type 1 ; Angiotensin II (11128-99-7)
Language	English
Publishing date	2018-11-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-018-34211-2
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