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  1. Article ; Online: Getting to the Heart of the Heart-Brain Connection: Association or Causation?

    Janssen, Esther / de Leeuw, Frank-Erik

    Neurology

    2023  Volume 101, Issue 2, Page(s) 57–58

    MeSH term(s) Humans ; Heart ; Brain ; Causality ; Head
    Language English
    Publishing date 2023-05-18
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000207520
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The association between reverse total shoulder arthroplasty neck-shaft angle on postoperative patient experienced shoulder disability: a retrospective cohort study.

    Engelen, Bob / Janssen, Esther / Lambers Heerspink, Okke

    JSES international

    2022  Volume 7, Issue 2, Page(s) 264–269

    Abstract: Background: The neck-shaft angle (NSA) of the glenoid component used in reverse total shoulder arthroplasty (RTSA) was reduced to improve functional outcomes. This led to a decreased abduction but increased external rotation ability of patients who ... ...

    Abstract Background: The neck-shaft angle (NSA) of the glenoid component used in reverse total shoulder arthroplasty (RTSA) was reduced to improve functional outcomes. This led to a decreased abduction but increased external rotation ability of patients who underwent RTSA. The impact of the decreased NSA on patient-reported shoulder disability is unknown but may have important implications for functional ability. Therefore, the aim of this study was to assess the difference in patient experienced shoulder disability between an NSA of 135° and 155° 12 months after RTSA.
    Methods: In this retrospective cohort study, 109 patients undergoing RTSA were included. In 68 patients, a glenoid component with an NSA of 135° was used and 41 patients received a glenoid component with an NSA of 155°. The primary outcome was Disabilities of the Arm, Shoulder, and Hand (DASH) scores at 12 months and change scores between baseline and 12-month follow-up. Secondary outcomes were complications, Constant Murley Score, Numeric Rating Scale, active forward elevation and external rotation ability. Differences between groups were tested with
    Results: A mean difference of 10.0 in 12 months postoperative DASH scores between NSA groups was observed in favor of the 135° NSA (
    Conclusions: No clinically important difference in patient-reported shoulder disability (DASH) was found between both groups, despite a larger range of motion in the 135° NSA group. This study is the first to show the impact of NSA on patient-reported shoulder disability using the DASH.
    Language English
    Publishing date 2022-12-23
    Publishing country United States
    Document type Journal Article
    ISSN 2666-6383
    ISSN (online) 2666-6383
    DOI 10.1016/j.jseint.2022.12.013
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  3. Article: Mid-term survival of the Optimys short stem: A prospective case series of 500 patients.

    Hamans, Bryan / de Waard, Sheryl / Kaarsemaker, Sjoerd / Janssen, Esther R C / Sierevelt, Inger N / Kerkhoffs, Gino M M J / Haverkamp, Daniël

    World journal of orthopedics

    2024  Volume 15, Issue 3, Page(s) 257–265

    Abstract: Background: In recent years, there has been an increase in the number of total hip arthroplasty procedures in the younger patient population. This active group has higher expectations of their prosthesis in comparison to the older population, and there ... ...

    Abstract Background: In recent years, there has been an increase in the number of total hip arthroplasty procedures in the younger patient population. This active group has higher expectations of their prosthesis in comparison to the older population, and there is a greater physical demand for the prosthesis. Short femoral stems were introduced to retain proximal bone stock and joint biomechanics and became more common to implant in this specific population. Currently, the long-term survival and functional outcomes of various short stems are still being investigated in different clinics.
    Aim: To determine the 5-year survival of the Optimys hip stem.
    Methods: This was a prospective multicenter cohort study of 500 patients conducted in two hospitals in the Netherlands. All patients received the Optimys short stem (Mathys Ltd, Bettlach, Switzerland). The primary outcome measure was survival of the hip stem, with revision as the endpoint. The secondary outcome measurements included patient-reported outcome measures (PROMs). Kaplan-Meier analysis was used to calculate the 5-year survival rate. Log-minus-log transformation was performed to calculate the 95% confidence interval (95%CI). Mixed model analyses were performed to assess the course of the PROMs during the 1
    Results: The mean age of the total 500 patients was 62.3 years (standard deviation: 10.6) and 202 were male (40%). At a median follow-up of 5.5 years (interquartile range: 4.5-6.7), 7 patients were deceased and 6 revisions were registered, for infection (
    Conclusion: The Optimys stem has a 5-year survival of 98.8%. Patient-reported outcome measures increased significantly in the 1
    Language English
    Publishing date 2024-03-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2649712-8
    ISSN 2218-5836
    ISSN 2218-5836
    DOI 10.5312/wjo.v15.i3.257
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  4. Article ; Online: Colorectal cancer health and care quality indicators in a federated setting using the Personal Health Train.

    Choudhury, Ananya / Janssen, Esther / Bongers, Bart C / van Meeteren, Nico L U / Dekker, Andre / van Soest, Johan

    BMC medical informatics and decision making

    2024  Volume 24, Issue 1, Page(s) 121

    Abstract: Objective: Hospitals and healthcare providers should assess and compare the quality of care given to patients and based on this improve the care. In the Netherlands, hospitals provide data to national quality registries, which in return provide annual ... ...

    Abstract Objective: Hospitals and healthcare providers should assess and compare the quality of care given to patients and based on this improve the care. In the Netherlands, hospitals provide data to national quality registries, which in return provide annual quality indicators. However, this process is time-consuming, resource intensive and risks patient privacy and confidentiality. In this paper, we presented a multicentric 'Proof of Principle' study for federated calculation of quality indicators in patients with colorectal cancer. The findings suggest that the proposed approach is highly time-efficient and consume significantly lesser resources.
    Materials and methods: Two quality indicators are calculated in an efficient and privacy presevering federated manner, by i) applying the Findable Accessible Interoperable and Reusable (FAIR) data principles and ii) using the Personal Health Train (PHT) infrastructure. Instead of sharing data to a centralized registry, PHT enables analysis by sending algorithms and sharing only insights from the data.
    Results: ETL process extracted data from the Electronic Health Record systems of the hospitals, converted them to FAIR data and hosted in RDF endpoints within each hospital. Finally, quality indicators from each center are calculated using PHT and the mean result along with the individual results plotted.
    Discussion and conclusion: PHT and FAIR data principles can efficiently calculate quality indicators in a privacy-preserving federated approach and the work can be scaled up both nationally and internationally. Despite this, application of the methodology was largely hampered by ELSI issues. However, the lessons learned from this study can provide other hospitals and researchers to adapt to the process easily and take effective measures in building quality of care infrastructures.
    MeSH term(s) Humans ; Colorectal Neoplasms/therapy ; Quality Indicators, Health Care/standards ; Netherlands ; Electronic Health Records/standards ; Registries/standards
    Language English
    Publishing date 2024-05-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Multicenter Study
    ZDB-ID 2046490-3
    ISSN 1472-6947 ; 1472-6947
    ISSN (online) 1472-6947
    ISSN 1472-6947
    DOI 10.1186/s12911-024-02526-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Handheld Ultrasound Does not Replace Magnetic Resonance Imaging for Diagnosis of Rotator Cuff Tears.

    van der Kraats, Annick M / Peeters, Nina H C / Janssen, Esther R C / Lambers Heerspink, F Okke

    Arthroscopy, sports medicine, and rehabilitation

    2023  Volume 5, Issue 2, Page(s) e381–e387

    Abstract: Purpose: The purpose of this study was to examine the reliability and validity of handheld ultrasound (HHUS) alone versus conventional ultrasound (US) or magnetic resonance imaging (MRI) for diagnosis of rotator cuff tears and versus MRI plus computed ... ...

    Abstract Purpose: The purpose of this study was to examine the reliability and validity of handheld ultrasound (HHUS) alone versus conventional ultrasound (US) or magnetic resonance imaging (MRI) for diagnosis of rotator cuff tears and versus MRI plus computed tomography (CT) for diagnosis of fatty infiltration.
    Methods: Adult patients with shoulder complaints were included in this study. HHUS of the shoulder was performed twice by an orthopedic surgeon and once by a radiologist. RCTs, tear width, retraction and FI were measured. Inter- and intrarater reliability of the HHUS was calculated using a Cohen's kappa coefficient. Criterion and concurrent validity were calculated using a Spearman's correlation coefficient.
    Results: Sixty-one patients (64 shoulders) were included in this study. Intra-rater agreement of HHUS for assessment of RCTs (к = 0.914, supraspinatus) and FI (к = 0.844, supraspinatus) was moderate to strong. Interrater agreement was none to minimal for the diagnosis of RCTs (к = 0.465, supraspinatus) and FI (к = 0.346, supraspinatus). Concurrent validity of HHUS compared to MRI was fair for diagnosis of RCTs (
    Conclusions: On the basis of findings in this study, we conclude that HHUS is an aid in diagnosis of RCTs and higher degrees of FI in patients who are not obese, but it does not replace MRI as the gold standard. Further clinical studies on the application of HHUS comparing HHUS devices in larger patient populations and healthy patients are required to identify its utility in clinical practice.
    Level of evidence: Level III.
    Language English
    Publishing date 2023-03-01
    Publishing country United States
    Document type Journal Article
    ISSN 2666-061X
    ISSN (online) 2666-061X
    DOI 10.1016/j.asmr.2023.01.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The prevalence and clinical course of shoulder injury related to vaccine administration (SIRVA) after COVID-19 vaccines in Dutch hospital workers.

    Janssen, Esther R C / van Montfoort, Astrid Z / Hollman, Freek / Lambers Heerspink, Frederik O

    Vaccine

    2023  Volume 41, Issue 41, Page(s) 6042–6047

    Abstract: Introduction: Shoulder Injury Related to Vaccine Administration (SIRVA) is a rare disorder characterized by persistent shoulder pain and limited range of motion presenting within 48 h after vaccine administration. With the widespread distribution of the ...

    Abstract Introduction: Shoulder Injury Related to Vaccine Administration (SIRVA) is a rare disorder characterized by persistent shoulder pain and limited range of motion presenting within 48 h after vaccine administration. With the widespread distribution of the COVID-19 vaccine, the incidence of SIRVA is expected to rise. This sudden rise in vaccine administration presents an ideal opportunity to estimate the prevalence of SIRVA and to better characterize SIRVA.
    Objective: This study aims to investigate the prevalence of SIRVA following COVID-19 vaccine administration among hospital workers in the Netherlands.
    Methods: A questionnaire was sent to all hospital workers from a single non-academic hospital in the Netherlands. Respondents who had active SIRVA complaints were invited for an outpatient orthopaedic clinic assessment. Data was collected on participant characteristics and physical examination including assessment of active and passive range of motion (ROM). An ultrasound was performed to identify potential abnormalities.
    Results: 32 out of 981 (3.3%) respondents reported shoulder pain with limited ROM occurring within 48 h after vaccine administration lasting for at least 7 days. Of these 32 respondents with SIRVA, 18 (56.2%) still reported active symptoms at the time of the survey. Clinical examination of 13 (72.2%) respondents with active SIRVA complaints showed limited glenohumeral ROM, limitations in activities of daily living and injection site pain. Twelve out of thirteen (92.3%) respondents with active SIRVA complaints showed abnormalities of the soft-tissue of the shoulder on ultrasound. Physiotherapy was the most common treatment modality for persistent SIRVA complaints (38.9%).
    Conclusions: The prevalence of SIRVA is estimated at 3% in the adult working population. Signs and symptoms of SIRVA are variable in severity, localization and timing. Soft-tissue abnormalities is the most common clinical sign. This study contributes to clinician's knowledge on SIRVA, aiding in early recognition and treatment, which are imperative for prevention of persistent and severe shoulder pathology.
    MeSH term(s) Adult ; Humans ; COVID-19 Vaccines/adverse effects ; Prevalence ; Activities of Daily Living ; Shoulder Pain/epidemiology ; Shoulder Pain/etiology ; COVID-19/epidemiology ; COVID-19/prevention & control ; Shoulder Injuries ; Hospitals ; Disease Progression
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2023-08-25
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2023.08.043
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  7. Article ; Online: Visit-to-visit blood pressure variability and progression of white matter hyperintensities over 14 years.

    Janssen, Esther / van Dalen, Jan Willem / Cai, Mengfei / Jacob, Mina A / Marques, José / Duering, Marco / Richard, Edo / Tuladhar, Anil M / de Leeuw, Frank-Erik / Hilkens, Nina

    Blood pressure

    2024  Volume 33, Issue 1, Page(s) 2314498

    Abstract: Purpose:: Materials and methods:: Results:: Conclusions: ...

    Abstract Purpose:
    Materials and methods:
    Results:
    Conclusions:
    MeSH term(s) Humans ; Blood Pressure/physiology ; White Matter ; Blood Pressure Determination/methods ; Magnetic Resonance Imaging ; Stroke ; Disease Progression
    Language English
    Publishing date 2024-03-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 1170048-8
    ISSN 1651-1999 ; 1651-2480 ; 0803-7051 ; 0803-8023
    ISSN (online) 1651-1999 ; 1651-2480
    ISSN 0803-7051 ; 0803-8023
    DOI 10.1080/08037051.2024.2314498
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  8. Article ; Online: Preoperative community based functional high intensity interval training (

    Janssen, Esther R C / Punt, Ilona M / Biemans, Camille F M / van Rhijn, Lodewijk / Willems, Paul C / van Meeteren, Nico L U

    Disability and rehabilitation

    2022  Volume 45, Issue 5, Page(s) 805–813

    Abstract: Purpose: To determine the feasibility, safety and preliminary effectiveness of preoperative functional high-intensity interval training (: Materials and methods: High-risk patients eligible for elective 1-3 level LSF were included. Feasibility and ... ...

    Abstract Purpose: To determine the feasibility, safety and preliminary effectiveness of preoperative functional high-intensity interval training (
    Materials and methods: High-risk patients eligible for elective 1-3 level LSF were included. Feasibility and safety of the preoperative f-HIIT program was determined by measuring participation and attrition rates, training adherence, adverse events, reached training intensity and preoperative progression in physical fitness. Preliminary effect of the preoperative f-HIIT program was estimated on time to postoperative functional recovery and length of hospital stay (LoS) between high-risk patients who did and did not participate in the prehabilitation program.
    Results: Eleven out of 23 high-risk patients opted to participate in the
    Conclusions: The preoperative
    MeSH term(s) Humans ; High-Intensity Interval Training ; Pilot Projects ; Spinal Fusion ; Physical Fitness ; Recovery of Function
    Language English
    Publishing date 2022-02-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 1104775-6
    ISSN 1464-5165 ; 0963-8288
    ISSN (online) 1464-5165
    ISSN 0963-8288
    DOI 10.1080/09638288.2022.2040618
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  9. Article ; Online: Exploring clinically relevant risk profiles in patients undergoing lumbar spinal fusion: a cohort study.

    Janssen, Esther R C / Prestigiacomo, F G / van Leent, E A P / van Meeteren, N L U / Hulsbosch, M

    European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

    2022  Volume 31, Issue 10, Page(s) 2473–2480

    Abstract: Purpose: To explore risk profiles of patients scheduled for lumbar spinal fusion (LSF) and their association with short-term recovery of patient after surgery.: Methods: Forty-nine patients scheduled for elective 1-3 level LSF between March 2019 and ... ...

    Abstract Purpose: To explore risk profiles of patients scheduled for lumbar spinal fusion (LSF) and their association with short-term recovery of patient after surgery.
    Methods: Forty-nine patients scheduled for elective 1-3 level LSF between March 2019 and June 2020 were included. Patients underwent a preoperative risk screening, consisting of an anamnesis, questionnaires and physical performance tests. A latent profile analysis (LPA) was used to identify possible risk profiles within this population.
    Results: Two risk profiles could be established: a fit and deconditioned risk profile. A significant between-profile difference was found in smoking status (p = 0.007), RAND36-PCS (p < 0.001), Timed Up and Go (TUG) (p < 0.001), de Morton Morbidity Index (DEMMI) (p < 0.001), finger floor distance (p = 0.050), motor control (p = 0.020) and steep ramp test (p = 0.005). Moreover, the fit risk profile had a significant shorter time to functional recovery (3.65 days versus 4.89 days, p = 0.013) and length of hospital stay (5.06 days versus 6.00 days, p = 0.008) compared to the deconditioned risk profile. No differences in complication rates between both risk profiles could be established. Allocation to a risk profile was associated with the functional recovery rate (p = 0.042), but not with LOS or complications.
    Conclusion: This study found a fit and deconditioned risk profile. The patients with a fit risk profile perceived a better quality of life, performed better in mobility, motor control, cardiopulmonary tests and showed also a significant shorter stay in the hospital and a shorter time to functional recovery. Preoperatively establishing a patient's risk profile could aid in perioperative care planning and preoperative decision-making.
    MeSH term(s) Cohort Studies ; Elective Surgical Procedures ; Humans ; Length of Stay ; Lumbar Vertebrae/surgery ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Postoperative Complications/surgery ; Quality of Life ; Retrospective Studies ; Spinal Fusion/adverse effects
    Language English
    Publishing date 2022-07-28
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1115375-1
    ISSN 1432-0932 ; 0940-6719
    ISSN (online) 1432-0932
    ISSN 0940-6719
    DOI 10.1007/s00586-022-07325-5
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  10. Article ; Online: The validity of ultrasound and shear wave elastography to assess the quality of the rotator cuff.

    Peeters, Nina H C / van der Kraats, Annick M / van der Krieken, Thomas E / van Iersel, Dave / Janssen, Esther R C / Heerspink, Frederik O Lambers

    European radiology

    2023  Volume 34, Issue 3, Page(s) 1971–1978

    Abstract: Objectives: US with shear wave elastography (SWE) could reduce the burden and costs of the diagnostic process for patients with rotator cuff disorders. The aim of this study is to investigate the validity of US and SWE in preoperative assessment of ... ...

    Abstract Objectives: US with shear wave elastography (SWE) could reduce the burden and costs of the diagnostic process for patients with rotator cuff disorders. The aim of this study is to investigate the validity of US and SWE in preoperative assessment of fatty infiltration (FI) and muscle atrophy of the supraspinatus (SSP) and infraspinatus (ISP) muscles.
    Methods: Patients with a rotator cuff disorder and a recent shoulder CT or MRI scan were eligible to participate. Goutallier and Warner stages of the SSP and ISP muscle were measured on the scan, for assessment of FI and muscle atrophy, respectively. These findings were compared with shear wave velocities (SWVs) assessed on US. Visual assessment of FI on US was compared with the Goutallier stage. To quantify the amount of muscle atrophy, the occupation ratio between SSP fossa and muscle was measured on MRI and US.
    Results: Seventy-eight shoulders were included in the analysis. The correlation found between the occupation ratio on US and Warner and Goutallier stage and ratio on MRI ranged between r =  - 0.550 to 0.589. The Goutallier stage of ISP and SSP muscle assessed on US showed a fair correlation with the Goutallier stage on a scan of r = 0.574 and r = 0.582, respectively. There was a poor correlation between the SWVs and scan results (r =  - 0.116 to 0.07).
    Conclusion: SWE is not a valid method to measure the amount of FI or muscle atrophy in the SSP muscle. Therefore, SWE is not a suitable alternative for MRI in standard preoperative diagnostics in rotator cuff pathologies.
    Clinical relevance statement: Shear wave elastography should not be used in the diagnostics of rotator cuff pathologies.
    Key points: • There is a fair correlation between the Goutallier stage of the supraspinatus and infraspinatus muscle assessed on MRI and CT and visual assessment of fatty infiltration achieved on US. • Shear wave elastography is not a valid tool for the determination of the amount of fatty infiltration or muscle atrophy. • Shear wave elastography should not be used as a cheaper and less burdensome alternative for diagnostics in rotator cuff pathologies.
    MeSH term(s) Humans ; Rotator Cuff/pathology ; Elasticity Imaging Techniques ; Shoulder ; Shoulder Joint/diagnostic imaging ; Magnetic Resonance Imaging ; Muscular Atrophy/diagnostic imaging ; Muscular Atrophy/pathology ; Adipose Tissue/diagnostic imaging ; Adipose Tissue/pathology ; Rotator Cuff Injuries/diagnostic imaging
    Language English
    Publishing date 2023-08-30
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1085366-2
    ISSN 1432-1084 ; 0938-7994 ; 1613-3749
    ISSN (online) 1432-1084
    ISSN 0938-7994 ; 1613-3749
    DOI 10.1007/s00330-023-10037-z
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