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  1. Article ; Online: Unweaving the NET: Microbial strategies for neutrophil extracellular trap evasion.

    Janssen, Luis / Muller, Herick Sampaio / Martins, Vicente de Paulo

    Microbial pathogenesis

    2022  Volume 171, Page(s) 105728

    Abstract: Circa 20 years ago, a new type of defense mechanism was described in neutrophils. At the time, this mechanism corresponded to the extrusion of DNA, associated with histones, granular and cytosolic proteins from the cell and it was produced in response to ...

    Abstract Circa 20 years ago, a new type of defense mechanism was described in neutrophils. At the time, this mechanism corresponded to the extrusion of DNA, associated with histones, granular and cytosolic proteins from the cell and it was produced in response to exposure to pathogens or interleukins. The resulting NET-like structure was described as to entrap and/or kill microbes. However, shortly after the discovery the so-called Neutrophil Extracellular Traps, it was soon noticed and often mentioned in the literature that certain microbes are able to evade NET-mediated entrapment and/or death, to the point where its antimicrobial capacities were questioned, depending on the infection context. In this review, we summarize the diversity of strategies published thus far that viruses, fungi, bacteria and protists employ as to prevent or endure NETs. Moreover, we point to a few perspectives on the matter and a few evolutionary speculations on NETs evasion.
    MeSH term(s) Anti-Infective Agents/metabolism ; DNA/metabolism ; Extracellular Traps/metabolism ; Histones/metabolism ; Neutrophils/microbiology
    Chemical Substances Anti-Infective Agents ; Histones ; DNA (9007-49-2)
    Language English
    Publishing date 2022-08-24
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 632772-2
    ISSN 1096-1208 ; 0882-4010
    ISSN (online) 1096-1208
    ISSN 0882-4010
    DOI 10.1016/j.micpath.2022.105728
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2136: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article: Unweaving the NET: Microbial strategies for neutrophil extracellular trap evasion

    Janssen, Luis / Muller, Herick Sampaio / Martins, Vicente de Paulo

    Microbial pathogenesis. 2022 Oct., v. 171

    2022  

    Abstract: Circa 20 years ago, a new type of defense mechanism was described in neutrophils. At the time, this mechanism corresponded to the extrusion of DNA, associated with histones, granular and cytosolic proteins from the cell and it was produced in response to ...

    Abstract Circa 20 years ago, a new type of defense mechanism was described in neutrophils. At the time, this mechanism corresponded to the extrusion of DNA, associated with histones, granular and cytosolic proteins from the cell and it was produced in response to exposure to pathogens or interleukins. The resulting NET-like structure was described as to entrap and/or kill microbes. However, shortly after the discovery the so-called Neutrophil Extracellular Traps, it was soon noticed and often mentioned in the literature that certain microbes are able to evade NET-mediated entrapment and/or death, to the point where its antimicrobial capacities were questioned, depending on the infection context. In this review, we summarize the diversity of strategies published thus far that viruses, fungi, bacteria and protists employ as to prevent or endure NETs. Moreover, we point to a few perspectives on the matter and a few evolutionary speculations on NETs evasion.
    Keywords DNA ; death ; extrusion ; histones ; interleukins ; neutrophils ; pathogenesis ; protists
    Language English
    Dates of publication 2022-10
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 632772-2
    ISSN 1096-1208 ; 0882-4010
    ISSN (online) 1096-1208
    ISSN 0882-4010
    DOI 10.1016/j.micpath.2022.105728
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2136: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Isolation, characterization, and evaluation of putative new bacteriophages for controlling bacterial spot on tomato in Brazil.

    de Sousa, Dayane Maria / Janssen, Luis / Rosa, Raphael Barboza / Belmok, Aline / Yamada, Jaqueline Kiyomi / Corrêa, Roberto Franco Teixeira / de Souza Andrade, Miguel / Inoue-Nagata, Alice Kazuko / Ribeiro, Bergmann Morais / de Carvalho Pontes, Nadson

    Archives of virology

    2023  Volume 168, Issue 9, Page(s) 222

    Abstract: Bacterial spot is a highly damaging tomato disease caused by members of several species of the genus Xanthomonas. Bacteriophages have been studied for their potential use in the biological control of bacterial diseases. In the current study, ... ...

    Abstract Bacterial spot is a highly damaging tomato disease caused by members of several species of the genus Xanthomonas. Bacteriophages have been studied for their potential use in the biological control of bacterial diseases. In the current study, bacteriophages were obtained from soil and tomato leaves in commercial fields in Brazil with the aim of obtaining biological control agents against bacterial spot. Phage isolation was carried out by co-cultivation with isolates of Xanthomonas euvesicatoria pv. perforans, which was prevalent in the collection areas. In a host range evaluation, none of the phage isolates was able to induce a lytic cycle in all of the bacterial isolates tested. In in vivo tests, treatment of susceptible bacterial isolates with the corresponding phage prior to application to tomato plants led to a reduction in the severity of the resulting disease. The level of disease control provided by phage application was equal to or greater than that achieved using copper hydroxide. Electron microscopy analysis showed that all of the phages had similar morphology, with head and tail structures similar to those of viruses belonging to the class Caudoviricetes. The presence of short, non-contractile tubular tails strongly suggested that these phages belong to the family Autographiviridae. This was confirmed by phylogenetic analysis, which further revealed that they all belong to the genus Pradovirus. The phages described here are closely related to each other and potentially belong to a new species within the genus. These phages will be evaluated in future studies against other tomato xanthomonad strains to assess their potential as biological control agents.
    MeSH term(s) Bacteriophages/genetics ; Solanum lycopersicum ; Phylogeny ; Brazil ; Biological Control Agents ; Plant Diseases/prevention & control ; Plant Diseases/microbiology ; Caudovirales
    Chemical Substances Biological Control Agents
    Language English
    Publishing date 2023-08-07
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 7491-3
    ISSN 1432-8798 ; 0304-8608
    ISSN (online) 1432-8798
    ISSN 0304-8608
    DOI 10.1007/s00705-023-05846-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  4. Article: A Novel Multidrug Resistant, Non-Tn

    Janssen, Luis / de Almeida, Felipe Marques / Damasceno, Thais Amanda Silva / Baptista, Rodrigo de Paula / Pappas, Georgios Joannis / de Campos, Tatiana Amabile / Martins, Vicente de Paulo

    Frontiers in microbiology

    2021  Volume 12, Page(s) 732324

    Abstract: Antimicrobial resistance (AMR) is an increasing and urgent issue for human health worldwide, as it leads to the reduction of available antibiotics to treat bacterial infections, in turn increasing hospital stays and lethality. Therefore, the study and ... ...

    Abstract Antimicrobial resistance (AMR) is an increasing and urgent issue for human health worldwide, as it leads to the reduction of available antibiotics to treat bacterial infections, in turn increasing hospital stays and lethality. Therefore, the study and genomic surveillance of bacterial carriers of resistance in and outside of clinical settings is of utter importance. A colony of multidrug resistant (MDR) bacteria identified as
    Language English
    Publishing date 2021-11-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2021.732324
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Schistosome-Derived Molecules as Modulating Actors of the Immune System and Promising Candidates to Treat Autoimmune and Inflammatory Diseases.

    Janssen, Luis / Silva Santos, Gisele Lorranna / Muller, Herick Sampaio / Vieira, Anderson Rodrigues Araújo / de Campos, Tatiana Amabile / de Paulo Martins, Vicente

    Journal of immunology research

    2016  Volume 2016, Page(s) 5267485

    Abstract: It is long known that some parasite infections are able to modulate specific pathways of host's metabolism and immune responses. This modulation is not only important in order to understand the host-pathogen interactions and to develop treatments against ...

    Abstract It is long known that some parasite infections are able to modulate specific pathways of host's metabolism and immune responses. This modulation is not only important in order to understand the host-pathogen interactions and to develop treatments against the parasites themselves but also important in the development of treatments against autoimmune and inflammatory diseases. Throughout the life cycle of schistosomes the mammalian hosts are exposed to several biomolecules that are excreted/secreted from the parasite infective stage, named cercariae, from their tegument, present in adult and larval stages, and finally from their eggs. These molecules can induce the activation and modulation of innate and adaptive responses as well as enabling the evasion of the parasite from host defense mechanisms. Immunomodulatory effects of helminth infections and egg molecules are clear, as well as their ability to downregulate proinflammatory cytokines, upregulate anti-inflammatory cytokines, and drive a Th2 type of immune response. We believe that schistosomes can be used as a model to understand the potential applications of helminths and helminth-derived molecules against autoimmune and inflammatory diseases.
    MeSH term(s) Animals ; Antigens, Helminth/immunology ; Autoimmune Diseases/therapy ; Disease Models, Animal ; Helminths/chemistry ; Host-Parasite Interactions/immunology ; Host-Pathogen Interactions ; Humans ; Immunomodulation ; Inflammation/therapy ; Life Cycle Stages ; Schistosoma/chemistry ; Schistosoma/immunology
    Chemical Substances Antigens, Helminth
    Language English
    Publishing date 2016
    Publishing country Egypt
    Document type Journal Article ; Review
    ZDB-ID 2817541-4
    ISSN 2314-7156 ; 2314-8861
    ISSN (online) 2314-7156
    ISSN 2314-8861
    DOI 10.1155/2016/5267485
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Yellow Fever Virus Maintained by

    de Oliveira, Cirilo H / Andrade, Miguel S / Campos, Fabrício S / da C Cardoso, Jader / Gonçalves-Dos-Santos, Maria Eduarda / Oliveira, Ramon Silva / Aquino-Teixeira, Sandy Micaele / Campos, Aline As / Almeida, Marco Ab / Simonini-Teixeira, Danilo / da P Sevá, Anaiá / Temponi, Andrea Oliveira Dias / Magalhães, Fernando Maria / da Silva Menezes, Agna Soares / Lopes, Bartolomeu Teixeira / Almeida, Hermes P / Pedroso, Ana Lúcia / Gonçalves, Giovani Pontel / Chaves, Danielle Costa Capistrano /
    de Menezes, Givaldo Gomes / Bernal-Valle, Sofía / Müller, Nicolas Fd / Janssen, Luis / Dos Santos, Edmilson / Mares-Guia, Maria A / Albuquerque, George R / Romano, Alessandro Pm / Franco, Ana C / Ribeiro, Bergmann M / Roehe, Paulo M / Lourenço-de-Oliveira, Ricardo / de Abreu, Filipe Vieira Santos

    Viruses

    2023  Volume 15, Issue 3

    Abstract: In recent decades, waves of yellow fever virus (YFV) from the Amazon Rainforest have spread and caused outbreaks in other regions of Brazil, including the Cerrado, a savannah-like biome through which YFV usually moves before arriving at the Atlantic ... ...

    Abstract In recent decades, waves of yellow fever virus (YFV) from the Amazon Rainforest have spread and caused outbreaks in other regions of Brazil, including the Cerrado, a savannah-like biome through which YFV usually moves before arriving at the Atlantic Forest. To identify the vectors involved in the maintenance of the virus in semiarid environments, an entomological survey was conducted after confirmation of yellow fever (YF) epizootics at the peak of the dry season in the Cerrado areas of the state of Minas Gerais. In total, 917 mosquitoes from 13 taxa were collected and tested for the presence of YFV. Interestingly, mosquitoes of the
    MeSH term(s) Humans ; Animals ; Yellow fever virus/genetics ; Culicidae ; Seasons ; Brazil/epidemiology ; Mosquito Vectors
    Language English
    Publishing date 2023-03-15
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15030757
    Database MEDical Literature Analysis and Retrieval System OnLINE

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