Article ; Online: Mechanical Stress Induces Sodium Entry and Osmoprotective Responses in Murine Synovial Fibroblasts.
2024 Volume 13, Issue 6
Abstract: Osteoarthritis (OA) is a multifactorial disease depending on molecular, genetic, and environmental factors like mechanical strain. Next to the cartilage and the subchondral bone, OA also affects the synovium, which is critically involved in the ... ...
| Abstract | Osteoarthritis (OA) is a multifactorial disease depending on molecular, genetic, and environmental factors like mechanical strain. Next to the cartilage and the subchondral bone, OA also affects the synovium, which is critically involved in the maintenance of joint homeostasis. As there is a correlation between the extracellular sodium content in the knee joint and OA, this study investigates the impact of sodium on OA-associated processes like inflammation and bone remodeling without and with mechanical loading in synovial fibroblasts. For that purpose, murine synovial fibroblasts from the knee joint were exposed to three different extracellular sodium chloride concentrations (-20 mM, ±0 mM and +50 mM NaCl) in the absence or presence of compressive or intermittent tensile strain. In addition to the intracellular Na |
|---|---|
| MeSH term(s) | Animals ; Mice ; Cyclooxygenase 2/metabolism ; Interleukin-6/metabolism ; Sodium/metabolism ; Stress, Mechanical ; Osteoarthritis/metabolism ; Receptor Activator of Nuclear Factor-kappa B/metabolism ; Fibroblasts/metabolism |
| Chemical Substances | Cyclooxygenase 2 (EC 1.14.99.1) ; Interleukin-6 ; Sodium (9NEZ333N27) ; Receptor Activator of Nuclear Factor-kappa B |
| Language | English |
| Publishing date | 2024-03-13 |
| Publishing country | Switzerland |
| Document type | Journal Article |
| ZDB-ID | 2661518-6 |
| ISSN | 2073-4409 ; 2073-4409 |
| ISSN (online) | 2073-4409 |
| ISSN | 2073-4409 |
| DOI | 10.3390/cells13060496 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.