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  1. Article: Impact of CytoSorb Hemoadsorption Therapy on Fluid Balance in Patients with Septic Shock.

    Kogelmann, Klaus / Hübner, Tobias / Drüner, Matthias / Jarczak, Dominik

    Journal of clinical medicine

    2024  Volume 13, Issue 1

    Abstract: Recent in vitro studies have investigated the effects of hemoadsorption therapy on endothelial function in sepsis showing a reduction in markers of endothelial dysfunction, but, to this day, there are no clinical studies proving whether this approach ... ...

    Abstract Recent in vitro studies have investigated the effects of hemoadsorption therapy on endothelial function in sepsis showing a reduction in markers of endothelial dysfunction, but, to this day, there are no clinical studies proving whether this approach could actually positively influence the disturbed vascular barrier function in septic conditions. We retrospectively analyzed data on administered fluid volumes and catecholamines in 124 septic shock patients. We collected catecholamine and volume requirements and calculated the volume balance within different time periods to obtain an assumption on the stability of the vascular barrier. Regarding the entire study cohort, our findings revealed a significant reduction in fluid balance at 72 h (T
    Language English
    Publishing date 2024-01-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13010294
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Septic Hyperinflammation-Is There a Role for Extracorporeal Blood Purification Techniques?

    Jarczak, Dominik / Kluge, Stefan / Nierhaus, Axel

    International journal of molecular sciences

    2024  Volume 25, Issue 6

    Abstract: This manuscript investigates the role of extracorporeal blood purification techniques in managing septic hyperinflammation, a critical aspect of sepsis characterized by an uncontrolled immune response leading to multiorgan dysfunction. We provide an ... ...

    Abstract This manuscript investigates the role of extracorporeal blood purification techniques in managing septic hyperinflammation, a critical aspect of sepsis characterized by an uncontrolled immune response leading to multiorgan dysfunction. We provide an overview of sepsis, focusing on the dynamics of immune response, the involvement of neutrophils, and the role of the endothelium in the disease's progression. It evaluates the effectiveness of various blood purification methods, including high-cut-off membranes, high-volume hemofiltration, adsorption techniques, and albumin dialysis, in removing cytokines and endotoxin and improving hemodynamic stability. Despite some very promising results, we conclude that the current evidence does not strongly support these techniques in significantly improving survival rates in septic patients, clearly underlining the need for further research.
    MeSH term(s) Humans ; Renal Dialysis ; Hemofiltration/methods ; Sepsis/therapy ; Cytokines ; Adsorption ; Shock, Septic
    Chemical Substances Cytokines
    Language English
    Publishing date 2024-03-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25063120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Cytokine Storm-Definition, Causes, and Implications.

    Jarczak, Dominik / Nierhaus, Axel

    International journal of molecular sciences

    2022  Volume 23, Issue 19

    Abstract: The human innate and adaptive immune systems consist of effector cells producing cytokines (interleukins, interferons, chemokines, and numerous other mediators). Usually, a fragile equilibrium of pro- and anti-inflammation effects is maintained by ... ...

    Abstract The human innate and adaptive immune systems consist of effector cells producing cytokines (interleukins, interferons, chemokines, and numerous other mediators). Usually, a fragile equilibrium of pro- and anti-inflammation effects is maintained by complex regulatory mechanisms. Disturbances of this homeostasis can lead to intricate chain reactions resulting in a massive release of cytokines. This may result in a drastic self-reinforcement of various feedback mechanisms, which can ultimately lead to systemic damage, multi-organ failure, or death. Not only pathogens can initiate such disturbances, but also congenital diseases or immunomodulatory therapies. Due to the complex and diverse interactions within the innate and adaptive immune systems, the understanding of this important clinical syndrome is incomplete to date and effective therapeutic approaches remain scarce.
    MeSH term(s) Chemokines ; Cytokine Release Syndrome ; Cytokines ; Humans ; Interferons ; Interleukins
    Chemical Substances Chemokines ; Cytokines ; Interleukins ; Interferons (9008-11-1)
    Language English
    Publishing date 2022-10-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms231911740
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Thesis: Inhibition der Replikation und Translation des Hepatitis-C-Virus durch Hairpin-Ribozyme in Kombination mit dem constitutive transport element und RNA-Interferenz

    Jarczak, Dominik

    2005  

    Author's details vorgelegt von Dominik Jarczak
    Subject code 616.3
    Language German
    Size V, 134 Bl., Ill., graph. Darst., 30 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Hannover, Med. Hochsch., Diss., 2007
    HBZ-ID HT015300140
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2007 E 1906 order for loan Magazin

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  5. Article ; Online: Septic shock due to

    Braunsteiner, Josephine / Siedler, Stephanie / Jarczak, Dominik / Kluge, Stefan / Nierhaus, Axel

    Journal of intensive medicine

    2023  Volume 4, Issue 2, Page(s) 265–268

    Language English
    Publishing date 2023-09-26
    Publishing country China
    Document type Case Reports
    ISSN 2667-100X
    ISSN (online) 2667-100X
    DOI 10.1016/j.jointm.2023.08.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Sepsis-Pathophysiology and Therapeutic Concepts.

    Jarczak, Dominik / Kluge, Stefan / Nierhaus, Axel

    Frontiers in medicine

    2021  Volume 8, Page(s) 628302

    Abstract: Sepsis is a life-threatening condition and a global disease burden. Today, the heterogeneous syndrome is defined as severe organ dysfunction caused by a dysregulated host response to infection, with renewed emphasis on immune pathophysiology. Despite all ...

    Abstract Sepsis is a life-threatening condition and a global disease burden. Today, the heterogeneous syndrome is defined as severe organ dysfunction caused by a dysregulated host response to infection, with renewed emphasis on immune pathophysiology. Despite all efforts of experimental and clinical research during the last three decades, the ability to positively influence course and outcome of the syndrome remains limited. Evidence-based therapy still consists of basic causal and supportive measures, while adjuvant interventions such as blood purification or targeted immunotherapy largely remain without proof of effectiveness so far. With this review, we aim to provide an overview of sepsis immune pathophysiology, to update the choice of therapeutic approaches targeting different immunological mechanisms in the course of sepsis and septic shock, and to call for a paradigm shift from the pathogen to the host response as a potentially more promising angle.
    Language English
    Publishing date 2021-05-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2021.628302
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Pharmacokinetics of meropenem during advanced organ support (ADVOS

    König, Christina / Kluge, Stefan / Fuhrmann, Valentin / Jarczak, Dominik

    The International journal of artificial organs

    2021  Volume 44, Issue 10, Page(s) 783–786

    Abstract: The advanced organ support (ADVOS) system allows to eliminate water-soluble as well as protein-bound molecules. Despite its clinical features, to date nothing is known about the elimination of clinically relevant drugs such as antiinfectives. Therefore, ... ...

    Abstract The advanced organ support (ADVOS) system allows to eliminate water-soluble as well as protein-bound molecules. Despite its clinical features, to date nothing is known about the elimination of clinically relevant drugs such as antiinfectives. Therefore, we report a case treated with ADVOS, continuous renal replacement therapy (CRRT), and meropenem (1 g 8-hourly) for empiric sepsis therapy monitored by meropenem drug levels. ADVOS showed more efficient elimination of meropenem compared to CRRT which has to be considered when evaluating dosing regimens.
    Language English
    Publishing date 2021-06-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80456-3
    ISSN 1724-6040 ; 0391-3988
    ISSN (online) 1724-6040
    ISSN 0391-3988
    DOI 10.1177/03913988211021101
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1439: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Use of Intravenous Immunoglobulins in Sepsis Therapy-A Clinical View.

    Jarczak, Dominik / Kluge, Stefan / Nierhaus, Axel

    International journal of molecular sciences

    2020  Volume 21, Issue 15

    Abstract: Sepsis is a life-threatening organ dysfunction, defined by a dysregulated host immune response to infection. During sepsis, the finely tuned system of immunity, inflammation and anti-inflammation is disturbed in a variety of ways. Both pro-inflammatory ... ...

    Abstract Sepsis is a life-threatening organ dysfunction, defined by a dysregulated host immune response to infection. During sepsis, the finely tuned system of immunity, inflammation and anti-inflammation is disturbed in a variety of ways. Both pro-inflammatory and anti-inflammatory pathways are upregulated, activation of the coagulation cascade and complement and sepsis-induced lymphopenia occur. Due to the manifold interactions in this network, the use of IgM-enriched intravenous immunoglobulins seems to be a promising therapeutic approach. Unfortunately, there is still a lack of evidence-based data to answer the important questions of appropriate patient populations, optimal timing and dosage of intravenous immunoglobulins. With this review, we aim to provide an overview of the role of immunoglobulins, with emphasis on IgM-enriched formulations, in the therapy of adult patients with sepsis and septic shock.
    MeSH term(s) Humans ; Immunoglobulin M/immunology ; Immunoglobulin M/therapeutic use ; Immunoglobulins, Intravenous/therapeutic use ; Immunologic Factors/immunology ; Immunologic Factors/therapeutic use ; Inflammation/blood ; Inflammation/immunology ; Inflammation/therapy ; Sepsis/blood ; Sepsis/immunology ; Sepsis/therapy ; Shock, Septic/immunology
    Chemical Substances Immunoglobulin M ; Immunoglobulins, Intravenous ; Immunologic Factors
    Keywords covid19
    Language English
    Publishing date 2020-08-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21155543
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Reply to Supady et al. On the Use of Hemadsorption with CytoSorb in Patients with Septic Shock. Comment on "Kogelmann et al. First Evaluation of a New Dynamic Scoring System Intended to Support Prescription of Adjuvant CytoSorb Hemoadsorption Therapy in Patients with Septic Shock.

    Kogelmann, Klaus / Hübner, Tobias / Schwameis, Franz / Drüner, Matthias / Scheller, Morten / Jarczak, Dominik

    Journal of clinical medicine

    2022  Volume 11, Issue 5

    Abstract: Thank you very much for your interest in our research [ ... ]. ...

    Abstract Thank you very much for your interest in our research [...].
    Language English
    Publishing date 2022-02-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11051192
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Acute-on-chronic liver failure alters linezolid pharmacokinetics in critically ill patients with continuous hemodialysis: an observational study.

    Tikiso, Tjokosela / Fuhrmann, Valentin / König, Christina / Jarczak, Dominik / Iwersen-Bergmann, Stefanie / Kluge, Stefan / Wicha, Sebastian G / Grensemann, Jörn

    Annals of intensive care

    2023  Volume 13, Issue 1, Page(s) 83

    Abstract: Background: In acute-on-chronic liver failure (ACLF), adequate antibiotic dosing is challenging due to changes of drug distribution and elimination. We studied the pharmacokinetics of linezolid in critically ill patients with ACLF during continuous ... ...

    Abstract Background: In acute-on-chronic liver failure (ACLF), adequate antibiotic dosing is challenging due to changes of drug distribution and elimination. We studied the pharmacokinetics of linezolid in critically ill patients with ACLF during continuous renal replacement therapy compared to patients without concomitant liver failure (NLF).
    Methods: In this prospective cohort study, patients received linezolid 600 mg bid. Linezolid serum samples were analyzed by high-performance liquid chromatography. Population pharmacokinetic modelling was performed followed by Monte-Carlo simulations of 150 mg bid, 300 mg bid, 450 mg bid, 600 mg bid, and 900 mg bid to assess trough concentration target attainment of 2-7 mg/L.
    Results: Eighteen patients were included in this study with nine suffering from ACLF. Linezolid body clearance was lower in the ACLF group with mean (standard deviation) 1.54 (0.52) L/h versus 6.26 (2.43) L/h for NLF, P < 0.001. A trough concentration of 2-7 mg/L was reached with the standard dose of 600 mg bid in the NLF group in 47%, with 42% being underexposed and 11% overexposed versus 20% in the ACLF group with 77% overexposed and 3% underexposed. The highest probability of target exposure was attained with 600 mg bid in the NLF group and 150 mg bid in the ACLF group with 53%.
    Conclusion: Linezolid body clearance in ACLF was markedly lower than in NLF. Given the overall high variability, therapeutic drug monitoring (TDM) with dose adjustments seems required to optimize target attainment. Until TDM results are available, a dose reduction may be considered in ACLF patients to prevent overexposure.
    Language English
    Publishing date 2023-09-12
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2617094-2
    ISSN 2110-5820
    ISSN 2110-5820
    DOI 10.1186/s13613-023-01184-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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