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  1. Article: Corrigendum to "Influence of caffeine on the protective activity of gabapentin and topiramate in a mouse model of generalized tonic-clonic seizures" [Pharmacol. Rep. 68 (2016) 680-685].

    Jargiełło-Baszak, Małgorzata / Chrościńska-Krawczyk, Magdalena / Andres-Mach, Marta / Łuszczki, Jarogniew J / Czuczwar, Stanisław J

    Pharmacological reports : PR

    2017  Volume 69, Issue 2, Page(s) 375

    Language English
    Publishing date 2017-02-06
    Publishing country Switzerland
    Document type Journal Article ; Published Erratum
    ZDB-ID 2186248-5
    ISSN 1734-1140
    ISSN 1734-1140
    DOI 10.1016/j.pharep.2016.12.008
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  2. Article: Influence of caffeine on the protective activity of gabapentin and topiramate in a mouse model of generalized tonic-clonic seizures.

    Jargiełło-Baszak, Małgorzata / Chrościńska-Krawczyk, Magdalena / Andres-Mach, Marta / Łuszczki, Jarogniew J / Czuczwar, Stanisław J

    Pharmacological reports : PR

    2016  Volume 68, Issue 4, Page(s) 680–685

    Abstract: Background: Caffeine may interact with classical antiepileptic drugs (AEDs), reducing their anticonvulsant effects in basic seizure models. The aim of the present study was to ascertain whether intraperitoneal caffeine (acute or chronic for 15 days) ... ...

    Abstract Background: Caffeine may interact with classical antiepileptic drugs (AEDs), reducing their anticonvulsant effects in basic seizure models. The aim of the present study was to ascertain whether intraperitoneal caffeine (acute or chronic for 15 days) could attenuate the anticonvulsant effect of some newer AEDs: gabapentin (GBP) and topiramate (TPM) against electroconvulsions in mice.
    Methods: Maximal electroshock (MES)-induced mouse seizure model was used for the estimation of the anticonvulsant activity of TPM whilst the protective activity of GBP was evaluated in the threshold test for maximal (tonic) convulsions. Adverse effects were evaluated by measurement of long-term memory (the step-through passive avoidance task) and motor coordination (chimney test). Plasma AED concentrations were also measured to determinate any pharmacokinetic contribution to the observed effects.
    Results: Caffeine (both acute and chronic at 23.1 and 46.2mg/kg) significantly reduced the protective effects of TPM against MES. As regards GBP, caffeine (acutely at 46.2mg/kg and chronically at 23.1 or 46.2mg/kg) significantly diminished the GBP-induced increases in the electroconvulsive threshold. In addition, caffeine did not affect the free plasma concentrations of TPM or GBP. Acute and chronic caffeine (23.1 and 46.2mg/kg) enhanced the impairment of motor coordination in mice pretreated with GBP whilst an opposite effect was observed in TPM injected mice and pretreated with chronic caffeine at 46.2mg/kg.
    Conclusion: The results indicate that newer AEDs, GBP or TPM behave in the exactly same way as classical antiepileptics in mice challenged with caffeine. This hazardous effect of caffeine is not subject to tolerance.
    MeSH term(s) Amines/antagonists & inhibitors ; Amines/blood ; Amines/pharmacokinetics ; Animals ; Anticonvulsants/pharmacokinetics ; Anticonvulsants/pharmacology ; Caffeine/administration & dosage ; Caffeine/pharmacology ; Cyclohexanecarboxylic Acids/antagonists & inhibitors ; Cyclohexanecarboxylic Acids/blood ; Cyclohexanecarboxylic Acids/pharmacokinetics ; Dose-Response Relationship, Drug ; Drug Interactions ; Electroshock ; Fructose/analogs & derivatives ; Fructose/antagonists & inhibitors ; Fructose/blood ; Fructose/pharmacokinetics ; Gabapentin ; Injections, Intraperitoneal ; Male ; Memory, Long-Term/drug effects ; Mice ; Motor Skills/drug effects ; Seizures/prevention & control ; Topiramate ; gamma-Aminobutyric Acid/blood ; gamma-Aminobutyric Acid/pharmacokinetics
    Chemical Substances Amines ; Anticonvulsants ; Cyclohexanecarboxylic Acids ; Topiramate (0H73WJJ391) ; Fructose (30237-26-4) ; Caffeine (3G6A5W338E) ; gamma-Aminobutyric Acid (56-12-2) ; Gabapentin (6CW7F3G59X)
    Language English
    Publishing date 2016-03-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2186248-5
    ISSN 1734-1140
    ISSN 1734-1140
    DOI 10.1016/j.pharep.2016.03.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Aberrant TIRAP and MyD88 expression in B-cell chronic lymphocytic leukemia.

    Antosz, Halina / Sajewicz, Joanna / Marzec-Kotarska, Barbara / Dmoszyńska, Anna / Baszak, Jacek / Jargiełło-Baszak, Małgorzata

    Blood cells, molecules & diseases

    2013  Volume 51, Issue 1, Page(s) 48–55

    Abstract: TIRAP and Myd88 are adaptor proteins for Toll-like receptors-2 and -4 (TLR2/4) which are engaged in transducing the signal to downstream molecules. Several studies have shown the increased role of infection factors in pathogenesis of B cell chronic ... ...

    Abstract TIRAP and Myd88 are adaptor proteins for Toll-like receptors-2 and -4 (TLR2/4) which are engaged in transducing the signal to downstream molecules. Several studies have shown the increased role of infection factors in pathogenesis of B cell chronic lymphocytic leukemia (B-CLL). This prompted us to test whether there is a correlation between MyD88-TIRAP dynamics before and after inflammatory stimuli. We determined the mRNA and protein expression of TIRAP and MyD88 in CD5(+)CD19(+) B-CLL cells and in a subpopulation of normal B CD19(+) lymphocytes. Additionally we determined the influence of lipopolysaccharide Escherichia coli - TLR4-ligand (LPS) and Staphylococcus aureus strain Cowan I - TLR2-ligand (SAC) on TIR-domain-containing adaptor protein, also called MyD88 adaptor-like (TIRAP) and myeloid differentiation primary response protein 88 (MyD88) expression. We have found that the mRNA and protein expression of TIRAP and MyD88 in B-CLL lymphocytes is lower compared with that in normal B lymphocytes. LPS and SAC stimulation in normal lymphocytes significantly altered neither TIRAP nor MyD88 mRNA expression, whereas TIRAP protein level substantially decreased after TLR agonist treatment. We did not observe any changes in MyD88 protein level after B lymphocyte stimulation. There was a significant increase in TIRAP mRNA expression after LPS and SAC stimulation of B-CLL cells. MyD88 mRNA expression levels in B-CLL lymphocytes slightly decreased upon treatment with either stimulator. Stimulation with TLR agonists did not cause changes in TIRAP and MyD88 expression at the protein level in B-CLL lymphocytes. The results of our study suggest that there may exist a, yet unknown, defect of TIRAP and MyD88 proteins in B-CLL lymphocytes.
    MeSH term(s) Aged ; Antigens, CD/metabolism ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; Cells, Cultured ; Female ; Gene Expression Regulation, Leukemic ; Humans ; Immunophenotyping ; Leukemia, Lymphocytic, Chronic, B-Cell/genetics ; Leukemia, Lymphocytic, Chronic, B-Cell/metabolism ; Lipopolysaccharides/immunology ; Male ; Membrane Glycoproteins/genetics ; Membrane Glycoproteins/metabolism ; Middle Aged ; Myeloid Differentiation Factor 88/genetics ; Myeloid Differentiation Factor 88/metabolism ; Neoplasm Staging ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Receptors, Interleukin-1/genetics ; Receptors, Interleukin-1/metabolism
    Chemical Substances Antigens, CD ; Lipopolysaccharides ; Membrane Glycoproteins ; Myeloid Differentiation Factor 88 ; RNA, Messenger ; Receptors, Interleukin-1 ; TIRAP protein, human
    Language English
    Publishing date 2013-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1237083-6
    ISSN 1096-0961 ; 1079-9796
    ISSN (online) 1096-0961
    ISSN 1079-9796
    DOI 10.1016/j.bcmd.2013.01.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: TLR2 may influence the behavior of the malignant clone in B-CLL.

    Antosz, Halina / Sajewicz, Joanna / Marzec-Kotarska, Barbara / Dmoszyńska, Anna / Baszak, Jacek / Jargiełło-Baszak, Małgorzata

    Blood cells, molecules & diseases

    2012  Volume 49, Issue 1, Page(s) 32–40

    Abstract: B-cell receptor (BCR) and Toll-like receptor (TLR) stimulation and integration with signals from the pathogen or immune cells and their products determine the B-cell antibody response. Low expression of BCR is the hallmark of B lymphocytes in CLL, ... ...

    Abstract B-cell receptor (BCR) and Toll-like receptor (TLR) stimulation and integration with signals from the pathogen or immune cells and their products determine the B-cell antibody response. Low expression of BCR is the hallmark of B lymphocytes in CLL, however little is known about the expression and function of TLR in B-CLL. We studied TLR2, TLR4, IL-6 and mIL-6Rα expression on mRNA and protein level in CD19(+) subpopulation of normal lymphocytes and the CD19(+)CD5(+) subpopulation from B-CLL. Experiments were performed on unstimulated and stimulated lymphocytes [Staphylococcus aureus Cowan I (SAC) and lipopolysaccharide (LPS) from Escherichia coli - TLR2- and TLR4-specific agonists, respectively]. We showed undetectable or low IL-6 expression, which seems to be specific for B-CLL lymphocytes. Induction of TLR4 mRNA upon LPS stimulation affected the expression of IL-6, but not of mIL-6Rα. Increased expression of TLR2 (MFI) after LPS and SAC stimulation did not correlate with mIL-6Rα receptor expression. B-CLL CD19(+)CD5(+) lymphocytes showed a significant increase in TLR2 expression at the protein level after stimulation with SAC and LPS compared to normal CD19(+) lymphocytes. TLR2 may influence the behaviour of the malignant clone in B-CLL.
    MeSH term(s) Aged ; Aged, 80 and over ; Female ; Gene Expression Regulation, Leukemic/drug effects ; Gene Expression Regulation, Leukemic/immunology ; Humans ; Interleukin-6/biosynthesis ; Interleukin-6/immunology ; Leukemia, Lymphocytic, Chronic, B-Cell/immunology ; Leukemia, Lymphocytic, Chronic, B-Cell/metabolism ; Lipopolysaccharides/pharmacology ; Male ; Middle Aged ; Receptors, Antigen, B-Cell/biosynthesis ; Receptors, Antigen, B-Cell/immunology ; Staphylococcus aureus/immunology ; Toll-Like Receptor 2/biosynthesis ; Toll-Like Receptor 2/immunology ; Toll-Like Receptor 4/biosynthesis ; Toll-Like Receptor 4/immunology
    Chemical Substances IL6 protein, human ; Interleukin-6 ; Lipopolysaccharides ; Receptors, Antigen, B-Cell ; TLR2 protein, human ; TLR4 protein, human ; Toll-Like Receptor 2 ; Toll-Like Receptor 4
    Language English
    Publishing date 2012-06-15
    Publishing country United States
    Document type Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1237083-6
    ISSN 1096-0961 ; 1079-9796
    ISSN (online) 1096-0961
    ISSN 1079-9796
    DOI 10.1016/j.bcmd.2012.03.006
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  5. Article: Caffeine and the anticonvulsant potency of antiepileptic drugs: experimental and clinical data.

    Chrościńska-Krawczyk, Magdalena / Jargiełło-Baszak, Małgorzata / Wałek, Magdalena / Tylus, Bożydar / Czuczwar, Stanisław J

    Pharmacological reports : PR

    2011  Volume 63, Issue 1, Page(s) 12–18

    Abstract: Caffeine (1,3,7-trimethylxanthine) is the most commonly ingested stimulant in the world. The daily consumption of this methylxanthine in coffee, tea and soft drinks is approximately 200 mg per person, which yields a pharmacologically active blood ... ...

    Abstract Caffeine (1,3,7-trimethylxanthine) is the most commonly ingested stimulant in the world. The daily consumption of this methylxanthine in coffee, tea and soft drinks is approximately 200 mg per person, which yields a pharmacologically active blood concentration. Experimental data indicate that caffeine may either lower the convulsive threshold in experimental models of epilepsy or induce seizure activity in doses over 400 mg/kg in rodents. Interestingly, animal data have demonstrated that caffeine, at doses far below its convulsive potential, diminishes the protective effects of conventional antiepileptic drugs (AEDs--carbamazepine, phenobarbital, phenytoin, valproate) and the newer AED, topiramate against electroconvulsions in mice. However, in contrast to these AEDs, caffeine did not impair the anticonvulsant efficacy of other newer AEDs, lamotrigine, tiagabine, and oxcarbazepine in this experimental model of epileptic seizure. Although limited, the clinical data generally confirm the experimental findings, suggesting increased seizure frequency in epileptic patients who began ingesting caffeine in high quantities. Thus far, no analysis has been performed in epileptic patients to determine whether the hazardous effects of caffeine are dependent upon individual antiepileptic treatments. These data clearly indicate that methylxanthines should be avoided in epileptic patients.
    MeSH term(s) Animals ; Anticonvulsants/pharmacology ; Caffeine/administration & dosage ; Caffeine/pharmacology ; Central Nervous System Stimulants/administration & dosage ; Central Nervous System Stimulants/pharmacology ; Disease Models, Animal ; Drug Interactions ; Epilepsy/drug therapy ; Humans ; Mice ; Seizures/drug therapy
    Chemical Substances Anticonvulsants ; Central Nervous System Stimulants ; Caffeine (3G6A5W338E)
    Language English
    Publishing date 2011-03-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2186248-5
    ISSN 1734-1140
    ISSN 1734-1140
    DOI 10.1016/s1734-1140(11)70394-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: IL-6, IL-10, c-Jun and STAT3 expression in B-CLL.

    Antosz, Halina / Wojciechowska, Katarzyna / Sajewicz, Joanna / Choroszyńska, Dorota / Marzec-Kotarska, Barbara / Osiak, Magdalena / Pająk, Natalia / Tomczak, Waldemar / Jargiełło-Baszak, Małgorzata / Baszak, Jacek

    Blood cells, molecules & diseases

    2015  Volume 54, Issue 3, Page(s) 258–265

    Abstract: Chronic lymphocytic leukemia is characterized by the accumulation of functionally abnormal, monoclonal B lymphocytes in the peripheral blood, bone marrow, lymph nodes and spleen, resulting in a reduction count of normal immunocompetent cells and their ... ...

    Abstract Chronic lymphocytic leukemia is characterized by the accumulation of functionally abnormal, monoclonal B lymphocytes in the peripheral blood, bone marrow, lymph nodes and spleen, resulting in a reduction count of normal immunocompetent cells and their impaired immune function. The defect in transmission of signals from various types of extracellular receptors, leading to aberrant cytokines and transcription factors gene expression, may underlie the basis of immune failure in B-CLL. The aim of the study was to assess of IL-6, IL-10, c-Jun, and STAT3 expression. In response to antigenic stimulation IL-6, IL-10, c-Jun, and STAT3 proteins induce mutual activity. The subject of the study was subpopulations of leukemic lymphocytes (CD5+ CD19+) and CD19+ B cells from healthy donors (control group). Our results provide evidence that the regulation of IL-6, IL-10, c-Jun, and STAT3 gene expression in CLL B cells is clearly different from normal B lymphocytes. In B-CLL STAT3 expression in unstimulated lymphocytes is significantly higher (p<0.0001) compared with normal subpopulation of B cell. In contrast, IL-6, IL-10, and c-Jun mRNA expressions are statistically lower in B-CLL in comparison with the control group, in all cases (p<0.0001). When analyzing the relationship between c-Jun expression and B-CLL stage according Rai we revealed decreasing c-Jun expression, both at the mRNA and protein levels, along with advancing stage of disease.
    MeSH term(s) Aged ; Aged, 80 and over ; B-Lymphocytes/metabolism ; B-Lymphocytes/pathology ; Female ; Gene Expression Regulation, Leukemic ; Humans ; Interleukin-10/analysis ; Interleukin-10/genetics ; Interleukin-6/analysis ; Interleukin-6/genetics ; Leukemia, Lymphocytic, Chronic, B-Cell/genetics ; Leukemia, Lymphocytic, Chronic, B-Cell/pathology ; Male ; Middle Aged ; Proto-Oncogene Proteins c-jun/analysis ; Proto-Oncogene Proteins c-jun/genetics ; RNA, Messenger/genetics ; STAT3 Transcription Factor/analysis ; STAT3 Transcription Factor/genetics
    Chemical Substances Interleukin-6 ; Proto-Oncogene Proteins c-jun ; RNA, Messenger ; STAT3 Transcription Factor ; Interleukin-10 (130068-27-8)
    Language English
    Publishing date 2015-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1237083-6
    ISSN 1096-0961 ; 1079-9796
    ISSN (online) 1096-0961
    ISSN 1079-9796
    DOI 10.1016/j.bcmd.2014.11.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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