Article: Cyfip2 controls the acoustic startle threshold through FMRP, actin polymerization, and GABA
bioRxiv : the preprint server for biology
2024
Abstract: Animals process a constant stream of sensory input, and to survive they must detect and respond to dangerous stimuli while ignoring innocuous or irrelevant ones. Behavioral responses are elicited when certain properties of a stimulus such as its ... ...
| Abstract | Animals process a constant stream of sensory input, and to survive they must detect and respond to dangerous stimuli while ignoring innocuous or irrelevant ones. Behavioral responses are elicited when certain properties of a stimulus such as its intensity or size reach a critical value, and such behavioral thresholds can be a simple and effective mechanism to filter sensory information. For example, the acoustic startle response is a conserved and stereotyped defensive behavior induced by sudden loud sounds, but dysregulation of the threshold to initiate this behavior can result in startle hypersensitivity that is associated with sensory processing disorders including schizophrenia and autism. Through a previous forward genetic screen for regulators of the startle threshold a nonsense mutation in |
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| Language | English |
| Publishing date | 2024-02-05 |
| Publishing country | United States |
| Document type | Preprint |
| DOI | 10.1101/2023.12.22.573054 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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