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  1. Article ; Online: Physiological Condition-Dependent Changes in Ciliary GPCR Localization in the Brain.

    Brewer, Kathryn M / Engle, Staci E / Bansal, Ruchi / Brewer, Katlyn K / Jasso, Kalene R / McIntyre, Jeremy C / Vaisse, Christian / Reiter, Jeremy F / Berbari, Nicolas F

    eNeuro

    2023  Volume 10, Issue 3

    Abstract: Primary cilia are cellular appendages critical for diverse types of Signaling. They are found on most cell types, including cells throughout the CNS. Cilia preferentially localize certain G-protein-coupled receptors (GPCRs) and are critical for mediating ...

    Abstract Primary cilia are cellular appendages critical for diverse types of Signaling. They are found on most cell types, including cells throughout the CNS. Cilia preferentially localize certain G-protein-coupled receptors (GPCRs) and are critical for mediating the signaling of these receptors. Several of these neuronal GPCRs have recognized roles in feeding behavior and energy homeostasis. Cell and model systems, such as
    MeSH term(s) Mice ; Animals ; Receptors, G-Protein-Coupled/metabolism ; Signal Transduction ; Brain/metabolism ; Caenorhabditis elegans ; Mammals/metabolism
    Chemical Substances Receptors, G-Protein-Coupled
    Language English
    Publishing date 2023-03-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2800598-3
    ISSN 2373-2822 ; 2373-2822
    ISSN (online) 2373-2822
    ISSN 2373-2822
    DOI 10.1523/ENEURO.0360-22.2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Neuron-specific cilia loss differentially alters locomotor responses to amphetamine in mice.

    Ramos, Carlos / Roberts, Jonté B / Jasso, Kalene R / Ten Eyck, Tyler W / Everett, Thomas / Pozo, Patricia / Setlow, Barry / McIntyre, Jeremy C

    Journal of neuroscience research

    2020  Volume 99, Issue 3, Page(s) 827–842

    Abstract: The neural mechanisms that underlie responses to drugs of abuse are complex, and impacted by a number of neuromodulatory peptides. Within the past 10 years it has been discovered that several of the receptors for neuromodulators are enriched in the ... ...

    Abstract The neural mechanisms that underlie responses to drugs of abuse are complex, and impacted by a number of neuromodulatory peptides. Within the past 10 years it has been discovered that several of the receptors for neuromodulators are enriched in the primary cilia of neurons. Primary cilia are microtubule-based organelles that project from the surface of nearly all mammalian cells, including neurons. Despite what we know about cilia, our understanding of how cilia regulate neuronal function and behavior is still limited. The primary objective of this study was to investigate the contributions of primary cilia on specific neuronal populations to behavioral responses to amphetamine. To test the consequences of cilia loss on amphetamine-induced locomotor activity we selectively ablated cilia from dopaminergic or GAD2-GABAergic neurons in mice. Cilia loss had no effect on baseline locomotion in either mouse strain. In mice lacking cilia on dopaminergic neurons, locomotor activity compared to wild- type mice was reduced in both sexes in response to acute administration of 3.0 mg/kg amphetamine. In contrast, changes in the locomotor response to amphetamine in mice lacking cilia on GAD2-GABAergic neurons were primarily driven by reductions in locomotor activity in males. Following repeated amphetamine administration (1.0 mg kg
    MeSH term(s) Amphetamine/pharmacology ; Animals ; Central Nervous System Stimulants/pharmacology ; Cilia/drug effects ; Cilia/genetics ; Cilia/pathology ; Dopamine ; Dopaminergic Neurons/pathology ; Female ; Male ; Mice ; Mice, Knockout ; Motor Activity/drug effects ; Neuronal Plasticity
    Chemical Substances Central Nervous System Stimulants ; Amphetamine (CK833KGX7E) ; Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2020-11-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 195324-2
    ISSN 1097-4547 ; 0360-4012
    ISSN (online) 1097-4547
    ISSN 0360-4012
    DOI 10.1002/jnr.24755
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1232: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: An N-terminal fusion allele to study melanin concentrating hormone receptor 1.

    Jasso, Kalene R / Kamba, Tisianna K / Zimmerman, Arthur D / Bansal, Ruchi / Engle, Staci E / Everett, Thomas / Wu, Chang-Hung / Kulaga, Heather / Reed, Randal R / Berbari, Nicolas F / McIntyre, Jeremy C

    Genesis (New York, N.Y. : 2000)

    2021  Volume 59, Issue 7-8, Page(s) e23438

    Abstract: Cilia on neurons play critical roles in both the development and function of the central nervous system (CNS). While it remains challenging to elucidate the precise roles for neuronal cilia, it is clear that a subset of G-protein-coupled receptors (GPCRs) ...

    Abstract Cilia on neurons play critical roles in both the development and function of the central nervous system (CNS). While it remains challenging to elucidate the precise roles for neuronal cilia, it is clear that a subset of G-protein-coupled receptors (GPCRs) preferentially localize to the cilia membrane. Further, ciliary GPCR signaling has been implicated in regulating a variety of behaviors. Melanin concentrating hormone receptor 1 (MCHR1), is a GPCR expressed centrally in rodents known to be enriched in cilia. Here we have used MCHR1 as a model ciliary GPCR to develop a strategy to fluorescently tag receptors expressed from the endogenous locus in vivo. Using CRISPR/Cas9, we inserted the coding sequence of the fluorescent protein mCherry into the N-terminus of Mchr1. Analysis of the fusion protein (
    MeSH term(s) Alleles ; Animals ; Cilia/metabolism ; Homozygote ; Melanins/metabolism ; Mice ; Mice, Inbred C57BL ; Neurons/metabolism ; Neurons/physiology ; Receptors, Somatostatin/genetics ; Receptors, Somatostatin/metabolism ; Synapses/metabolism ; Synapses/physiology ; Synaptic Potentials
    Chemical Substances Mchr1 protein, mouse ; Melanins ; Receptors, Somatostatin
    Language English
    Publishing date 2021-06-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2004544-X
    ISSN 1526-968X ; 1526-954X
    ISSN (online) 1526-968X
    ISSN 1526-954X
    DOI 10.1002/dvg.23438
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2772: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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