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  1. Article ; Online: Roles of Matrix Metalloproteinases and Their Natural Inhibitors in Metabolism: Insights into Health and Disease.

    Molière, Sébastien / Jaulin, Amélie / Tomasetto, Catherine-Laure / Dali-Youcef, Nassim

    International journal of molecular sciences

    2023  Volume 24, Issue 13

    Abstract: Matrix metalloproteinases (MMPs) are a family of zinc-activated peptidases that can be classified into six major classes, including gelatinases, collagenases, stromelysins, matrilysins, membrane type metalloproteinases, and other unclassified MMPs. The ... ...

    Abstract Matrix metalloproteinases (MMPs) are a family of zinc-activated peptidases that can be classified into six major classes, including gelatinases, collagenases, stromelysins, matrilysins, membrane type metalloproteinases, and other unclassified MMPs. The activity of MMPs is regulated by natural inhibitors called tissue inhibitors of metalloproteinases (TIMPs). MMPs are involved in a wide range of biological processes, both in normal physiological conditions and pathological states. While some of these functions occur during development, others occur in postnatal life. Although the roles of several MMPs have been extensively studied in cancer and inflammation, their function in metabolism and metabolic diseases have only recently begun to be uncovered, particularly over the last two decades. This review aims to summarize the current knowledge regarding the metabolic roles of metalloproteinases in physiology, with a strong emphasis on adipose tissue homeostasis, and to highlight the consequences of impaired or exacerbated MMP actions in the development of metabolic disorders such as obesity, fatty liver disease, and type 2 diabetes.
    MeSH term(s) Humans ; Diabetes Mellitus, Type 2 ; Tissue Inhibitor of Metalloproteinases/metabolism ; Collagenases ; Gelatinases ; Matrix Metalloproteinase 3 ; Matrix Metalloproteinase Inhibitors/pharmacology ; Matrix Metalloproteinase Inhibitors/therapeutic use
    Chemical Substances Tissue Inhibitor of Metalloproteinases ; Collagenases (EC 3.4.24.-) ; Gelatinases (EC 3.4.24.-) ; Matrix Metalloproteinase 3 (EC 3.4.24.17) ; Matrix Metalloproteinase Inhibitors
    Language English
    Publishing date 2023-06-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241310649
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Fast Ultrasound Scanning is a Rapid, Sensitive, Precise and Cost-Effective Method to Monitor Tumor Grafts in Mice.

    Molière, Sébastien / Martinet, Arthur / Jaulin, Amélie / Lodi, Massimo / Chamaraux-Tran, Thien-Nga / Alpy, Fabien / Bierry, Guillaume / Tomasetto, Catherine

    Journal of mammary gland biology and neoplasia

    2024  Volume 29, Issue 1, Page(s) 2

    Abstract: In preclinical studies, accurate monitoring of tumor dynamics is crucial for understanding cancer biology and evaluating therapeutic interventions. Traditional methods like caliper measurements and bioluminescence imaging (BLI) have limitations, ... ...

    Abstract In preclinical studies, accurate monitoring of tumor dynamics is crucial for understanding cancer biology and evaluating therapeutic interventions. Traditional methods like caliper measurements and bioluminescence imaging (BLI) have limitations, prompting the need for improved imaging techniques. This study introduces a fast-scan high-frequency ultrasound (HFUS) protocol for the longitudinal assessment of syngeneic breast tumor grafts in mice, comparing its performance with caliper, BLI measurements and with histological analysis. The E0771 mammary gland tumor cell line, engineered to express luciferase, was orthotopically grafted into immunocompetent C57BL/6 mice. Tumor growth was monitored longitudinally at multiple timepoints using caliper measurement, HFUS, and BLI, with the latter two modalities assessed against histopathological standards post-euthanasia. The HFUS protocol was designed for rapid, anesthesia-free scanning, focusing on volume estimation, echogenicity, and necrosis visualization. All mice developed tumors, only 20.6% were palpable at day 4. HFUS detected tumors as small as 2.2 mm in average diameter from day 4 post-implantation, with an average scanning duration of 47 s per mouse. It provided a more accurate volume assessment than caliper, with a lower average bias relative to reference tumor volume. HFUS also revealed tumor necrosis, correlating strongly with BLI in terms of tumor volume and cellularity. Notable discrepancies between HFUS and BLI growth rates were attributed to immune cell infiltration. The fast HFUS protocol enables precise and efficient tumor assessment in preclinical studies, offering significant advantages over traditional methods in terms of speed, accuracy, and animal welfare, aligning with the 3R principle in animal research.
    MeSH term(s) Animals ; Mice ; Mice, Inbred C57BL ; Cost-Benefit Analysis ; Ultrasonography ; Cell Line, Tumor ; Mammary Neoplasms, Animal ; Necrosis
    Language English
    Publishing date 2024-01-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1327345-0
    ISSN 1573-7039 ; 1083-3021
    ISSN (online) 1573-7039
    ISSN 1083-3021
    DOI 10.1007/s10911-024-09555-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Matrix Metalloproteinase-11 Promotes Early Mouse Mammary Gland Tumor Growth through Metabolic Reprogramming and Increased IGF1/AKT/FoxO1 Signaling Pathway, Enhanced ER Stress and Alteration in Mitochondrial UPR.

    Tan, Bing / Jaulin, Amélie / Bund, Caroline / Outilaft, Hassiba / Wendling, Corinne / Chenard, Marie-Pierrette / Alpy, Fabien / Cicek, A Ercüment / Namer, Izzie J / Tomasetto, Catherine / Dali-Youcef, Nassim

    Cancers

    2020  Volume 12, Issue 9

    Abstract: Matrix metalloproteinase 11 (MMP11) is an extracellular proteolytic enzyme belonging to the matrix metalloproteinase (MMP11) family. These proteases are involved in extracellular matrix (ECM) remodeling and activation of latent factors. MMP11 is a ... ...

    Abstract Matrix metalloproteinase 11 (MMP11) is an extracellular proteolytic enzyme belonging to the matrix metalloproteinase (MMP11) family. These proteases are involved in extracellular matrix (ECM) remodeling and activation of latent factors. MMP11 is a negative regulator of adipose tissue development and controls energy metabolism in vivo. In cancer, MMP11 expression is associated with poorer survival, and preclinical studies in mice showed that MMP11 accelerates tumor growth. How the metabolic role of MMP11 contributes to cancer development is poorly understood. To address this issue, we developed a series of preclinical mouse mammary gland tumor models by genetic engineering. Tumor growth was studied in mice either deficient (Loss of Function-LOF) or overexpressing MMP11 (Gain of Function-GOF) crossed with a transgenic model of breast cancer induced by the polyoma middle T antigen (PyMT) driven by the murine mammary tumor virus promoter (MMTV) (MMTV-PyMT). Both GOF and LOF models support roles for MMP11, favoring early tumor growth by increasing proliferation and reducing apoptosis. Of interest, MMP11 promotes Insulin-like Growth Factor-1 (IGF1)/protein kinase B (AKT)/Forkhead box protein O1 (FoxO1) signaling and is associated with a metabolic switch in the tumor, activation of the endoplasmic reticulum stress response, and an alteration in the mitochondrial unfolded protein response with decreased proteasome activity. In addition, high resonance magic angle spinning (HRMAS) metabolomics analysis of tumors from both models established a metabolic signature that favors tumorigenesis when MMP11 is overexpressed. These data support the idea that MMP11 contributes to an adaptive metabolic response, named metabolic flexibility, promoting cancer growth.
    Language English
    Publishing date 2020-08-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers12092357
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Interleukin-32 Contributes to Human Nonalcoholic Fatty Liver Disease and Insulin Resistance.

    Dali-Youcef, Nassim / Vix, Michel / Costantino, Federico / El-Saghire, Houssein / Lhermitte, Benoit / Callari, Cosimo / D'Agostino, Jacopo / Perretta, Silvana / Paveliu, Stefan / Gualtierotti, Monica / Dumeny, Edith / Oudot, Marine A / Jaulin, Amélie / Dembélé, Doulaye / Zeisel, Mirjam B / Tomasetto, Catherine / Baumert, Thomas F / Doffoël, Michel

    Hepatology communications

    2019  Volume 3, Issue 9, Page(s) 1205–1220

    Abstract: Nonalcoholic fatty liver disease (NAFLD) is a metabolic disorder due to increased accumulation of fat in the liver and in many cases to enhanced inflammation. Although the contribution of inflammation in the pathogenesis of NAFLD is well established, the ...

    Abstract Nonalcoholic fatty liver disease (NAFLD) is a metabolic disorder due to increased accumulation of fat in the liver and in many cases to enhanced inflammation. Although the contribution of inflammation in the pathogenesis of NAFLD is well established, the cytokines that are involved and how they influence liver transformation are still poorly characterized. In addition, with other modifiers, inflammation influences NAFLD progression to liver cirrhosis and hepatocellular carcinoma, demonstrating the need to find new molecular targets with potential future therapeutic applications. We investigated gene signatures in 38 liver biopsies from patients with NAFLD and obesity who had received bariatric surgery and compared these to 10 control patients who had received a cholecystectomy, using DNA microarray technology. A subset of differentially expressed genes was then validated on a larger cohort of 103 patients who had received bariatric surgery for obesity; data were thoroughly analyzed in terms of correlations with NAFLD pathophysiological parameters. Finally, the impact of a specific cytokine, interleukin-32 (
    Language English
    Publishing date 2019-07-19
    Publishing country United States
    Document type Journal Article
    ISSN 2471-254X
    ISSN (online) 2471-254X
    DOI 10.1002/hep4.1396
    Database MEDical Literature Analysis and Retrieval System OnLINE

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