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  1. Article ; Online: Pharmacoeconomic Aspects of Diabetes Mellitus: Outcomes and Analysis of Health Benefits Approach.

    Jaura, Ravinder Singh / Baishnab, Suman / Sharma, Saksham / Garg, Honey / Singh, Thakur Gurjeet

    Current diabetes reviews

    2023  

    Abstract: Pharmacoeconomics is an important tool for investigating and restructuring healthcare policies. In India, recent statistical studies have shown that the number of diabetic patients is rapidly increasing in the rural, middle and upper-class settings. The ... ...

    Abstract Pharmacoeconomics is an important tool for investigating and restructuring healthcare policies. In India, recent statistical studies have shown that the number of diabetic patients is rapidly increasing in the rural, middle and upper-class settings. The aim of this review is to call attention towards the need to carry out pharmacoeconomic studies for diabetes mellitus and highlight the outcome of these studies on healthcare. A well-structured literature search from PubMed, Embase, Springer, ScienceDirect, and Cochrane was done. Studies that evaluated the cost-effectiveness of various anti-diabetic agents for type 2 diabetes were eligible for inclusion in the analysis and review. Two independent reviewers sequentially assessed the titles, abstracts, and full articles to select studies that met the predetermined inclusion and exclusion criteria for data abstraction. Any discrepancies between the reviewers were resolved through consensus. By employing search terms such as pharmacoeconomics, diabetes mellitus, cost-effective analysis, cost minimization analysis, cost-utility analysis, and cost-benefit analysis, a total of 194 papers were gathered. Out of these, 110 papers were selected as they aligned with the defined search criteria and underwent the removal of duplicate entries. This review outlined four basic pharmacoeconomic studies carried out on diabetes mellitus. It gave a direction that early detection, patient counseling, personalized medication, appropriate screening intervals, and early start of pharmacotherapy proved to be a cost-effective as well as health benefits approach.
    Language English
    Publishing date 2023-10-11
    Publishing country United Arab Emirates
    Document type Journal Article
    ISSN 1875-6417
    ISSN (online) 1875-6417
    DOI 10.2174/0115733998246567230924134603
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Exploring various novel diagnostic and therapeutic approaches in treating diabetic retinopathy.

    Sood, Ankita / Baishnab, Suman / Gautam, Isha / Choudhary, Priya / Lang, Damanpreet Kaur / Jaura, Ravinder Singh / Singh, Thakur Gurjeet

    Inflammopharmacology

    2023  Volume 31, Issue 2, Page(s) 773–786

    Abstract: Diabetic retinopathy is regarded as a common manifestation of diabetes mellitus, being a prominent cause of visual impairment and blindness. This microvascular complication is marked by the appearance of microaneurysms, elevated vascular permeability, ... ...

    Abstract Diabetic retinopathy is regarded as a common manifestation of diabetes mellitus, being a prominent cause of visual impairment and blindness. This microvascular complication is marked by the appearance of microaneurysms, elevated vascular permeability, capillary blockage, and proliferation of neovasculature. The etiology behind retinopathy is ambiguous and the efficacy of current treatment strategies is minimal. Early diagnosis of this complication using a biomarker with high sensitivity and specificity is very essential for providing better therapeutic strategies. The current available therapeutic options are limited with various adverse effects. Laser treatment is not beneficial in all the situations, economic constraints being the major challenge. Surgical interventions are employed when pharmacotherapy and laser treatment fail. New pharmacological treatments are becoming a necessity for treating the condition. This review highlights the use of various diagnostic tools, emerging biomarkers for early detection of diabetic retinopathy, pathological mechanisms associated with the disease, current therapeutic approaches used and future strategies for more enhanced treatment options and more potent pharmacological actions.
    MeSH term(s) Humans ; Diabetic Retinopathy/diagnosis ; Diabetic Retinopathy/drug therapy ; Biomarkers ; Diabetes Mellitus
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-02-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1080058-x
    ISSN 1568-5608 ; 0925-4692
    ISSN (online) 1568-5608
    ISSN 0925-4692
    DOI 10.1007/s10787-023-01143-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3274: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Serum protease-activated receptor (PAR-1) levels as a potential biomarker for diagnosis of inflammation in type 2 diabetic patients.

    Goyal, Sanjay / Sood, Ankita / Gautam, Isha / Pradhan, Soumyadip / Mondal, Puskar / Singh, Gaaminepreet / Jaura, Ravinder Singh / Singh, Thakur Gurjeet / Sibia, Raminderpal Singh

    Inflammopharmacology

    2022  Volume 30, Issue 5, Page(s) 1843–1851

    Abstract: Background: Inflammation is a prominent clinical manifestation in type 2 diabetes mellitus (T: Aim of the study: The present study has been designed to check the serum levels of PAR-1 and correlate with various clinical manifestations and ... ...

    Abstract Background: Inflammation is a prominent clinical manifestation in type 2 diabetes mellitus (T
    Aim of the study: The present study has been designed to check the serum levels of PAR-1 and correlate with various clinical manifestations and inflammatory cytokines levels in type 2 diabetic subjects.
    Material and methods: The study population was divided into two groups, healthy volunteers (n = 15): normal glycated hemoglobin (HbA1c) (4.26 ± 0.55) and type 2 diabetic subjects (n = 30): HbA1c levels (7.80 ± 2.41). The serum levels of PAR-1 (ELISA method) were studied in both groups and correlated with demographic parameters age, weight, body mass index (BMI), and conventional inflammation biomarkers like C-reactive protein (CRP), interleukin 6 (IL-6), interleukin 8 (IL-8), and tumour necrosis factor-alpha (TNF-α).
    Results: The demographic variables including the body weight (77.38 ± 10.00 vs. controls 55.26 ± 6.99), BMI (29.39 ± 3.61 vs. controls 25.25 ± 4.01), glycemic index HbA1c (7.80 ± 2.41 vs. controls 4.26 ± 0.55) were found to be statistically increased in T
    Conclusion: Our findings indicate that the elevated serum PAR-1 levels serve as an independent predictor of inflammation in T
    MeSH term(s) Biomarkers ; Blood Glucose/metabolism ; Body Weight ; C-Reactive Protein/analysis ; Cytokines ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/diagnosis ; Glycated Hemoglobin A/analysis ; Glycated Hemoglobin A/metabolism ; Humans ; Inflammation/complications ; Inflammation/diagnosis ; Interleukin-6 ; Interleukin-8 ; Receptor, PAR-1/blood ; Tumor Necrosis Factor-alpha
    Chemical Substances Biomarkers ; Blood Glucose ; Cytokines ; Glycated Hemoglobin A ; Interleukin-6 ; Interleukin-8 ; Receptor, PAR-1 ; Tumor Necrosis Factor-alpha ; C-Reactive Protein (9007-41-4)
    Language English
    Publishing date 2022-08-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1080058-x
    ISSN 1568-5608 ; 0925-4692
    ISSN (online) 1568-5608
    ISSN 0925-4692
    DOI 10.1007/s10787-022-01049-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3274: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Elevated serum PAR-1 levels as an emerging biomarker of inflammation to predict the dengue infection severity.

    Sibia, Raminderpal Singh / Sood, Ankita / Subedi, Arshula / Sharma, Anushya / Mittal, Anirudh / Singh, Gaaminepreet / Singh, Thakur Gurjeet / Jaura, Ravinder Singh / Goyal, Sanjay

    Journal of medical virology

    2022  Volume 95, Issue 1, Page(s) e28152

    Abstract: The present study was designed to check the serum levels of protease-activated receptor (PAR-1) in patients during different phases of dengue severity. Moreover, a correlation between serum PAR-1 levels and hematological parameters, inflammatory cytokine ...

    Abstract The present study was designed to check the serum levels of protease-activated receptor (PAR-1) in patients during different phases of dengue severity. Moreover, a correlation between serum PAR-1 levels and hematological parameters, inflammatory cytokine levels, and liver functional changes was also determined. Based on the World Health Organization criteria, the study population was divided into: nonsevere dengue fever (DF; n = 30), severe dengue hemorrhagic fever (DHF; n = 19), and severe dengue shock syndrome (DSS; n = 11). The platelet count (PLT) and hematocrit (HCT) were analyzed using an automated hematology analyzer and liver function enzymes aspartate transaminase (AST), alanine transaminase (ALT), and alkaline phosphate (ALP), bilirubin were checked by auto-analyzer using diagnostic kits. Moreover, the levels of inflammatory mediators C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-17 (IL-17), and PAR-1 were determined using respective ELISA kits. The HCT levels were elevated and platelet count decreased significantly during dengue complications (DHF and DSS) compared to the DF patients, while the levels of liver functional biomarkers AST, ALT, ALP, and bilirubin remained elevated in DHF and DSS groups than in the corresponding DF group. Similarly, the inflammatory cytokine levels of CRP, TNF-α, IL-6, and IL-17 in DHF and DSS subjects were markedly increased when observed against DF subjects. Notably, the PAR-1 levels were significantly elevated in DHF and DSS groups than in the DF group and positively correlated with changes in HCT levels, inflammatory biomarkers, and liver enzymes. Our findings conclude that PAR-1 levels persistently increased with the severity of the dengue infection and are strongly associated with various clinical manifestations. Thus, PAR-1 levels can be used as a diagnostic marker for assessing dengue severity.
    MeSH term(s) Humans ; Severe Dengue ; Interleukin-17 ; Tumor Necrosis Factor-alpha ; Interleukin-6 ; Cytokines ; Biomarkers ; Bilirubin ; Alanine Transaminase ; Aspartate Aminotransferases ; C-Reactive Protein ; Inflammation ; Dengue
    Chemical Substances Interleukin-17 ; Tumor Necrosis Factor-alpha ; Interleukin-6 ; Cytokines ; Biomarkers ; Bilirubin (RFM9X3LJ49) ; Alanine Transaminase (EC 2.6.1.2) ; Aspartate Aminotransferases (EC 2.6.1.1) ; C-Reactive Protein (9007-41-4)
    Language English
    Publishing date 2022-09-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.28152
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1320: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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