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  1. Article ; Online: Cardiac magnetic resonance assessment of athletic myocardial fibrosis; Benign bystander or malignant marker?

    Javed, Wasim / Malhotra, Aneil / Swoboda, Peter

    International journal of cardiology

    2023  Volume 394, Page(s) 131382

    Abstract: The benefits of exercise are irrefutable with a well-established dose-dependent relationship between exercise intensity and reduction in cardiovascular disease. Differentiating the physiological adaptation to exercise, termed the "athlete's heart" from ... ...

    Abstract The benefits of exercise are irrefutable with a well-established dose-dependent relationship between exercise intensity and reduction in cardiovascular disease. Differentiating the physiological adaptation to exercise, termed the "athlete's heart" from cardiomyopathies, has been advanced by the advent of more sophisticated imaging modalities such as cardiac magnetic resonance imaging (CMR). Myocardial fibrosis on CMR is a mutual finding amongst seemingly healthy endurance athletes and individuals with cardiomyopathy. As a substrate for arrhythmias, fibrosis is traditionally associated with increased cardiovascular risk. In this article, we discuss the aetiologies, distribution and potential implications of myocardial fibrosis in athletes.
    MeSH term(s) Humans ; Predictive Value of Tests ; Cardiomyopathies/diagnostic imaging ; Cardiomyopathies/pathology ; Magnetic Resonance Imaging ; Sports/physiology ; Fibrosis ; Athletes ; Magnetic Resonance Spectroscopy
    Language English
    Publishing date 2023-09-22
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2023.131382
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Iron-modified biochar improves plant physiology, soil nutritional status and mitigates Pb and Cd-hazard in wheat (

    Algethami, Jari S / Irshad, Muhammad Kashif / Javed, Wasim / Alhamami, Mohsen A M / Ibrahim, Muhammad

    Frontiers in plant science

    2023  Volume 14, Page(s) 1221434

    Abstract: Environmental quality and food safety is threatened by contamination of lead (Pb) and cadmium (Cd) heavy metals in agricultural soils. Therefore, it is necessary to develop effective techniques for remediation of such soils. In this study, we prepared ... ...

    Abstract Environmental quality and food safety is threatened by contamination of lead (Pb) and cadmium (Cd) heavy metals in agricultural soils. Therefore, it is necessary to develop effective techniques for remediation of such soils. In this study, we prepared iron-modified biochar (Fe-BC) which combines the unique characteristics of pristine biochar (BC) and iron. The current study investigated the effect of pristine and iron modified biochar (Fe-BC) on the nutritional values of soil and on the reduction of Pb and Cd toxicity in wheat plants (
    Language English
    Publishing date 2023-08-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2023.1221434
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Unveiling the detrimental effects of polylactic acid microplastics on rice seedlings and soil health.

    Irshad, Muhammad Kashif / Kang, Min Woo / Aqeel, Muhammad / Javed, Wasim / Noman, Ali / Khalid, Noreen / Lee, Sang Soo

    Chemosphere

    2024  Volume 355, Page(s) 141771

    Abstract: The environmental impact of biodegradable polylactic acid microplastics (PLA-MPs) has become a global concern, with documented effects on soil health, nutrient cycling, water retention, and crop growth. This study aimed to assess the repercussions of ... ...

    Abstract The environmental impact of biodegradable polylactic acid microplastics (PLA-MPs) has become a global concern, with documented effects on soil health, nutrient cycling, water retention, and crop growth. This study aimed to assess the repercussions of varying concentrations of PLA-MPs on rice, encompassing aspects such as growth, physiology, and biochemistry. Additionally, the investigation delved into the influence of PLA-MPs on soil bacterial composition and soil enzyme activities. The results illustrated that the highest levels of PLA-MPs (2.5%) impaired the photosynthesis activity of rice plants and hampered plant growth. Plants exposed to the highest concentration of PLA-MPs (2.5%) displayed a significant reduction of 51.3% and 47.7% in their root and shoot dry weights, as well as a reduction of 53% and 49% in chlorophyll a and b contents, respectively. The activities of catalase (CAT), superoxide dismutase (SOD), peroxidase (POD), and ascorbate peroxidase (APX) in rice leaves increased by 3.1, 2.8, 3.5, and 5.2 folds, respectively, with the highest level of PLA-MPs (2.5%). Soil enzyme activities, such as CAT, urease, and dehydrogenase (DHA) increased by 19.2%, 10.4%, and 22.5%, respectively, in response to the highest level of PLA-MPs (2.5%) application. In addition, PLA-MPs (2.5%) resulted in a remarkable increase in the relative abundance of soil Proteobacteria, Nitrospirae, and Firmicutes by 60%, 31%, and 98.2%, respectively. These findings highlight the potential adverse effects of PLA-MPs on crops and soils. This study provides valuable insights into soil-rice interactions, environmental risks, and biodegradable plastic regulation, underscoring the need for further research.
    MeSH term(s) Soil ; Seedlings ; Oryza ; Microplastics/toxicity ; Plastics/toxicity ; Chlorophyll A ; Polyesters ; Biodegradable Plastics
    Chemical Substances Soil ; poly(lactide) (459TN2L5F5) ; Microplastics ; Plastics ; Chlorophyll A (YF5Q9EJC8Y) ; Polyesters ; Biodegradable Plastics
    Language English
    Publishing date 2024-03-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 120089-6
    ISSN 1879-1298 ; 0045-6535 ; 0366-7111
    ISSN (online) 1879-1298
    ISSN 0045-6535 ; 0366-7111
    DOI 10.1016/j.chemosphere.2024.141771
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Risk assessment of toxic and hazardous metals in paddy agroecosystem by biochar-for bio-membrane applications.

    Irshad, Muhammad Kashif / Zhu, Sihang / Javed, Wasim / Lee, Jong Cheol / Mahmood, Abid / Lee, Sang Soo / Jianying, Shang / Albasher, Gadah / Ali, Atif

    Chemosphere

    2023  Volume 340, Page(s) 139719

    Abstract: Toxic and carcinogenic metal (loid)s, such arsenic (As) and cadmium (Cd), found in contaminated paddy soils pose a serious danger to environmental sustainability. Their geochemical activities are complex, making it difficult to manage their contamination. ...

    Abstract Toxic and carcinogenic metal (loid)s, such arsenic (As) and cadmium (Cd), found in contaminated paddy soils pose a serious danger to environmental sustainability. Their geochemical activities are complex, making it difficult to manage their contamination. Rice grown in Cd and As-polluted soils ends up in people's bellies, where it can cause cancer, anemia, and the deadly itai sickness. Solving this issue calls for research into eco-friendly and cost-effective remediation technology to lower rice's As and Cd levels. This research delves deeply into the origins of As and Cd in paddy soils, as well as their mobility, bioavailability, and uptake mechanisms by rice plants. It also examines the current methods and reactors used to lower As and Cd contamination in rice. Iron-modified biochar (Fe-BC) is a promising technology for reducing As and Cd toxicity in rice, improving soil health, and boosting rice's nutritional value. Biochar's physiochemical characteristics are enhanced by the addition of iron, making it a potent adsorbent for As and Cd ions. In conclusion, Fe-BC's biomembrane properties make them an attractive option for remediating As- and Cd-contaminated paddy soils. More efficient mitigation measures, including the use of biomembrane technology, can be developed when sustainable agriculture practices are combined with these technologies.
    MeSH term(s) Humans ; Cadmium/analysis ; Iron/chemistry ; Arsenic/analysis ; Soil/chemistry ; Oryza/chemistry ; Risk Assessment ; Soil Pollutants/analysis
    Chemical Substances Cadmium (00BH33GNGH) ; biochar ; Iron (E1UOL152H7) ; Arsenic (N712M78A8G) ; Soil ; Soil Pollutants
    Language English
    Publishing date 2023-08-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 120089-6
    ISSN 1879-1298 ; 0045-6535 ; 0366-7111
    ISSN (online) 1879-1298
    ISSN 0045-6535 ; 0366-7111
    DOI 10.1016/j.chemosphere.2023.139719
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Greenhouse gas emissions, carbon stocks and wheat productivity following biochar, compost and vermicompost amendments: comparison of non-saline and salt-affected soils.

    Farooqi, Zia Ur Rahman / Qadir, Ayesha Abdul / Khalid, Sehrish / Murtaza, Ghulam / Ashraf, Muhammad Nadeem / Shafeeq-Ur-Rahman / Javed, Wasim / Waqas, Muhammad Ahmed / Xu, Minggang

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 7752

    Abstract: Understanding the impact of greenhouse gas (GHG) emissions and carbon stock is crucial for effective climate change assessment and agroecosystem management. However, little is known about the effects of organic amendments on GHG emissions and dynamic ... ...

    Abstract Understanding the impact of greenhouse gas (GHG) emissions and carbon stock is crucial for effective climate change assessment and agroecosystem management. However, little is known about the effects of organic amendments on GHG emissions and dynamic changes in carbon stocks in salt-affected soils. We conducted a pot experiment with four treatments including control (only fertilizers addition), biochar, vermicompost, and compost on non-saline and salt-affected soils, with the application on a carbon equivalent basis under wheat crop production. Our results revealed that the addition of vermicompost significantly increased soil organic carbon content by 18% in non-saline soil and 52% in salt-affected soil compared to the control leading to improvements in crop productivity i.e., plant dry biomass production by 57% in non-saline soil with vermicompost, while 56% with the same treatment in salt-affected soil. The grain yield was also noted 44 and 50% more with vermicompost treatment in non-saline and salt-affected soil, respectively. Chlorophyll contents were observed maximum with vermicompost in non-saline (24%), and salt-affected soils (22%) with same treatments. Photosynthetic rate (47% and 53%), stomatal conductance (60% and 12%), and relative water contents (38% and 27%) were also noted maximum with the same treatment in non-saline and salt-affected soils, respectively. However, the highest carbon dioxide emissions were observed in vermicompost- and compost-treated soils, leading to an increase in emissions of 46% in non-saline soil and 74% in salt-affected soil compared to the control. The compost treatment resulted in the highest nitrous oxide emissions, with an increase of 57% in non-saline soil and 62% in salt-affected soil compared to the control. In saline and non-saline soils treated with vermicompost, the global warming potential was recorded as 267% and 81% more than the control, respectively. All treatments, except biochar in non-saline soil, showed increased net GHG emissions due to organic amendment application. However, biochar reduced net emissions by 12% in non-saline soil. The application of organic amendments increased soil organic carbon content and crop yield in both non-saline and salt-affected soils. In conclusion, biochar is most effective among all tested organic amendments at increasing soil organic carbon content in both non-saline and salt-affected soils, which could have potential benefits for soil health and crop production.
    MeSH term(s) Soil ; Greenhouse Gases ; Agriculture/methods ; Triticum ; Carbon ; Composting ; Charcoal ; Sodium Chloride ; Sodium Chloride, Dietary ; Nitrous Oxide/analysis ; Carbon Dioxide/analysis
    Chemical Substances Soil ; Greenhouse Gases ; biochar ; Carbon (7440-44-0) ; Charcoal (16291-96-6) ; Sodium Chloride (451W47IQ8X) ; Sodium Chloride, Dietary ; Nitrous Oxide (K50XQU1029) ; Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2024-04-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-56381-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Risk assessment of toxic and hazardous metals in paddy agroecosystem by biochar-for bio-membrane applications

    Irshad, Muhammad Kashif / Zhu, Sihang / Javed, Wasim / Lee, Jong Cheol / Mahmood, Abid / Lee, Sang Soo / Jianying, Shang / Albasher, Gadah / Ali, Atif

    Chemosphere. 2023 Aug. 05, p.139719-

    2023  , Page(s) 139719–

    Abstract: Toxic and carcinogenic metal (loid)s, such arsenic (As) and cadmium (Cd), found in contaminated paddy soils pose a serious danger to environmental sustainability. Their geochemical activities are complex, making it difficult to manage their contamination. ...

    Abstract Toxic and carcinogenic metal (loid)s, such arsenic (As) and cadmium (Cd), found in contaminated paddy soils pose a serious danger to environmental sustainability. Their geochemical activities are complex, making it difficult to manage their contamination. Rice grown in Cd and As-polluted soils ends up in people's bellies, where it can cause cancer, anemia, and the deadly itai sickness. Solving this issue calls for research into eco-friendly and cost-effective remediation technology to lower rice's As and Cd levels. This research delves deeply into the origins of As and Cd in paddy soils, as well as their mobility, bioavailability, and uptake mechanisms by rice plants. It also examines the current methods and reactors used to lower As and Cd contamination in rice. Iron-modified biochar (Fe-BC) is a promising technology for reducing As and Cd toxicity in rice, improving soil health, and boosting rice's nutritional value. Biochar's physiochemical characteristics are enhanced by the addition of iron, making it a potent adsorbent for As and Cd ions. In conclusion, Fe-BC's biomembrane properties make them an attractive option for remediating As- and Cd-contaminated paddy soils. More efficient mitigation measures, including the use of biomembrane technology, can be developed when sustainable agriculture practices are combined with these technologies.
    Keywords adsorbents ; agroecosystems ; anemia ; arsenic ; bioavailability ; biochar ; cadmium ; carcinogenicity ; cell membranes ; cost effectiveness ; iron ; nutritive value ; paddies ; people ; remediation ; rice ; risk assessment ; soil quality ; sustainable agriculture ; Carcinogen ; Environmental sustainability ; Food safety ; Health hazard ; Environmental remediation ; Biomembrane
    Language English
    Dates of publication 2023-0805
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Pre-press version
    ZDB-ID 120089-6
    ISSN 1879-1298 ; 0045-6535 ; 0366-7111
    ISSN (online) 1879-1298
    ISSN 0045-6535 ; 0366-7111
    DOI 10.1016/j.chemosphere.2023.139719
    Database NAL-Catalogue (AGRICOLA)

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  7. Article: Early prediction of left ventricular function improvement in patients with new-onset heart failure and presumed non-ischaemic aetiology.

    Goh, Ze Ming / Javed, Wasim / Shabi, Mubien / Klassen, Joel R L / Saunderson, Christopher E D / Farley, Jonathan / Spurr, Melanie / Dall'Armellina, Erica / Levelt, Eylem / Greenwood, John / Halliday, Brian / Plein, Sven / Swoboda, Peter

    Open heart

    2023  Volume 10, Issue 2

    Abstract: Objectives: To determine baseline characteristics predictive of left ventricular ejection fraction (LVEF) recovery in patients diagnosed with heart failure with reduced ejection fraction (HFrEF) and presumed non-ischaemic aetiology.: Methods: We ... ...

    Abstract Objectives: To determine baseline characteristics predictive of left ventricular ejection fraction (LVEF) recovery in patients diagnosed with heart failure with reduced ejection fraction (HFrEF) and presumed non-ischaemic aetiology.
    Methods: We prospectively recruited patients who were diagnosed with HFrEF (LVEF ≤40%) on echocardiography and subsequently underwent cardiac MRI. Patients were excluded if they had a known history of coronary artery disease (>70% on invasive coronary angiography), myocardial infarction, coronary revascularisation or anginal symptoms. At cardiac MRI assessment, patients were categorised as either ongoing HFrEF or heart failure with improved ejection fraction (HFimpEF, LVEF >40% with ≥10% of absolute improvement). Clinical characteristics were compared between the groups. Logistic regression was performed to identify variables that were associated with LVEF recovery. Optimal cut-offs in QRISK3 score and baseline LVEF for prediction of LVEF recovery were identified through receiver operating characteristic curve analysis.
    Results: A total of 407 patients were diagnosed with HFrEF, and 139 (34%) attained HFimpEF at cardiac MRI assessment (median 63 days, IQR 41-119 days). Mean age of the patients was 63±12 years, and 260 (63.9%) were male. At multivariate logistic regression, both QRISK3 score (HR 0.978; 95% CI 0.963 to 0.993, p=0.004) and baseline LVEF (HR 1.044; 95% CI 1.015 to 1.073, p=0.002) were independent predictors of HFimpEF. Among patients with baseline LVEF ≤25%, only 22 (21.8%) recovered. In patients with baseline LVEF 25-40%, QRISK3 score >18% was associated with lack of recovery (HR 2.75; 95% CI 1.70 to 4.48, p<0.001). Additionally, QRISK3 score was associated with the presence of ischaemic late gadolinium enhancement (HR 1.035; 95% CI 1.018 to 1.053, p<0.001).
    Conclusions: The QRISK3 score helps identify patients with HFrEF with undiagnosed vascular disease. Patients with either a very low baseline LVEF or a high QRISK3 score have less chance of left ventricular recovery and should be prioritised for early cardiac MRI and close monitoring.
    MeSH term(s) Humans ; Male ; Middle Aged ; Aged ; Female ; Ventricular Function, Left ; Stroke Volume ; Heart Failure/diagnostic imaging ; Heart Failure/etiology ; Contrast Media ; Gadolinium
    Chemical Substances Contrast Media ; Gadolinium (AU0V1LM3JT)
    Language English
    Publishing date 2023-08-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2747269-3
    ISSN 2053-3624
    ISSN 2053-3624
    DOI 10.1136/openhrt-2023-002429
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: 4D Flow Cardiac MR in Primary Mitral Regurgitation.

    Gorecka, Miroslawa / Cole, Charlotte / Bissell, Malenka M / Craven, Thomas P / Chew, Pei G / Dobson, Laura E / Brown, Louise A E / Paton, Maria F / Higgins, David M / Thirunavukarasu, Sharmaine / Sharrack, Noor / Javed, Wasim / Kotha, Sindhoora / Giannoudi, Marilena / Procter, Henry / Parent, Martine / Kidambi, Ananth / Swoboda, Peter P / Plein, Sven /
    Levelt, Eylem / Garg, Pankaj / Greenwood, John P

    Journal of magnetic resonance imaging : JMRI

    2024  

    Abstract: Background: Four-dimensional-flow cardiac MR (4DF-MR) offers advantages in primary mitral regurgitation. The relationship between 4DF-MR-derived mitral regurgitant volume (MR-Rvol) and the post-operative left ventricular (LV) reverse remodeling has not ... ...

    Abstract Background: Four-dimensional-flow cardiac MR (4DF-MR) offers advantages in primary mitral regurgitation. The relationship between 4DF-MR-derived mitral regurgitant volume (MR-Rvol) and the post-operative left ventricular (LV) reverse remodeling has not yet been established.
    Purpose: To ascertain if the 4DF-MR-derived MR-Rvol correlates with the LV reverse remodeling in primary mitral regurgitation.
    Study type: Prospective, single-center, two arm, interventional vs. nonintervention observational study.
    Population: Forty-four patients (male N = 30; median age 68 [59-75]) with at least moderate primary mitral regurgitation; either awaiting mitral valve surgery (repair [MVr], replacement [MVR]) or undergoing "watchful waiting" (WW).
    Field strength/sequence: 5 T/Balanced steady-state free precession (bSSFP) sequence/Phase contrast imaging/Multishot echo-planar imaging pulse sequence (five shots).
    Assessment: Patients underwent transthoracic echocardiography (TTE), phase-contrast MR (PMRI), 4DF-MR and 6-minute walk test (6MWT) at baseline, and a follow-up PMRI and 6MWT at 6 months. MR-Rvol was quantified by PMRI, 4DF-MR, and TTE by one observer. The pre-operative MR-Rvol was correlated with the post-operative decrease in the LV end-diastolic volume index (LVEDVi).
    Statistical tests: Included Student t-test/Mann-Whitney test/Fisher's exact test, Bland-Altman plots, linear regression analysis and receiver operating characteristic curves. Statistical significance was defined as P < 0.05.
    Results: While Bland-Altman plots demonstrated similar bias between all the modalities, the limits of agreement were narrower between 4DF-MR and PMRI (bias 15; limits of agreement -36 mL to 65 mL), than between 4DF-MR and TTE (bias -8; limits of agreement -106 mL to 90 mL) and PMRI and TTE (bias -23; limits of agreement -105 mL to 59 mL). Linear regression analysis demonstrated a significant association between the MR-Rvol and the post-operative decrease in the LVEDVi, when the MR-Rvol was quantified by PMRI and 4DF-MR, but not by TTE (P = 0.73). 4DF-MR demonstrated the best diagnostic performance for reduction in the post-operative LVEDVi with the largest area under the curve (4DF-MR 0.83; vs. PMRI 0.78; and TTE 0.51; P = 0.89).
    Data conclusion: This study demonstrates the potential clinical utility of 4DF-MR in the assessment of primary mitral regurgitation.
    Evidence level: 2 TECHNICAL EFFICACY: Stage 5.
    Language English
    Publishing date 2024-02-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1146614-5
    ISSN 1522-2586 ; 1053-1807
    ISSN (online) 1522-2586
    ISSN 1053-1807
    DOI 10.1002/jmri.29284
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  9. Article ; Online: ICT Integration in India

    Javed Wasim / Sunil Kumar Sharma / Jamshed Siddiqui

    International Journal of Computer & Electronics Research, Vol 3, Iss 1, Pp 20-

    Approaches Taken and to be Taken

    2014  Volume 25

    Abstract: In the presence of great social diversity in India, it is difficult to change the social background of students, parents and their economical conditions. Therefore the only option left for us is to provide uniform or standardize teaching learning ... ...

    Abstract In the presence of great social diversity in India, it is difficult to change the social background of students, parents and their economical conditions. Therefore the only option left for us is to provide uniform or standardize teaching learning resources or methods. For high quality education throughout India there must be some nation-wide network, which provides equal quality education to all students, including the student from the rural areas and villages. this paper addresses about higher education impacts on learning by the integration of ICT (Information and Communication Technology) for education activities in India by assessing its readiness, the factors which lead to the successful implementation of the projects and measuring those initiatives’ impact on the educational ecosystem.
    Keywords ICT ; higher education ; ICT technology ; ICT spend ; Higher Education ; GER ; Electronic computers. Computer science ; QA75.5-76.95 ; Instruments and machines ; QA71-90 ; Mathematics ; QA1-939 ; Science ; Q
    Subject code 370
    Language English
    Publishing date 2014-03-01T00:00:00Z
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: An acute increase in Left Atrial volume and left ventricular filling pressure during Adenosine administered myocardial hyperaemia: CMR First-Pass Perfusion Study.

    Garg, Pankaj / Javed, Wasim / Assadi, Hosamadin / Alabed, Samer / Grafton-Clarke, Ciaran / Swift, Andrew J / Williams, Gareth / Al-Mohammad, Abdallah / Sawh, Chris / Vassiliou, Vassilios S / Khanji, Mohammed Y / Ricci, Fabrizio / Greenwood, John P / Plein, Sven / Swoboda, Peter

    BMC cardiovascular disorders

    2023  Volume 23, Issue 1, Page(s) 246

    Abstract: Objective: To investigate whether left atrial (LA) volume and left ventricular filling pressure (LVFP) assessed by cardiovascular magnetic resonance (CMR) change during adenosine delivered myocardial hyperaemia as part of a first-pass stress perfusion ... ...

    Abstract Objective: To investigate whether left atrial (LA) volume and left ventricular filling pressure (LVFP) assessed by cardiovascular magnetic resonance (CMR) change during adenosine delivered myocardial hyperaemia as part of a first-pass stress perfusion study.
    Methods and results: We enrolled 33 patients who had stress CMR. These patients had a baseline four-chamber cine and stress four-chamber cine, which was done at peak myocardial hyperaemic state after administering adenosine. The left and right atria were segmented in the end ventricular diastolic and systolic phases. Short-axis cine stack was segmented for ventricular functional assessment. At peak hyperaemic state, left atrial end ventricular systolic volume just before mitral valve opening increased significantly from baseline in all (91 ± 35ml vs. 81 ± 33ml, P = 0.0002), in males only (99 ± 35ml vs. 88 ± 33ml, P = 0.002) and females only (70 ± 26ml vs. 62 ± 22ml, P = 0.02). The right atrial end ventricular systolic volume increased less significantly from baseline (68 ± 21ml vs. 63 ± 20ml, P = 0.0448). CMR-derived LVFP (equivalent to pulmonary capillary wedge pressure) increased significantly at the peak hyperaemic state in all (15.1 ± 2.9mmHg vs. 14.4 ± 2.8mmHg, P = 0.0002), females only (12.9 ± 2.1mmHg vs. 12.3 ± 1.9mmHg, P = 0.029) and males only (15.9 ± 2.8mmHg vs. 15.2 ± 2.7mmHg, P = 0.002) cohorts.
    Conclusion: Left atrial volume assessment by CMR can measure acute and dynamic changes in preloading conditions on the left ventricle. During adenosine administered first-pass perfusion CMR, left atrial volume and LVFP rise significantly.
    MeSH term(s) Male ; Female ; Humans ; Atrial Fibrillation ; Hyperemia ; Heart Atria/diagnostic imaging ; Magnetic Resonance Imaging ; Perfusion ; Stroke Volume ; Magnetic Resonance Imaging, Cine/methods ; Ventricular Function, Left
    Language English
    Publishing date 2023-05-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2059859-2
    ISSN 1471-2261 ; 1471-2261
    ISSN (online) 1471-2261
    ISSN 1471-2261
    DOI 10.1186/s12872-023-03230-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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