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  1. Article: Dynamic blood flow phantom with negative and positive photoacoustic contrasts.

    Jawad, Hind J / Sarimollaoglu, Mustafa / Biris, Alexandru S / Zharov, Vladimir P

    Biomedical optics express

    2018  Volume 9, Issue 10, Page(s) 4702–4713

    Abstract: ... In ... ...

    Abstract In vivo
    Language English
    Publishing date 2018-09-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2572216-5
    ISSN 2156-7085
    ISSN 2156-7085
    DOI 10.1364/BOE.9.004702
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Towards rainbow portable Cytophone with laser diodes for global disease diagnostics.

    Jawad, Hind J / Yadem, Aayire C / Menyaev, Yulian A / Sarimollaoglu, Mustafa / Armstrong, Jillian N / Watanabe, Fumiya / Biris, Alexandru S / Stumhofer, Jason S / Nedosekin, Dmitry / Suen, James Y / Parikh, Sunil / Zharov, Vladimir P

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 8671

    Abstract: In vivo, Cytophone has demonstrated the capability for the early diagnosis of cancer, infection, and cardiovascular disorders through photoacoustic detection of circulating disease markers directly in the bloodstream with an unprecedented 1,000-fold ... ...

    Abstract In vivo, Cytophone has demonstrated the capability for the early diagnosis of cancer, infection, and cardiovascular disorders through photoacoustic detection of circulating disease markers directly in the bloodstream with an unprecedented 1,000-fold improvement in sensitivity. Nevertheless, a Cytophone with higher specificity and portability is urgently needed. Here, we introduce a novel Cytophone platform that integrates a miniature multispectral laser diode array, time-color coding, and high-speed time-resolved signal processing. Using two-color (808 nm/915 nm) laser diodes, we demonstrated spectral identification of white and red clots, melanoma cells, and hemozoin in malaria-infected erythrocytes against a blood background and artifacts. Data from a Plasmodium yoelii murine model and cultured human P. falciparum were verified in vitro with confocal photothermal and fluorescent microscopy. With these techniques, we detected infected cells within 4 h after invasion, which makes hemozoin promising as a spectrally selective marker at the earliest stages of malaria progression. Along with the findings from our previous application of Cytophone with conventional lasers for the diagnosis of melanoma, bacteremia, sickle anemia, thrombosis, stroke, and abnormal hemoglobin forms, this current finding suggests the potential for the development of a portable rainbow Cytophone with multispectral laser diodes for the identification of these and other diseases.
    MeSH term(s) Animals ; Early Detection of Cancer ; Erythrocytes ; Lasers, Semiconductor ; Malaria/diagnosis ; Melanoma ; Mice ; Plasmodium falciparum ; Plasmodium yoelii
    Language English
    Publishing date 2022-05-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-11452-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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