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  1. Article ; Online: Parkinson's Disease and MicroRNAs: A Duel Between Inhibition and Stimulation of Apoptosis in Neuronal Cells.

    Saadh, Mohamed J / Faisal, Ahmed / Adil, Mohaned / Zabibah, Rahman S / Mamadaliev, Abdurakhmon Mamatkulovich / Jawad, Mahmood Jasem / Alsaikhan, Fahad / Farhood, Bagher

    Molecular neurobiology

    2024  

    Abstract: Parkinson's disease (PD) is one of the most prevalent diseases of central nervous system that is caused by degeneration of the substantia nigra's dopamine-producing neurons through apoptosis. Apoptosis is regulated by initiators' and executioners' ... ...

    Abstract Parkinson's disease (PD) is one of the most prevalent diseases of central nervous system that is caused by degeneration of the substantia nigra's dopamine-producing neurons through apoptosis. Apoptosis is regulated by initiators' and executioners' caspases both in intrinsic and extrinsic pathways, further resulting in neuronal damage. In that context, targeting apoptosis appears as a promising therapeutic approach for treating neurodegenerative diseases. Non-coding RNAs-more especially, microRNAs, or miRNAs-are a promising target for the therapy of neurodegenerative diseases because they are essential for a number of cellular processes, including signaling, apoptosis, cell proliferation, and gene regulation. It is estimated that a substantial portion of coding genes (more than 60%) are regulated by miRNAs. These small regulatory molecules can have wide-reaching consequences on cellular processes like apoptosis, both in terms of intrinsic and extrinsic pathways. Furthermore, it was recommended that a disruption in miRNA expression levels could also result in perturbation of typical apoptosis pathways, which may be a factor in certain diseases like PD. The latest research on miRNAs and their impact on neural cell injury in PD models by regulating the apoptosis pathway is summarized in this review article. Furthermore, the importance of lncRNA/circRNA-miRNA-mRNA network for regulating apoptosis pathways in PD models and treatment is explored. These results can be utilized for developing new strategies in PD treatment.
    Language English
    Publishing date 2024-03-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 645020-9
    ISSN 1559-1182 ; 0893-7648
    ISSN (online) 1559-1182
    ISSN 0893-7648
    DOI 10.1007/s12035-024-04111-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Natural killer cell-mediated immune surveillance in cancer: Role of tumor microenvironment.

    Saadh, Mohamed J / Rasulova, Irodakhon / Khalil, Mohamed / Farahim, Farha / Sârbu, Ioan / Ciongradi, Carmen Iulia / Omar, Thabit Moath / Alhili, Ahmed / Jawad, Mahmood Jasem / Hani, Thamer / Ali, Talat / Lakshmaiya, Natrayan

    Pathology, research and practice

    2024  Volume 254, Page(s) 155120

    Abstract: In the immunological surveillance against cancer, natural killer (NK) cells are essential effectors that help eradicate altered cells. The complex interactions that occur between NK cells and the tumor microenvironment (TME) are thoroughly examined in ... ...

    Abstract In the immunological surveillance against cancer, natural killer (NK) cells are essential effectors that help eradicate altered cells. The complex interactions that occur between NK cells and the tumor microenvironment (TME) are thoroughly examined in this review. The review examines how cytokine stimulation affects NK cell activation, focusing on the dynamic modulation of NK cell function within the TME. It looks at NK cell-related biomarkers such as PD-1/PD-L1, methylation HOXA9 (Homeobox A9), Stroma AReactive Invasion Front Areas (SARIFA), and NKG2A/HLA-E, providing critical information about prognosis and treatment outcomes. The changing landscape of immunotherapies-including checkpoint inhibitors, CAR-NK cells, and cytokine-based interventions-is examined in the context of enhancing NK cell activity. The review highlights the potential pathways for precision medicine going forward, focusing on customized immunotherapies based on unique biomarker profiles and investigating combination medicines to produce more robust anti-tumor responses.
    MeSH term(s) Humans ; Tumor Microenvironment ; Immunologic Surveillance ; Killer Cells, Natural ; Neoplasms/pathology ; Cytokines/metabolism
    Chemical Substances Cytokines
    Language English
    Publishing date 2024-01-11
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 391889-0
    ISSN 1618-0631 ; 0344-0338
    ISSN (online) 1618-0631
    ISSN 0344-0338
    DOI 10.1016/j.prp.2024.155120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Dendritic cell-derived exosomes (Dex): Underlying the role of exosomes derived from diverse DC subtypes in cancer pathogenesis.

    Tuluwengjiang, Gulixian / Rasulova, Irodakhon / Ahmed, Shamim / Kiasari, Bahman Abedi / Sârbu, Ioan / Ciongradi, Carmen Iulia / Omar, Thabit Moath / Hussain, Farah / Jawad, Mahmood Jasem / Castillo-Acobo, Roxana Yolanda / Hani, Thamer / Lakshmaiya, Natrayan / Samaniego, Severo Simeón Calderón

    Pathology, research and practice

    2024  Volume 254, Page(s) 155097

    Abstract: Exosomes are nanometric membrane vesicles of late endosomal origin that are released by most, if not all, cell types as a sophisticated means of intercellular communication. They play an essential role in the movement of materials and information between ...

    Abstract Exosomes are nanometric membrane vesicles of late endosomal origin that are released by most, if not all, cell types as a sophisticated means of intercellular communication. They play an essential role in the movement of materials and information between cells, transport a variety of proteins, lipids, RNA, and other vital data, and over time, they become an essential part of the drug delivery system and a marker for the early detection of many diseases. Dendritic cells have generated interest in cancer immunotherapy due to their ability to initiate and modify effective immune responses. Apart from their cytokine release and direct interactions with other cell types, DCs also emit nanovesicles, such as exosomes, that contribute to their overall activity. Numerous studies have demonstrated exosomes to mediate and regulate immune responses against cancers. Dendritic cell-derived exosomes (DCs) have attracted a lot of attention as immunotherapeutic anti-cancer treatments since it was found that they contain functional MHC-peptide complexes along with a variety of other immune-stimulating components that together enable immune cell-dependent tumor rejection. By enhancing tumor and immunosuppressive immune cells or changing a pro-inflammatory milieu to inhibit tumor advancement, exosomes generated from dendritic cells can initiate and support tumor growth. This study reviewed the immunogenicity of dendritic cell-derived exosomes and strategies for expanding their immunogenic potential as novel and effective anti-cancer therapies.
    MeSH term(s) Humans ; Exosomes/genetics ; Dendritic Cells ; Neoplasms/pathology ; Immunity ; Immunotherapy
    Language English
    Publishing date 2024-01-05
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 391889-0
    ISSN 1618-0631 ; 0344-0338
    ISSN (online) 1618-0631
    ISSN 0344-0338
    DOI 10.1016/j.prp.2024.155097
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: MicroRNA-155 and cancer metastasis: Regulation of invasion, migration, and epithelial-to-mesenchymal transition.

    Moutabian, Hossein / Radi, Usama Kadem / Saleman, Abdulkarem Younis / Adil, Mohaned / Zabibah, Rahman S / Chaitanya, Mv N L / Saadh, Mohamed J / Jawad, Mahmood Jasem / Hazrati, Ebrahi / Bagheri, Hamed / Pal, Rashmi Saxena / Akhavan-Sigari, Reza

    Pathology, research and practice

    2023  Volume 250, Page(s) 154789

    Abstract: Among the leading causes of death globally has been cancer. Nearly 90% of all cancer-related fatalities are attributed to metastasis, which is the growing of additional malignant growths out of the original cancer origin. Therefore, a significant ... ...

    Abstract Among the leading causes of death globally has been cancer. Nearly 90% of all cancer-related fatalities are attributed to metastasis, which is the growing of additional malignant growths out of the original cancer origin. Therefore, a significant clinical need for a deeper comprehension of metastasis exists. Beginning investigations are being made on the function of microRNAs (miRNAs) in the metastatic process. Tiny non-coding RNAs called miRNAs have a crucial part in controlling the spread of cancer. Some miRNAs regulate migration, invasion, colonization, cancer stem cells' properties, the epithelial-mesenchymal transition (EMT), and the microenvironment, among other processes, to either promote or prevent metastasis. One of the most well-conserved and versatile miRNAs, miR-155 is primarily distinguished by overexpression in a variety of illnesses, including malignant tumors. It has been discovered that altered miR-155 expression is connected to a number of physiological and pathological processes, including metastasis. As a result, miR-155-mediated signaling pathways were identified as possible cancer molecular therapy targets. The current research on miR-155, which is important in controlling cancer cells' invasion, and metastasis as well as migration, will be summarized in the current work. The crucial significance of the lncRNA/circRNA-miR-155-mRNA network as a crucial regulator of carcinogenesis and a player in the regulation of signaling pathways or related genes implicated in cancer metastasis will be covered in the final section. These might provide light on the creation of fresh treatment plans for controlling cancer metastasis.
    Language English
    Publishing date 2023-09-12
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 391889-0
    ISSN 1618-0631 ; 0344-0338
    ISSN (online) 1618-0631
    ISSN 0344-0338
    DOI 10.1016/j.prp.2023.154789
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Advances in chitosan-based hydrogels for pharmaceutical and biomedical applications: A comprehensive review.

    Almajidi, Yasir Qasim / Gupta, Jitendra / Sheri, Fatime Satar / Zabibah, Rahman S / Faisal, Ahmed / Ruzibayev, Akbarali / Adil, Mohaned / Saadh, Mohamed J / Jawad, Mahmood Jasem / Alsaikhan, Fahad / Narmani, Asghar / Farhood, Bagher

    International journal of biological macromolecules

    2023  Volume 253, Issue Pt 6, Page(s) 127278

    Abstract: The treatment of diseases, such as cancer, is one of the most significant issues correlated with human beings health. Hydrogels (HGs) prepared from biocompatible and biodegradable materials, especially biopolymers, have been effectively employed for the ... ...

    Abstract The treatment of diseases, such as cancer, is one of the most significant issues correlated with human beings health. Hydrogels (HGs) prepared from biocompatible and biodegradable materials, especially biopolymers, have been effectively employed for the sort of pharmaceutical and biomedical applications, including drug delivery systems, biosensors, and tissue engineering. Chitosan (CS), one of the most abundant bio-polysaccharide derived from chitin, is an efficient biomaterial in the prognosis, diagnosis, and treatment of diseases. CS-based HGs possess some potential advantages, like high values of bioactive encapsulation, efficient drug delivery to a target site, sustained drug release, good biocompatibility and biodegradability, high serum stability, non-immunogenicity, etc., which made them practical and useful for pharmaceutical and biomedical applications. In this review, we summarize recent achievements and advances associated with CS-based HGs for drug delivery, regenerative medicine, disease detection and therapy.
    MeSH term(s) Humans ; Chitosan/therapeutic use ; Hydrogels ; Biocompatible Materials/therapeutic use ; Regenerative Medicine ; Tissue Engineering ; Drug Delivery Systems
    Chemical Substances Chitosan (9012-76-4) ; Hydrogels ; Biocompatible Materials
    Language English
    Publishing date 2023-10-06
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2023.127278
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Recent progress and the emerging role of lncRNAs in cancer drug resistance; focusing on signaling pathways.

    Saadh, Mohamed J / Rasulova, Irodakhon / Almoyad, Muhammad Ali Abdullah / Kiasari, Bahman Abedi / Ali, Ronak Taher / Rasheed, Tariq / Faisal, Ahmed / Hussain, Farah / Jawad, Mahmood Jasem / Hani, Thamer / Sârbu, Ioan / Lakshmaiya, Natrayan / Ciongradi, Carmen Iulia

    Pathology, research and practice

    2023  Volume 253, Page(s) 154999

    Abstract: It is becoming more and more apparent that many of the genetic alterations associated with cancer are located in areas that do not encode proteins. lncRNAs are a class of RNAs that do not code for proteins but play a crucial role in maintaining cell ... ...

    Abstract It is becoming more and more apparent that many of the genetic alterations associated with cancer are located in areas that do not encode proteins. lncRNAs are a class of RNAs that do not code for proteins but play a crucial role in maintaining cell function and regulating various cellular processes. By doing this, they have recently introduced what may be a brand-new and essential layer of biological control. These have more than 200 nucleotides and are linked to several diseases; as a result, they have become potential tools for therapeutic intervention. Emerging technologies suggest the presence of mutations on genomic loci that give rise to lncRNAs rather than proteins in a disease as complex as cancer. These lncRNAs play essential parts in gene regulation, which impacts several cellular homeostasis processes, including proliferation, survival, migration, and genomic stability. The leading cause of death in the world today is cancer. Delays in diagnosis and a lack of standard and efficient treatments are the leading causes of the high death rate. Clinically, surgery is frequently used successfully to remove cancers that have not spread, but it is less successful in treating metastatic cancer, which has a drastically lower chance of survival. Chemotherapeutic drugs are a typical therapy to treat the cancer that has spread to other organs. Drug resistance to chemotherapy, however, presents a significant challenge to achieving positive outcomes and is frequently the cause of treatment failure. A substantial barrier to progress in medical oncology is cancer drug resistance. Resistance can develop clinically either before or after cancer treatment. According to this study, lncRNAs influence drug resistance through several different methods. LncRNAs often impact drug resistance by controlling the expression of a few intermediary regulatory variables rather than by directly affecting drug resistance. Additionally, lncRNAs have a variety of roles in cancer medication resistance. Most lncRNAs induce drug resistance when overexpressed; however, other lncRNAs have inhibitory effects. This study provides an overview of the current understanding of lncRNAs, relevance to cancer, and potential therapeutic applications.
    MeSH term(s) Humans ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/pathology ; Drug Resistance, Neoplasm/genetics ; Signal Transduction/genetics
    Chemical Substances RNA, Long Noncoding
    Language English
    Publishing date 2023-11-29
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 391889-0
    ISSN 1618-0631 ; 0344-0338
    ISSN (online) 1618-0631
    ISSN 0344-0338
    DOI 10.1016/j.prp.2023.154999
    Database MEDical Literature Analysis and Retrieval System OnLINE

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